Muscle SorenessRECOFASTNCT04946981
Recovery and Muscle Function After Supplementation With Turmeric
A study testing Turmipure Gold® in people with Muscle Soreness and Pain, run by Givaudan France Naturals at 1 site in Ireland.
Trial summary
The objective of the study is to test the capacity of a five-day supplementation of Turmipure Gold® to improve exercise-induced muscle pain and function recovery in moderately active adults after exercise-induced muscle damage Read more about this study
- Who is it for?
- Ages 25 to 45 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Soreness, Pain, Muscle Damage
- What is being tested?
- Turmipure Gold®
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 45 participants
- Where
- 1 siteIreland
- Study dates
- 12 Jul 2021to 1 Apr 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 45 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy free-living males
- Age: 25-45 years old
- Have a BMI between 18.5 and 28 kg/m²
- Moderately active with running 15-20 km per week
- With 1 to 4h of training per week, with maximum 1h of lower body heavy-load or resistance training (e.g., Hill running or hiking, HIT exercise, Squats, Lunges, Leg-press, Bench steps, etc.)
- Consent to the study protocol and to comply with study product
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- Willing to limit caffeine, smoking, and alcohol consumption during the entire study period with no more than 5 cigarettes per day and 2 drinks. Also, alcohol consumption will not be allowed 24hours prior to exercise-induced muscular damage
- Willing to refrain from training for 3 days before the first test, 5 days before each damage-inducing exercise and during each supplementation phase, including active recovery exercises such as swimming, cycling at low intensity, unusual distance walking (however such should be encouraged during the 14 days wash-out)
- Willing to refrain the use of anti-inflammatory/pain reliever drugs such as paracetamol, NSAIDs, etc., during each supplementation phase, from 24 hours prior to 72 hours following the exercise-induced muscular damage
- Willing to refrain from 'recovery' treatments over the 72 hours following the damage inducing exercise such as:
- Hydrotherapy - cold water immersion, hot water immersion, or contrast therapy (as well as Jacuzzis, Steam baths, or Saunas)
- Massage - self, foam rolling, etc.
- Stretching
- Compression garments
- Topical applications - Tiger Balm, Deep Heat etc.
Who cannot join
- Participants with any indicators of arthritis, joint disorders chronic pain syndrome, muscle disorder diseases (e.g., fibromyalgia, etc.)
- History of surgery or significant injury in joints or in the lower limb in the last six months prior to study enrolment, or an anticipated need for surgical or invasive procedure that will be performed during the study
- Using omega-3-fatty acid, probiotic supplements, vitamins, minerals, or any dietary supplements (including botanicals), especially to maintain joint health 4 weeks prior to screening and during the entire study. Potential supplements include but are not limited to Beta-alanine, Creatine, HMB, Carnosine, Taurine, androstenedione, DHEA, Whey protein, or a pre-workout supplement
- Following any specific diet such as high-protein, vegetarian, vegan, etc
- Taking any drugs such as antibiotics, laxatives, or immunosuppressant drugs
- History of glucocorticoid injection or hyaluronic acid injections within 3 months prior to enrolment
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- Participants near or in the peak of training for an athletic race (half or marathon, cycling tour or triathlon)
- History or current significant cardiovascular, pulmonary, renal, liver, digestive (including an inflammatory bowel disease), infectious disease, systemic disease, immune disorder, or metabolic/endocrine disorders (including diabetes mellitus) or other disease that would preclude supplement ingestion and/or assessment of study objectives, including uncontrolled hypertension, uncontrolled thyroidism or lipidaemia that is not on stable medication for at least 3 months.
- Participant has any concurrent medical or psychiatric condition that, in the opinion of the Investigator, would compromise his/her ability to comply with the study requirements
- Participant with history of drug and / or alcohol abuse at the time of enrolment
- Any previous or current cancer diagnosis (including a benign or malign tumour of intestine or colon)
- Current illnesses which could interfere with the study (e.g., prolonged severe diarrhoea, regurgitation/severe, difficulty swallowing)
- Known allergy to components of the test product or sensitivity to herbal products or with a medical history of food allergies
- Participants taking any anticoagulant or heparin treatment (including aspirin)
- Clinically significant abnormal laboratory results at screening
- Participant currently involved in any other clinical trial or having participated in a trial within 90 days prior to randomisation.
- Any other condition which in the Investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject.
- History of non-compliance with medical treatments or recommendations.
