AzTrials
AzTrials

Chronic Heart Failure With Reduced Ejection FractionPhase 3VICTORNCT05093933

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

A Phase 3 study testing Vericiguat in people with Chronic Heart Failure With Reduced Ejection Fraction, run by Merck Sharp & Dohme LLC at 519 sites in 36 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV)… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
Vericiguat
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
6,106 participants
Where
519 sitesin 36 countries
Study dates
2 Nov 2021to 5 Feb 2025
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • History of chronic HF [New York Heart Association (NYHA) Class II to IV] on guideline-directed medical therapy for heart failure (GDMT) with no HF hospitalization within 6 months or outpatient IV diuretic use within 3 months before randomization.
  • Left ventricular ejection fraction (LVEF) of ≤40%, assessed within 12 months before randomization by any imaging method.
  • Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.
  • A female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP), or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention.

Who cannot join

  • Has SBP <100 mm Hg or symptomatic hypotension.
  • Awaiting heart transplantation, is receiving continuous IV infusion of an inotrope, or has or anticipates receiving an implanted ventricular assist device.
  • Amyloidosis or sarcoidosis.
  • Primary valvular heart disease requiring surgical procedure or intervention or has undergone a valvular surgical procedure or intervention within 3 months before randomization.
  • Hypertrophic cardiomyopathy.
  • Acute myocarditis or Takotsubo cardiomyopathy.
Show all 15Show fewer
  • History of heart transplant.
  • Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia.
  • Acute coronary syndrome, or undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within 3 months before randomization.
  • History of symptomatic carotid stenosis, transient ischemic attack (TIA), or stroke within 3 months before randomization.
  • Malignancy or other noncardiac condition limiting life expectancy to <3 years.
  • Requires continuous home oxygen for severe pulmonary disease.
  • Interstitial lung disease.
  • Discontinuation or dose modification of GDMT or vericiguat within 4 weeks before randomization.
  • Recent history (within the last year) of drug or alcohol abuse or dependence.

Trial locations and contacts

519 sites in 36 countries.

519 sites in 36 countries

United States84 sites

  • Advanced Cardiovascular - Alexander City ( Site 0038)

    Alexander City, Alabama, 35010

  • Cambridge Medical Trials ( Site 0041)

    Alexandria, Louisiana, 71301

  • Emory University School of Medicine ( Site 0123)

    Atlanta, Georgia, 30322

  • Maryland Cardiovascular Specialists ( Site 0056)

    Baltimore, Maryland, 21229

  • University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153)

    Birmingham, Alabama, 35294

  • Excel Medical Clinical Trials ( Site 0008)

    Boca Raton, Florida, 33434

  • Erie County Medical Center ( Site 0160)

    Buffalo, New York, 14215

  • Aultman Hospital-Cardiology Clinical Trials ( Site 0064)

    Canton, Ohio, 44710

  • Accellacare - Charleston ( Site 0141)

    Charleston, South Carolina, 29464

  • Mount Sinai Hospital ( Site 0050)

    Chicago, Illinois, 60608

  • University of Cincinnati Medical Center-Cardiology ( Site 0071)

    Cincinnati, Ohio, 45219

  • University of Missouri Hospital ( Site 0163)

    Columbia, Missouri, 65212

  • IACT Health ( Site 0106)

    Columbus, Georgia, 31904

  • New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127)

    Cortlandt Manor, New York, 10567

  • Valley Clinical Trials, Inc. ( Site 0085)

    Covina, California, 91723

  • Dallas VA Medical Center ( Site 0084)

    Dallas, Texas, 75216

  • Southwest Family Medicine Associates ( Site 0131)

    Dallas, Texas, 75235

  • Universal Axon Clinical Research, LLC ( Site 0022)

    Doral, Florida, 33166

  • Doylestown Hospital-Cardiology ( Site 0030)

    Doylestown, Pennsylvania, 18901

  • Medresearch Inc ( Site 0043)

    El Paso, Texas, 79935

  • INOVA Fairfax Medical Campus ( Site 0136)

    Falls Church, Virginia, 22042

  • Holy Cross Hospital ( Site 0100)

    Fort Lauderdale, Florida, 33308

  • Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075)

    Gilbert, Arizona, 85297

  • Louisiana Heart Center - Hammond ( Site 0004)

    Hammond, Louisiana, 70403

  • The Heart Clinic - Hammond ( Site 0155)

    Hammond, Louisiana, 70403

  • Chicago Medical Research ( Site 0086)

    Hazel Crest, Illinois, 60429

  • Indago Research and Health Center Inc ( Site 0011)

    Hialeah, Florida, 33012

  • South Florida Research Solutions ( Site 0058)

    Hollywood, Florida, 33021

  • Cardiovascular Institute of the South ( Site 0072)

    Houma, Louisiana, 70360

  • West Houston Area Clinical Trial Consultants ( Site 0014)

    Houston, Texas, 77094

  • Heart Center Research, LLC ( Site 0156)

