AzTrials
AzTrials

Non-diabetic Chronic Kidney DiseasePhase 3FIND-CKDNCT05047263

A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease

A Phase 3 study testing Finerenone (BAY94-8862) in people with Non-diabetic Chronic Kidney Disease, run by Bayer at 326 sites in 24 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Non-diabetic Chronic Kidney Disease
What is being tested?
Finerenone (BAY94-8862)
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
1,584 participants
Where
326 sitesin 24 countries
Study dates
21 Sep 2021to 2 Feb 2026
Phase
Phase 3
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • A clinical diagnosis of chronic kidney disease and:
  • Urine albumin/creatinine ratio (UACR) of ≥ 200 but ≤ 3500 mg/g and estimated glomerular filtration rate (eGFR) ≥ 25 but < 90 mL/min/1.73m^2 at screening, and
  • Documentation of albuminuria/proteinuria in the participant's medical records at least 3 months prior to screening.
  • Stable and maximum tolerated labeled dose of an Angiotensin-converting enzyme inhibitor (ACEI) or Angiotensin receptor blocker (ARB) for at least 4 weeks prior to screening
  • K+ ≤ 4.8 mmol/L at screening

Who cannot join

  • Established diagnosis of Type 1 or 2 Diabetes mellitus, or HbA1c ≥ 6.5% (48 mmol/mol)
  • Autosomal dominant or autosomal recessive polycystic kidney disease
  • Lupus nephritis or anti-neutrophilic cytoplasmic autoantibody (ANCA) -associated vasculitis or any other primary or secondary kidney disease requiring immunosuppressive therapy within 6 months prior to screening
  • Symptomatic heart failure with reduced ejection fraction with class 1A indication for Mineralocorticoid receptor antagonists (MRAs)

Trial locations and contacts

326 sites in 24 countries.

326 sites in 24 countries

United States57 sites

  • UNM Clinical and Translational Science Center - Nephrology

    Albuquerque, New Mexico, 87131

  • Mountain Kidney & Hypertension Associates

    Asheville, North Carolina, 28801

  • Grady Memorial Hospital - Endocrinology

    Atlanta, Georgia, 30303

  • Southeastern Clinical Research Institute, LLC

    Augusta, Georgia, 30904

  • University of Colorado | Renal Research Office

    Aurora, Colorado, 80045

  • Johns Hopkins Hospital - Nephrology

    Baltimore, Maryland, 21287

  • Northeast Clinical Research Center | Bethlehem, PA

    Bethlehem, Pennsylvania, 18017

  • Research Physicians Network Alliance

    Boca Raton, Florida, 33431

  • Florida Kidney Physicians - Boca Raton

    Boca Raton, Florida, 33487

  • Tufts Medical Center | Nephrology Department

    Boston, Massachusetts, 02111

  • UNC Hospitals Outpatient Center at Eastowne - Nephrology

    Chapel Hill, North Carolina, 27514

  • Northwestern Medicine - Feinberg School of Medicine - Nephrology and Hypertension

    Chicago, Illinois, 60611

  • Research by Design, LLC | Chicago, IL

    Chicago, Illinois, 60643

  • Balboa Research SMO+ - Chula Vista - West

    Chula Vista, California, 91910

  • UH Cleveland Medical Center - Nephrology

    Cleveland, Ohio, 44106

  • Cleveland Clinic | Urological and Kidney Department

    Cleveland, Ohio, 44195

  • Dallas Renal Group - Medical City

    Dallas, Texas, 75230

  • Geisinger Medical Center - Nephrology

    Danville, Pennsylvania, 17822

  • DaVita Clinical Research | Edina, MN

    Edina, Minnesota, 55435

  • Balboa Research SMO+ - El Centro

    El Centro, California, 92243

  • El Paso Medical Research Institute (MedResearch Inc) | El Paso, TX

    El Paso, Texas, 79902

  • Nephrology Associates of Northern Virginia - Fair Oaks

    Fairfax, Virginia, 22033

  • East Carolina University | Nephrology & Hypertension

    Greenville, North Carolina, 27834

  • Nephrology Associates of Northern Illinois and Indiana - Hinsdale

    Hinsdale, Illinois, 60521

  • DaVita Clinical Research | Houston, TX

    Houston, Texas, 77054

  • Nephrology Consultants, LLC

    Huntsville, Alabama, 35805

  • University of Iowa Health Care Medical Center - Cardiology

    Iowa City, Iowa, 52242

  • University Hospital - UMMC - Nephrology

    Jackson, Mississippi, 39216

  • KUMC Clinical and Translational Science Unit - Nephrology

    Kansas City, Kansas, 66160

  • Clinical Research Consultants, a JCCT Company

    Kansas City, Missouri, 64111

  • Knoxville Kidney Center, PLLC

    Knoxville, Tennessee, 37923

  • UCLA Clinical and Translational Research Center - Nephrology

    Los Angeles, California, 90095

  • Central Georgia Kidney Specialists - Macon

    Macon, Georgia, 31201

  • Gamma Medical Research, Inc.

