AzTrials
AzTrials

Metastatic Malignant Neoplasm in the LiverPhase 2NCT05040360

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

A Phase 2 study testing Capecitabine and Temozolomide in people with Metastatic Malignant Neoplasm in the Liver and Pancreatic Neuroendocrine Tumor, run by SWOG Cancer Research Network at 448 sites in 3 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This phase II trial studies the effect of capecitabine and temozolomide after surgery in treating patients with high-risk well-differentiated pancreatic neuroendocrine tumors. Chemotherapy drugs, such as capecitabine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
Capecitabine and Temozolomide
Could I receive a placebo?
No, everyone receives an active treatment
How many people
141 participants
Where
448 sitesin 3 countries
Study dates
5 May 2022to 31 Mar 2027
Phase
Phase 2
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Participants must have a histologic diagnosis of well-differentiated pancreatic neuroendocrine tumor (pNET) that was resected between 14 and 120 days prior to registration. Participants must have a scan within 90 days prior to registration without evidence of metastatic disease. Acceptable scans are multiphase computed tomography (CT) abdomen, magnetic resonance imaging (MRI) with intravenous (IV) contrast of the abdomen, or positron emission tomography (PET)-CT DOTATATE imaging if the DOTATATE PET-CT included IV iodine contrast for the CT portion of the exam
  • Resection must have been an R0 or R1 per treating investigator's assessment and/or pathology report
  • Ki-67 testing, which is considered part of standard of care in the pathology report, must have been performed between 14 and 90 days prior to registration and the result must be >= 3% and =< 55%. Treating investigators are encouraged to contact the S2104 Study Chairs and/or the study pathology chair with questions. If more than one Ki-67 is reported (e.g., primary tumor versus lymph node or metastatic site), the highest one should be considered for the study eligibility criteria
  • Participants with localized resected pNETS must have a Zaidi score of >= 3 derived by the following factors and points:
  • 1 point; symptomatic tumor defined as one of the following:
  • Gastrointestinal bleed
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  • Jaundice
  • Gastrointestinal obstruction
  • Pain from primary tumor prior to surgical resection
  • Pancreatitis
  • 2 points; primary pancreas tumor size > 2 cm
  • 1 point; Ki-67 3% to 20%
  • 1 point; lymph node positivity = 1
  • 6 points; Ki-67 21% to 55%
  • Participants may have received resection/ablation of liver oligo-metastatic disease (up to 5 liver metastases) at the time of well-differentiated pNET resection
  • Participants must have recovered from effects of surgery as determined by the treating investigator
  • Participants must be >= 18 years old
  • Participants must have Zubrod performance status of 0-2
  • Participants must have a complete medical history and physical exam within 28 days prior to registration
  • Leukocytes >= 3 x 10^3/uL (within 28 days prior to registration)
  • Absolute neutrophil count >= 1.5 x 10^3/uL (within 28 days prior to registration)
  • Platelets >= 100 x 10^3/uL (within 28 days prior to registration)
  • Total bilirubin =< institutional upper limit of normal (ULN) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin =< 5 x institutional ULN (within 28 days prior to registration)
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x institutional ULN (within 28 days prior to registration)
  • Serum creatinine =< 1.5 x institutional ULN (within 28 days prior to registration)
  • Calculated creatinine clearance >= 50 ml/min (within 28 days prior to registration)
  • Participants must be able to swallow pills
  • Participants must be able to tolerate CT or magnetic resonance (MR) imaging including contrast agents as required for their treatment and the protocol
  • No other active malignancy or history of prior malignancy is allowed, except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the participant is currently in complete remission, or any other cancer from which the participant has been disease free for two years
  • Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines

Who cannot join

  • Participants must not have unresected or unablated metastatic disease
  • Participants must not have clinically apparent central nervous system metastases or carcinomatous meningitis
  • Participants must not have received prior neoadjuvant therapy for treatment of pancreatic neuroendocrine tumor. Use of somatostatin analogs prior to surgery is permitted
  • Participants must not have received somatostatin analogs after surgery
  • Participants must not be planning to receive warfarin while on protocol treatment. Other anticoagulants are allowed
  • Participants must not have history of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or capecitabine
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  • Participants must not have known absorption issues that would limit the ability to absorb study agents
  • Participants must not have had an arterial thromboembolic event, unstable angina, or myocardial infarction within 12 months prior to registration
  • Participants must not have active or uncontrolled infection
  • Participants must not have serious medical or psychiatric illness that could affect study participation in the judgement of the treating investigator
  • Participants must not be pregnant due to the possibility of harm to the fetus. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen

Trial locations and contacts

448 sites in 3 countries. Contact the study team or a site near you to ask about taking part.

