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Healthy VolunteersPhase 1NCT04840927

A Study to Evaluate the Relative Bioavailability of E7386 Following Oral Administration of Targeted Release (TR) Tablets Compared to an E7386 Immediate Release (IR) Tablet in Healthy Adult Participants

A Phase 1 study testing E7386 in people with Healthy Volunteers, run by Eisai Limited at 1 site in United Kingdom.

Withdrawn

Withdrawn. The study stopped before anyone enrolled.

Official record
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Trial summary

The primary purpose of this study is to evaluate the pharmacokinetic (PK) profile of E7386 following oral administration of E7386 enteric coated TR prototype tablet formulations (TR1, TR2 and optional TR3) and to evaluate the relative bioavailability of E7386 TR tablets compared to E7386 IR reference tablet. Read more about this study

Who is it for?
Ages 30 to 55 yearsHealthy volunteers can take part
Conditions the study is for
Healthy Volunteers
What is being tested?
E7386
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
0 participants
Where
1 siteUnited Kingdom
Study dates
9 Apr 2021to 17 May 2023
Phase
Phase 1
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 30 to 55 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Healthy male or female (women of nonchildbearing potential [WNCBP]) aged greater than or equal to (>=) 30 years and less than or equal to (<=) 55 years old inclusive at the time of signing informed consent
  • Body Mass Index (BMI) >=18.0 and <=30.0 kilogram per square meter (kg/m^2) as measured at screening
  • Participants must demonstrate their ability to swallow an empty size 000 capsule (26.1*9.91 millimeter [mm]) at screening and must be willing and able to take the SmartPill^Trade Mark (TM) (27*12 mm)
  • Provide written informed consent
  • Willing and able to comply with all aspects of the protocol
  • Participant must have regular bowel movements (that is, average stool production of >=1 and <=3 stools per day)
  • Must agree to adhere to the contraception requirements

