Cognitive DeclineNCT05016336
Cognitive Training and Social Interaction Effects on Cognitive Performance of Older Adults
A study testing Social interaction combined with cognitive training based on mnemonic strategies. and Social interaction group in people with Cognitive Decline, run by Bar-Ilan University, Israel at 1 site in Israel.
Trial summary
Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive functioning for older adults. Read more about this study
- Who is it for?
- Ages 64 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cognitive Decline
- What is being tested?
- Social interaction combined with cognitive training based on mnemonic strategies. and Social interaction group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 siteIsrael
- Study dates
- 18 Nov 2018to 24 Feb 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 64 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy participants who are active in a designated group in the community.
Who cannot join
- Any diagnosis of cognitive decline.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Strategy Based Cognitive Training Effects on Cognitive Performance of Older Adults in a Socially Interactive Learning Group
Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive functioning for older adults. Furthermore, accumulative evidence suggests that strategy-based cognitive training may also improve the trainee's memory. In this study, the investigators examined the effects of a combined strategy-based cognitive training and a socially interactive learning method on cognitive performance and transfer effects in older adults.
Read the detailed description
A major concern with the aging of the world's population is a higher prevalence of age-related impairment of cognitive functions. This concern highlights the need to identify quick and effective interventions that can preserve cognitive functions.
A growing body of literature supports the notion that cognitive training may assist in promoting healthy brain aging and improve a wide range of cognitive abilities.
Cognitive training refers to a protocol consisting of a set of exercises designed to improve performance in one or several cognitive abilities. One approach to cognitive training mentioned in the literature is strategy training. Strategy training usually focuses on teaching specific strategies designed to help encode or retrieve information and involves techniques such as rehearsal, chunking, mental imagery, and story-formation.
A possible means for improving cognitive training outcomes is employing a socially interactive group-based cognitive training program versus an individual one. An abundance of studies has shown that social interaction may contribute to the slowing down of cognitive decline in old age.
Recent studies suggest that social interaction alone may not be beneficial for enhancing cognitive abilities, but when combined with a mental stimulus that requires cognitive effort, such improvement might be achieved.
Only a few studies to date have investigated the advantage of strategy training performed in-group vs individually and even fewer studies focused specifically on socially interactive learning methods. A recent pilot study combined cognitive training with social interaction for people with mild to moderate dementia and reported a significant cognitive improvement in favor of the social interaction group compared to the control group who was engaged in cognitive training only.
Social cognition is supported by an extensive system of limbic, cortical and subcortical brain regions. Many of these regions are also involved in episodic memory, semantic memory and other cognitive functions. Thus, it is possible that aspects of cognitive processing, which are activated through social interaction will also strengthen these cognitive abilities.
Engaging in social interaction usually consists of complex cognitive and memory challenges, which in turn may aid in enhancing cognitive abilities and cognitive reserve Training in a group setting can provide participants with an opportunity to problem-solve with a relevant peer group and allow individuals to gain comfort from sharing their concerns about memory.
The purpose of the current study was therefore to determine the effectiveness of a strategy-based cognitive training approach combined with a socially interactive learning method on cognitive performance and transferability of training gains for older adults.
Procedure:
Meetings of both groups were held in public community centers. A pre-session meeting was devoted to explaining the research objectives and signing consent forms. Prior to the first training meeting and after the program ended, cognitive evaluation measurements were taken individually from each subject. Before the final cognitive evaluation, participants were reminded to use the learned strategies.
Sample size assessment:
A priori power analysis using pilot data and the SimR package in R (version 1.0.5) suggested that 30 participants would provide sufficient power (power > 80%) to detect the critical strategy training plus social interaction effect on cognitive performance.
Statistical analysis plan:
Data will be analyzed with IBM SPSS Statistics for Windows, version 23 (IBM Corp., Armonk, N.Y., USA). The main analysis 'שד a mixed-design analysis that compares the experimental conditions (between-subject factors) regarding their effect on cognitive performance in 4 cognitive tests and 2-time points (within-subjects variables).
- Conditions
- Cognitive Decline
- Being tested
- Social interaction combined with cognitive training based on mnemonic strategies., Social interaction group
- Keywords
- Cognitive training, Strategy training, Older adults, Mnemonic, Social interaction
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Social interaction combined with cognitive training based on mnemonic strategies.Other
In the first six sessions, participants in the experimental group learned and practiced six different mnemonic strategies: Story-Formation strategy, Face-Name strategy, Peg-Word strategy, Chunking strategy, Key-Word strategy and the Method of Loci. In the following six sessions, in order to assimilate the strategies they learned, participants practiced the same tasks.
Social interaction groupOther
In the control group, each session also began with a conversation between the participants. The sessions then dealt with the content of interpersonal communication and the acquisition of tools for creating interpersonal relationships. Participants were asked to share the way they used the tools they acquired between sessions and received feedback from the other participants
| Study group | Role | What they receive |
|---|---|---|
| strategy-based cognitive training + social interaction | Experimental | The experimental group received twelve 60 minutes sessions of strategy-based cognitive training. (i.e., training in mnemonic memory strategies). We chose to train multiple strategies instead of a single one in effort to reach larger training gains. each session began with engaging conversations between the researcher and participants. After each practice trial, participants were encouraged to share their ideas/stories/associations or visual images (mnemonic uses) in turn. All other participants were allowed to give feedback relating to what can be learned from each mnemonic use or give their own ideas on how they think it can be improved. Receives: Other: Social interaction combined with cognitive training based on mnemonic strategies. |
| social interaction | Active comparator | The social interaction control group received the same number of group meetings but without the strategy training. Meetings content consisted of providing tools for making social connections, providing tools for interpersonal communication and raising the participant's sense of personal well-being through group contact. Receives: Other: Social interaction group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Verbal Fluency Test (Chiu et al., 1997)
Participants were asked to say aloud as many words as possible belonging to a given category (animal's category and fruit and vegetables category) within a period of sixty seconds.
Measured: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Secondary outcomes (3)
Wechsler Digit Span Test (Wechsler 2008)
Series of digits were presented verbally at a rate of one digit per second. Subjects were required to repeat the digits verbally in the order presented.
Measured: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Words Recall Test (Fairchild et al., 2013)
Subjects were asked to remember a list of 16 words and to recall the list after a 5-min delay.
Measured: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Corsi Block-Tapping Test (Corsi 1972)
The task involves mimicking the researcher as he taps a sequence of up to nine identical spatially separated blocks.
Measured: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Aug 2021
- Study start18 Nov 2018
- Primary completion3 Feb 2019
- Study completion24 Feb 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (18)Papers the sponsor has linked to this study.
- Other trials for Cognitive DeclineStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- The study included 32 subjects, 20 in the experimental group and 12 in the control group. The experimental group received 12 sessions of strategy-based cognitive training combined with a socially interactive learning method. The control group received the same number of meetings but without the strategy training. Participants were recruited from designated active groups in the community.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bar-Ilan University, Israel
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Michal Lavidor, Bar-Ilan University, Israel
- Investigators
- Michal Lavidor, Prof., Principal investigator, Department of Psychology, and the Gonda Brain Research center, Bar Ilan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05016336
- Sponsor's protocol ID
- 08082021ML
- Status last verified
- Aug 2021
- First submitted
- 17 Aug 2021
- Last updated
- 26 Aug 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The datasets generated during and/or analyzed during the current study are available from the main author.
Publications
Choi M. Association between social participation and cognitive function among community-dwelling older adults living alone: Analysis of a nationally representative survey. Int J Nurs Pract. 2020 Aug;26(4):e12841. doi: 10.1111/ijn.12841. Epub 2020 May 27.
PubMed 32458529Hikichi H, Kondo K, Takeda T, Kawachi I. Social interaction and cognitive decline: Results of a 7-year community intervention. Alzheimers Dement (N Y). 2016 Dec 21;3(1):23-32. doi: 10.1016/j.trci.2016.11.003. eCollection 2017 Jan.
PubMed 29067317Krueger KR, Wilson RS, Kamenetsky JM, Barnes LL, Bienias JL, Bennett DA. Social engagement and cognitive function in old age. Exp Aging Res. 2009 Jan-Mar;35(1):45-60. doi: 10.1080/03610730802545028.
PubMed 19173101Park DC, Gutchess AH, Meade ML, Stine-Morrow EA. Improving cognitive function in older adults: nontraditional approaches. J Gerontol B Psychol Sci Soc Sci. 2007 Jun;62 Spec No 1:45-52. doi: 10.1093/geronb/62.special_issue_1.45.
PubMed 17565164Chan MY, Haber S, Drew LM, Park DC. Training Older Adults to Use Tablet Computers: Does It Enhance Cognitive Function? Gerontologist. 2016 Jun;56(3):475-84. doi: 10.1093/geront/gnu057. Epub 2014 Jun 13.
PubMed 24928557Iizuka A, Suzuki H, Ogawa S, Kobayashi-Cuya KE, Kobayashi M, Inagaki H, Sugiyama M, Awata S, Takebayashi T, Fujiwara Y. Does social interaction influence the effect of cognitive intervention program? A randomized controlled trial using Go game. Int J Geriatr Psychiatry. 2019 Feb;34(2):324-332. doi: 10.1002/gps.5024. Epub 2018 Dec 10.
