Chronic Idiopathic PruritusNCT04829578
Hypnosis for Chronic Idiopathic Pruritus
A study testing Hypnosis in people with Chronic Idiopathic Pruritus, run by Centre Hospitalier Universitaire de Nice at 1 site in France.
Trial summary
Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, for which there is no specific treatment. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP. Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- Chronic Idiopathic Pruritus
- What is being tested?
- Hypnosis
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteFrance
- Study dates
- 13 Apr 2021to 31 Oct 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Male or female of at least 18 years at screening
- Diagnosis of chronic (at least 6 wks.) idiopathic pruritus
- Pruritus Numeric Rating Scale > = 4
Who cannot join
- Pruritus caused by a dermatological or a systemic conditions
- Suicidal crisis, moderate, or severe
- Psychosis (schizophrenia, persistent delusional disorder)
- Bipolar disorder, not stabilized or decompensating
- Personality disorder, decompensated
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Prospective Study of Hypnosis for Chronic Idiopathic Pruritus
Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, for which there is no specific treatment. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.
Read the detailed description
Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, with significative impact on quality of life. At present, there is no specific treatment for CIP. Topical steroids are frequently used, with partial efficacy, and adverse effects. Hypnosis is a specific state of conscience. It differs from waking state, sleeping state, relaxation, or meditation. In this state, the person is highly responsive to suggestion. In medicine, hypnosis can be used to engage the internal resources of the person against unpleasant feelings. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.
- Conditions
- Chronic Idiopathic Pruritus
- Being tested
- Hypnosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
HypnosisOther
Chronic idiopathic pruritus is treated by hypnosis
| Study group | Role | What they receive |
|---|---|---|
| Hypnosis | Other | hyspnosis treatment Receives: Other: Hypnosis |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change From Baseline in Pruritus Numeric Rating Scale
Assessment of the intensity of pruritis in Pruritus Numeric Rating Scal; the minimum and maximum values 0 to 10
Measured: Day 84
Secondary outcomes (6)
Change From Baseline in Pruritus Verbal Rating Scale
Assessment of Pruritus by pruritus Verbal Rating Scale; the minimum and maximum values 0 to 4
Measured: Day 84
Change From Baseline in Sleeping Scale
assessment in sleeping scale ; the minimum and maximum values 0 to 10
Measured: Day 84
Change From Baseline in DLQI scale
assessment in DLQI scale; result between 0 to 30
Measured: Day 84
Change From Baseline in HAD scale
assessment in HAD scale; result between 0 to 42
Measured: Day 84
Change From Baseline in usage of topical steroids
assessment in usage of topical steroids
Measured: Day 84
Evaluation of tolerance of hypnosis
assessment of tolerance of hypnosis with report of adverse event
Measured: Day 84
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2021
- Study start13 Apr 2021
- Primary completion13 Sep 2021
- Study completion31 Oct 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Chronic Idiopathic PruritusStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de Nice
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- BAHADORAN PHILIPPE, Principal investigator, Centre Hospitalier Universitaire de Nice
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04829578
- Sponsor's protocol ID
- 20-AOIP-01
- Other IDs
- 2020-A03263-36
- Status last verified
- Mar 2026
- First submitted
- 26 Mar 2021
- Last updated
- 24 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Bertold C, Delaunay P, Cathelineau AC, Chassang M, Passeron T, Bahadoran P. Efficacy of hypnotherapy in chronic idiopathic pruritus: a single-arm prospective pilot study. Br J Dermatol. 2024 Sep 18;191(4):644-645. doi: 10.1093/bjd/ljae244. No abstract available.
PubMed 38913389
Study at a glance
From the registry record, last updated by the sponsor on 24 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective Study of Hypnosis for Chronic Idiopathic Pruritus
- ClinicalTrials.gov ID
- NCT04829578
- Acronym / sponsor ID
- 20-AOIP-01
- Conditions
- Chronic Idiopathic Pruritus
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de NiceUniversity, hospital or other
- Study start
- 13 Apr 2021 (actual)
- Primary completion
- 13 Sep 2021 (actual)
- Study completion
- 31 Oct 2022 (actual)
- First posted
- 2 Apr 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, for which there is no specific treatment. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.
Detailed description
Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, with significative impact on quality of life. At present, there is no specific treatment for CIP. Topical steroids are frequently used, with partial efficacy, and adverse effects. Hypnosis is a specific state of conscience. It differs from waking state, sleeping state, relaxation, or meditation. In this state, the person is highly responsive to suggestion. In medicine, hypnosis can be used to engage the internal resources of the person against unpleasant feelings. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Hypnosis | Other | Other: Hypnosishyspnosis treatment |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Male or female of at least 18 years at screening
- Diagnosis of chronic (at least 6 wks.) idiopathic pruritus
- Pruritus Numeric Rating Scale > = 4
Key exclusion criteria (5 listed)
- Pruritus caused by a dermatological or a systemic conditions
- Suicidal crisis, moderate, or severe
- Psychosis (schizophrenia, persistent delusional disorder)
- Bipolar disorder, not stabilized or decompensating
- Personality disorder, decompensated
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| HypnosisChronic idiopathic pruritus is treated by hypnosis | Other | Hypnosis |
Primary outcome
Change From Baseline in Pruritus Numeric Rating Scale
Time frame: Day 84
Assessment of the intensity of pruritis in Pruritus Numeric Rating Scal; the minimum and maximum values 0 to 10
6 secondary outcomes
Change From Baseline in Pruritus Verbal Rating Scale
Time frame: Day 84
Change From Baseline in Sleeping Scale
Time frame: Day 84
Change From Baseline in DLQI scale
Time frame: Day 84
Change From Baseline in HAD scale
Time frame: Day 84
Change From Baseline in usage of topical steroids
Time frame: Day 84
Evaluation of tolerance of hypnosis
Time frame: Day 84
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Mar 2026.
- Results publication: PubMed 38913389Bertold C, Delaunay P, Cathelineau AC, Chassang M, Passeron T, Bahadoran P. Efficacy of hypnotherapy in chronic idiopathic pruritus: a single-arm prospective pilot study. Br J Dermatol. 2024 Sep 18;191(4):644-645. doi: 10.1093/bjd/ljae244. No abstract available.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
BAHADORAN PHILIPPE principal investigator
Centre Hospitalier Universitaire de Nice
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hypnosis in people with Chronic Idiopathic Pruritus, run by Centre Hospitalier Universitaire de Nice at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change From Baseline in Pruritus Numeric Rating Scale (time frame: Day 84). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04829578, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Mar 2026.