Who cannot join

  • Radiation exposure, including that from the present study, excluding background radiation but including diagnostic x-rays and other medical exposures, exceeding 5 millisieverts (mSv) in the last 12 months or 10 mSv in the last 5 years prior to Day -1 of Period 1. No occupationally exposed worker, as defined in the Ionising Radiation Regulations 2017, shall participate in the study
  • Male participants with pregnant or breastfeeding partners
  • Males who are unwilling to follow the contraception rules of the study for up to 92 days after last dose of the study drug
  • Females who are of childbearing potential or breastfeeding or pregnant at screening or admission/predose (as documented by a positive beta-human chorionic gonadotropin [or human chorionic gonadotropin {hCG} test with a minimum sensitivity of 25 international units per liter {IU/L} or equivalent units of beta-hCG {or hCG}]. A separate baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the first dose of study drug)
  • Clinically significant illness that requires medical treatment within 8 weeks or a clinically significant infection that requires medical treatment within 4 weeks of dosing
  • Evidence of disease that may influence the outcome of the study within 4 weeks of the participants first planned dose; example, disorders of the gastrointestinal (GI) tract especially peptic ulceration, GI bleeding, ulcerative colitis, Crohn's Disease or Irritable Bowel Syndrome, liver, kidney, chronic respiratory system, dermatological system, endocrine system, hematological system, neurological system, or cardiovascular system, or participants who have a congenital abnormality in metabolism. Participants with Gilbert's Syndrome are not allowed
Show all 31Show fewer
  • Any history of GI or abdominal surgery or conditions that may affect absorption, metabolism or excretion of E7386 example, intestinal resections, hepatectomy, nephrectomy, digestive organ resection, fistulas or physiological/mechanical GI obstruction at screening
  • Contraindications to SmartPill^TM use: history of gastric bezoar, swallowing disorders, suspected or known strictures, severe dysphagia to food or pills, Crohn's disease or diverticulitis
  • Presence of non-removable metal objects such as metal plates, screws, etc, in the abdominal region of the body. Very small metal items (example, sterilization clips, hernia repair staples) are permitted
  • Acute diarrhea or constipation in the 7 days before the predicted Day 1. If screening occurs greater than (>) 7 days before the Day 1, this criterion will be determined on Day 1. Diarrhea will be defined as the passage of liquid feces and/or a stool frequency of >3 times per day. Constipation will be defined as a failure to open the bowels more frequently than every other day
  • Any abnormal clinical symptom or organ impairment found by medical history at screening, and physical examinations, clinical laboratory tests and vital signs
  • Hemoglobin, total white cell count, neutrophils or platelets below the lower limit of normal at screening. Alanine aminotransferase (ALT) >1.2*upper limit of normal (ULN) that is, up to 60 IU/L (men) and 42 IU/L (women) at screening
  • A prolonged QT/corrected QT (QTc) interval (corrected QT interval by Fridericia's formula [QTcF] >450 millisecond [msec]) as demonstrated by a repeated electrocardiogram at screening or baseline or a history of risk factors for torsade de pointes (example, heart failure, hypokalemia, family history of long QT Syndrome) or the use of concomitant medications that prolonged the QT/QTc interval
  • Known history of clinically significant drug or food allergies or presently experiencing any seasonal or perennial allergy at screening
  • Positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab) or human immunodeficiency virus (HIV) antibody results at screening
  • History of drug or alcohol dependency or abuse within the 2 years before screening, or those who have a positive urine drug test or breath alcohol test at screening or admission
  • Alcohol consumption in males >21 units per week and females >14 units per week (1 unit=1/2 pint beer, or a 25 milliliter (mL) shot of 40 percent (%) spirit, 1.5 to 2 units=125 mL glass of wine, depending on type)
  • Current smokers and those who have smoked within the last 12 months. A confirmed breath carbon monoxide reading of >10 parts per million (ppm) at screening or admission
  • Current users of e-cigarettes and nicotine replacement products and those who have used these products within the last 12 months
  • Currently enrolled in another clinical study or used any investigational drug or device within the 90 days prior to Day 1 or Period 1
  • Participants who are, or are immediate family members of, a study site or sponsor employee
  • Participants who do not have suitable veins for multiple venipunctures/cannulation as assessed by the investigator or delegate at screening
  • Receipt of blood products within 4 weeks of dosing, or donation of blood or plasma within the previous 3 months or loss of >400 mL of blood
  • Use of recreational drugs is prohibited
  • Use of any prescription drugs/herbal remedies or over-the-counter medications within 4 weeks or 14 days, respectively, before dosing (other than occasional use of up to 4 gram of paracetamol per day)
  • Any history of or concomitant medical condition that in the opinion of the investigator would compromise the participants ability to safely complete the study
  • Any lifetime history of psychiatric disease (including but not limited to depression or other mood disorders, bipolar disorder, psychotic disorders, including schizophrenia, panic attacks, anxiety disorders [if ever treated with medication]). The absence of a history of psychiatric disease should be documented by a checklist in the electronic case report form
  • Any lifetime suicidal behavior or ideation (per the Suicidal Behavior section of the Columbia-Suicide Severity Rating Scale [C-SSRS]) at screening
  • History or ongoing psychiatric disorder or psychiatric symptoms as evaluated by a physician at screening. Whenever possible, medical records should be reviewed to determine any history of psychiatric disorder or use of medications to treat psychiatric disorders
  • Evidence of current corona virus disease (COVID) 19 infection or ongoing/unrecovered sequelae COVID-19
  • Failure to satisfy the investigator of fitness to participate for any other reason

Trial locations and contacts

1 site in 1 country.

United Kingdom1 site

  • Quotient Sciences

    Nottingham

Other trials in United Kingdom

About this study

Official title: An Open-Label, Single Center, Randomized, Pharmacoscintigraphic Study to Evaluate the Relative Bioavailability of E7386 Following Oral Administration of Targeted Release Tablets Compared to an E7386 Immediate Release Tablet in Healthy Adult Subjects

The primary purpose of this study is to evaluate the pharmacokinetic (PK) profile of E7386 following oral administration of E7386 enteric coated TR prototype tablet formulations (TR1, TR2 and optional TR3) and to evaluate the relative bioavailability of E7386 TR tablets compared to E7386 IR reference tablet.

Being tested
E7386
Keywords
Relative Bioavailability, Pharmacoscintigraphic, Pharmacokinetic, E7386

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • E7386Drug

    Regimen A: 40 milligram (mg) IR Oral Tablet.