PubMed 30430635Myhre JW, Mehl MR, Glisky EL. Cognitive Benefits of Online Social Networking for Healthy Older Adults. J Gerontol B Psychol Sci Soc Sci. 2017 Sep 1;72(5):752-760. doi: 10.1093/geronb/gbw025.
PubMed 26984523Cavallini E, Dunlosky J, Bottiroli S, Hertzog C, Vecchi T. Promoting transfer in memory training for older adults. Aging Clin Exp Res. 2010 Aug;22(4):314-23. doi: 10.3275/6704. Epub 2009 Nov 27.
PubMed 19966535Valentijn SA, van Hooren SA, Bosma H, Touw DM, Jolles J, van Boxtel MP, Ponds RW. The effect of two types of memory training on subjective and objective memory performance in healthy individuals aged 55 years and older: a randomized controlled trial. Patient Educ Couns. 2005 Apr;57(1):106-14. doi: 10.1016/j.pec.2004.05.002.
PubMed 15797159Rouse HJ, Small BJ, Faust ME. Assessment of Cognitive Training & Social Interaction in People with Mild to Moderate Dementia: A Pilot Study. Clin Gerontol. 2019 Jul-Sep;42(4):421-434. doi: 10.1080/07317115.2019.1590489. Epub 2019 Mar 21.
PubMed 30895883Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS. The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 2006 May;5(5):406-12. doi: 10.1016/S1474-4422(06)70417-3.
PubMed 16632311Ertel KA, Glymour MM, Berkman LF. Effects of social integration on preserving memory function in a nationally representative US elderly population. Am J Public Health. 2008 Jul;98(7):1215-20. doi: 10.2105/AJPH.2007.113654. Epub 2008 May 29.
PubMed 18511736Verhaeghen P, Marcoen A, Goossens L. Improving memory performance in the aged through mnemonic training: a meta-analytic study. Psychol Aging. 1992 Jun;7(2):242-51. doi: 10.1037//0882-7974.7.2.242.
PubMed 1535198Flynn TM, Storandt M. Supplemental group discussions in memory training for older adults. Psychol Aging. 1990 Jun;5(2):178-81. doi: 10.1037//0882-7974.5.2.178.
PubMed 2378683Chiu HF, Chan CK, Lam LC, Ng KO, Li SW, Wong M, Chan WF. The modified Fuld Verbal Fluency Test: a validation study in Hong Kong. J Gerontol B Psychol Sci Soc Sci. 1997 Sep;52(5):P247-50. doi: 10.1093/geronb/52b.5.p247.
PubMed 9310094
Study at a glance
From the registry record, last updated by the sponsor on 26 Aug 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Strategy Based Cognitive Training Effects on Cognitive Performance of Older Adults in a Socially Interactive Learning Group
- ClinicalTrials.gov ID
- NCT05016336
- Acronym / sponsor ID
- 08082021ML
- Conditions
- Cognitive Decline
- Keywords
- Cognitive training, Strategy training, Older adults, Mnemonic, Social interaction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Bar-Ilan University, IsraelUniversity, hospital or other
- Study start
- 18 Nov 2018 (actual)
- Primary completion
- 3 Feb 2019 (actual)
- Study completion
- 24 Feb 2019 (actual)
- First posted
- 23 Aug 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Aging is associated with a decline in almost all aspects of cognitive functions, particularly memory. Recent research suggests that combining cognitive training with ongoing social interaction may aid in improving cognitive functioning for older adults. Furthermore, accumulative evidence suggests that strategy-based cognitive training may also improve the trainee's memory. In this study, the investigators examined the effects of a combined strategy-based cognitive training and a socially interactive learning method on cognitive performance and transfer effects in older adults.
Detailed description
A major concern with the aging of the world's population is a higher prevalence of age-related impairment of cognitive functions. This concern highlights the need to identify quick and effective interventions that can preserve cognitive functions.
A growing body of literature supports the notion that cognitive training may assist in promoting healthy brain aging and improve a wide range of cognitive abilities.
Cognitive training refers to a protocol consisting of a set of exercises designed to improve performance in one or several cognitive abilities. One approach to cognitive training mentioned in the literature is strategy training. Strategy training usually focuses on teaching specific strategies designed to help encode or retrieve information and involves techniques such as rehearsal, chunking, mental imagery, and story-formation.