    McAllen, Texas, 78503

  • Frenova Renal Research | Boise Kidney and Hypertension

    Meridian, Idaho, 83642

  • DaVita Clinical Research | Middlebury, CT

    Middlebury, Connecticut, 55404

  • Vanderbilt University Medical Center - Nephrology Clinical Trials Center

    Nashville, Tennessee, 37232

  • Yale University | Nephrology Clinical Research

    New Haven, Connecticut, 06520

  • South Carolina Clinical Reserach

    Orangeburg, South Carolina, 29118

  • AdventHealth Translational Research Institute

    Orlando, Florida, 32804

  • Temple Health - Nephrology

    Philadelphia, Pennsylvania, 19140

  • Balboa Nephrology Medical Group - Poway

    Poway, California, 92064

  • University of Utah School of Medicine | Kidney Research Clinic

    Salt Lake City, Utah, 84132

  • Texas Diabetes Institute - Renal Clinic

    San Antonio, Texas, 78207

  • Clinical Advancement Center, PLLC

    San Antonio, Texas, 78212

  • North America Research Institute - San Dimas

    San Dimas, California, 91773

  • DaVita Clinical Research | North Houston, TX

    Shenandoah, Texas, 77384

  • Northwest Louisiana Nephrology - Shreveport - 1800 Buckner St.

    Shreveport, Louisiana, 71101

  • United Clinical Research & Innovations

    South Gate, California, 90280

  • Utah Kidney Research Institute | Salt Lake City, UT

    South Salt Lake, Utah, 84115

  • Providence Medical Research Center

    Spokane Valley, Washington, 99204

  • St. Louis Heart and Vascular, PC - Christian Hospital Office

    St Louis, Missouri, 63136

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708

  • Kansas Nephrology Research Institute

    Wichita, Kansas, 67214

  • Wichita Nephrology Group, PA

    Wichita, Kansas, 67214

  • Eastern Nephrology Associates | Wilmington

    Wilmington, North Carolina, 28401

  • Mendez Center For Clinical Research | Woodbridge, VA

    Woodbridge, Virginia, 22192

Other trials in United States

China45 sites

  • The First Affiliated Hospital of Baotou Medical College

    Baotou, Inner Mongolia, 14010

  • Beijing Anzhen Hospital, Capital Medical University

    Beijing, 100029

  • China-Japan Friendship Hospital

    Beijing, 100029

  • Chinese PLA General Hospital

    Beijing, 100853

  • Beijing Tsinghua Changgung Hospital

    Beijing, 102218

  • The First Affiliated Hospital of Bengbu Medical College

    Bengbu, Anhui, MISSING

  • The Second Hospital of Jilin University

    Changchun, Jilin, 130000

  • 1st Peopl's Hosp of Changzhou 3rd Affil Hosp of Soochow Univ

    Changzhou, Jiangsu, 213003

  • SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos

    Chengdu, Sichuan, 610072

  • Sichuan University West China Hospital

    Chengdu, Sichuan, MISSING

  • Daping Hospital, 3rd Affil Hosp. 3rd Military Med Univ PLA

    Chongqing, 400042

  • The First Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning, 116011

  • Zhujiang Hospital of Southern Medical University

    Guangzhou, Guangdong, 510280

  • The First Affiliated Hospital of Guangzhou University of TCM

    Guangzhou, Guangdong, 510405

  • The First Affiliated Hospital of Jinan University

    Guangzhou, Guangdong, 510630

  • The Affiliated Hospital of Guizhou Medical University

    Guiyang, Guizhou, 550004

  • The Second Hospital of Anhui medical university

    Hefei, Anhui, 230601

  • Huai'an First People's Hospital, Nanjing Medical University

    Huai'an, Jiangsu, 223300

  • Huizhou Central People's Hospital

    Huizhou, Guangdong, 516001

  • Jiangmen Wuyi Hospital of traditional Chinese Medicine

    Jiangmen, Guangdong, 529099

  • Qilu Hosp., Shandong Univ.

    Jinan, Shandong, 250000

  • Lanzhou University Second Hospital

    Lanzhou, Gansu, 730030

  • Liuzhou Worker's Hospital

    Liuzhou, Guangxi, 545005

  • People's Hospital of Liuzhou City

    Liuzhou, Guangxi, 545006

  • The First Affiliated Hospital of NanChang University

    Nanchang, Jiangxi, 330006

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu, 210009

  • Jiangsu Province Hospital of Chinese Medicine

    Nanjing, Jiangsu, 210029

  • The People's Hospital of Guangxi Zhuang Autonomous Region

    Nanning, Guangxi, 530021

  • Hwa Mei Hospital, University of Chinese Academy Sciences

    Ningbo, Zhejiang, 31510

  • Jiangxi PingXiang people's Hospital

    Pingxiang, Jiangxi, 337055

  • Zhongshan Hospital, Fudan University - Oncology Department

    Shanghai, 200032

  • Xinhua Hos Affiliated to SH Jiaotong Uni School of Medicine

    Shanghai, 200092

  • Shanghai Fifth People's Hospital,Fudan University

    Shanghai, 200240

  • Central Hospital of Minhang District, Shanghai

    Shanghai, 201199

  • Siping Central Hospital

    Siping, Jilin, MISSING

  • Tianjin Union Medicine Centre (People's Hospital of Tianjin)

