AdultNCT04971486
Feedback, Motor Sequence Learning, and Brain Connectivity
A study testing Motor Sequence Task in people with Adult, run by University of South Carolina at 1 site in United States.
Trial summary
Feedback delivered during motor practice can help promote motor skill learning, enhance confidence, and alter brain connectivity. However, the optimal way to provide feedback to promote learning, confidence and brain connectivity is unknown. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Adult
- What is being tested?
- Motor Sequence Task
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 33 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Apr 2021to 10 Jan 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 18 to 40 years
- Right-hand dominant
Who cannot join
- Medical diagnosis or medication that affects dopamine (e.g. dopamine reuptake inhibitors)
- Musculoskeletal issues that limit upper extremity movement
- Contraindications for magnetic resonance imaging (MRI)
Trial locations and contacts
1 site in 1 country.
United States1 site
University of South Carolina
Columbia, South Carolina, 29208
About this study
Official title: Effects of Feedback on Learning of a Motor Sequence Task and Resting State Connectivity
Feedback delivered during motor practice can help promote motor skill learning, enhance confidence, and alter brain connectivity. However, the optimal way to provide feedback to promote learning, confidence and brain connectivity is unknown. This project will study how the feedback that is provided during practice of a movement skill can help people learn and build confidence and whether these correspond to changes in brain function. The investigators will measure motor skill performance, confidence, and resting state brain connectivity before and after a session of motor practice.
Read the detailed description
Positive social comparative feedback, which indicate to the learner that they are performing above average, is one way to enhance a learner's expectancies about future performance. Expectancies include the learners' perceived competence about their ability to perform the task, expectations about task outcome (success or failure), and predictions of extrinsic reward or positive experiences related to performance. Positive feedback during motor practice enhances expectancies, which is hypothesized to be rewarding to the learner, leading to better skill performance and learning. Reward is a powerful shaper of behavior. However, while social comparative feedback supports motor skill learning, it is unclear whether positive social comparative feedback induces a response in the dopamine reward network. Therefore, the purpose of this study is to determine the effects of social comparative feedback during motor practice on the functional connectivity of the reward neural network. The study aims to recruit 40 participants who will be randomized into 1 of 2 feedback groups (performance feedback or performance plus positive feedback). Participants will practice a motor sequence task on a single day and then return for retention performance testing about 24 hours later. Measures of brain function and brain structure will be collected before and after practice on day 1. Changes in performance (response time to complete a sequence) and self-efficacy will be measured from baseline to 24 hours later at retention. Changes in brain functional connectivity over practice on day 1 will be assessed in the reward network and the motor network.
- Conditions
- Adult
- Being tested
- Motor Sequence Task
- Keywords
- Motor Learning, Feedback, Brain Function
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Motor Sequence TaskBehavioural
Participants will be seated at a laptop with the right hand on a standard joystick. The movement of the joystick will move a cursor on the computer screen. Targets will appear on the laptop screen as a circle in one of twelve spatially distinct locations. The learner must move the joystick "cursor" to inside the target before the next target will appear.
| Study group | Role | What they receive |
|---|---|---|
| Performance Feedback | Experimental | Practice of a joystick based motor sequence task. Participants receive feedback on their response time to complete the trials in the practice block. Receives: Behavioral: Motor Sequence Task |
| Performance plus Positive Feedback | Experimental | Practice of a joystick based motor sequence task. Participants receive feedback on their response time to complete the trials in the practice block plus positive social comparative feedback. Receives: Behavioral: Motor Sequence Task |
What is being measured
The primary outcome is the main question the study is designed to answer.
Response Time
Time to complete one sequence
Measured: Change from baseline to retention at 24 hours
Task Confidence
Self-reported confidence in ability to complete a sequence in a given time on a scale of 0 to 10 with a 10 equating to higher confidence
Measured: Change from baseline to retention at 24 hours
Brain Connectivity
Resting state connectivity between pairs of brain regions
Measured: Change from baseline to immediately after practice
Secondary outcomes (15)
Peak Velocity
Average speed to capture a target within a sequence
Measured: Change from baseline to retention at 24 hours
Total Path Distance
Total distance traveled to complete one sequence
Measured: Change from baseline to retention at 24 hours
Time to Peak Velocity
Mean time to peak velocity for movement to a target within a sequence
Measured: Change from baseline to retention at 24 hours
Perceived Competence
Mean score on the Perceived Competence subscale of the Intrinsic Motivation Inventory where each item ranges from 0 to 7 with a higher value equating to higher competence
Measured: Change from baseline to retention at 24 hours
Perceived Interest/Enjoyment
Mean score on the Interest/Enjoyment subscale of the Intrinsic Motivation Inventory where each item ranges from 0 to 7 with a higher value equating to higher enjoyment
Measured: Change from baseline to retention at 24 hours
Positive Affect
Total score for general positive affect on the Positive and Negative Affect Scale with a range from 10 to 50 with higher scores equating to higher positive affect
Measured: Change from baseline to retention at 24 hours
Peak Velocity
Average speed to capture a target within a sequence
Measured: Change from baseline to immediately after practice
Total Path Distance
Total distance traveled to complete one sequence
Measured: Change from baseline to immediately after practice
Time to Peak Velocity
Mean time to peak velocity for movement to a target within a sequence
Measured: Change from baseline to immediately after practice
Perceived Competence
Mean score on the Perceived Competence subscale of the Intrinsic Motivation Inventory where each item ranges from 0 to 7 with a higher value equating to higher competence
Measured: Change from baseline to immediately after practice
Perceived Interest/Enjoyment
Mean score on the Interest/Enjoyment subscale of the Intrinsic Motivation Inventory where each item ranges from 0 to 7 with a higher value equating to higher enjoyment
Measured: Change from baseline to immediately after practice
Positive Affect
Total score for general positive affect on the Positive and Negative Affect Scale with a range from 10 to 50 with higher scores equating to higher positive affect
Measured: Change from baseline to immediately after practice
Response Time
Time to complete one sequence
Measured: Change from baseline to immediately after practice
Task Confidence
Self-reported confidence in ability to complete a sequence in a given time on a scale of 0 to 10 with a 10 equating to higher confidence
Measured: Change from baseline to immediately after practice
Brain Structure
Structural integrity of white matter pathways in the brain
Measured: Baseline assessment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jul 2021
- Study start1 Apr 2021
- Primary completion10 Jan 2022
- Study completion10 Jan 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AdultStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 33 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of South Carolina
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jill Stewart, PT, PhD, University of South Carolina
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04971486
- Sponsor's protocol ID
- Pro00097070
- Status last verified
- Jan 2022
- First submitted
- 20 Jul 2021
- Last updated
- 13 Jan 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified data will be made available per reasonable request to the principal investigator 1 year after study completion.
Study at a glance
From the registry record, last updated by the sponsor on 13 Jan 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Feedback on Learning of a Motor Sequence Task and Resting State Connectivity
- ClinicalTrials.gov ID
- NCT04971486
- Acronym / sponsor ID
- Pro00097070
- Conditions
- Adult
- Keywords
- Motor Learning, Feedback, Brain Function
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 33 participants (actual)
- Lead sponsor
- University of South CarolinaUniversity, hospital or other
- Study start
- 1 Apr 2021 (actual)
- Primary completion
- 10 Jan 2022 (actual)
- Study completion
- 10 Jan 2022 (actual)
- First posted
- 21 Jul 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Feedback delivered during motor practice can help promote motor skill learning, enhance confidence, and alter brain connectivity. However, the optimal way to provide feedback to promote learning, confidence and brain connectivity is unknown. This project will study how the feedback that is provided during practice of a movement skill can help people learn and build confidence and whether these correspond to changes in brain function. The investigators will measure motor skill performance, confidence, and resting state brain connectivity before and after a session of motor practice.
Detailed description
Positive social comparative feedback, which indicate to the learner that they are performing above average, is one way to enhance a learner's expectancies about future performance. Expectancies include the learners' perceived competence about their ability to perform the task, expectations about task outcome (success or failure), and predictions of extrinsic reward or positive experiences related to performance. Positive feedback during motor practice enhances expectancies, which is hypothesized to be rewarding to the learner, leading to better skill performance and learning. Reward is a powerful shaper of behavior. However, while social comparative feedback supports motor skill learning, it is unclear whether positive social comparative feedback induces a response in the dopamine reward network. Therefore, the purpose of this study is to determine the effects of social comparative feedback during motor practice on the functional connectivity of the reward neural network. The study aims to recruit 40 participants who will be randomized into 1 of 2 feedback groups (performance feedback or performance plus positive feedback). Participants will practice a motor sequence task on a single day and then return for retention performance testing about 24 hours later. Measures of brain function and brain structure will be collected before and after practice on day 1. Changes in performance (response time to complete a sequence) and self-efficacy will be measured from baseline to 24 hours later at retention. Changes in brain functional connectivity over practice on day 1 will be assessed in the reward network and the motor network.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Performance Feedback | Experimental | Behavioral: Motor Sequence TaskPractice of a joystick based motor sequence task. Participants receive feedback on their response time to complete the trials in the practice block. |
| Performance plus Positive Feedback | Experimental | Behavioral: Motor Sequence TaskPractice of a joystick based motor sequence task. Participants receive feedback on their response time to complete the trials in the practice block plus positive social comparative feedback. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Age 18 to 40 years
- Right-hand dominant
Key exclusion criteria (3 listed)
- Medical diagnosis or medication that affects dopamine (e.g. dopamine reuptake inhibitors)
- Musculoskeletal issues that limit upper extremity movement
- Contraindications for magnetic resonance imaging (MRI)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Motor Sequence TaskParticipants will be seated at a laptop with the right hand on a standard joystick. The movement of the joystick will move a cursor on the computer screen. Targets will appear on the laptop screen as a circle in one of twelve spatially distinct locations. The learner must move the joystick "cursor" to inside the target before the next target will appear. | Behavioural | Performance Feedback, Performance plus Positive Feedback |
Primary outcome
Response Time
Time frame: Change from baseline to retention at 24 hours
Time to complete one sequence
Task Confidence
Time frame: Change from baseline to retention at 24 hours
Self-reported confidence in ability to complete a sequence in a given time on a scale of 0 to 10 with a 10 equating to higher confidence
Brain Connectivity
Time frame: Change from baseline to immediately after practice
Resting state connectivity between pairs of brain regions
15 secondary outcomes
Peak Velocity
Time frame: Change from baseline to retention at 24 hours
Total Path Distance
Time frame: Change from baseline to retention at 24 hours
Time to Peak Velocity
Time frame: Change from baseline to retention at 24 hours
Perceived Competence
Time frame: Change from baseline to retention at 24 hours
Perceived Interest/Enjoyment
Time frame: Change from baseline to retention at 24 hours
Positive Affect
Time frame: Change from baseline to retention at 24 hours
Peak Velocity
Time frame: Change from baseline to immediately after practice
Total Path Distance
Time frame: Change from baseline to immediately after practice
Time to Peak Velocity
Time frame: Change from baseline to immediately after practice
Perceived Competence
Time frame: Change from baseline to immediately after practice
Perceived Interest/Enjoyment
Time frame: Change from baseline to immediately after practice
Positive Affect
Time frame: Change from baseline to immediately after practice
Response Time
Time frame: Change from baseline to immediately after practice
Task Confidence
Time frame: Change from baseline to immediately after practice
Brain Structure
Time frame: Baseline assessment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jan 2022.
- Individual participant dataSharing planned: Yes. De-identified data will be made available per reasonable request to the principal investigator 1 year after study completion.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Motor Sequence Task in people with Adult, run by University of South Carolina at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Jan 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Response Time (time frame: Change from baseline to retention at 24 hours). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jan 2022.