302 sites in 3 countries

United States300 sites, 248 recruiting

  • Providence Regional Cancer System-Aberdeen

    Aberdeen, Washington, 98520

    Site Public Contact, 360-412-8958, deidre.dillon@providence.org

    Charles W. Drescher

    Recruiting

  • Riverwood Healthcare Center

    Aitkin, Minnesota, 56431

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106

    Site Public Contact, 505-925-0348, HSC-ClinicalTrialInfo@salud.unm.edu

    Erika Maestas

    Recruiting

  • University Cancer Specialists - Alcoa

    Alcoa, Tennessee, 37701

    Site Public Contact, 865-305-5120, bherbert@utmck.edu

    Ryan K. Schmocker

    Recruiting

  • OSF Saint Anthony's Health Center

    Alton, Illinois, 62002

    Site Public Contact, 618-463-5623

    Jay W. Carlson

    Recruiting

  • Mary Greeley Medical Center

    Ames, Iowa, 50010

    Site Public Contact, 515-956-4132

    Joseph J. Merchant

    Recruiting

  • McFarland Clinic - Ames

    Ames, Iowa, 50010

    Site Public Contact, 515-239-4734, ksoder@mcfarlandclinic.com

    Joseph J. Merchant

    Recruiting

  • Community Hospital of Anaconda

    Anaconda, Montana, 59711

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, 98508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Anchorage Radiation Therapy Center

    Anchorage, Alaska, 99504

    Suspended

  • Alaska Breast Care and Surgery LLC

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Alaska Oncology and Hematology LLC

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Alaska Women's Cancer Care

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Anchorage Oncology Centre

    Anchorage, Alaska, 99508

    Suspended

  • Katmai Oncology Group

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • Providence Alaska Medical Center

    Anchorage, Alaska, 99508

    Site Public Contact, 907-212-6871, AKPAMC.OncologyResearchSupport@providence.org

    Charles W. Drescher

    Recruiting

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan, 48109

    Site Public Contact, 800-865-1125, slusserb@med.umich.edu

    Vaibhav Sahai

    Recruiting

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, California, 93420

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • PCR Oncology

    Arroyo Grande, California, 93420

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Duluth Clinic Ashland

    Ashland, Wisconsin, 54806

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Northwest Wisconsin Cancer Center

    Ashland, Wisconsin, 54806

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308

    Site Public Contact, 888-946-7447

    Mohammad Y. Zaidi

    Recruiting

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322

    Site Public Contact, 404-778-1868

    Mohammad Y. Zaidi

    Recruiting

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342

    Site Public Contact, 404-851-7115

    Mohammad Y. Zaidi

    Recruiting

  • Rocky Mountain Cancer Centers-Aurora

    Aurora, Colorado, 80012

    Active, not recruiting

  • Rush-Copley Medical Center

    Aurora, Illinois, 60504

    Site Public Contact, 630-978-6212, RCMC_Cancer_Research@rush.edu

    Tanmay Sahai

    Recruiting

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio, 44011

    Site Public Contact, 800-641-2422

    Amr Mohamed

    Recruiting

  • Saint Alphonsus Cancer Care Center-Baker City

    Baker City, Oregon, 97814

    Suspended

  • Mercy Oncology and Hematology - Clayton-Clarkson

    Ballwin, Missouri, 63011

    Site Public Contact, 888-446-3729

    Jay W. Carlson

    Recruiting

  • Mercy Medical Center

    Baltimore, Maryland, 21202

    Site Public Contact, 410-951-7956, acline@mdmercy.com

    Sandy D. Kotiah

    Recruiting

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287

    Site Public Contact, 410-955-8804, jhcccro@jhmi.edu

    Ana D. De Jesus Acosta

    Recruiting

  • Flaget Memorial Hospital

    Bardstown, Kentucky, 40004

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Essentia Health - Baxter Clinic

    Baxter, Minnesota, 56425

    Site Public Contact, 218-828-2880

    Bret E. Friday

    Recruiting

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio, 44122

    Site Public Contact, 800-641-2422, CTUReferral@UHhospitals.org

    Amr Mohamed

    Recruiting

  • Overlake Medical Center

    Bellevue, Washington, 98004

    Suspended

  • PeaceHealth Saint Joseph Medical Center

    Bellingham, Washington, 98225

    Site Public Contact, 360-788-8223

    Charles W. Drescher

    Recruiting

  • Saint Charles Health System

    Bend, Oregon, 97701

    Site Public Contact, 541-706-2909, nosall@stcharleshealthcare.org

    Charles W. Drescher

    Recruiting

  • Tower Cancer Research Foundation

    Beverly Hills, California, 90211

    Site Public Contact, towercancerresearch@toweroncology.com

    Andrew E. Hendifar

    Recruiting

  • Billings Clinic Cancer Center

    Billings, Montana, 59101

    Site Public Contact, 800-996-2663, research@billingsclinic.org

    John M. Schallenkamp

    Recruiting

  • Saint Vincent Healthcare

    Billings, Montana, 59101

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    Patrick W. Cobb

    Recruiting

  • Saint Vincent Frontier Cancer Center

    Billings, Montana, 59102

    Site Public Contact, 800-648-6274

    Patrick W. Cobb

    Recruiting

  • Intermountain Health West End Clinic

    Billings, Montana, 59106

    Site Public Contact, 406-238-6685

    Patrick W. Cobb

    Recruiting

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina, 29316

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, 83706

    Suspended

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • Central Care Cancer Center - Bolivar

    Bolivar, Missouri, 65613

    Site Public Contact, 913-948-5588, aroland@kccop.org

    Jay W. Carlson

    Recruiting

  • Schulze Family Foundation Cancer Clinic - Bonita Health Center

    Bonita Springs, Florida, 34135

    Site Public Contact, 239-343-9660, RCCR@leehealth.org

    Paul M. Bloomston

    Recruiting

  • McFarland Clinic - Boone

    Boone, Iowa, 50036

    Site Public Contact, 515-956-4132

    Joseph J. Merchant

    Recruiting

  • Boulder Community Foothills Hospital

    Boulder, Colorado, 80303

    Active, not recruiting

  • Rocky Mountain Cancer Centers-Boulder

    Boulder, Colorado, 80304

    Active, not recruiting

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Essentia Health Saint Joseph's Medical Center

