InfluenzaNCT05052190
Patient Portal Flu Vaccine Reminders_RCT 4
A study testing Text Message R/R with Direct Appointment Schedule Link, Text Message R/R without Direct Appointment Schedule Link and Text Pre-Appointment Reminder in people with Influenza and Respiratory Tract Infections, run by University of California, Los Angeles at 1 site in United States.
Trial summary
This trial is taking place in Los Angeles, CA at clinics within the UCLA Health System. The study design is a 2x2 nested factorial design. Patients will be randomized into 1) receiving text based reminder messages, 2) portal-based reminder messages or 3) the control group. Read more about this study
- Who is it for?
- Ages 6 months and older
- Conditions the study is for
- Influenza, Respiratory Tract Infections
- What is being tested?
- Text Message R/R with Direct Appointment Schedule Link, Text Message R/R without Direct Appointment Schedule Link and Text Pre-Appointment Reminder
- Type of treatment
- Vaccines, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 239,567 participants
- Where
- 1 siteUnited States
- Study dates
- 14 Oct 2021to 1 Apr 2022
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 months and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Active Portal Users A patient within the UCLA Health System identified as a primary care patient per an internal algorithm
Who cannot join
- A patient within the UCLA Health System not identified as a primary care patient per an internal algorithm
Trial locations and contacts
1 site in 1 country.
United States1 site
University of California LA
Los Angeles, California, 99095
About this study
Official title: Improving Influenza Vaccination Delivery Across a Health System by the Electronic Health Records Patient Portal RCT 4
This trial is taking place in Los Angeles, CA at clinics within the UCLA Health System.
The study design is a 2x2 nested factorial design. Patients will be randomized into 1) receiving text based reminder messages, 2) portal-based reminder messages or 3) the control group. Patients randomized to the intervention arms will receive reminders if they are due for influenza vaccine.
Read more
Nested within the reminder arms (text or portal), we will have 2 additional components for which patients will be randomized separately:
- A direct scheduling link within the reminder letter enabling the patient to schedule an influenza vaccine only visit (direct scheduling link vs. no direct scheduling link).
- A pre-appointment reminder, encouraging patients to ask for their influenza vaccine at their upcoming appointment (pre-appointment reminder encouraging influenza vaccination vs. standard pre-appointment reminder not mentioning influenza vaccination)
Despite the Advisory Committee on Immunization Practices (ACIP) recommendation in 2010 that all people above 6 months of age should receive an annual flu vaccine, vaccination rates remain low: at 6m-4.9 yrs. (70%), 5-17.9 yrs. (56%), 18-64.9 yrs. (38%), and >65 yrs. (63%). The investigators will assess the effectiveness of MyChart R/R messages and text R/R messages as compared to the standard of care control (no messages).
Read the detailed description
Sub-optimal vaccination rates are a significant problem in the U.S., despite their effectiveness in preventing morbidity and mortality from vaccine-preventable illness. For influenza specifically, annual epidemics of influenza cause substantial morbidity in the U.S. with up to 40,00-80,000 deaths/year and many hospitalizations, emergency and outpatient visits, and significant costs.
Reminder/recall (R/R), sent by phone, mail or other modality, can improve child and adult influenza vaccination rates. However, the majority of pediatric or adult primary care practices do not conduct R/R. Barriers are lack of finances, personnel, and algorithms to identify eligible patients.
A technological breakthrough that might overcome these barriers involves patient portals-- secure, web-based communication systems, embedded within electronic health records (EHRs), for patients and providers to communicate with each other via email and the internet. Portals are used by about half of Americans and half of UCLA patients. Another is text messaging at the health system level.
This randomized controlled trial will assess the effectiveness of reminders messages sent to portal users, encouraging influenza vaccination, on increasing influenza vaccination rates within a health system. Patients will be randomized into three groups: 1) one-third of patients will receive reminder letters via the portal, 2) one-third will receive reminders via text messages sent by the health system and 3) one-third will not receive reminders.
Patients in the reminder arms will be further randomized (separately) for two additional components: 1) direct appointment scheduling and 2) pre-appointment reminders.
Direct scheduling: The convenience of scheduling an appointment for influenza vaccination may increase the likelihood that patients receive an influenza vaccination. Patients receiving reminders will be randomized to receive one of two types of reminder letters: 1) one half will receive flu vaccine reminder letters with a link to the MyChart direct appointment scheduling page and 2) one half will receive flu vaccine reminder message without the direct appointment scheduling link.