    Huntsville, Alabama, 35801

  • Franciscan Physician Network - Indiana Heart Physicians ( Site 0087)

    Indianapolis, Indiana, 46237

  • University of Iowa ( Site 0005)

    Iowa City, Iowa, 52242

  • Phillips Medical Services ( Site 0070)

    Jackson, Mississippi, 39209

  • The University of Mississippi Medical Center-Cardiovascular ( Site 0073)

    Jackson, Mississippi, 39216

  • Apex Research Foundation ( Site 0001)

    Jackson, Tennessee, 38301

  • University of Florida - Jacksonville ( Site 0169)

    Jacksonville, Florida, 32209

  • East Coast Institute for Research, LLC ( Site 0047)

    Jacksonville, Florida, 32216

  • NSC Research ( Site 0068)

    Johns Creek, Georgia, 30024

  • Logan Health Research ( Site 0017)

    Kalispell, Montana, 59901

  • South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024)

    Kerrville, Texas, 78028

  • Cardiovascular Institute of the South, 3 ( Site 0096)

    Lafayette, Louisiana, 70503

  • Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167)

    Lanham, Maryland, 20706

  • VA West Los Angeles Medical Center-Cardiology ( Site 0149)

    Los Angeles, California, 90073

  • Norton Healthcare-Norton Heart Specialist ( Site 0062)

    Louisville, Kentucky, 40205

  • Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134)

    Lumberton, North Carolina, 28358

  • Georgia Arrhythmia Consultants and Research Institute ( Site 0042)

    Macon, Georgia, 31201

  • Carient Heart & Vascular - Manassas ( Site 0059)

    Manassas, Virginia, 20109

  • The Heart Center of Lake County Research Institute-Research ( Site 0147)

    Merrillville, Indiana, 46410

  • Cardiovascular Research Center of South Florida ( Site 0074)

    Miami, Florida, 33173

  • ProLive Medical Research ( Site 0032)

    Miami, Florida, 33175

  • IMA Clinical Research ( Site 0112)

    Monroe, Louisiana, 71201

  • Cardiovascular Research of Northwest Indiana ( Site 0036)

    Munster, Indiana, 46321

  • Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060)

    Nashville, Tennessee, 37232

  • Icahn School of Medicine at Mount Sinai ( Site 0161)

    New York, New York, 10029-5674

  • Sentara Norfolk General Hospital ( Site 0114)

    Norfolk, Virginia, 23507

  • Valley Clinical Trials Inc ( Site 0006)

    Northridge, California, 91325

  • Cardiovascular Institute of the South ( Site 0081)

    Opelousas, Louisiana, 70570

  • OSF Healthcare Cardiovascular Institute ( Site 0122)

    Peoria, Illinois, 61614

  • Methodist Medical Center of Illinois ( Site 0098)

    Peoria, Illinois, 61636

  • Peace River Cardiovascular Center ( Site 0088)

    Port Charlotte, Florida, 33952

  • Pulse Heart Institute - Puyallup ( Site 0119)

    Puyallup, Washington, 98372

  • Amici Clinical Research LLC-Research ( Site 0037)

    Raritan, New Jersey, 08869

  • Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168)

    Reno, Nevada, 89502

  • Reid Physician Associates ( Site 0054)

    Richmond, Indiana, 47374

  • Dominion Medical Associates, Inc. ( Site 0089)

    Richmond, Virginia, 23219

  • The Valley Hospital ( Site 0035)

    Ridgewood, New Jersey, 07450

  • BAYCARE MEDICAL GROUP ( Site 0099)

    Safety Harbor, Florida, 34695

  • East Coast Institute for Research - St. Augustine ( Site 0016)

    Saint Augustine, Florida, 32086

  • South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020)

    San Antonio, Texas, 78201

  • Cardiovascular Center of Sarasota ( Site 0154)

    Sarasota, Florida, 34239

  • Ascension Providence Hospital ( Site 0094)

    Southfield, Michigan, 48075

  • MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102)

    Spokane, Washington, 99204

  • Washington University-Department of Medicine ( Site 0044)

    St Louis, Missouri, 63110

  • St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029)

    St Louis, Missouri, 63136

  • CHEAR Center LLC ( Site 0009)

    The Bronx, New York, 10455

  • Cardiovascular Consultants of South Georgia, LLC ( Site 0137)

    Thomasville, Georgia, 31792

  • ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061)

    Toledo, Ohio, 43606

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010)

    Torrance, California, 90502

  • Tyler Cardiovascular Consultants ( Site 0039)

    Tyler, Texas, 75701

  • Blue Coast Research Center ( Site 0053)

    Vista, California, 92081

  • Cardiovascular Associates of the Delaware Valley ( Site 0097)

    Washington Township, New Jersey, 08080

  • Alliance for Multispecialty Research, LLC ( Site 0143)

    Wichita, Kansas, 67207

  • Accellacare - Wilmington ( Site 0090)