    Brainerd, Minnesota, 56401

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Cox Cancer Center Branson

    Branson, Missouri, 65616

    Site Public Contact, 417-269-4520

    Jay W. Carlson

    Recruiting

  • University of Michigan - Brighton Center for Specialty Care

    Brighton, Michigan, 48116

    Site Public Contact, 800-865-1125

    Vaibhav Sahai

    Recruiting

  • Henry Ford Cancer Institute-Downriver

    Brownstown, Michigan, 48183

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Saint Joseph Regional Cancer Center

    Bryan, Texas, 77802

    Suspended

  • Keck Medicine of USC Buena Park

    Buena Park, California, 90621

    Site Public Contact, 714-522-0908

    Syma Iqbal

    Recruiting

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    Burbank, California, 91505

    Site Public Contact, 818-847-4793, Najee.Boucher@providence.org

    Charles W. Drescher

    Recruiting

  • Highline Medical Center-Main Campus

    Burien, Washington, 98166

    Suspended

  • University of Vermont Medical Center

    Burlington, Vermont, 05401

    Site Public Contact, 802-656-4101, rpo@uvm.edu

    Jaime Pineda

    Recruiting

  • University of Vermont and State Agricultural College

    Burlington, Vermont, 05405

    Site Public Contact, 802-656-8990, rpo@uvm.edu

    Jaime Pineda

    Recruiting

  • Minnesota Oncology - Burnsville

    Burnsville, Minnesota, 55337

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Saint James Community Hospital and Cancer Treatment Center

    Butte, Montana, 59701

    Site Public Contact, 406-723-2621

    Patrick W. Cobb

    Recruiting

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, 83605

    Suspended

  • Cambridge Medical Center

    Cambridge, Minnesota, 55008

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Mercy Cancer Center - Cape Girardeau

    Cape Girardeau, Missouri, 63703

    Site Public Contact, 888-446-3729

    Jay W. Carlson

    Recruiting

  • Mercy Cancer Center - Carmichael

    Carmichael, California, 95608

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Mercy San Juan Medical Center

    Carmichael, California, 95608

    Site Public Contact, 916-556-3301, OncologyResearch@DignityHealth.org

    Shahzad Siddique

    Recruiting

  • Carson Tahoe Regional Medical Center

    Carson City, Nevada, 89703

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Rocky Mountain Cancer Centers - Centennial

    Centennial, Colorado, 80112

    Active, not recruiting

  • Miami Valley Hospital South

    Centerville, Ohio, 45459

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Saint Mary's Hospital

    Centralia, Illinois, 62801

    Site Public Contact, protocols@swog.org

    Jay W. Carlson

    Recruiting

  • Providence Regional Cancer System-Centralia

    Centralia, Washington, 98531

    Site Public Contact, 360-412-8958, deidre.dillon@providence.org

    Charles W. Drescher

    Recruiting

  • Medical University of South Carolina

    Charleston, South Carolina, 29425

    Site Public Contact, 843-792-9321, hcc-clinical-trials@musc.edu

    William G. Hawkins

    Recruiting

  • Northwestern University

    Chicago, Illinois, 60611

    Site Public Contact, 312-695-1301, cancer@northwestern.edu

    Mary F. Mulcahy

    Recruiting

  • University of Illinois

    Chicago, Illinois, 60612

    Site Public Contact, 312-355-3046

    Shikha Jain

    Recruiting

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637

    Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu

    Chih-Yi Liao

    Recruiting

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219

    Site Public Contact, 513-584-7698, cancer@uchealth.com

    Davendra P. Sohal

    Recruiting

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Bethesda North Hospital

    Cincinnati, Ohio, 45242

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45247

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • TriHealth Cancer Institute-Anderson

    Cincinnati, Ohio, 45255

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Nikolaos Trikalinos

    Recruiting

  • Clackamas Radiation Oncology Center

    Clackamas, Oregon, 97015

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Charles W. Drescher

    Recruiting

  • Providence Cancer Institute Clackamas Clinic

    Clackamas, Oregon, 97015

    Suspended

  • Case Western Reserve University

    Cleveland, Ohio, 44106

    Site Public Contact, 800-641-2422, CTUReferral@UHhospitals.org

    Amr Mohamed

    Recruiting

  • Henry Ford Hematology Oncology - Hayes

    Clinton Township, Michigan, 48038

    Site Public Contact, 313-916-1784, tpearce1@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Henry Ford Macomb Hospital-Clinton Township

    Clinton Township, Michigan, 48038

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325

    Suspended

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa, 50325

    Suspended

  • Billings Clinic-Cody

    Cody, Wyoming, 82414

    Site Public Contact, 800-996-2663, research@billingsclinic.org

    John M. Schallenkamp

    Recruiting

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho, 83814

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee, 38017

    Site Public Contact, 901-226-1366, BCCclintrials@bmhcc.org

    Stephen W. Behrman

    Recruiting

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, 80907

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado, 80907

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Saint Francis Cancer Center

    Colorado Springs, Colorado, 80923

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210

    Site Public Contact, 800-293-5066, Jamesline@osumc.edu

    Jordan M. Cloyd

    Recruiting

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Bay Area Hospital

    Coos Bay, Oregon, 97420

    Site Public Contact, 541-269-8392, cherie.cox@bayareahospital.org

    Charles W. Drescher

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, 33146

    Site Public Contact, 305-243-2647

    Peter J. Hosein

    Recruiting

  • Commonwealth Cancer Center-Corbin

    Corbin, Kentucky, 40701

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Alegent Health Mercy Hospital