Pre-appointment flu reminders: Finally, a missed opportunities for vaccination occurs when patients are eligible for vaccination but are not offered a vaccine at their medical appointment. Pre-appointment reminders, sent in advance of an upcoming appointment, encouraging the patient talk to their doctor about influenza vaccination, may increase the likelihood of that patient receiving a vaccine. Patients will be randomized to one of two groups: 1) one half will receive modified pre-appointment reminders that mention influenza vaccination and 2) one half will receive the standard pre-appointment reminders for an upcoming appointment (no mention of influenza vaccination).
Interventions that apply Behavioral Economics principles in vaccine promotion messaging can increase vaccine receipt. We will include ownership language in the pre-appointment messages. Additionally, the convenience of reminders sent via text and with a Direct Appointment Schedule link included enables patients to self-schedule a flu vaccine only visit, reducing friction for vaccine receipt.
For the primary analysis, the primary outcome will be the patient's end of flu season vaccination status. Intervention effects will be assessed using mixed effects log-binomial models. Models will contain terms for messaging modality (text v. portal v. none), pre-appointment reminders (sent v. not sent), and direct scheduling link (included v. not included).
The R/R text and portal messages (with and without direct scheduling links) and pre-appointment reminders and will all begin in October of 2021.
- Conditions
- Influenza, Respiratory Tract Infections
- Being tested
- Text Message R/R with Direct Appointment Schedule Link, Text Message R/R without Direct Appointment Schedule Link, Text Pre-Appointment Reminder, Portal Message R/R with Direct Appointment Schedule Link, Portal Message R/R without Direct Appointment Schedule Link
- Keywords
- Reminder Recall (R/R), Influenza Vaccine, Electronic Health Record, Text Message, Vaccine
- Medical subject headings
- Influenza, Human, Respiratory Tract Infections
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Text Message R/R with Direct Appointment Schedule LinkBehavioural
Participants in this arm will receive up to 3 R/R messages by text reminding them to get a flu vaccine with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment.
Text Message R/R without Direct Appointment Schedule LinkBehavioural
Participants in this arm will receive up to 3 R/R messages by text reminding them to get a flu vaccine without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment.
Text Pre-Appointment ReminderBehavioural
Participants will receive a Pre-Appointment Reminder via text when they schedule a visit during the study period advising them to get the flu vaccine at their upcoming appointment.
Portal Message R/R with Direct Appointment Schedule LinkBehavioural
Participants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment.
Portal Message R/R without Direct Appointment Schedule LinkBehavioural
Participants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment.
Portal Pre-Appointment ReminderBehavioural
Participants will receive a Pre-Appointment Reminder via the portal advising them to ask their doctor for the flu vaccine at their upcoming appointment via text when they schedule a visit during the study period.
| Study group | Role | What they receive |
|---|---|---|
| Text Message R/R with Direct Appointment Schedule Link | Active comparator | Participants in this arm will receive up to 3 R/R messages by text. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Receives: Behavioral: Text Message R/R with Direct Appointment Schedule Link |
| Text Message R/R without Direct Appointment Schedule Link | Active comparator | Participants in this arm will receive up to 3 R/R messages by text with no link to schedule an appointment. Receives: Behavioral: Text Message R/R without Direct Appointment Schedule Link |
| Text Message R/R with Direct Appointment Schedule Link + text Pre-Appointment Reminder | Active comparator | Participants in this arm will receive up to 3 R/R messages by text. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder via text when they schedule a visit during the study period. Receives: Behavioral: Text Message R/R with Direct Appointment Schedule Link; Behavioral: Text Pre-Appointment Reminder |
| Text Message R/R without Direct Appointment Schedule Link + Text Pre-Appointment Reminder | Active comparator | Participants in this arm will receive up to 3 R/R messages by text. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder via text when they schedule a visit during the study period. Receives: Behavioral: Text Message R/R without Direct Appointment Schedule Link; Behavioral: Text Pre-Appointment Reminder |
| Portal Message R/R with Direct Appointment Schedule Link | Active comparator | Participants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Receives: Behavioral: Portal Message R/R with Direct Appointment Schedule Link |
| Portal Message R/R without Direct Appointment Schedule Link | Active comparator | Participants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Receives: Behavioral: Portal Message R/R without Direct Appointment Schedule Link |
| Portal Message R/R with Direct Appointment Schedule Link + Portal Pre-Appointment Reminder | Active comparator | Participants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder advising them to ask their doctor for the flu vaccine at their upcoming appointment via portal when they schedule a visit during the study period. Receives: Behavioral: Portal Message R/R with Direct Appointment Schedule Link; Behavioral: Portal Pre-Appointment Reminder |
| Portal Message R/R without Direct Appointment Schedule Link + Portal Pre-Appointment Reminder | Active comparator | Participants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder advising them to ask their doctor for the flu vaccine at their upcoming appointment via portal when they schedule a visit during the study period. Receives: Behavioral: Portal Message R/R without Direct Appointment Schedule Link; Behavioral: Portal Pre-Appointment Reminder |
| No R/R Message or Pre-Appointment Reminder | No intervention | Participants do not receive any flu vaccine R/R message or Pre-Appointment Reminder advising them to ask their doctor for the flu vaccine at their upcoming appointment during the specified flu season. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Receipt of the Annual Influenza Vaccine Among Adult and Pediatric Index Patients
Percent of patients with annual influenza vaccination (between 10/1/21 - 4/1/22) among adult and pediatric index patients. Outcomes will be assessed via vaccine data extraction from the electronic health record and external claims and pharmacy data.