    Tianjin, 300121

  • The First Affiliated Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang, 830011

  • The First Affiliated Hospital of Wenzhou Medical Univ (New)

    Wenzhou, Zhejiang, 325000

  • Wuhan Hospital Of Traditional Chinese And Western Medicine

    Wuhan, Hubei, 430022

  • Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech

    Wuhan, Hubei, 430034

  • Renmin Hosp., Wuhan Univ.

    Wuhan, Hubei, 430040

  • The First Affiliated Hospital of Xi'an Jiaotong University

    Xi’an, Shanxi, 710061

  • The First Affiliated Hospital of Xiamen University

    Xiamen, Fujian, 361003

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, 750004

  • The First affiliated Hospital of Hebei North University

    Zhangjiakou, Hebei, 075000

Other trials in China

Japan41 sites

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431

  • The University of Tokyo Hospital

    Bunkyo-ku, Tokyo, 113-8655

  • University of Yamanashi Hospital

    Chūō, Yamanashi, 409-3898

  • Tokyo Metropolitan Tama Medical Center

    Fuchū, Tokyo, 183-8524

  • Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital

    Fukuoka, 811-0213

  • Fukuoka University Hospital

    Fukuoka, 814-0180

  • Seirei Hamamatsu General Hospital

    Hamamatsu, Shizuoka, 430-8558

  • Hiratsuka Kyosai Hospital

    Hiratsuka, Kanagawa, 254-8502

  • Aso Iizuka Hospital

    Iizuka, Fukuoka, 820-8505

  • Saitama Medical University Hospital

    Irima-gun, Saitama, 350-0495

  • Tokai University Hospital

    Isehara, Kanagawa, 259-1193

  • Kanazawa University Hospital

    Kanazawa, Ishikawa-ken, 920-8641

  • National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office

    Kanazawa, Ishikawa-ken, 920-8650

  • St. Marianna University Hospital

    Kawasaki, Kanagawa, 216-8511

  • Kokura Memorial Hospital

    Kitakyushu, Fukuoka, 802-8555

  • JCHO Kyushu Hospital

    Kitakyushu, Fukuoka, 806-8501

  • Kobe University Hospital

    Kobe, Hyōgo, 650-0017

  • Koshigaya Municipal Hospital

    Koshigaya, Saitama, 343-8577

  • Japanese Red Cross Kumamoto Hospital

    Kumamoto, 861-8520

  • Kawasaki Medical School Hospital

    Kurashiki, Okayama-ken, 701-0192

  • Matsumoto City Hospital

    Matsumoto, Nagano, 390-1401

  • Shinshu University Hospital

    Matsumoto, Nagano, 390-8621

  • Central Japan International Medical Center

    Minokamo, Gifu, 505-8510

  • Iwate Prefectural Central Hospital

    Morioka, Iwate, 020-0066

  • Chubu Rosai Hospital

    Nagoya, Aichi-ken, 455-8530

  • Daido Clinic

    Nagoya, Aichi-ken, 457-8511

  • Nagoya City University Hospital

    Nagoya, Aichi-ken, 467-8602

  • Nara Prefecture General Medical Center

    Nara, 630-8581

  • Hyogo Prefectural Nishinomiya Hospital

    Nishinomiya, Hyōgo, 662-0918

  • Saga-Ken Medical Centre Koseikan

    Saga, 840-8571

  • Japanese Red Cross Saitama Hospital

    Saitama, 330-8553

  • Osaka Rosai Hospital

    Sakai, Osaka, 591-8025

  • Tokyo Medical University Hospital

    Shinjuku-ku, Tokyo, 160-0023

  • Nihon University Itabashi Hospital

    tabashi City, Tokyo, 173-8610

  • JA Toride Medical Center

    Toride, Ibaraki, 302-0022

  • Tsuchiura Kyodo General Hospital

    Tsuchiura, Ibaraki, 300-0028

  • Juntendo University Urayasu Hospital

    Urayasu, Chiba, 279-0021

  • Kainan Hospital

    Yatomi, Aichi-ken, 498-8502

  • Saiseikai Yokohamashi Nanbu Hospital

    Yokohama, Kanagawa, 234-0054

  • Yokohama City University Hospital

    Yokohama, Kanagawa, 236-0004

  • Yokohama Sakae Kyosai Hospital

    Yokohama, Kanagawa, 247-8581

Other trials in Japan

South Korea17 sites

  • Hallym University Sacred Heart Hospital

    Anyang-si, Gyeonggido, 14068

  • Inje University Busan Paik Hospital

    Busan, 47392

  • Chung Nam National University Hospital

