CancerCCPWNCT04947098
Prevent Cancer- Greenville
An observational study of Cancer and High-Risk Cancer, run by Prisma Health-Upstate at 1 site in United States.
Trial summary
Prevent Cancer-Greenville was created to provide individuals with the opportunity to have their risk of developing cancer studied. Some individuals may be at a higher risk due to their personal lifestyle, family history and/or exposures. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cancer, High-Risk Cancer
- How many people
- 1,000 participants
- Where
- 1 siteUnited States
- Study dates
- 8 Nov 2018to 8 Nov 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Individuals 18 years or older
Who may be able to join
- 18 years or older
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Prisma Health-Upstate
Greenville, South Carolina, 29605
Patricia Wilson, MSN Ed. OCN ONNCG, 864-455-4897, CCPW@prismahealth.org
Joe Stephenson, MD
About this study
Official title: Prevent Cancer-Greenville: A Center for Cancer Prevention and Wellness Research Project
Prevent Cancer-Greenville was created to provide individuals with the opportunity to have their risk of developing cancer studied. Some individuals may be at a higher risk due to their personal lifestyle, family history and/or exposures. If subjects are found to be at high risk for developing a disease, they will be sent to a healthcare provider for further care.
Read the detailed description
Participants' personal history, lifestyle behaviors and blood, urine, and cheek swab specimens will be used to detect changes or trends that might put them at risk for developing cancer. Some individuals may be at an above average risk of cancer due to lifestyle, family background, personal genetic makeup, or environmental exposures. This will be determined by a process called risk stratification. Risk stratification involves looking at all health-related aspects of a person, determining their individualized risk through screening, and educating them on measures to reduce potential for disease. Participants will complete a yearly health assessment which includes measurements for nutrition, activity, individual risk factors and body composition, including weight height and a special scale which measures fluid and fat.
- Conditions
- Cancer, High-Risk Cancer
- Medical subject headings
- Neoplasms
What is being measured
The primary outcome is the main question the study is designed to answer.
Assess changes in nutrition by nutrition questionnaire
Nutrition will be assessed yearly by a questionnaire based on nutrition recommendations from the American Institute for Cancer Research and the U.S. Department of Health and Human Services.
Measured: Yearly follow up for 10 years
Assess changes in physical activity by physical activity questionnaire
Physical activity will be assessed yearly a questionnaire based on physical activity recommendations from the U.S. Department of Health and Human Services.
Measured: Yearly follow up for 10 years
Assess changes in smoking habits
Participants will be educated on healthy lifestyle habits and smoking habits will be assessed yearly.
Measured: Yearly follow up for 10 years
Assess changes in alcohol use
Participants will be educated on healthy lifestyle habits and alcohol use will be assessed yearly.
Measured: Yearly follow up for 10 years
Assess hereditary risk through family history review
Each participant's family history will be reviewed to make recommendations for screening or genetic testing based on National Comprehensive Cancer Network guidelines.
Measured: Yearly follow up for 10 years
Assess lifetime breast cancer risk through the Tyrer-Cuzick version 8 breast risk evaluation tool
Participants' breast cancer risk will be assessed using the Tyrer-Cuzick breast cancer risk model. Participants will be referred to appropriate clinics if lifetime risk is greater than 20 percent.
Measured: Yearly follow up for 10 years
Assess 5- year breast cancer risk through the GAIL breast risk evaluation tool
Participants' breast cancer risk will be assessed using the National Cancer Institute's GAIL model. Participants will be referred to appropriate clinics if GAIL 5 year risk is greater than 1.7 percent.
Measured: Yearly follow up for 10 years
Early detection of malignancies through screening
Participants will be educated on screening recommendations by the American Cancer Society. Malignancies will be recorded yearly if found by recommended screenings.
Measured: Yearly follow up for 10 years
Assess changes in fat mass by SOZO measurements
Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure fat mass.
Measured: Yearly follow up for 10 years
Assess changes in muscle mass by SOZO measurements
Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure muscle mass.
Measured: Yearly follow up for 10 years
Secondary outcomes (1)
Assess changes in quality of life by the 5-level EuroQol-5D version (EQ-5D-5L) questionnaire
Quality of life will be assessed yearly by the EQ-5D-5L questionnaire. Participants' will self-report their health on a scale numbered 0-100. 100 means the best health you can imagine and 0 means the worst health you can imagine.