The index patients must also be an active UCLA Health MyChart user (>= 1 login over the last 12 months from 8/1/21, excluding activity on the user's initial profile activation date). Individuals not affiliated with any primary care practice will be excluded from the primary analysis.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Sep 2021
- Study start14 Oct 2021
- Primary completion1 Apr 2022
- Study completion1 Apr 2022
Why it stopped: IT error which contaminated study arms
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for InfluenzaStudies of the same condition, open and under way.
- More trials run by University of California, Los AngelesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Factorial
- Model description
- Pragmatic comparative effectiveness trial with a standard-of-care control group
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 239,567 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of California, Los Angeles
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Peter G Szilagyi, MD MPH, University of California, Los Angeles
- Investigators
- Peter Szilagyi, MPH, MD, Principal investigator, University of California, Los Angeles
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05052190
- Sponsor's protocol ID
- 17-001889-AM-00015
- Other IDs
- R01AI135029-04
- Status last verified
- Mar 2025
- First submitted
- 31 Aug 2021
- Last updated
- 11 Apr 2025
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Improving Influenza Vaccination Delivery Across a Health System by the Electronic Health Records Patient Portal RCT 4
- ClinicalTrials.gov ID
- NCT05052190
- Acronym / sponsor ID
- 17-001889-AM-00015
- Conditions
- Influenza, Respiratory Tract Infections
- Keywords
- Reminder Recall (R/R), Influenza Vaccine, Electronic Health Record, Text Message, Vaccine
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: IT error which contaminated study arms
- Enrolment
- 239,567 participants (actual)
- Lead sponsor
- University of California, Los AngelesUniversity, hospital or other
- Collaborators
- National Institute of Allergy and Infectious Diseases (NIAID)
- Study start
- 14 Oct 2021 (actual)
- Primary completion
- 1 Apr 2022 (actual)
- Study completion
- 1 Apr 2022 (actual)
- First posted
- 22 Sep 2021 (actual)
- Results
- Posted 11 Apr 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This trial is taking place in Los Angeles, CA at clinics within the UCLA Health System.
The study design is a 2x2 nested factorial design. Patients will be randomized into 1) receiving text based reminder messages, 2) portal-based reminder messages or 3) the control group. Patients randomized to the intervention arms will receive reminders if they are due for influenza vaccine.
Nested within the reminder arms (text or portal), we will have 2 additional components for which patients will be randomized separately:
- A direct scheduling link within the reminder letter enabling the patient to schedule an influenza vaccine only visit (direct scheduling link vs. no direct scheduling link).
- A pre-appointment reminder, encouraging patients to ask for their influenza vaccine at their upcoming appointment (pre-appointment reminder encouraging influenza vaccination vs. standard pre-appointment reminder not mentioning influenza vaccination)
Despite the Advisory Committee on Immunization Practices (ACIP) recommendation in 2010 that all people above 6 months of age should receive an annual flu vaccine, vaccination rates remain low: at 6m-4.9 yrs. (70%), 5-17.9 yrs. (56%), 18-64.9 yrs. (38%), and >65 yrs. (63%). The investigators will assess the effectiveness of MyChart R/R messages and text R/R messages as compared to the standard of care control (no messages).
Detailed description
Sub-optimal vaccination rates are a significant problem in the U.S., despite their effectiveness in preventing morbidity and mortality from vaccine-preventable illness. For influenza specifically, annual epidemics of influenza cause substantial morbidity in the U.S. with up to 40,00-80,000 deaths/year and many hospitalizations, emergency and outpatient visits, and significant costs.
Reminder/recall (R/R), sent by phone, mail or other modality, can improve child and adult influenza vaccination rates. However, the majority of pediatric or adult primary care practices do not conduct R/R. Barriers are lack of finances, personnel, and algorithms to identify eligible patients.
A technological breakthrough that might overcome these barriers involves patient portals-- secure, web-based communication systems, embedded within electronic health records (EHRs), for patients and providers to communicate with each other via email and the internet. Portals are used by about half of Americans and half of UCLA patients. Another is text messaging at the health system level.
This randomized controlled trial will assess the effectiveness of reminders messages sent to portal users, encouraging influenza vaccination, on increasing influenza vaccination rates within a health system. Patients will be randomized into three groups: 1) one-third of patients will receive reminder letters via the portal, 2) one-third will receive reminders via text messages sent by the health system and 3) one-third will not receive reminders.
Patients in the reminder arms will be further randomized (separately) for two additional components: 1) direct appointment scheduling and 2) pre-appointment reminders.
Direct scheduling: The convenience of scheduling an appointment for influenza vaccination may increase the likelihood that patients receive an influenza vaccination. Patients receiving reminders will be randomized to receive one of two types of reminder letters: 1) one half will receive flu vaccine reminder letters with a link to the MyChart direct appointment scheduling page and 2) one half will receive flu vaccine reminder message without the direct appointment scheduling link.
Pre-appointment flu reminders: Finally, a missed opportunities for vaccination occurs when patients are eligible for vaccination but are not offered a vaccine at their medical appointment. Pre-appointment reminders, sent in advance of an upcoming appointment, encouraging the patient talk to their doctor about influenza vaccination, may increase the likelihood of that patient receiving a vaccine. Patients will be randomized to one of two groups: 1) one half will receive modified pre-appointment reminders that mention influenza vaccination and 2) one half will receive the standard pre-appointment reminders for an upcoming appointment (no mention of influenza vaccination).
Interventions that apply Behavioral Economics principles in vaccine promotion messaging can increase vaccine receipt. We will include ownership language in the pre-appointment messages. Additionally, the convenience of reminders sent via text and with a Direct Appointment Schedule link included enables patients to self-schedule a flu vaccine only visit, reducing friction for vaccine receipt.
For the primary analysis, the primary outcome will be the patient's end of flu season vaccination status. Intervention effects will be assessed using mixed effects log-binomial models. Models will contain terms for messaging modality (text v. portal v. none), pre-appointment reminders (sent v. not sent), and direct scheduling link (included v. not included).
The R/R text and portal messages (with and without direct scheduling links) and pre-appointment reminders and will all begin in October of 2021.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind (participant)
- Number of arms
- 9
- Model description
- Pragmatic comparative effectiveness trial with a standard-of-care control group
| Arm | Type | Receives |
|---|---|---|
| Text Message R/R with Direct Appointment Schedule Link | Active comparator | Behavioral: Text Message R/R with Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by text. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. |
| Text Message R/R without Direct Appointment Schedule Link | Active comparator | Behavioral: Text Message R/R without Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by text with no link to schedule an appointment. |
| Text Message R/R with Direct Appointment Schedule Link + text Pre-Appointment Reminder | Active comparator | Behavioral: Text Message R/R with Direct Appointment Schedule Link, Behavioral: Text Pre-Appointment ReminderParticipants in this arm will receive up to 3 R/R messages by text. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder via text when they schedule a visit during the study period. |
| Text Message R/R without Direct Appointment Schedule Link + Text Pre-Appointment Reminder | Active comparator | Behavioral: Text Message R/R without Direct Appointment Schedule Link, Behavioral: Text Pre-Appointment ReminderParticipants in this arm will receive up to 3 R/R messages by text. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder via text when they schedule a visit during the study period. |
| Portal Message R/R with Direct Appointment Schedule Link | Active comparator | Behavioral: Portal Message R/R with Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. |
| Portal Message R/R without Direct Appointment Schedule Link | Active comparator | Behavioral: Portal Message R/R without Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. |
| Portal Message R/R with Direct Appointment Schedule Link + Portal Pre-Appointment Reminder | Active comparator | Behavioral: Portal Message R/R with Direct Appointment Schedule Link, Behavioral: Portal Pre-Appointment ReminderParticipants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder advising them to ask their doctor for the flu vaccine at their upcoming appointment via portal when they schedule a visit during the study period. |