    Council Bluffs, Iowa, 51503

    Suspended

  • Greater Regional Medical Center

    Creston, Iowa, 50801

    Suspended

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Nikolaos Trikalinos

    Recruiting

  • Essentia Health - Saint Joseph's Crosslake Clinic

    Crosslake, Minnesota, 56442

    Site Public Contact, 218-692-1010

    Bret E. Friday

    Recruiting

  • Carle at The Riverfront

    Danville, Illinois, 61832

    Site Public Contact, 800-446-5532, Research@Carle.com

    Tanmay Sahai

    Recruiting

  • Miami Valley Hospital

    Dayton, Ohio, 45409

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Premier Blood and Cancer Center

    Dayton, Ohio, 45409

    Site Public Contact, 937-276-8320

    Tarek M. Sabagh

    Recruiting

  • Miami Valley Hospital North

    Dayton, Ohio, 45415

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Henry Ford Medical Center-Fairlane

    Dearborn, Michigan, 48126

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Emory Decatur Hospital

    Decatur, Georgia, 30033

    Site Public Contact, 440-778-1868, clinicaltrialsoncology@dekalbmedical.org

    Mohammad Y. Zaidi

    Recruiting

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota, 56636

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, 33442

    Site Public Contact, 305-243-2647

    Peter J. Hosein

    Recruiting

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois, 60115

    Site Public Contact, 630-352-5360, Donald.Smith3@nm.org

    Mary F. Mulcahy

    Recruiting

  • Cancer Center of Colorado at Sloan's Lake

    Denver, Colorado, 80204

    Site Public Contact, 303-777-2663

    Patrick W. Cobb

    Recruiting

  • National Jewish Health-Main Campus

    Denver, Colorado, 80206

    Site Public Contact, 877-225-5654, glicht@co-cancerresearch.org

    Patrick W. Cobb

    Recruiting

  • The Women's Imaging Center

    Denver, Colorado, 80209

    Active, not recruiting

  • AdventHealth Porter

    Denver, Colorado, 80210

    Suspended

  • Colorado Blood Cancer Institute

    Denver, Colorado, 80218

    Active, not recruiting

  • Presbyterian - Saint Lukes Medical Center - Health One

    Denver, Colorado, 80218

    Active, not recruiting

  • Rocky Mountain Cancer Centers-Midtown

    Denver, Colorado, 80218

    Active, not recruiting

  • Saint Joseph Hospital - Cancer Centers of Colorado

    Denver, Colorado, 80218

    Site Public Contact, 303-318-3413

    Patrick W. Cobb

    Recruiting

  • Rocky Mountain Cancer Centers-Rose

    Denver, Colorado, 80220

    Active, not recruiting

  • Smilow Cancer Hospital-Derby Care Center

    Derby, Connecticut, 06418

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Pamela L. Kunz

    Recruiting

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314

    Suspended

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa, 50314

    Suspended

  • Henry Ford Hospital

    Detroit, Michigan, 48202

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Essentia Health Saint Mary's - Detroit Lakes Clinic

    Detroit Lakes, Minnesota, 56501

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Epic Care-Dublin

    Dublin, California, 94568

    Active, not recruiting

  • Essentia Health Cancer Center

    Duluth, Minnesota, 55805

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Essentia Health Saint Mary's Medical Center

    Duluth, Minnesota, 55805

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Miller-Dwan Hospital

    Duluth, Minnesota, 55805

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • CommonSpirit Cancer Center Mercy

    Durango, Colorado, 81301

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Mercy Medical Center

    Durango, Colorado, 81301

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina, 29640

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Fairview Southdale Hospital

    Edina, Minnesota, 55435

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington, 98026

    Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org

    Charles W. Drescher

    Recruiting

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401

    Site Public Contact, 800-446-5532, Research@carle.com

    Tanmay Sahai

    Recruiting

  • Mercy Cancer Center - Elk Grove

    Elk Grove, California, 95758

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Essentia Health - Ely Clinic