- Participants who are required to perform squatting motions or descend a lot of stairs in their daily work activities, which may be painful following the Exercise Induced Muscle Damage.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Placebo Controlled, Randomised, Crossover Clinical Trial to Evaluate the Effect of Turmipure Gold® in Muscle Pain and Function Recovery in Moderately Active Adults
The objective of the study is to test the capacity of a five-day supplementation of Turmipure Gold® to improve exercise-induced muscle pain and function recovery in moderately active adults after exercise-induced muscle damage
- Conditions
- Muscle Soreness, Pain, Muscle Damage
- Being tested
- Turmipure Gold®, Placebo
- Keywords
- Turmeric, Curcuminoids, Sport performance & recovery
- Medical subject headings
- Myalgia, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Turmipure Gold®Dietary supplement
TPG: Turmipure GOLD® - 1 capsule per day - as prescribed
PlaceboDietary supplement
Placebo: colored acacia gum - 1 capsule per day - as prescribed
| Study group | Role | What they receive |
|---|---|---|
| Randomized Crossover_Sequence 1 | Other | Participants who meet the eligibility criteria will be randomized and will receive first the experimental product Turmipure GOLD® during the first study phase and then the placebo control during the second study phase. Both study phases are separated by a washout period of minimum 14 days. Receives: Dietary Supplement: Turmipure Gold®; Dietary Supplement: Placebo |
| Randomized Crossover_Sequence 2 | Other | Participants who meet the eligibility criteria will be randomized and will receive first the placebo control during the first study phase and then the experimental product Turmipure GOLD® during the second study phase. Both study phases are separated by a washout period of minimum 14 days. Receives: Dietary Supplement: Turmipure Gold®; Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change on Perceived Muscle Soreness
Perceived Muscle Soreness in quadriceps during squatting activities assessed by VAS (0-100 mm, after two tries)
Measured: 72 hours
Secondary outcomes (7)
Change on Muscle damage
Muscle damage assessed by circulating levels of Creatine kinase in blood samples
Measured: 72 hours
Change on Isometric Muscle function recovery
Muscle function recovery assessed on quadriceps muscular function during isometric contractions recording the torque (Nm) using Biodex
Measured: 72 hours
Change on Isokinetic Muscle function recovery
Muscle function recovery assessed on quadriceps muscular function during isokinetic extensions recording the torque (Nm) using Biodex
Measured: 72 hours
Change on Muscle power recovery
Muscle power recovery assessed by Peak power (Watts) using vertical jump tests (best performance and average of 3 tries)
Measured: 72 hours
Change on Muscle ROM recovery
Muscle ROM recovery assessed by Range Of Movement using a goniometer (knee flexion)
Measured: 72 hours
Change on Perceived wellness and well-being
Perceived wellness and well-being is assessed by a psychometric test evaluating fatigue, sleep quality, general muscle soreness, stress, and mood (0-25, 25 indicating best feelings of wellness and well-being)
Measured: 72 hours
Change on Perceived exertion during exercise
Perceived exertion through breathing difficulty during exercise assessed by the Borg Rating of Perceived Exertion (0-10, 10 indicating maximal difficulty)
Measured: 30 min
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2021
- Study start12 Jul 2021
- Primary completion1 Apr 2022
- Study completion1 Apr 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Muscle SorenessStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Givaudan France Naturals
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Atlantia Food Clinical Trials
- Responsible party
- Sponsor
- Investigators
- Timothy Dinan, Professor, Principal investigator, Atlantia Food Clinical TrialsTrevor Wood, PhD, Principal investigator, Sport Physiologist University College Cork
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04946981
- Sponsor's protocol ID
- AFCRO-128
- Acronym
- RECOFAST
- Status last verified
- Dec 2022
- First submitted
- 21 Jun 2021
- Last updated
- 12 Dec 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Schonenberger KA, Laval J, Woods T, Truillet R, Naranjo-Modad S, Mettler S, Fanca-Berthon P. A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults. J Int Soc Sports Nutr. 2025 Dec;22(1):2568048. doi: 10.1080/15502783.2025.2568048. Epub 2025 Oct 3.