    Wilmington, North Carolina, 28401

Other trials in United States

China48 sites

  • BAO TOU CENTRAL HOSPITAL ( Site 0866)

    Baotou, Inner Mongolia, 014040

  • Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 0856)

    Beijing, Beijing Municipality, 100029

  • Aero Space Center Hospital ( Site 0918)

    Beijing, Beijing Municipality, 100049

  • Beijing Friendship Hospital-Cardology ( Site 0865)

    Beijing, Beijing Municipality, 100050

  • Beijing Tsinghua Changgung Hospital ( Site 0911)

    Beijing, Beijing Municipality, 102218

  • China-Japan Union Hospital-department of cardiology ( Site 0916)

    Changchun, Jilin, 130033

  • Changsha Central Hospital ( Site 0854)

    Changsha, Hunan, 410004

  • Hunan Provincial People's Hospital ( Site 0857)

    Changsha, Hunan, 410005

  • Xiangya Hospital Central South University-Cardiological Department ( Site 0899)

    Changsha, Hunan, 410008

  • The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860)

    Changsha, Hunan, 410013

  • West China Hospital Sichuan University ( Site 0904)

    Chengdu, Sichuan, 610041

  • The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908)

    Chongqing, Chongqing Municipality, 400010

  • The First People's Hospital of Foshan ( Site 0898)

    Foshan, Guangdong, 528041

  • Guangdong Provincial People's Hospital-Cardiology ( Site 0852)

    Guangzhou, Guangdong, 510080

  • Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868)

    Guangzhou, Guangdong, 510120

  • The First Affiliated Hospital of Jinan University ( Site 0897)

    Guangzhou, Guangdong, 510630

  • Hainan General Hospital ( Site 0894)

    Haikou, Hainan, 570311

  • The First Affiliated Hospital, Zhejiang University ( Site 0907)

    Hangzhou, Zhejiang, 310003

  • The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0909)

    Hangzhou, Zhejiang, 310052

  • Zhejiang Provincial People's Hospital ( Site 0914)

    Hangzhou, Zhejiang, 311599

  • The First Hospital of Harbin Medical University-Cardiology ( Site 0903)

    Harbin, Heilongjiang, 150001

  • Anhui Provincil Hospital South District ( Site 0920)

    Hefei, Anhui, 230036

  • Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863)

    Lanzhou, Gansu, 730030

  • People's Hospital of Lishui City-department of cardiovascular ( Site 0862)

    Lishui, Zhejiang, 323000

  • The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912)

    Nanchang, Jiangxi, 330006

  • Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy

    Nanjing, Jiangsu, 210000

  • The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900)

    Nanjing, Jiangsu, 210011

  • Shanghai Jiaotong University School of Medicine Ruijin Hospital-Cardiology Department ( Site 0855)

    Shanghai, Shanghai Municipality, 200001

  • Zhongshan Hospital,Fudan University-Cardiology ( Site 0851)

    Shanghai, Shanghai Municipality, 200032

  • Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905)

    Shanghai, Shanghai Municipality, 200065

  • Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876)

    Shanghai, Shanghai Municipality, 200090

  • Shanghai Xuhui Central Hospital-Cardiovascular Department ( Site 0872)

    Shanghai, Shanghai Municipality

  • The People's Hospital of Liaoning Province ( Site 0859)

    Shenyang, Liaoning, 110016

  • The University of Hong Kong - Shenzhen Hospital-Cardiovascular department ( Site 0895)

    Shenzhen, Guangdong, 518053

  • Siping Central People's Hospital-Cardiovascular Department ( Site 0915)

    Siping, Jilin, 136000

  • The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902)

    Tianjin, Tianjin Municipality, 300211

  • Tianjin Chest Hospital-Cardiology ( Site 0901)

    Tianjin, Tianjin Municipality, 300222

  • Tianjin People' s Hospital ( Site 0867)

    Tianjin, Tianjin Municipality

  • Chongqing Three Gorges Central Hospital ( Site 0913)

    Wanzhou, Chongqing Municipality, 404199

  • The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874

    Wenzhou, Zhejiang, 325000

  • Wuhan Union Hospital ( Site 0919)

    Wuhan, Hubei, 430022

  • Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877)

    Wuxi, Jiangsu, 214002

  • Wuxi People's Hospital-Cardiovascular Department ( Site 0870)

    Wuxi, Jiangsu, 214023

  • The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit

    Xi'an, Shaanxi, 710061

  • Shaanxi provincial people's hospital ( Site 0853)

    Xi'an, Shaanxi, 710068

  • The Affiliated Hospital of Xuzhou Medical College ( Site 0910)

    Xuzhou, Jiangsu, 221006

  • Northern Jiangsu People's Hospital ( Site 0861)

    Yangzhou, Jiangsu, 225001

  • Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917)

    Zhenjiang, Jiangsu, 212001

Other trials in China

Ukraine24 sites

  • Communal non-profit enterprise "Cherkasy Regional Hospital of Сherkasy Regional Council" ( