Tic DisordersRegisTICsNCT05090943
Adult Tic Disorders Registry
An observational study of Tic Disorders, run by Assistance Publique - Hôpitaux de Paris at 7 sites in France.
Trial summary
The purpose of this study is to develop the adult tic disorders registry in order to characterize the relationship between tic severity and tic-related impairment in women compared to men with tic disorders. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Tic Disorders
- What is being tested?
- QOL to be completed by the participant
- How many people
- 450 participants
- Where
- 7 sitesFrance
- Study dates
- 1 Dec 2021to 1 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patient with tics disorders
Who may be able to join
- Age >18 years
- Patients with Tic disorders
- Given the non-opposition
- Non Inclusion criteria
- No affiliation to a French health social insurance
- Significant congenital disorders that may affect understanding of assessments
- Patients under guardianship or curatorship
Who cannot join
None listed.
Trial locations and contacts
7 sites in 1 country. Contact the study team or a site near you to ask about taking part.
7 sites in 1 country
France7 sites, 7 recruiting
- Recruiting
CHU Clermont-Ferrand
Clermont-Ferrand, 63003
Isabelle JALENQUES, MD, 0033 4 73 75 21 05, ijalenques@chu-clermontferrand.fr
Isabelle JALENQUES, MD
- Recruiting
CHU Limoges
Limoges, 87042
Jean-Luc HOUETO, MD, 0033 5 55 05 65 60, jean-luc.houeto@chu-limoges.fr
Jean-Luc HOUETO, MD
- Recruiting
CHU Marseille
Marseille, 13003
Tatiana WITJAS, MD, 0033 4 91 38 43 33, Tatiana.WITJAS@ap-hm.fr
Tatiana WITJAS, MD
- Recruiting
Service de Neurologie, GH Pitié Salpêtrière
Paris, 75013
Emmanuel FLAMAND-ROZE, MD, 01 42 16 24 81 ext. +33, emmanuel.flamand-roze@aphp.fr
- Recruiting
CHU Poitiers
Poitiers, 86000
Solène ANSQUER, MD, 0033 5 49 44 44 44, solene.ansquer@chu-poitiers.fr
Solène ANSQUER, MD
- Recruiting
CHU Nantes
Saint-Herblain, 44800
Philippe DAMIER, MD, 0033 2 40 16 52 12, philippe.damier@chu-nantes.fr
Philippe DAMIER, MD
- Recruiting
CHU Strasbourg
Strasbourg, 67200
Mathieu ANHEIM, MD, 0033 3 88 12 85 85, mathieu.anheim@chru-strasbourg.fr
Mathieu ANHEIM, MD
About this study
The purpose of this study is to develop the adult tic disorders registry in order to characterize the relationship between tic severity and tic-related impairment in women compared to men with tic disorders.
- Conditions
- Tic Disorders
- Being tested
- QOL to be completed by the participant
- Medical subject headings
- Tic Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
QOL to be completed by the participantOther
The scales (PUTS, OCI, TS-QOL, ASRS, GAD-7, PHQ9, TAPS) to be completed by the participant
| Study group | Role | What they receive |
|---|---|---|
| Quality of life questionnaires | Not described Receives: Other: QOL to be completed by the participant |
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation between Quality of Life and TICs severity
Severity of the tics measurement (YGTSS Impairment Score) and the quality of life (TS-QOL) between men and women with tic disorders, while controlling for the YGTSS Total Tic Score
Measured: 6 months
Secondary outcomes (1)
Change in TICs
Change in tic inventories/tic migrations with the YGTSS tic inventories
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Oct 2021
- Study start1 Dec 2021
- Primary completion1 Dec 2027 (estimated)
- Study completion1 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tic DisordersStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 450 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05090943
- Sponsor's protocol ID
- APHP210801
- Acronym
- RegisTICs
- Status last verified
- Aug 2025
- First submitted
- 22 Sep 2021
- Last updated
- 4 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Adult Tic Disorders Registry
- ClinicalTrials.gov ID
- NCT05090943
- Acronym / sponsor ID
- RegisTICs / APHP210801
- Conditions
- Tic Disorders
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 450 participants (estimated)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Study start
- 1 Dec 2021 (actual)
- Primary completion
- 1 Dec 2027 (estimated)
- Study completion
- 1 Dec 2027 (estimated)
- First posted
- 25 Oct 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to develop the adult tic disorders registry in order to characterize the relationship between tic severity and tic-related impairment in women compared to men with tic disorders.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Quality of life questionnaires | – | Other: QOL to be completed by the participant |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patient with tics disorders
Key inclusion criteria (7 listed)
- Age >18 years
- Patients with Tic disorders
- Given the non-opposition
- Non Inclusion criteria
- No affiliation to a French health social insurance
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| QOL to be completed by the participantThe scales (PUTS, OCI, TS-QOL, ASRS, GAD-7, PHQ9, TAPS) to be completed by the participant | Other | Quality of life questionnaires |
Primary outcome
Correlation between Quality of Life and TICs severity
Time frame: 6 months
Severity of the tics measurement (YGTSS Impairment Score) and the quality of life (TS-QOL) between men and women with tic disorders, while controlling for the YGTSS Total Tic Score
1 secondary outcome
Change in TICs
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
7 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Tic Disorders, run by Assistance Publique - Hôpitaux de Paris at 7 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 7 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Emmanuel Flamand-Roze, MD, PhD (1 42 16 06 45 ext. +33, emmanuel.flamand-roze@aphp.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation between Quality of Life and TICs severity (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2025.