    Ely, Minnesota, 55731

    Site Public Contact, 218-365-7900

    Bret E. Friday

    Recruiting

  • Bay Area Breast Surgeons Inc

    Emeryville, California, 94608

    Active, not recruiting

  • Epic Care Partners in Cancer Care

    Emeryville, California, 94608

    Active, not recruiting

  • Mountain Blue Cancer Care Center - Swedish

    Englewood, Colorado, 80113

    Active, not recruiting

  • Rocky Mountain Cancer Centers - Swedish

    Englewood, Colorado, 80113

    Active, not recruiting

  • The Melanoma and Skin Cancer Institute

    Englewood, Colorado, 80113

    Active, not recruiting

  • Saint Elizabeth Hospital

    Enumclaw, Washington, 98022

    Suspended

  • Providence Regional Cancer Partnership

    Everett, Washington, 98201

    Site Public Contact, 425-261-3529, marilyn.birchman@providence.org

    Charles W. Drescher

    Recruiting

  • Fairbanks Memorial Hospital

    Fairbanks, Alaska, 99701

    Active, not recruiting

  • Smilow Cancer Hospital Care Center-Fairfield

    Fairfield, Connecticut, 06824

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Pamela L. Kunz

    Recruiting

  • Essentia Health Cancer Center-South University Clinic

    Fargo, North Dakota, 58103

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Farmington Health Center

    Farmington, Utah, 84025

    Site Public Contact, 888-424-2100, cancerinfo@hci.utah.edu

    Heloisa P. Soares

    Recruiting

  • Saint Francis Hospital

    Federal Way, Washington, 98003

    Suspended

  • Lake Region Healthcare Corporation-Cancer Care

    Fergus Falls, Minnesota, 56537

    Suspended

  • McFarland Clinic - Trinity Cancer Center

    Fort Dodge, Iowa, 50501

    Site Public Contact, 515-956-4132

    Joseph J. Merchant

    Recruiting

  • Regional Cancer Center-Lee Memorial Health System

    Fort Myers, Florida, 33905

    Site Public Contact, protocols@swog.org

    Paul M. Bloomston

    Recruiting

  • Mercy Hospital Fort Smith

    Fort Smith, Arkansas, 72903

    Site Public Contact, 800-378-9373

    Jay W. Carlson

    Recruiting

  • Essentia Health - Fosston

    Fosston, Minnesota, 56542

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio, 45005-1066

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Saint Luke's Cancer Institute - Fruitland

    Fruitland, Idaho, 83619

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610

    Active, not recruiting

  • Central Care Cancer Center - Garden City

    Garden City, Kansas, 67846

    Site Public Contact, 913-948-5588, aroland@kccop.org

    Jay W. Carlson

    Recruiting

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois, 60134

    Site Public Contact, 630-352-5360, Donald.Smith3@nm.org

    Mary F. Mulcahy

    Recruiting

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234

    Site Public Contact, 602-747-9738

    Zachary Yeung

    Recruiting

  • Smilow Cancer Hospital Care Center at Glastonbury

    Glastonbury, Connecticut, 06033

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Pamela L. Kunz

    Recruiting

  • Northwestern Medicine Glenview Outpatient Center

    Glenview, Illinois, 60026

    Site Public Contact, 312-695-1102

    Mary F. Mulcahy

    Recruiting

  • National Jewish Health-Western Hematology Oncology

    Golden, Colorado, 80401

    Site Public Contact, 303-777-2663, glicht@co-cancerresearch.org

    Patrick W. Cobb

    Recruiting

  • CHI Health Saint Francis

    Grand Island, Nebraska, 68803

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Nebraska Cancer Specialists/Oncology Hematology West PC

    Grand Island, Nebraska, 68803

    Suspended

  • Saint Mary's Hospital and Regional Medical Center

    Grand Junction, Colorado, 81501

    Site Public Contact, 303-777-2663, ccrp@co-cancerresearch.org

    Patrick W. Cobb

    Recruiting

  • Northwestern Medicine Grayslake Outpatient Center

    Grayslake, Illinois, 60030

    Site Public Contact, 312-695-1102

    Mary F. Mulcahy

    Recruiting

  • Central Care Cancer Center - Great Bend

    Great Bend, Kansas, 67530

    Site Public Contact, 913-948-5588, aroland@kccop.org

    Jay W. Carlson

    Recruiting

  • Benefis Sletten Cancer Institute

    Great Falls, Montana, 59405

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Great Falls Clinic

    Great Falls, Montana, 59405

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio, 45331

    Site Public Contact, 937-569-7515

    Tarek M. Sabagh

    Recruiting

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina, 29605

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Prisma Health Greenville Memorial Hospital

    Greenville, South Carolina, 29605

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina, 29615

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Smilow Cancer Hospital Care Center at Greenwich

    Greenwich, Connecticut, 06830

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Pamela L. Kunz

    Recruiting

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina, 29650

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Smilow Cancer Hospital Care Center - Guilford

    Guilford, Connecticut, 06437

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Pamela L. Kunz

    Recruiting

  • Smilow Cancer Hospital Care Center at Saint Francis

    Hartford, Connecticut, 06105

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Pamela L. Kunz

    Recruiting

  • Hi-Line Sletten Cancer Center

    Havre, Montana, 59501

    Site Public Contact, protocols@swog.org

    John M. Schallenkamp

    Recruiting

  • Essentia Health-Hayward Clinic

    Hayward, Wisconsin, 54843

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Tamarack Health Hayward Medical Center

    Hayward, Wisconsin, 54843

    Site Public Contact, 218-568-4416

    Bret E. Friday

    Recruiting

  • Cancer and Blood Specialists-Henderson

    Henderson, Nevada, 89052

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada - Henderson

    Henderson, Nevada, 89052

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada-Horizon Ridge

    Henderson, Nevada, 89052

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Cancer Center-Henderson

    Henderson, Nevada, 89052

    Suspended

  • OptumCare Cancer Care at Seven Hills

    Henderson, Nevada, 89052

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada-Southeast Henderson

    Henderson, Nevada, 89074

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Urology - Green Valley

    Henderson, Nevada, 89074

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Urology - Pebble

    Henderson, Nevada, 89074

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Oncology Las Vegas - Henderson