    Daejeon, 35015

  • Dongguk University Ilsan Hospital

    Goyang-si, Gyeonggido, 10326

  • Inje University Ilsan Paik Hospital

    Goyang-si, Gyeonggido, 411-706

  • Ansan Hospital | Nephrology

    Gyeonggi-do, 425-707

  • The Catholic University of Korea, Incheon St.Mary's Hospital

    Incheon, Incheon Gwang''yeogsi, 21431

  • CHA Bundang Medical Center | Nephrology

    Seongnam-si, Gyeonggido, 13496

  • The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital

    Seoul, Seoul Teugbyeolsi, 03312

  • Severance Hospital, Yonsei University Health System - Cardiology

    Seoul, Seoul Teugbyeolsi, 03722

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi, 3080

  • Samsung Medical Center - Cardiology

    Seoul, 06351

  • Kyung Hee University Hospital at Gangdong

    Seoul, 5278

  • Seoul National University Boramae Medical Center

    Seoul, 7061

  • Kangnam Sacred Heart Hospital

    Seoul, 7441

  • Kangdong Sacred Heart Hospital

    Teugbyeolsi, Seoul, 134-701

  • Yonsei University Wonju Christian Hospital

    Wŏnju, Gang''weondo, 26426

Other trials in South Korea

Israel12 sites

  • Assuta Ashdod Public Hospital (R.A)

    Ashdod, 7747629

  • Barzilai Medical Center | Department of Nephrology and Hypertension

    Ashkelon, 7830604

  • Clalit Health | Soroka Medical Center - Internal Medicine Department

    Beersheba, 8410101

  • Rambam Health Corporation

    Haifa, 3109601

  • Meir Medical Center

    Kfar Saba, 4428164

  • Health Corporation of Galilee Medical Center

    Nahariya, 2210001

  • Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department

    Petah Tikva, 4941492

  • Chaim Sheba Medical Center

    Ramat Gan, 5262000

  • Kaplan Medical Center

    Rehovot, 7610001

  • Tel-Aviv Sourasky Medical Center

    Tel Aviv, 6423906

  • Poria Medical Center | Nephrology and Hypertension Department

    Tiberias, 1528001

  • Shamir Medical Center (Assaf Harofeh)

    Tsrifin, 7030000

Other trials in Israel

Italy12 sites

  • Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto

    Bologna, Emilia-Romagna, 40138

  • Azienda Ospedaliera Per L'Emergenza Cannizzaro - Nefrologia e Dialisi

    Catania, Sicily, 95126

  • Azienda Socio Sanitaria Territoriale Della Brianza_Ospedale Pio XI - Nefrologia e Dialisi

    Desio, Lombardy, 20832

  • Azienda Socio Sanitaria Territoriale Ovest Milanese_Legnano - Nefrologia e Dialisi

    Legnano, Lombardy, 20025

  • Azienda Ospedaliero Universitaria di Modena_Policlinico - Nefrologia, Dialisi e Trapianto di Rene

    Modena, Emilia-Romagna, 41124

  • A.O.U. Universita' Degli Studi Della Campania Luigi Vanvitelli - Nefrologia

    Naples, Campania, 80131

  • Azienda Ospedaliero Universitaria Parma - SC Nefrologia

    Parma, Emilia-Romagna, 43126

  • Istituti Clinici Scientifici Maugeri S.p.A._Pavia - Nefrologia

    Pavia, Lombardy, 27100

  • Istituto Ricerche Farmacologiche Mario Negri - Unità Operativa Complessa Malattie Renali

    Ranica, Lombardy, 24020

  • Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Nefrologia e Dialisi

    Reggio Emilia, Emilia-Romagna, 42123

  • Azienda Socio Sanitaria Territoriale Rhodense

    Rho, Lombardy, 20017

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Nefrologia

    Rome, Lazio, 00168

Other trials in Italy

Russia12 sites

  • First City Clinical Hospital n.a. E.E. Volosevich

    Arkhangelsk, 163001

  • Izhevsk City Clinical Hospital #9

    Izhevsk, 426063

  • Kemerovo Regional Clinical Hospital

    Kemerovo, 650066

  • City clinical hospital n.a. V.V. Vinogradov

    Moscow, 117292

  • City Hospital #52

    Moscow, 123182

  • City Clinical Hospital of Emergency Care #1

    Omsk, 644112

  • Rostov State Medical University

    Rostov-on-Don, 344022

  • Limited liability company "MK-Med"

    Saint Petersburg, 197082

  • Saratov City Clinical Hospital #9

    Saratov, 410030

  • City clinical hospital #40 Sestroretsk

    Sestroretsk, 197706

  • Voronezh Regional Clinical Consultancy-Diagnostic Center

    Voronezh, 394018

  • Regional Clinical Hospital Yaroslavl

    Yaroslavl, 150062

Other trials in Russia

India11 sites

  • Mavani Research Center

    Ahmedabad, Gujarat, 380052

  • Shalby Hospital

    Ahmedabad, Gujarat, 380054

  • All India Institute of Medical Sciences

    Bhubaneswar, Odisha, 751019

  • Madras Medical College

    Chennai, Tamil Nadu, 600003

  • Noble Hospital

    Hadapsar, Maharashtra, 411013

  • Institute of Post-Graduate Medical Education and Research

    Kolkata, West Bengal, 700020

  • P. D. Hinduja Hospital and Medical Research Centre

    Mumbai, Maharashtra, 400016

  • Shree Siddhivinayak Maternity & Nursing Home

    Nashik, Maharashtra, 422002

  • Max Super Speciality Hospital, Saket

    New Delhi, National Capital Territory of Delhi, 110017

  • Osmania General Hospital

    Telangana, Telangana, 500012

  • Government Medical College Thiruvananthapuram

    Thiruvananthapuram, Kerala, 695011

Other trials in India

Malaysia11 sites

  • Hospital Sultan Abdul Halim

    Kedah, 8000

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50586

  • Universiti Malaya Medical Centre

    Kuala Lumpur, 59100

  • Hospital Tengku Ampuan Afzan

    Kuala Pahang, 25100

  • Hospital Kajang

    Kuala Selangor, 43000

  • Hospital Pakar Sultanah Fatimah

    Muar town, 84000

  • Hospital Tuanku Jaafar | Nephrology Department

    Negeri Sembilan, 70300

  • Hospital Raja Permaisuri Bainun

    Perak, 30450

  • Hospital Seri Manjung

    Perak, 32040

  • Hospital Pulau Pinang

    Pulau Pinang, 10450

  • Hospital Selayang

    Shah Alam, Selangor, 68100

Other trials in Malaysia

Spain11 sites

  • Hospital Universitario Central De Asturias | Nefrologia

    Alcalá de Henares, Madrid, 28805

  • Hospital del Mar | Nephrology Department

    Barcelona, 08003

  • Hospital Universitari Vall D Hebron | Nefrologia

    Barcelona, 08035

  • Hospital Publico Da Marina | Nefrologia

    Burela de Cabo, Lugo, 27880

  • Area Sanitaria De Ferrol | Medicina Interna

    Ferrol, A Coruña, 15405

  • Bellvitge Hospital Universitari | Nefrologia

    L'Hospitalet de Llobregat, Barcelona, 8907

  • Hospital Universitario Ramon Y Cajal | Medicina Interna

    Madrid, 28034

  • Hospital Universitario 12 De Octubre | Nefrologia

    Madrid, 28041

  • Hospital Clinico Universitario De Valencia | Nefrologia

    Valencia, 46010

  • Hospital Universitario Dr Peset Aleixandre | Nefrologia

    Valencia, 46017

  • Hospital Universitario Y Politecnico La Fe | Nefrologia

    Valencia, 46026

Other trials in Spain

Argentina10 sites

  • Asociacion de Fomento y Sala de Primeros Auxilios Alberto Mignaburu | Berazategui, Argentina

    Berazategui, Buenos Aires, B1837

  • Centro de Investigación y Prevención Cardiovascular

    Buenos Aires, C1061AAS

  • CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina

    CABA, Ciudad Auton. de Buenos Aires, C1018DES

  • Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina

    Ciudad Autónoma de Buenos Aire, Buenos Aires, C1056ABI

  • Clinica Privada Velez Sarsfield

    Córdoba, X5016KET

  • Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina

    Lanus, Buenos Aires, B1824

  • Instituto de Investigaciones Clinicas de Mar del Plata | Mar del Plata, Argentina

    Mar del Plata, Buenos Aires, B7600FZ0

  • Centro de Rehabilitacion Cardiovascular | San Luis, Argentina

    San Luis, San Luis Province, D5700CGR

  • Clinica de Nefrologia Urologia y Enfermedades Cardiovascular

    Santa Fe, 3000

  • Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina

    Santa Fe, S3000FWO

Other trials in Argentina

Czechia10 sites

  • Fakultní nemocnice Brno - Interní gastroenterologická klinika

    Brno, South Moravian, 625 00

  • MUDr.Petr Bucek s.r.o.

    Frýdek-Místek, 738 01

  • CTC Hodonín, s.r.o.

    Hodonín, 695 01

  • Fakultni nemocnice Ostrava

    Ostrava, 708 52

  • Privamed s.r.o.

    Pilsen, 323 33

  • Všeobecná fakultní nemocnice v Praze

    Prague, 12808

  • Nefrologicka ambulance

    Prague, 140 00

  • Nefromed s.r.o.

    Prague, 160 00

  • Vestra Clinics s.r.o.

