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Overweight and ObesityNCT05092061

Resistance Training in Adults With Obesity

A study testing Moderate-repetition resistance training and High-repetition resistance training in people with Overweight and Obesity, run by Norwegian University of Science and Technology at 1 site in Norway.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for
Overweight and Obesity
What is being tested?
Moderate-repetition resistance training and High-repetition resistance training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
31 participants
Where
1 siteNorway
Study dates
14 Oct 2021to 28 Feb 2022
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Obesity (BMI ≥ 30) or
  • Central obesity (defined according to the International Diabetes Federation).

Who cannot join

  • Unstable angina
  • recent cardiac infarction (last 4 weeks)
  • uncompensated heart failure
  • severe valvular illness
  • pulmonary disease
  • uncontrolled hypertension
Show all 11Show fewer
  • kidney failure
  • orthopaedic/neurological limitations
  • cardiomyopathy
  • planned operations during the research period
  • participation in a parallel study

Trial locations and contacts

1 site in 1 country.

Norway1 site

  • Department of Circulation and Medical Imaging

    Trondheim, 7491

Other trials in Norway

About this study

Official title: Acute and Chronic Effects of Two Different Types of Resistance Training on Cardiometabolic Health in Adults With Obesity

The purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. The project will include 30 adults with obesity (defined as BMI ≥ 30 or abdominal obesity according to the International Diabetes Federation). In the acute phase blood lactate, heart rate, enjoyment and perceived exertion will be assessed after the two resistance training protocols. In addition, the mean 24-h blood glucose concentration after exercise will be compared between the two protocols.

For the long-term effects blood markers of cardiometabolic health, blood pressure, body composition, objectively measured physical activity and physical fitness will be assessed before and after the intervention. Also, perceived health-related quality of life will be assessed before and after the intervention.

Being tested
Moderate-repetition resistance training, High-repetition resistance training
Keywords
Exercise therapy, Muscular strength, Resistance training, Fitness testing, Healthy lifestyle
Medical subject headings
Overweight, Obesity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Moderate-repetition resistance trainingOther

    Will undertake resistance training with moderate loads, and moderate repetitions 3 times per week for 7 weeks.

  • High-repetition resistance trainingOther

    Will undertake resistance training with low loads, and high repetitions 3 times per week for 7 weeks.

Study groups in NCT05092061
Study groupRoleWhat they receive
Moderate-repetition resistance trainingExperimentalThe participants will undergo a full-body resistance training protocol with moderate repetitions (6-12), moderate load (70-85% of 1RM), and moderate rest between sets (60-90s). Training will be undertaken three times per week.
Receives: Other: Moderate-repetition resistance training
High-repetition resistance trainingExperimentalThe participants will undergo a full-body resistance training protocol with high repetitions (15+), low load (<60% of 1RM), and short rest between sets (30s). Training will be undertaken three times per week.
Receives: Other: High-repetition resistance training

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Glycated haemoglobin (HbA1c)

    Measured: 7 weeks

Secondary outcomes (16)

  1. Fasting glucose

    Measured: 7 weeks

  2. Blood lipid concentration

    Measured: 7 weeks

  3. C-reactive protein

    Measured: 7 weeks

  4. Systolic blood pressure

    Measured: 7 weeks

  5. Diastolic blood pressure

    Measured: 7 weeks

  6. Body fat

    Measured by bioelectrical impedance (InBody 770)

    Measured: 7 weeks

  7. Fat-free mass

    Measured by bioelectrical impedance (InBody 770)

    Measured: 7 weeks

  8. Body mass

    Measured by bioelectrical impedance (InBody 770)

    Measured: 7 weeks

  9. Visceral fat area

    Measured by bioelectrical impedance (InBody 770)

    Measured: 7 weeks

  10. Waist circumference

    Measured: 7 weeks

  11. VO2max (maximal aerobic capacity)

    Measured: 7 weeks

  12. Rate of force development

    Measured by Kistler force plate

    Measured: 7 weeks

  13. Muscular strength (1RM)

    Leg press and bench press

    Measured: 7 weeks

  14. Muscular endurance

    Maximum number of repetitions using 50% of 1-RM

    Measured: 7 weeks

  15. Physical activity

    Assessed at three timepoints throughout the intervention using SenseWear armband activity monitors and/or Personal Activity IntelligenceTM (using heart rate monitors and smart phone application).

    Measured: Baseline (before intervention), 4 and 7 weeks.

  16. Health-Related Quality of Life

    Using the Short-Form 36 survey and Satisfaction with Physical Function and Appearance Survey

    Measured: 7 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Oct 2021
  2. Study start14 Oct 2021
  3. Primary completion28 Feb 2022
  4. Study completion28 Feb 2022

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Model description
The study will consist of both a crossover study model (acute phase) and parallel model (chronic phase).
Masking
None (open label)
Enrolment
31 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05092061
Sponsor's protocol ID
246888
Status last verified
May 2022
First submitted
20 Sep 2021
Last updated
26 May 2022
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Moderate-repetition resistance training and High-repetition resistance training in people with Overweight and Obesity, run by Norwegian University of Science and Technology at 1 site in Norway.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 26 May 2022. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Glycated haemoglobin (HbA1c) (time frame: 7 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05092061.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 May 2022.

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