A possible means for improving cognitive training outcomes is employing a socially interactive group-based cognitive training program versus an individual one. An abundance of studies has shown that social interaction may contribute to the slowing down of cognitive decline in old age.
Recent studies suggest that social interaction alone may not be beneficial for enhancing cognitive abilities, but when combined with a mental stimulus that requires cognitive effort, such improvement might be achieved.
Only a few studies to date have investigated the advantage of strategy training performed in-group vs individually and even fewer studies focused specifically on socially interactive learning methods. A recent pilot study combined cognitive training with social interaction for people with mild to moderate dementia and reported a significant cognitive improvement in favor of the social interaction group compared to the control group who was engaged in cognitive training only.
Social cognition is supported by an extensive system of limbic, cortical and subcortical brain regions. Many of these regions are also involved in episodic memory, semantic memory and other cognitive functions. Thus, it is possible that aspects of cognitive processing, which are activated through social interaction will also strengthen these cognitive abilities.
Engaging in social interaction usually consists of complex cognitive and memory challenges, which in turn may aid in enhancing cognitive abilities and cognitive reserve Training in a group setting can provide participants with an opportunity to problem-solve with a relevant peer group and allow individuals to gain comfort from sharing their concerns about memory.
The purpose of the current study was therefore to determine the effectiveness of a strategy-based cognitive training approach combined with a socially interactive learning method on cognitive performance and transferability of training gains for older adults.
Procedure:
Meetings of both groups were held in public community centers. A pre-session meeting was devoted to explaining the research objectives and signing consent forms. Prior to the first training meeting and after the program ended, cognitive evaluation measurements were taken individually from each subject. Before the final cognitive evaluation, participants were reminded to use the learned strategies.
Sample size assessment:
A priori power analysis using pilot data and the SimR package in R (version 1.0.5) suggested that 30 participants would provide sufficient power (power > 80%) to detect the critical strategy training plus social interaction effect on cognitive performance.
Statistical analysis plan:
Data will be analyzed with IBM SPSS Statistics for Windows, version 23 (IBM Corp., Armonk, N.Y., USA). The main analysis 'שד a mixed-design analysis that compares the experimental conditions (between-subject factors) regarding their effect on cognitive performance in 4 cognitive tests and 2-time points (within-subjects variables).
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- The study included 32 subjects, 20 in the experimental group and 12 in the control group. The experimental group received 12 sessions of strategy-based cognitive training combined with a socially interactive learning method. The control group received the same number of meetings but without the strategy training. Participants were recruited from designated active groups in the community.
| Arm | Type | Receives |
|---|---|---|
| strategy-based cognitive training + social interaction | Experimental | Other: Social interaction combined with cognitive training based on mnemonic strategies.The experimental group received twelve 60 minutes sessions of strategy-based cognitive training. (i.e., training in mnemonic memory strategies). We chose to train multiple strategies instead of a single one in effort to reach larger training gains. each session began with engaging conversations between the researcher and participants. After each practice trial, participants were encouraged to share their ideas/stories/associations or visual images (mnemonic uses) in turn. All other participants were allowed to give feedback relating to what can be learned from each mnemonic use or give their own ideas on how they think it can be improved. |
| social interaction | Active comparator | Other: Social interaction groupThe social interaction control group received the same number of group meetings but without the strategy training. Meetings content consisted of providing tools for making social connections, providing tools for interpersonal communication and raising the participant's sense of personal well-being through group contact. |
Who may qualify
- Ages
- 64 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Healthy participants who are active in a designated group in the community.
Key exclusion criteria (1 listed)
- Any diagnosis of cognitive decline.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Social interaction combined with cognitive training based on mnemonic strategies.In the first six sessions, participants in the experimental group learned and practiced six different mnemonic strategies: Story-Formation strategy, Face-Name strategy, Peg-Word strategy, Chunking strategy, Key-Word strategy and the Method of Loci. In the following six sessions, in order to assimilate the strategies they learned, participants practiced the same tasks. | Other | strategy-based cognitive training + social interaction |
| Social interaction groupIn the control group, each session also began with a conversation between the participants. The sessions then dealt with the content of interpersonal communication and the acquisition of tools for creating interpersonal relationships. Participants were asked to share the way they used the tools they acquired between sessions and received feedback from the other participants | Other | social interaction |
Primary outcome
Verbal Fluency Test (Chiu et al., 1997)
Time frame: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Participants were asked to say aloud as many words as possible belonging to a given category (animal's category and fruit and vegetables category) within a period of sixty seconds.
3 secondary outcomes
Wechsler Digit Span Test (Wechsler 2008)
Time frame: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Words Recall Test (Fairchild et al., 2013)
Time frame: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Corsi Block-Tapping Test (Corsi 1972)
Time frame: Change from baseline (before treatment) to immediately after treatment (12 weeks)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Aug 2021.