    Rychnov nad Kněžnou, 516 01

  • Nemocnice Znojmo

    Znojmo, 669 02

Other trials in Czechia

Greece9 sites

  • General Hospital of Arta | Nephrology Department

    Arta, 47132

  • General Hospital of Athens LAIKO

    Athens, 11527

  • HIPPOKRATION General Hospital of Athens

    Athens, 11527

  • General Hospital Of Thessaloniki Papageorgiou-Renal Department

    Efkarpia, Thessaloniki, 56429

  • University General Hospital of Heraklion-Nephrology Clinic

    Heraklion, 71500

  • University General Hospital Of Ioannina-Nephrology Clinic

    Ioannina, 45500

  • University General Hospital of Patras | Nephrology Clinic

    Pátrai, Achaia, 26504

  • Ippokratio General Hospital Of Thessaloniki- 1st Department of Nephrology

    Thessaloniki, 54642

  • Geniko Nosokomeio Thessalonikis George Papanikolaou-Nephrology Department

    Thessaloniki, 57010

Other trials in Greece

Taiwan9 sites

  • Changhua Christian Hospital

    Changhua, 50006

  • National Taiwan University Hospital, Hsin-Chu Branch

    Hsinchu, Hsinchu, 300

  • Chang Gung Memorial Hospital Kaohsiung

    Kaohsiung City, 833

  • Far Eastern Memorial Hospital | Nephrology Department

    New Taipei City, Taipei, 220

  • China Medical University Hospital

    Taichung, 404327

  • Taichung Veterans General Hospital

    Taichung, 40705

  • National Taiwan University Hospital

    Taipei, 100

  • Taipei Medical University | Clinical Research Center

    Taipei, 110

  • Chang Gung Memorial Hospital at Linkou

    Taoyuan, 33305

Other trials in Taiwan

Australia8 sites

  • Sunshine Coast University Hospital

    Birtinya, Queensland, 4575

  • Eastern Health Integrated Renal Service

    Box Hill, Victoria, 3128

  • Concord Repatriation General Hospital

    Concord, New South Wales, 2139

  • St George Hospital

    Kogarah, New South Wales, 2217

  • Melbourne Renal Research Group

    Reservoir, Victoria, 3073

  • Sunshine Hospital

    St Albans, Victoria, 3021

  • Illawarra Shoalhaven Local Health District

    Wollongong, New South Wales, 2500

  • Princess Alexandra Hospital Australia

    Woolloongabba, Queensland, 4102

Other trials in Australia

Bulgaria8 sites

  • Medical Center ''4Life''

    Burgas, Burgas Province, 8000

  • Viva Phoenix Medical Center | Clinical Trials Department

    Dobrich, Dobrich Province, 9300

  • Multiprofile Hospital for Active Treatment St. Ivan Rilski - Gorna Oryahovitsa | Nephrology Department

    Gorna Oryahovitsa, Veliko Tarnovo Province, 5100

  • Medical Center Hera | Montana Branch

    Montana, Montana Province, 3400

  • Multiprofile Hospital for Active Treatment Sveti Georgi OOD, Pernik - Department of Cardiology

    Pernik, Pernik Province, 2300

  • Diagnostic-Consultative Center XX | Nephrology Department

    Sofia, Sofia City Province, 1618

  • Medical Center Zara-Med EOOD | Nephrology Department

    Stara Zagora, Stara Zagora Province, 6010

  • Medical Center ''Nevromedics''

    Veliko Tarnovo, Veliko Tarnovo Province, 5600

Other trials in Bulgaria

Hungary7 sites

  • Del-pesti Centrumkorhaz - Orszagos Hematologiai és Infektologiai Intezet

    Budapest, 1097

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz

    Kaposvár, 7400

  • Kistarcsai Flor Ferenc Korhaz

    Kistarcsa, 2143

  • Nagykanizsai Kanizsai Dorottya Korhaz

    Nagykanizsa, 8800

  • Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.

    Nyíregyháza, 4400

  • Pecsi Tudomanyegyetem Klinikai Kozpont

    Pécs, 7624

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz

    Szombathely, 9700

Other trials in Hungary

Belgium6 sites

  • CU Saint-Luc/UZ St-Luc

    Bruxelles - Brussel, 1200

  • UZ Gent

    Ghent, 9000

  • AZ Groeninge Campus Kennedylaan | Nephrology

    Kortrijk, West-Vlaanderen, 8500

  • UZ Leuven Gasthuisberg

    Leuven, 3000

  • CHU de Liège

    Liège, 4000

  • AZ Delta / Nephrology

    Roeselare, 8800

Other trials in Belgium

Denmark6 sites

  • Rigshospitalet, Copenhagen University Hospital | Department of Nefrology

    Copenhagen, 2100

  • Hospital of South West Jutland | Department of Endocrinology Research

    Esbjerg, 6700

  • Herlev Hospital | Nephrology Department

    Herlev, 2730

  • Region Midtjylland | Regionshospitalet Godstrup - Nephrology Department

    Herning, DK-7400

  • Region Sjælland | Holbaek Sygehus - Cardiology department

    Holbæk, 4300

  • Odense University Hospital | Department of Kidney Medicine

    Odense C, 5000

Other trials in Denmark

United Kingdom6 sites

  • Kent and Canterbury Hospital | Renal Research Delivery Team

    Canterbury, Kent, CT1 3NG

  • Cardiff and Vale University Health Board | University Hospital of Wales - Nephrology and Transplant