Measured: Yearly follow up for 10 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2021
- Study start8 Nov 2018
- Primary completion8 Nov 2028 (estimated)
- Study completion8 Nov 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Ecologic or community
- Time perspective
- Prospective
- Enrolment
- 1,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Prisma Health-Upstate
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Joe Stephenson, MD, Principal investigator, Prisma Health-Upstate
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04947098
- Sponsor's protocol ID
- Pro00077309
- Acronym
- CCPW
- Status last verified
- Feb 2026
- First submitted
- 29 Apr 2021
- Last updated
- 17 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified data sets will be available upon requests following institutional approval.
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prevent Cancer-Greenville: A Center for Cancer Prevention and Wellness Research Project
- ClinicalTrials.gov ID
- NCT04947098
- Acronym / sponsor ID
- CCPW / Pro00077309
- Conditions
- Cancer, High-Risk Cancer
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 1,000 participants (estimated)
- Lead sponsor
- Prisma Health-UpstateUniversity, hospital or other
- Study start
- 8 Nov 2018 (actual)
- Primary completion
- 8 Nov 2028 (estimated)
- Study completion
- 8 Nov 2029 (estimated)
- First posted
- 1 Jul 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Prevent Cancer-Greenville was created to provide individuals with the opportunity to have their risk of developing cancer studied. Some individuals may be at a higher risk due to their personal lifestyle, family history and/or exposures. If subjects are found to be at high risk for developing a disease, they will be sent to a healthcare provider for further care.
Detailed description
Participants' personal history, lifestyle behaviors and blood, urine, and cheek swab specimens will be used to detect changes or trends that might put them at risk for developing cancer. Some individuals may be at an above average risk of cancer due to lifestyle, family background, personal genetic makeup, or environmental exposures. This will be determined by a process called risk stratification. Risk stratification involves looking at all health-related aspects of a person, determining their individualized risk through screening, and educating them on measures to reduce potential for disease. Participants will complete a yearly health assessment which includes measurements for nutrition, activity, individual risk factors and body composition, including weight height and a special scale which measures fluid and fat.
Study design
- Observational model
- Ecologic or community
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Individuals 18 years or older
Key inclusion criteria (1 listed)
- 18 years or older
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Assess changes in nutrition by nutrition questionnaire
Time frame: Yearly follow up for 10 years
Nutrition will be assessed yearly by a questionnaire based on nutrition recommendations from the American Institute for Cancer Research and the U.S. Department of Health and Human Services.
Assess changes in physical activity by physical activity questionnaire
Time frame: Yearly follow up for 10 years
Physical activity will be assessed yearly a questionnaire based on physical activity recommendations from the U.S. Department of Health and Human Services.
Assess changes in smoking habits
Time frame: Yearly follow up for 10 years
Participants will be educated on healthy lifestyle habits and smoking habits will be assessed yearly.
Assess changes in alcohol use
Time frame: Yearly follow up for 10 years
Participants will be educated on healthy lifestyle habits and alcohol use will be assessed yearly.
Assess hereditary risk through family history review
Time frame: Yearly follow up for 10 years
Each participant's family history will be reviewed to make recommendations for screening or genetic testing based on National Comprehensive Cancer Network guidelines.
Assess lifetime breast cancer risk through the Tyrer-Cuzick version 8 breast risk evaluation tool
Time frame: Yearly follow up for 10 years
Participants' breast cancer risk will be assessed using the Tyrer-Cuzick breast cancer risk model. Participants will be referred to appropriate clinics if lifetime risk is greater than 20 percent.
Assess 5- year breast cancer risk through the GAIL breast risk evaluation tool
Time frame: Yearly follow up for 10 years
Participants' breast cancer risk will be assessed using the National Cancer Institute's GAIL model. Participants will be referred to appropriate clinics if GAIL 5 year risk is greater than 1.7 percent.
Early detection of malignancies through screening
Time frame: Yearly follow up for 10 years
Participants will be educated on screening recommendations by the American Cancer Society. Malignancies will be recorded yearly if found by recommended screenings.
Assess changes in fat mass by SOZO measurements
Time frame: Yearly follow up for 10 years
Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure fat mass.
Assess changes in muscle mass by SOZO measurements
Time frame: Yearly follow up for 10 years
Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure muscle mass.
1 secondary outcome
Assess changes in quality of life by the 5-level EuroQol-5D version (EQ-5D-5L) questionnaire
Time frame: Yearly follow up for 10 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2026.
- Education resourcesLink provided by the sponsor.
- Screening guidelinesLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. De-identified data sets will be available upon requests following institutional approval.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Joe Stephenson, MD principal investigator
Prisma Health-Upstate
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cancer and High-Risk Cancer, run by Prisma Health-Upstate at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Patricia Wilson, MSN Ed. OCN ONNCG (864-455-4897, ccpw@prismahealth.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Assess changes in nutrition by nutrition questionnaire (time frame: Yearly follow up for 10 years). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2026.