Sedentary BehaviorBénéfiSITNCT05013021
Sprint Interval Training on the Endurance, Strength and Velocity Capacities of Healthy Sedentary Subjects
A study testing Sprint Interval Training in people with Sedentary Behavior, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
Trial summary
The present study aims to analyse first, the acute effects generated by a single bout of Sprint Interval Training (SIT) and, secondly, the effects of a long-term intervention on sedentary participants. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Sedentary Behavior
- What is being tested?
- Sprint Interval Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 23 participants
- Where
- 1 siteFrance
- Study dates
- 27 Sep 2021to 29 Mar 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- untrained healthy (less than 2 hours of sport per week)
- free from muscular, bone or joint injuries
- free from neurologic disease
Who cannot join
- taking neuroactive substances that can alter corticospinal excitability
- Heart or respiratory failure.
- Subjects who have taken corticosteroids within 3 months (inhalation, infiltration or history of corticosteroid therapy).
- Pregnant woman
- Subject under guardianship
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Sprint Interval Training (SIT) on the Endurance, Strength and Velocity Capacities of Healthy Sedentary Subjects
The present study aims to analyse first, the acute effects generated by a single bout of Sprint Interval Training (SIT) and, secondly, the effects of a long-term intervention on sedentary participants.
Read the detailed description
The main goal is to determine the optimal dose of high-intensity exercise that enhances the best physiological adaptations.
The cumulative effects of SIT, will be assessed by a series of measures placed throughout the time-course (before, after the 1st , the 2nd and the 3rd block of SIT). Those measures consist of physiological measurements (VO2max), neuromuscular capacities (force-velocity profile) the autonomic nervous system responses (heart rate variability) and blood markers (lactate, Creatine phosphoKinase (CK), cytokinases, µRNA). Acute effects will be measured in the familiarisation sessions (after short (8 sprints) and long (14 sprints) sets) by performing a battery of neuromuscular, perceptual, and autonomic nervous system tests before and after the single session of SIT.
- Conditions
- Sedentary Behavior
- Being tested
- Sprint Interval Training
- Keywords
- Sprint Interval Training, VO2max, acute fatigue, chronic fatigue, force-velocity profile
- Medical subject headings
- Sedentary Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sprint Interval TrainingOther
The Sprint Interval Training (SIT) training consists of 3 successive blocks of 5 training sessions each. The sessions are 24 to 48 hours apart.
. One block lasts two weeks. After the end of one block, the following block begins the day after.
The Sprint Interval Training lasts 6 weeks.
Each session consists of a series of sprints, the number of which varies from 8 to 14. Thus a session will last from 30 to 45 min approximately
So, the time frame of this study is Baseline, Block 1, Block 2 and Block 3 (Not in day or week or month)
| Study group | Role | What they receive |
|---|---|---|
| Sedentary participants | Other | Series of measures placed throughout the time-course (before, after the 1st , the 2nd and the 3rd block of SIT).
These measurements consist of physiological measurements (VO2max), neuromuscular capacities (force-speed profile), autonomic nervous system responses (heart rate variability) and blood markers (lactate, CK, cytokinases, µRNA). Receives: Other: Sprint Interval Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
oxygen uptake (VO2max) - ml/min/kg
consumption oxygen uptake (VO2max) measured on a cycle ergometer
The main objective is to determine at which time frame of sprint interval training blocks, the endurance performance (VO2max) is best.
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary outcomes (9)
Maximum power (W)
It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively.
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Maximum theoretical force (N.m)
It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively.
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Maximum theoretical speed (m/s)
It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively.
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Maximum isometric force (N.m)
It is measured by means of a voluntary maximum contraction test in which the maximum force generated voluntarily is compared to that voluntarily generated force will be compared to that evoked using electrical stimulation of the femoral nerve.
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
heart rate variability (HRV)
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Lactate (mmol/l)
Blood sample
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Cytokines (pg/ml)
Blood sample
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Creatine Kinase (UI/l)
Blood sample
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
muscle microRNA
Blood sample
Measured: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Aug 2021
- Study start27 Sep 2021
- Primary completion8 Mar 2023
- Study completion29 Mar 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Sedentary BehaviorStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de Saint EtienneThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Sedentary participants
- Masking
- None (open label)
- Enrolment
- 23 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Leonard FEASSON, MD-PhD, Principal investigator, Centre Hospitalier Universitaire de Saint Etienne
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05013021
- Sponsor's protocol ID
- 20CH238
- Other IDs
- ANSM
- Acronym
- BénéfiSIT
- Status last verified
- Jun 2022
- First submitted
- 10 Aug 2021
- Last updated
- 19 Jul 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Lloria-Varella J, Koral J, Ravel A, Murias JM, Feasson L, Busso T. Cardiorespiratory and Neuromuscular Improvements Plateau after 2 wk of Sprint Interval Training in Sedentary Individuals. Med Sci Sports Exerc. 2024 May 1;56(5):876-884. doi: 10.1249/MSS.0000000000003357. Epub 2023 Dec 13.