Study groups in NCT04840927
Study groupRoleWhat they receive
Cohort 1: E7386 40 mgExperimentalParticipants will be randomized to one of the 3 treatment sequences: Treatment sequence 1: Participants will receive Regimen A on Day 1 of treatment period 1 then Regimen B on Day 1 of treatment period 2 then Regimen C on Day 1 of treatment period 3 and an optional Regimen D on Day 1 of an optional treatment period 4. Treatment sequence 2: Participants will receive Regimen B on Day 1 of treatment period 1 then Regimen C on Day 1 of treatment period 2 then Regimen A on Day 1 of treatment period 3 and an optional Regimen D on Day 1 of an optional treatment period 4. Treatment sequence 3: Participants will receive Regimen C on Day 1 of treatment period 1 then Regimen A on Day 1 of treatment period 2 then Regimen B on Day 1 of treatment period 3 and an optional Regimen D on Day 1 of an optional treatment period 4. A maximum wash out period of 10 days will be maintained between treatment periods 1, 2 and 3.
Receives: Drug: E7386
Cohort 2: E7386 40 mgExperimentalParticipants will be randomized to one of the 3 treatment sequences: Treatment sequence 4: Participants will receive Regimen C on Day 1 of treatment period 1 then Regimen B on Day 1 of treatment period 2 then Regimen A on Day 1 of treatment period 3 and an optional Regimen D on Day 1 of an optional treatment period 4. Treatment sequence 5: Participants will receive Regimen A on Day 1 of treatment period 1 then Regimen C on Day 1 of treatment period 2 then Regimen B on Day 1 of treatment period 3 and an optional Regimen D on Day 1 of an optional treatment period 4. Treatment sequence 6: Participants will receive Regimen B on Day 1 of treatment period 1 then Regimen A on Day 1 of treatment period 2 then Regimen C on Day 1 of treatment period 3 and an optional Regimen D on Day 1 of an optional treatment period 4. A maximum wash out period of 10 days will be maintained between treatment periods 1, 2 and 3.
Receives: Drug: E7386

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Cmax: Maximum Observed Plasma Concentration for E7386

    Measured: Day 1: 0-48 hours post-dose

  2. Tmax: Time to Reach the Maximum Plasma Concentration (Cmax) for E7386

    Measured: Day 1: 0-48 hours post-dose

  3. AUC (0-t): Area Under the Concentration-time Curve From Zero (Pre-dose) to Time of Last Quantifiable Concentration for E7386

    Measured: Day 1: 0-48 hours post-dose

  4. AUC (0-inf): Area Under the Concentration-time Curve From Zero (Pre-dose) Extrapolated to Infinite Time for E7386

    Measured: Day 1: 0-48 hours post-dose

  5. T1/2: Terminal Elimination Phase Half-life for E7386

    Measured: Day 1: 0-48 hours post-dose

  6. CL/F: Apparent Total Clearance Following Extravascular Administration for E7386

    Measured: Day 1: 0-48 hours post-dose

  7. Vz/F: Apparent Volume of Distribution at Terminal Phase for E7386

    Measured: Day 1: 0-48 hours post-dose

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted12 Apr 2021
  2. Study start9 Apr 2021
  3. Primary completion17 May 2023
  4. Study completion17 May 2023

Why it stopped: Delay in availability of IMP

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1
Primary purpose
Other
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
0 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT04840927
Sponsor's protocol ID
E7386-E044-002
Other IDs
QSC203335, 2020-005638-13
Status last verified
Nov 2023
First submitted
8 Apr 2021
Last updated
24 Nov 2023
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: Eisai's data sharing commitment and further information on how to request data can be found on our website http://eisaiclinicaltrials.com/.

Questions about this trial

What is this clinical trial studying?

A Phase 1 study testing E7386 in people with Healthy Volunteers, run by Eisai Limited at 1 site in United Kingdom.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 31 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: withdrawn, as of the sponsor's last update on 24 Nov 2023. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study was withdrawn before enrolling participants, so there are no results.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Cmax: Maximum Observed Plasma Concentration for E7386 (time frame: Day 1: 0-48 hours post-dose). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT04840927.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Nov 2023.

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