    Henderson, Nevada, 89074

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Urology Specialists of Nevada - Green Valley

    Henderson, Nevada, 89074

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Essentia Health Hibbing Clinic

    Hibbing, Minnesota, 55746

    Site Public Contact, 218-786-3308

    Bret E. Friday

    Recruiting

  • Providence Hood River Memorial Hospital

    Hood River, Oregon, 97031

    Site Public Contact, 503-215-1979, canrsrchstudies@provdience.org

    Charles W. Drescher

    Recruiting

  • Keck Medicine of USC Huntington Beach

    Huntington Beach, California, 92648

    Site Public Contact, 714-861-1000, karenn@pacshoresoncology.com

    Syma Iqbal

    Recruiting

  • Essentia Health - International Falls Clinic

    International Falls, Minnesota, 56649

    Site Public Contact, 218-283-9431

    Bret E. Friday

    Recruiting

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    Irvine, California, 92612

    Site Public Contact, 877-827-8839, ucstudy@uci.edu

    Jennifer B. Valerin

    Recruiting

  • Swedish Cancer Institute-Issaquah

    Issaquah, Washington, 98029

    Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org

    Charles W. Drescher

    Recruiting

  • Allegiance Health

    Jackson, Michigan, 49201

    Site Public Contact, 313-916-3721, CTOResearch@hfhs.org

    Haythem Y. Ali

    Recruiting

  • Essentia Health - Jamestown Clinic

    Jamestown, North Dakota, 58401

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • McFarland Clinic - Jefferson

    Jefferson, Iowa, 50129

    Site Public Contact, 515-956-4132

    Joseph J. Merchant

    Recruiting

  • Freeman Health System

    Joplin, Missouri, 64804

    Site Public Contact, 417-347-4030, LJCrockett@freemanhealth.com

    Jay W. Carlson

    Recruiting

  • Mercy Hospital Joplin

    Joplin, Missouri, 64804

    Site Public Contact, 417-556-3074, esmeralda.carrillo@mercy.net

    Jay W. Carlson

    Recruiting

  • Logan Health Medical Center

    Kalispell, Montana, 59901

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • CHI Health Good Samaritan

    Kearney, Nebraska, 68847

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington, 99336

    Site Public Contact, 509-783-4637, research@kadlecmed.org

    Charles W. Drescher

    Recruiting

  • Kingman Regional Medical Center

    Kingman, Arizona, 86401

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • University of Tennessee - Knoxville

    Knoxville, Tennessee, 37920

    Site Public Contact, 865-544-9773

    Ryan K. Schmocker

    Recruiting

  • Gundersen Lutheran Medical Center

    La Crosse, Wisconsin, 54601

    Site Public Contact, 608-775-2385, cancerctr@gundersenhealth.org

    David E. Marinier

    Recruiting

  • Providence Regional Cancer System-Lacey

    Lacey, Washington, 98503

    Site Public Contact, 360-412-8958, deidre.dillon@providence.org

    Charles W. Drescher

    Recruiting

  • Good Samaritan Hospital - Cancer Centers of Colorado

    Lafayette, Colorado, 80026

    Site Public Contact, peaksresearch@imail.org

    Patrick W. Cobb

    Recruiting

  • Northwestern Medicine Lake Forest Hospital

    Lake Forest, Illinois, 60045

    Site Public Contact, cancertrials@northwestern.edu

    Mary F. Mulcahy

    Recruiting

  • Rocky Mountain Cancer Centers-Lakewood

    Lakewood, Colorado, 80228

    Active, not recruiting

  • Saint Anthony Hospital

    Lakewood, Colorado, 80228

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Saint Clare Hospital

    Lakewood, Washington, 98499

    Suspended

  • Las Vegas Urology - Pecos

    Las Vegas, Nevada, 89074

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada, 89102

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada, 89102

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Hope Cancer Care of Nevada

    Las Vegas, Nevada, 89103

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Radiation Oncology Centers of Nevada Central

    Las Vegas, Nevada, 89106

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Urology Specialists of Nevada - Central

    Las Vegas, Nevada, 89106

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Sunrise Hospital and Medical Center

    Las Vegas, Nevada, 89109

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Prostate Cancer Center

    Las Vegas, Nevada, 89113

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Urology - Sunset

    Las Vegas, Nevada, 89113

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Urology Specialists of Nevada - Southwest

    Las Vegas, Nevada, 89113

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Radiation Oncology Centers of Nevada Southeast

    Las Vegas, Nevada, 89119

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Ann M Wierman MD LTD

    Las Vegas, Nevada, 89128

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada - Northwest

    Las Vegas, Nevada, 89128

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Urology - Cathedral Rock

    Las Vegas, Nevada, 89128

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Urology - Smoke Ranch

    Las Vegas, Nevada, 89128

    Site Public Contact, research@smcrf.org

    John A. Ellerton

    Recruiting

  • Oncology Las Vegas - Tenaya

    Las Vegas, Nevada, 89128

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • OptumCare Cancer Care at MountainView

    Las Vegas, Nevada, 89128

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Urology Specialists of Nevada - Northwest

    Las Vegas, Nevada, 89128

    Site Public Contact, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada, 89135

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada - Town Center

    Las Vegas, Nevada, 89144

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada-Summerlin

    Las Vegas, Nevada, 89144

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada, 89144

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Las Vegas Cancer Center-Medical Center

    Las Vegas, Nevada, 89148-2405

    Suspended

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89148

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada, 89148

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Comprehensive Cancer Centers of Nevada - Central Valley

    Las Vegas, Nevada, 89169

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • University Cancer Center

    Las Vegas, Nevada, 89169

    Site Public Contact, 702-384-0013, research@sncrf.org

    John A. Ellerton

    Recruiting

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756

    Site Public Contact, 800-639-6918, cancer.research.nurse@dartmouth.edu

    Kathryn C. Hourdequin

    Recruiting

  • Saint Joseph Hospital

    Lexington, Kentucky, 40504

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Saint Joseph Radiation Oncology Resource Center

    Lexington, Kentucky, 40504

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Saint Joseph Hospital East

    Lexington, Kentucky, 40509

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536

    Site Public Contact, 859-257-3379

    Michael J. Cavnar

    Recruiting

  • Saint Elizabeth Regional Medical Center

    Lincoln, Nebraska, 68510

    Suspended

  • CARTI Cancer Center

    Little Rock, Arkansas, 72205

    Site Public Contact, 501-906-4199, Research@CARTI.com

    Jay W. Carlson

    Recruiting

  • Rocky Mountain Cancer Centers-Littleton

    Littleton, Colorado, 80120

    Active, not recruiting

  • AdventHealth Littleton

    Littleton, Colorado, 80122

    Suspended

  • Saint Joseph London

    London, Kentucky, 40741

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Rocky Mountain Cancer Centers-Sky Ridge

    Lone Tree, Colorado, 80124

    Active, not recruiting

  • Longmont United Hospital

    Longmont, Colorado, 80501

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Rocky Mountain Cancer Centers-Longmont

    Longmont, Colorado, 80501

    Active, not recruiting

  • PeaceHealth Saint John Medical Center

    Longview, Washington, 98632

    Site Public Contact, 360-514-2016, kmakin-bond@peacehealth.org

    Charles W. Drescher

    Recruiting

  • Keck Medicine of USC Koreatown

    Los Angeles, California, 90020

    Site Public Contact, 213-388-0908

    Syma Iqbal

    Recruiting

  • Los Angeles General Medical Center

    Los Angeles, California, 90033

    Site Public Contact, 323-865-0451, uscnorrisinfo@med.usc.edu

    Syma Iqbal

    Recruiting

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033

    Site Public Contact, 323-865-0451

    Syma Iqbal

    Recruiting

  • Cedars Sinai Medical Center

    Los Angeles, California, 90048

    Site Public Contact, 310-423-8965

    Andrew E. Hendifar

    Recruiting

  • Jewish Hospital

    Louisville, Kentucky, 40202

    Suspended

  • Saints Mary and Elizabeth Hospital

    Louisville, Kentucky, 40215

    Suspended

  • UofL Health Medical Center Northeast

    Louisville, Kentucky, 40245

    Suspended

  • Fairview Clinics and Surgery Center Maple Grove

    Maple Grove, Minnesota, 55369

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Minnesota Oncology Hematology PA-Maplewood

    Maplewood, Minnesota, 55109

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Saint John's Hospital - Healtheast

    Maplewood, Minnesota, 55109

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • McFarland Clinic - Marshalltown

    Marshalltown, Iowa, 50158

    Site Public Contact, 515-956-4132

    Joseph J. Merchant

    Recruiting

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Contra Costa Regional Medical Center

    Martinez, California, 94553-3156

    Active, not recruiting

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938

    Site Public Contact, 800-446-5532, Research@carle.com

    Tanmay Sahai

    Recruiting

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee, 38120

    Site Public Contact, 901-226-1366, BCCclintrials@bmhcc.org

    Stephen W. Behrman

    Recruiting

  • Mercy Cancer Center

    Merced, California, 95340

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • Idaho Urologic Institute-Meridian

    Meridian, Idaho, 83642

    Suspended

  • Saint Luke's Cancer Institute - Meridian

    Meridian, Idaho, 83642

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • East Jefferson General Hospital

    Metairie, Louisiana, 70006

    Site Public Contact, 504-210-3539, emede1@lsuhsc.edu

    Mary Hobbs Maluccio

    Recruiting

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136

    Site Public Contact, 305-243-2647

    Peter J. Hosein

    Recruiting

  • UM Sylvester Comprehensive Cancer Center at Kendall

    Miami, Florida, 33176

    Site Public Contact, 305-243-2647

    Peter J. Hosein

    Recruiting

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota, 55407

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Health Partners Inc

    Minneapolis, Minnesota, 55454

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin, 54548

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Seth O. Fagbemi

    Recruiting

  • Saint Patrick Hospital - Community Hospital

    Missoula, Montana, 59802

    Site Public Contact, 406-327-3118, amy.hanneman@providence.org

    Charles W. Drescher

    Recruiting

  • Community Medical Center

    Missoula, Montana, 59804

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Monticello Cancer Center

    Monticello, Minnesota, 55362

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Essentia Health - Moose Lake Clinic