    Cardiff, Wales, CF14 4XW

  • Gloucestershire Hospitals NHS Foundation Trust | Gloucestershire Royal Hospital - Nephrology

    Gloucester, GL1 3NN

  • Barts Health NHS Trust - Royal London Hospital - Nephrology

    London, Greater London, E1 1BB

  • King's College Hospital NHS Foundation Trust | King's College Hospital - Nephrology Department

    London, Greater London, SE5 9RS

  • Sheffield Teaching Hospitals NHS Foundation Trust | Northern General Hospital - NIHR Sheffield Clinical Research Facility

    Sheffield, South Yorkshire, S5 7AU

Other trials in United Kingdom

Portugal5 sites

  • Unidade Local de Saude Almada-Seixal | Hospital Garcia de Orta - Research Department

    Almada, Setúbal District, 2805-267

  • Unidade Local De Saúde De Lisboa Ocidental E.P.E.

    Carnaxide, Lisbon District, 2790-134

  • Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center

    Leiria, 2410-197

  • Centro Hospitalar Universitario de Lisboa Central | Hospital Curry Cabral - Nephrology Department

    Lisbon, 1069-166

  • Centro Hospitalar do Medio Tejo | Unidade de Torres Novas - Nephrology Department

    Torres Novas, Santarém District, 2350-754

Other trials in Portugal

Singapore5 sites

  • National University Hospital Medical Centre

    Singapore, 119074

  • Singapore General Hospital

    Singapore, 169608

  • Tan Tock Seng Hospital

    Singapore, 308433

  • SingHealth Polyclinics - Pasir Ris

    Singapore, 519457

  • Khoo Teck Puat Hospital

    Singapore, 768828

Other trials in Singapore

Hong Kong4 sites

  • Prince of Wales Hospital

    Hong Kong, Hong Kong SAR, 00000

  • Princess Margaret Hospital

    Hong Kong, Hong Kong SAR, 00000

  • Queen Mary Hospital

    Hong Kong, Hong Kong SAR, 00000

  • Tung Wah Hospital

    Sheung Wan, Hong Kong Island, 00000

Other trials in Hong Kong

Mexico4 sites

  • Sitio Alfredo Chew Wong | Aguascalientes, Mexico

    Aguascalientes, 20124

  • SINACOR | Culiacan, Mexico

    Culiacán, Sinaloa, 80230

  • Fundacion Cardiovascular de Aguascalientes | Aguascalientes, Mexico

    Missing, Aguascalientes, 20230

  • Sociedad de Metabolismo y Corazon S.C. | Veracruz, Mexico

    Puerto de Veracruz, Veracruz, 91900

Other trials in Mexico

About this study

Official title: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Phase 3 Study to Investigate the Efficacy and Safety of FInerenone, in Addition to Standard of Care, on the Progression of Kidney Disease in Patients With Non-Diabetic Chronic Kidney Disease

Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD.

In this trial, the researchers want to learn if finerenone helps to slow down the worsening of the participants' non-diabetic CKD compared to a placebo. A placebo looks like a trial treatment but does not have any medicine in it. The trial will include about 1,580 men and women who are at least 18 years old.

Read more

The participants will take finerenone or a placebo once a day as tablets by mouth. All of the participants will also continue to take their current medicine for their CKD. The participants will be in the trial for up to about 50 months.

During the trial, the doctors will collect blood and urine samples and check the participants' health. The participants will also answer questions about how they are feeling and what adverse events they are having. An adverse event is a medical problem that happens during the trial. Doctors keep track of all adverse events that happen in trials, even if they do not think the adverse events might be related to the trial treatments.

Being tested
Finerenone (BAY94-8862), Placebo

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Finerenone (BAY94-8862)Drug

    Tablet, 10 mg or 20 mg, once daily (OD), oral

  • PlaceboDrug

    Tablet, once daily, oral

Study groups in NCT05047263
Study groupRoleWhat they receive
Finerenone (BAY94-8862)ExperimentalParticipants will receive finerenone.
Receives: Drug: Finerenone (BAY94-8862)
PlaceboPlacebo comparatorParticipants will receive placebo.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Mean rate of change as measured by the total slope of eGFR from baseline to Month-32.

    eGFR: Estimated glomerular filtration rate

    Measured: From baseline to month 32

Secondary outcomes (4)

  1. Time to the composite of kidney failure, sustained eGFR decline of >= 57%, heart failure hospitalization or Cardiovascular (CV) death

