HealthyNCT04922684
Can Mimic Emotional Expression Training Help Improve Emotion Processing
A study testing Mimic facial expressions in people with Healthy, run by University of Electronic Science and Technology of China at 1 site in China.
Trial summary
The main aim of the present study is to investigate whether mimicking emotional expressions training via FaceReader software can improve emotional processing and recognition in healthy subjects, especially individuals with hityer autistic traits. Read more about this study
- Who is it for?
- Ages 17 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Mimic facial expressions
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteChina
- Study dates
- 30 Mar 2020to 30 Mar 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 17 to 30 years
- Men only
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Healthy subjects without past or current psychiatric or neurological disorders
Who cannot join
- history of head injury;
- pregnant, menstruating, taking oral contraceptives;
- medical or psychiatric illness.
Trial locations and contacts
1 site in 1 country.
China1 site, 1 recruiting
- Recruiting
University of Electronic Science and Technology of China
Chengdu, Sichuan, 611731
About this study
The main aim of the present study is to investigate whether mimicking emotional expressions training via FaceReader software can improve emotional processing and recognition in healthy subjects, especially individuals with hityer autistic traits.
Read the detailed description
Some mood and trait questionnaires such as Autism Spectrum Quotient, Social Responsiveness Scale,State-Trait Anxiety Inventory,Beck's Depression Inventory etc are asked to complete. 90 healthy male subjects will receive 16 times (4 times a week , 4 weeks) of mimicking emotional expressions training via Facereader. During training, 3 times of fNIRS (t2,t9 and t16) were recorded simultaneously. fMRI scanning, including emotion processing and emotion recognition tasks, 7 minutes resting data, ans DTI data will be collected before and after the training. After fMRI scaning, behavioral ratings (i.e. intensity and valence) and eye-tracking data will be collected.
- Conditions
- Healthy
- Being tested
- Mimic facial expressions
- Keywords
- Mimic facial expression training, Autistic trait, Mirror neuron system, Emotion processing, Emotion recognition
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mimic facial expressionsBehavioural
16 times (4 times a week, last 4 weeks) of mimicking facial expressions.
| Study group | Role | What they receive |
|---|---|---|
| Lower austic sub-group | Active comparator | 16 times of mimicking emotional expressions Receives: Behavioral: Mimic facial expressions |
| Higher austic sub-group | Experimental | 16 times of mimicking emotional expressions Receives: Behavioral: Mimic facial expressions |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intensity score of subjects' mimic facial emotions
The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into intensity, ranging from 0 to 1.
Measured: an average of 4 weeks
Valence score of subjects' mimic facial emotions
The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into valence, ranging from -1 to 1.
Measured: an average of 4 weeks
Arousal score of subjects' mimic facial emotions
The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into arousal, ranging from 0 to 1.
Measured: an average of 4 weeks
Task-dependent functional MRI data
Neural activities of brain regions, notably mirror neuron system will be collected for analysis when the subjects participate in a face processing and emotion recognition task in a MRI scanner before and after the 4-week training session.
Measured: an average of 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2021
- Study start30 Mar 2020
- Primary completion30 Dec 2021 (estimated)
- Study completion30 Mar 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Electronic Science and Technology of China
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Keith Kendrick, University of Electronic Science and Technology of China
- Investigators
- Weihua Zhao, Dr., Study chair, University of Electronic Science and Technology of China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04922684
- Sponsor's protocol ID
- UESTC-neuSCAN-66
- Status last verified
- Jun 2021
- First submitted
- 14 May 2021
- Last updated
- 11 Jun 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Can Mimic Emotional Expression Training Help Improve Emotion Processing
- ClinicalTrials.gov ID
- NCT04922684
- Acronym / sponsor ID
- UESTC-neuSCAN-66
- Conditions
- Healthy
- Keywords
- Mimic facial expression training, Autistic trait, Mirror neuron system, Emotion processing, Emotion recognition
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- University of Electronic Science and Technology of ChinaUniversity, hospital or other
- Study start
- 30 Mar 2020 (actual)
- Primary completion
- 30 Dec 2021 (estimated)
- Study completion
- 30 Mar 2022 (estimated)
- First posted
- 11 Jun 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The main aim of the present study is to investigate whether mimicking emotional expressions training via FaceReader software can improve emotional processing and recognition in healthy subjects, especially individuals with hityer autistic traits.
Detailed description
Some mood and trait questionnaires such as Autism Spectrum Quotient, Social Responsiveness Scale,State-Trait Anxiety Inventory,Beck's Depression Inventory etc are asked to complete. 90 healthy male subjects will receive 16 times (4 times a week , 4 weeks) of mimicking emotional expressions training via Facereader. During training, 3 times of fNIRS (t2,t9 and t16) were recorded simultaneously. fMRI scanning, including emotion processing and emotion recognition tasks, 7 minutes resting data, ans DTI data will be collected before and after the training. After fMRI scaning, behavioral ratings (i.e. intensity and valence) and eye-tracking data will be collected.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Lower austic sub-group | Active comparator | Behavioral: Mimic facial expressions16 times of mimicking emotional expressions |
| Higher austic sub-group | Experimental | Behavioral: Mimic facial expressions16 times of mimicking emotional expressions |
Who may qualify
- Ages
- 17 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (1 listed)
- Healthy subjects without past or current psychiatric or neurological disorders
Key exclusion criteria (3 listed)
- history of head injury;
- pregnant, menstruating, taking oral contraceptives;
- medical or psychiatric illness.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mimic facial expressions16 times (4 times a week, last 4 weeks) of mimicking facial expressions. | Behavioural | Higher austic sub-group, Lower austic sub-group |
Primary outcome
Intensity score of subjects' mimic facial emotions
Time frame: an average of 4 weeks
The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into intensity, ranging from 0 to 1.
Valence score of subjects' mimic facial emotions
Time frame: an average of 4 weeks
The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into valence, ranging from -1 to 1.
Arousal score of subjects' mimic facial emotions
Time frame: an average of 4 weeks
The measurement was monitored and analyzed by FaceReader software before and after the 4-week training session and subjects' facial expressions of mimicking certain emotions will be calculated into arousal, ranging from 0 to 1.
Task-dependent functional MRI data
Time frame: an average of 4 weeks
Neural activities of brain regions, notably mirror neuron system will be collected for analysis when the subjects participate in a face processing and emotion recognition task in a MRI scanner before and after the 4-week training session.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2021.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Weihua Zhao, Dr. study chair
University of Electronic Science and Technology of China
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mimic facial expressions in people with Healthy, run by University of Electronic Science and Technology of China at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 11 Jun 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Keith Kendrick, Dr. (86-28-61830811, k.kendrick.uestc@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intensity score of subjects' mimic facial emotions (time frame: an average of 4 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2021.