- Results publication: PubMed 32458529Choi M. Association between social participation and cognitive function among community-dwelling older adults living alone: Analysis of a nationally representative survey. Int J Nurs Pract. 2020 Aug;26(4):e12841. doi: 10.1111/ijn.12841. Epub 2020 May 27.
- Results publication: PubMed 29067317Hikichi H, Kondo K, Takeda T, Kawachi I. Social interaction and cognitive decline: Results of a 7-year community intervention. Alzheimers Dement (N Y). 2016 Dec 21;3(1):23-32. doi: 10.1016/j.trci.2016.11.003. eCollection 2017 Jan.
- Results publication: PubMed 19173101Krueger KR, Wilson RS, Kamenetsky JM, Barnes LL, Bienias JL, Bennett DA. Social engagement and cognitive function in old age. Exp Aging Res. 2009 Jan-Mar;35(1):45-60. doi: 10.1080/03610730802545028.
- Results publication: PubMed 17565164Park DC, Gutchess AH, Meade ML, Stine-Morrow EA. Improving cognitive function in older adults: nontraditional approaches. J Gerontol B Psychol Sci Soc Sci. 2007 Jun;62 Spec No 1:45-52. doi: 10.1093/geronb/62.special_issue_1.45.
- Results publication: PubMed 24928557Chan MY, Haber S, Drew LM, Park DC. Training Older Adults to Use Tablet Computers: Does It Enhance Cognitive Function? Gerontologist. 2016 Jun;56(3):475-84. doi: 10.1093/geront/gnu057. Epub 2014 Jun 13.
- Results publication: PubMed 30430635Iizuka A, Suzuki H, Ogawa S, Kobayashi-Cuya KE, Kobayashi M, Inagaki H, Sugiyama M, Awata S, Takebayashi T, Fujiwara Y. Does social interaction influence the effect of cognitive intervention program? A randomized controlled trial using Go game. Int J Geriatr Psychiatry. 2019 Feb;34(2):324-332. doi: 10.1002/gps.5024. Epub 2018 Dec 10.
- Results publication: PubMed 26984523Myhre JW, Mehl MR, Glisky EL. Cognitive Benefits of Online Social Networking for Healthy Older Adults. J Gerontol B Psychol Sci Soc Sci. 2017 Sep 1;72(5):752-760. doi: 10.1093/geronb/gbw025.
- Results publication: PubMed 19966535Cavallini E, Dunlosky J, Bottiroli S, Hertzog C, Vecchi T. Promoting transfer in memory training for older adults. Aging Clin Exp Res. 2010 Aug;22(4):314-23. doi: 10.3275/6704. Epub 2009 Nov 27.
- Results publication: PubMed 15797159Valentijn SA, van Hooren SA, Bosma H, Touw DM, Jolles J, van Boxtel MP, Ponds RW. The effect of two types of memory training on subjective and objective memory performance in healthy individuals aged 55 years and older: a randomized controlled trial. Patient Educ Couns. 2005 Apr;57(1):106-14. doi: 10.1016/j.pec.2004.05.002.
- Results publication: PubMed 30895883Rouse HJ, Small BJ, Faust ME. Assessment of Cognitive Training & Social Interaction in People with Mild to Moderate Dementia: A Pilot Study. Clin Gerontol. 2019 Jul-Sep;42(4):421-434. doi: 10.1080/07317115.2019.1590489. Epub 2019 Mar 21.
- Results publication: PubMed 16632311Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS. The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 2006 May;5(5):406-12. doi: 10.1016/S1474-4422(06)70417-3.
- Results publication: PubMed 18511736Ertel KA, Glymour MM, Berkman LF. Effects of social integration on preserving memory function in a nationally representative US elderly population. Am J Public Health. 2008 Jul;98(7):1215-20. doi: 10.2105/AJPH.2007.113654. Epub 2008 May 29.
- Individual participant dataSharing planned: No. The datasets generated during and/or analyzed during the current study are available from the main author.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Michal Lavidor, Prof. principal investigator
Department of Psychology, and the Gonda Brain Research center, Bar Ilan University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Social interaction combined with cognitive training based on mnemonic strategies. and Social interaction group in people with Cognitive Decline, run by Bar-Ilan University, Israel at 1 site in Israel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Aug 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Verbal Fluency Test (Chiu et al., 1997) (time frame: Change from baseline (before treatment) to immediately after treatment (12 weeks)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05016336, which also lists 18 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Aug 2021.