    Measured: Up to end of study visit (up to approximately 49 months)

  2. Time to the composite of kidney failure or sustained eGFR decline of >= 57%

    Measured: Up to end of study visit (up to approximately 49 months)

  3. Time to the composite to heart failure hospitalization or CV death

    Measured: Up to end of study visit (up to approximately 49 months)

  4. Number of participants with Treatment-emergent adverse events (TEAEs), Treatment-emergent serious adverse events (TESAEs) and Adverse events of special interest (AESI)

    Measured: Up to approximately 50 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted17 Sep 2021
  2. Study start21 Sep 2021
  3. Primary completion31 Dec 2025
  4. Study completion2 Feb 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
1,584 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05047263
Sponsor's protocol ID
21177
Other IDs
2021-000421-27
Acronym
FIND-CKD
Status last verified
Feb 2026
First submitted
12 Sep 2021
Last updated
13 Feb 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
No: Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.clinicalstudydatarequest.com to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the Study sponsors section of the portal.

Publications

  • Heerspink HJL, Beernink JM, Agarwal R, Cherney DZI, Lam CSP, Neuen BL, Perkovic V, Tuttle KR, Sarafidis P, Birne R, Chen X, Hornum M, Maldonado RA, Nangaku M, Nicholas SB, Ohashi A, Pergola PE, Yeo SC, Jongs N, Smeijer JD, Aldworth C, Brinker M, Kolkhof P, Reis JD, Scalise A, Wanner C; FIND-CKD Investigators. Finerenone in hypertensive non-diabetic chronic kidney disease: a FIND-CKD subgroup analysis. Eur Heart J. 2026 Aug 30:ehag729. doi: 10.1093/eurheartj/ehag729. Online ahead of print.

    PubMed 42669052

  • Heerspink HJL, Neuen BL, Agarwal R, Cherney DZI, Lam CSP, Tuttle KR, Wanner C, Sarafidis P, Jongs N, Smeijer JD, Brinker M, Rethemeier N, Schloemer P, Vesterinen P, Goldsbury D, Dizayee S, Mares JW, Perkovic V; FIND-CKD Investigators. Finerenone in Persons with Chronic Kidney Disease without Diabetes. N Engl J Med. 2026 Aug 6;395(6):533-545. doi: 10.1056/NEJMoa2604625. Epub 2026 Jun 4.

    PubMed 42246672

  • Neuen BL, Perkovic V, Agarwal R, Cherney DZI, Lam CSP, Wanner C, Tuttle KR, Sarafidis P, Barratt J, Burgner A, Chen X, Chew-Wong A, Dobronravov VA, Floege J, McCafferty K, Nangaku M, Packham D, Papachristou E, Pergola PE, Speeckaert MM, Subbiah A, Tang SCW, Tang S, Yeo SC, Jongs N, Smeijer JD, Berger M, Brinker M, Dayoub R, Elliott J, Li N, Mueller K, Rethemeier N, Finkelsztein MY, Heerspink HJL; FIND-CKD Investigators. Finerenone in Patients With Chronic Kidney Disease Due to Glomerular Diseases: A Randomized Clinical Trial. JAMA. 2026 Jul 21;336(3):224-235. doi: 10.1001/jama.2026.9923.

    PubMed 42246414

  • Ostrominski JW, Filippatos G, Claggett BL, Miao ZM, Desai AS, Jhund PS, Henderson A, Rohwedder K, Brinker MD, Scalise A, Schloemer P, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Rossing P, Ruilope LM, Anker SD, Pitt B, Agarwal R, McMurray JJV, Solomon SD, Vaduganathan M. Effect of Finerenone on Morbidity and Mortality in CKD. J Am Soc Nephrol. 2026 Feb 1;37(2):312-325. doi: 10.1681/ASN.0000000823. Epub 2025 Sep 12.

    PubMed 40938666

  • Li Y, Feng J, Guo X, Zhang W, Yang T, Guan T, Xu B. Efficacy and safety of finerenone in non-diabetic CKD patients: a single-center, real-world, retrospective study. BMC Nephrol. 2025 Jul 1;26(1):323. doi: 10.1186/s12882-025-04241-w.

    PubMed 40597854

  • Zachariah T, Radhakrishnan J. Potential Role of Mineralocorticoid Receptor Antagonists in Nondiabetic Chronic Kidney Disease and Glomerular Disease. Clin J Am Soc Nephrol. 2024 Nov 1;19(11):1499-1512. doi: 10.2215/CJN.0000000000000540. Epub 2024 Jul 22.

    PubMed 39037799

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Finerenone (BAY94-8862) in people with Non-diabetic Chronic Kidney Disease, run by Bayer at 326 sites in 24 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 326 sites in United States, China, Japan, South Korea, Israel and 19 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Mean rate of change as measured by the total slope of eGFR from baseline to Month-32. (time frame: From baseline to month 32). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05047263, which also lists 6 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Feb 2026.

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