Muscle MetabolismSCAMNCT05016557
The Muscle Protein Synthetic Response of Algal and Fungal Protein
A study testing Protein ingestion in people with Muscle Metabolism, run by University of Exeter at 1 site in United Kingdom.
Trial summary
Dietary protein intake is vital for the maintenance of skeletal muscle mass and health. The production of animal-based proteins sources is associated with growing environmental and ethical challenges. As such, sustainable alternatives are needed. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Metabolism
- What is being tested?
- Protein ingestion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 19 Dec 2020to 24 Jun 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- BMI between 18.5 and 30
- Recreationally active (<3 times per week structured resistance exercise training)
Who cannot join
- Any metabolic impairment
- Any cardiovascular impairment
- High blood pressure (>140/90 mmHg)
- A personal history of epilepsy, seizures or schizophrenia
- Smoking
- Chronic (>1 month) use of over the counter pharmaceuticals
- Chronic (>2 months) use of amino acid or protein supplements
- Allergic to Quorn/mycoprotein or algae products
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Muscle Protein Synthetic Response Following the Ingestion of a Single Bolus of Algal Protein When Compared to Fungal Protein in Healthy Young Adults
Dietary protein intake is vital for the maintenance of skeletal muscle mass and health. The production of animal-based proteins sources is associated with growing environmental and ethical challenges. As such, sustainable alternatives are needed. Algae are sustainably produced high-protein sources and it is predicted that algae will become one of the most consumed proteins in the next decades. However, the effects of algae on the stimulation of muscle mass growth are unknown. Therefore, we aim to assess the rate of digestion and absorption, and the effects on muscle growth of two types of algae (spirulina and chlorella) when compared to a sustainable non-animal derived fungal reference protein (mycoprotein), a source known to elicit a robust anabolic response.
- Conditions
- Muscle Metabolism
- Being tested
- Protein ingestion
- Keywords
- Amino Acids, Protein metabolism, Resistance exercise, Muscle protein synthesis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Protein ingestionDietary supplement
Bolus ingestion of 25g protein
| Study group | Role | What they receive |
|---|---|---|
| Mycoprotein | Experimental | Bolus ingestion of mycoprotein providing 25g protein Receives: Dietary Supplement: Protein ingestion |
| Spirulina | Experimental | Bolus ingestion of spirulina providing 25g protein Receives: Dietary Supplement: Protein ingestion |
| Chlorella | Experimental | Bolus ingestion of chlorella providing 25g protein Receives: Dietary Supplement: Protein ingestion |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Protein Synthesis
The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)
Measured: 7.5 hours
Secondary outcomes (4)
Plasma Amino Acid Kinetics
The rate of appearance of amino acid ingested in the drink
Measured: 7.5 hours
Serum Insulin
Basal and postprandial concentrations of serum insulin
Measured: 7.5 hours
Blood Glucose
Basal and postprandial concentrations of blood glucose
Measured: 7.5 hours
mTOR phosphorylation
The amount of mTOR that has been activated in the muscle cell
Measured: 7.5 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Aug 2021
- Study start19 Dec 2020
- Primary completion24 Jun 2022
- Study completion24 Jun 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle MetabolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Exeter
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Benjamin T Wall, PhD, Principal investigator, Professor of Nutritional Physiology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05016557
- Sponsor's protocol ID
- 200506/B/01
- Acronym
- SCAM
- Status last verified
- Jan 2024
- First submitted
- 17 Aug 2021
- Last updated
- 11 Jan 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Jan 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Muscle Protein Synthetic Response Following the Ingestion of a Single Bolus of Algal Protein When Compared to Fungal Protein in Healthy Young Adults
- ClinicalTrials.gov ID
- NCT05016557
- Acronym / sponsor ID
- SCAM / 200506/B/01
- Conditions
- Muscle Metabolism
- Keywords
- Amino Acids, Protein metabolism, Resistance exercise, Muscle protein synthesis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- University of ExeterUniversity, hospital or other
- Study start
- 19 Dec 2020 (actual)
- Primary completion
- 24 Jun 2022 (actual)
- Study completion
- 24 Jun 2022 (actual)
- First posted
- 23 Aug 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Dietary protein intake is vital for the maintenance of skeletal muscle mass and health. The production of animal-based proteins sources is associated with growing environmental and ethical challenges. As such, sustainable alternatives are needed. Algae are sustainably produced high-protein sources and it is predicted that algae will become one of the most consumed proteins in the next decades. However, the effects of algae on the stimulation of muscle mass growth are unknown. Therefore, we aim to assess the rate of digestion and absorption, and the effects on muscle growth of two types of algae (spirulina and chlorella) when compared to a sustainable non-animal derived fungal reference protein (mycoprotein), a source known to elicit a robust anabolic response.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Mycoprotein | Experimental | Dietary Supplement: Protein ingestionBolus ingestion of mycoprotein providing 25g protein |
| Spirulina | Experimental | Dietary Supplement: Protein ingestionBolus ingestion of spirulina providing 25g protein |
| Chlorella | Experimental | Dietary Supplement: Protein ingestionBolus ingestion of chlorella providing 25g protein |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- BMI between 18.5 and 30
- Recreationally active (<3 times per week structured resistance exercise training)
Key exclusion criteria (8 listed)
- Any metabolic impairment
- Any cardiovascular impairment
- High blood pressure (>140/90 mmHg)
- A personal history of epilepsy, seizures or schizophrenia
- Smoking
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Protein ingestionBolus ingestion of 25g protein | Dietary supplement | Chlorella, Mycoprotein, Spirulina |
Primary outcome
Muscle Protein Synthesis
Time frame: 7.5 hours
The rate of synthesis of new muscle protein (Fractional Synthetic Rate %/h)
4 secondary outcomes
Plasma Amino Acid Kinetics
Time frame: 7.5 hours
Serum Insulin
Time frame: 7.5 hours
Blood Glucose
Time frame: 7.5 hours
mTOR phosphorylation
Time frame: 7.5 hours
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jan 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Benjamin T Wall, PhD principal investigator
Professor of Nutritional Physiology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Protein ingestion in people with Muscle Metabolism, run by University of Exeter at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Jan 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Protein Synthesis (time frame: 7.5 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jan 2024.