    Moose Lake, Minnesota, 55767

    Site Public Contact, 218-485-4481

    Bret E. Friday

    Recruiting

  • Saint Joseph Mount Sterling

    Mount Sterling, Kentucky, 40353

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Shahzad Siddique

    Recruiting

  • SSM Health Good Samaritan

    Mount Vernon, Illinois, 62864

    Site Public Contact, 618-899-1894, gayla.hall@ssmhealth.com

    Jay W. Carlson

    Recruiting

  • Skagit Regional Health Cancer Care Center

    Mount Vernon, Washington, 98274

    Site Public Contact, 360-814-2182, rcccclinicalresearch@skagitvalleyhospital.org

    Charles W. Drescher

    Recruiting

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho, 83687

    Suspended

  • Saint Luke's Cancer Institute - Nampa

    Nampa, Idaho, 83687

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Charles W. Drescher

    Recruiting

  • Providence Queen of The Valley

    Napa, California, 94558

    Site Public Contact, 707-521-3830

    Charles W. Drescher

    Recruiting

  • Yale University

    New Haven, Connecticut, 06520

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Pamela L. Kunz

    Recruiting

  • UC Comprehensive Cancer Center at Silver Cross

    New Lenox, Illinois, 60451

    Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu

    Chih-Yi Liao

    Recruiting

  • Cancer Center of Western Wisconsin

    New Richmond, Wisconsin, 54017

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • New Ulm Medical Center

    New Ulm, Minnesota, 56073

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    David M. King

    Recruiting

  • Providence Newberg Medical Center

    Newberg, Oregon, 97132

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Charles W. Drescher

    Recruiting

Other trials in United States

Mexico1 site, 1 recruiting

  • Instituto Nacional De Cancerologia de Mexico

    Mexico City, Tlalpan, 14080

    Site Public Contact, (52) 5628-0400

    Erika B. Ruiz-Garcia

    Recruiting

Other trials in Mexico

Uruguay1 site

  • Hospital de Clinicas Dr Manuel Quintela

    Montevideo, 11600

    Suspended

Other trials in Uruguay

About this study

Official title: Randomized Phase II Trial of Postoperative Adjuvant Capecitabine and Temozolomide Versus Observation in High-Risk Pancreatic Neuroendocrine Tumors

This phase II trial studies the effect of capecitabine and temozolomide after surgery in treating patients with high-risk well-differentiated pancreatic neuroendocrine tumors. Chemotherapy drugs, such as capecitabine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving capecitabine and temozolomide after surgery could prevent or delay the return of cancer in patients with high-risk well-differentiated pancreatic neuroendocrine tumors.

Read the detailed description

PRIMARY OBJECTIVE:

  1. To evaluate recurrence-free survival (RFS) in participants with resected pancreatic neuroendocrine tumors (pNETs) randomized to treatment with capecitabine + temozolomide (CAPTEM) compared to observation only.

SECONDARY OBJECTIVES:

  1. To evaluate overall survival (OS) in participants randomized to treatment with CAPTEM compared to observation only.

II. To evaluate the safety and tolerability of CAPTEM compared to observation only.

BANKING OBJECTIVE:

  1. To bank specimens for future correlative studies.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive capecitabine orally (PO) twice daily (BID) on days 1-14 and temozolomide PO once daily (QD) on days 10-14. Treatment repeats every 28 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.

ARM II: Patients undergo surveillance with no active treatment.

After completion of study treatment, patients are followed up every 6 months for 3 years and then annually until 5 years from randomization.

Medical subject headings
Adenoma, Islet Cell

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • CapecitabineDrug

    Also called Ro 09-1978/000, Xeloda

    Given PO

  • TemozolomideDrug

    Also called CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831

    Given PO

Study groups in NCT05040360
Study groupRoleWhat they receive
Arm I (capecitabine, temozolomide)ExperimentalPatients receive capecitabine PO BID on days 1-14 and temozolomide PO once QD on days 10-14. Treatment repeats every 28 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.
Receives: Drug: Capecitabine; Drug: Temozolomide
Arm II (surveillance)No interventionPatients undergo surveillance with no active treatment.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Recurrence-free survival (RFS)

    Distribution of RFS in each arm will be estimated using the method of Kaplan-Meier and compared using the stratified log rank test.

    Measured: From date of randomization to progression/recurrence or death from any cause, assessed up to 5 years

Secondary outcomes (2)

  1. Overall survival (OS)

    Distribution of OS in each arm will be estimated using the method of Kaplan-Meier and compared using the stratified log rank test.

    Measured: From date of registration to date of death due to any cause, assessed up to 5 years

  2. Incidence of adverse events

    Evaluated using National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.

    Measured: Up to 30 days after completion of treatment

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted10 Sep 2021
  2. Study start5 May 2022
  3. Primary completion31 Mar 2027 (estimated)
  4. Study completion31 Mar 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
141 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05040360
Sponsor's protocol ID
S2104
Other IDs
NCI-2021-06619, S2104, S2104, U10CA180888
Status last verified
Dec 2025
First submitted
2 Sep 2021
Last updated
15 Dec 2025
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing Capecitabine and Temozolomide in people with Metastatic Malignant Neoplasm in the Liver and Pancreatic Neuroendocrine Tumor, run by SWOG Cancer Research Network at 448 sites in 3 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 30 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 15 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 448 sites in United States, Mexico, Uruguay. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Recurrence-free survival (RFS) (time frame: From date of randomization to progression/recurrence or death from any cause, assessed up to 5 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05040360.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Dec 2025.

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