| Portal Message R/R without Direct Appointment Schedule Link + Portal Pre-Appointment Reminder | Active comparator | Behavioral: Portal Message R/R without Direct Appointment Schedule Link, Behavioral: Portal Pre-Appointment ReminderParticipants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. Participants will receive a Pre-Appointment Reminder advising them to ask their doctor for the flu vaccine at their upcoming appointment via portal when they schedule a visit during the study period. |
| No R/R Message or Pre-Appointment Reminder | No intervention | –Participants do not receive any flu vaccine R/R message or Pre-Appointment Reminder advising them to ask their doctor for the flu vaccine at their upcoming appointment during the specified flu season. |
Who may qualify
- Ages
- 6 months and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Active Portal Users A patient within the UCLA Health System identified as a primary care patient per an internal algorithm
Key exclusion criteria (1 listed)
- A patient within the UCLA Health System not identified as a primary care patient per an internal algorithm
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Text Message R/R with Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by text reminding them to get a flu vaccine with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. | Behavioural | Text Message R/R with Direct Appointment Schedule Link, Text Message R/R with Direct Appointment Schedule Link + text Pre-Appointment Reminder |
| Text Message R/R without Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by text reminding them to get a flu vaccine without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. | Behavioural | Text Message R/R without Direct Appointment Schedule Link, Text Message R/R without Direct Appointment Schedule Link + Text Pre-Appointment Reminder |
| Text Pre-Appointment ReminderParticipants will receive a Pre-Appointment Reminder via text when they schedule a visit during the study period advising them to get the flu vaccine at their upcoming appointment. | Behavioural | Text Message R/R with Direct Appointment Schedule Link + text Pre-Appointment Reminder, Text Message R/R without Direct Appointment Schedule Link + Text Pre-Appointment Reminder |
| Portal Message R/R with Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent with a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. | Behavioural | Portal Message R/R with Direct Appointment Schedule Link, Portal Message R/R with Direct Appointment Schedule Link + Portal Pre-Appointment Reminder |
| Portal Message R/R without Direct Appointment Schedule LinkParticipants in this arm will receive up to 3 R/R messages by portal. R/R message will be sent without a Direct Appointment Scheduling link and instructions to make a flu vaccine appointment. | Behavioural | Portal Message R/R without Direct Appointment Schedule Link, Portal Message R/R without Direct Appointment Schedule Link + Portal Pre-Appointment Reminder |
| Portal Pre-Appointment ReminderParticipants will receive a Pre-Appointment Reminder via the portal advising them to ask their doctor for the flu vaccine at their upcoming appointment via text when they schedule a visit during the study period. | Behavioural | Portal Message R/R with Direct Appointment Schedule Link + Portal Pre-Appointment Reminder, Portal Message R/R without Direct Appointment Schedule Link + Portal Pre-Appointment Reminder |
Primary outcome
Receipt of the Annual Influenza Vaccine Among Adult and Pediatric Index Patients
Time frame: 6 months
Percent of patients with annual influenza vaccination (between 10/1/21 - 4/1/22) among adult and pediatric index patients. Outcomes will be assessed via vaccine data extraction from the electronic health record and external claims and pharmacy data. The index patients must also be an active UCLA Health MyChart user (>= 1 login over the last 12 months from 8/1/21, excluding activity on the user's initial profile activation date). Individuals not affiliated with any primary care practice will be excluded from the primary analysis.
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Apr 2025.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Related trials for Influenza
Enrolling by invitation
Personalized Ventilator Settings for Patients on ECMO
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
RecruitingPhase 2
BPL-1357 Against H1N1 Influenza Virus Challenge
Influenza, Human
Not yet recruitingPhase 1
Safety and Immunogenicity of Chimeric Hemagglutinin mRNA Vaccine Candidates
Influenza
RecruitingPhase 1
pH1N1 Blinded Challenge Study
Influenza
RecruitingPhase 3
A Study to Evaluate the Safety and Efficacy of MK-1406/CD388 for Prevention of Influenza (MK-1406-005/CD388.SQ.3.06)
Influenza
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Peter Szilagyi, MPH, MD principal investigator
University of California, Los Angeles
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Text Message R/R with Direct Appointment Schedule Link, Text Message R/R without Direct Appointment Schedule Link and Text Pre-Appointment Reminder in people with Influenza and Respiratory Tract Infections, run by University of California, Los Angeles at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 11 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 11 Apr 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Receipt of the Annual Influenza Vaccine Among Adult and Pediatric Index Patients (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Apr 2025.