PubMed 41040018
Study at a glance
From the registry record, last updated by the sponsor on 12 Dec 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Placebo Controlled, Randomised, Crossover Clinical Trial to Evaluate the Effect of Turmipure Gold® in Muscle Pain and Function Recovery in Moderately Active Adults
- ClinicalTrials.gov ID
- NCT04946981
- Acronym / sponsor ID
- RECOFAST / AFCRO-128
- Conditions
- Muscle Soreness, Pain, Muscle Damage
- Keywords
- Turmeric, Curcuminoids, Sport performance & recovery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Givaudan France NaturalsIndustry (pharma, biotech, devices)
- Collaborators
- Atlantia Food Clinical Trials
- Study start
- 12 Jul 2021 (actual)
- Primary completion
- 1 Apr 2022 (actual)
- Study completion
- 1 Apr 2022 (actual)
- First posted
- 1 Jul 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of the study is to test the capacity of a five-day supplementation of Turmipure Gold® to improve exercise-induced muscle pain and function recovery in moderately active adults after exercise-induced muscle damage
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Randomized Crossover_Sequence 1 | Other | Dietary Supplement: Turmipure Gold®, Dietary Supplement: PlaceboParticipants who meet the eligibility criteria will be randomized and will receive first the experimental product Turmipure GOLD® during the first study phase and then the placebo control during the second study phase. Both study phases are separated by a washout period of minimum 14 days. |
| Randomized Crossover_Sequence 2 | Other | Dietary Supplement: Turmipure Gold®, Dietary Supplement: PlaceboParticipants who meet the eligibility criteria will be randomized and will receive first the placebo control during the first study phase and then the experimental product Turmipure GOLD® during the second study phase. Both study phases are separated by a washout period of minimum 14 days. |
Who may qualify
- Ages
- 25 to 45 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (15 listed)
- Healthy free-living males
- Age: 25-45 years old
- Have a BMI between 18.5 and 28 kg/m²
- Moderately active with running 15-20 km per week
- With 1 to 4h of training per week, with maximum 1h of lower body heavy-load or resistance training (e.g., Hill running or hiking, HIT exercise, Squats, Lunges, Leg-press, Bench steps, etc.)
Key exclusion criteria (19 listed)
- Participants with any indicators of arthritis, joint disorders chronic pain syndrome, muscle disorder diseases (e.g., fibromyalgia, etc.)
- History of surgery or significant injury in joints or in the lower limb in the last six months prior to study enrolment, or an anticipated need for surgical or invasive procedure that will be performed during the study
- Using omega-3-fatty acid, probiotic supplements, vitamins, minerals, or any dietary supplements (including botanicals), especially to maintain joint health 4 weeks prior to screening and during the entire study. Potential supplements include but are not limited to Beta-alanine, Creatine, HMB, Carnosine, Taurine, androstenedione, DHEA, Whey protein, or a pre-workout supplement
- Following any specific diet such as high-protein, vegetarian, vegan, etc
- Taking any drugs such as antibiotics, laxatives, or immunosuppressant drugs
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Turmipure Gold®TPG: Turmipure GOLD® - 1 capsule per day - as prescribed | Dietary supplement | Randomized Crossover_Sequence 1, Randomized Crossover_Sequence 2 |
| PlaceboPlacebo: colored acacia gum - 1 capsule per day - as prescribed | Dietary supplement | Randomized Crossover_Sequence 1, Randomized Crossover_Sequence 2 |
Primary outcome
Change on Perceived Muscle Soreness
Time frame: 72 hours
Perceived Muscle Soreness in quadriceps during squatting activities assessed by VAS (0-100 mm, after two tries)
7 secondary outcomes
Change on Muscle damage
Time frame: 72 hours
Change on Isometric Muscle function recovery
Time frame: 72 hours
Change on Isokinetic Muscle function recovery
Time frame: 72 hours
Change on Muscle power recovery
Time frame: 72 hours
Change on Muscle ROM recovery
Time frame: 72 hours
Change on Perceived wellness and well-being
Time frame: 72 hours
Change on Perceived exertion during exercise
Time frame: 30 min
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Dec 2022.
- Derived from this study: PubMed 41040018Schonenberger KA, Laval J, Woods T, Truillet R, Naranjo-Modad S, Mettler S, Fanca-Berthon P. A randomized, placebo-controlled, crossover clinical trial to evaluate the effect of a turmeric formulation on muscle soreness and function recovery in moderately active adults. J Int Soc Sports Nutr. 2025 Dec;22(1):2568048. doi: 10.1080/15502783.2025.2568048. Epub 2025 Oct 3.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Timothy Dinan, Professor principal investigator
Atlantia Food Clinical Trials
Trevor Wood, PhD principal investigator
Sport Physiologist University College Cork
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Turmipure Gold® in people with Muscle Soreness and Pain, run by Givaudan France Naturals at 1 site in Ireland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 15 inclusion and 19 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Dec 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Ireland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change on Perceived Muscle Soreness (time frame: 72 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04946981, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Dec 2022.