PubMed 38109197
Study at a glance
From the registry record, last updated by the sponsor on 19 Jul 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Sprint Interval Training (SIT) on the Endurance, Strength and Velocity Capacities of Healthy Sedentary Subjects
- ClinicalTrials.gov ID
- NCT05013021
- Acronym / sponsor ID
- BénéfiSIT / 20CH238
- Conditions
- Sedentary Behavior
- Keywords
- Sprint Interval Training, VO2max, acute fatigue, chronic fatigue, force-velocity profile
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 23 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de Saint EtienneUniversity, hospital or other
- Study start
- 27 Sep 2021 (actual)
- Primary completion
- 8 Mar 2023 (actual)
- Study completion
- 29 Mar 2023 (actual)
- First posted
- 19 Aug 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The present study aims to analyse first, the acute effects generated by a single bout of Sprint Interval Training (SIT) and, secondly, the effects of a long-term intervention on sedentary participants.
Detailed description
The main goal is to determine the optimal dose of high-intensity exercise that enhances the best physiological adaptations.
The cumulative effects of SIT, will be assessed by a series of measures placed throughout the time-course (before, after the 1st , the 2nd and the 3rd block of SIT). Those measures consist of physiological measurements (VO2max), neuromuscular capacities (force-velocity profile) the autonomic nervous system responses (heart rate variability) and blood markers (lactate, Creatine phosphoKinase (CK), cytokinases, µRNA). Acute effects will be measured in the familiarisation sessions (after short (8 sprints) and long (14 sprints) sets) by performing a battery of neuromuscular, perceptual, and autonomic nervous system tests before and after the single session of SIT.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Sedentary participants
| Arm | Type | Receives |
|---|---|---|
| Sedentary participants | Other | Other: Sprint Interval TrainingSeries of measures placed throughout the time-course (before, after the 1st , the 2nd and the 3rd block of SIT). These measurements consist of physiological measurements (VO2max), neuromuscular capacities (force-speed profile), autonomic nervous system responses (heart rate variability) and blood markers (lactate, CK, cytokinases, µRNA). |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- untrained healthy (less than 2 hours of sport per week)
- free from muscular, bone or joint injuries
- free from neurologic disease
Key exclusion criteria (5 listed)
- taking neuroactive substances that can alter corticospinal excitability
- Heart or respiratory failure.
- Subjects who have taken corticosteroids within 3 months (inhalation, infiltration or history of corticosteroid therapy).
- Pregnant woman
- Subject under guardianship
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sprint Interval TrainingThe Sprint Interval Training (SIT) training consists of 3 successive blocks of 5 training sessions each. The sessions are 24 to 48 hours apart. . One block lasts two weeks. After the end of one block, the following block begins the day after. The Sprint Interval Training lasts 6 weeks. Each session consists of a series of sprints, the number of which varies from 8 to 14. Thus a session will last from 30 to 45 min approximately So, the time frame of this study is Baseline, Block 1, Block 2 and Block 3 (Not in day or week or month) | Other | Sedentary participants |
Primary outcome
oxygen uptake (VO2max) - ml/min/kg
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
consumption oxygen uptake (VO2max) measured on a cycle ergometer The main objective is to determine at which time frame of sprint interval training blocks, the endurance performance (VO2max) is best.
9 secondary outcomes
Maximum power (W)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Maximum theoretical force (N.m)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Maximum theoretical speed (m/s)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Maximum isometric force (N.m)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
heart rate variability (HRV)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Lactate (mmol/l)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Cytokines (pg/ml)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Creatine Kinase (UI/l)
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
muscle microRNA
Time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Jul 2023.
- Derived from this study: PubMed 38109197Lloria-Varella J, Koral J, Ravel A, Murias JM, Feasson L, Busso T. Cardiorespiratory and Neuromuscular Improvements Plateau after 2 wk of Sprint Interval Training in Sedentary Individuals. Med Sci Sports Exerc. 2024 May 1;56(5):876-884. doi: 10.1249/MSS.0000000000003357. Epub 2023 Dec 13.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Leonard FEASSON, MD-PhD principal investigator
Centre Hospitalier Universitaire de Saint Etienne
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sprint Interval Training in people with Sedentary Behavior, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Jul 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
oxygen uptake (VO2max) - ml/min/kg (time frame: At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05013021, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Jul 2023.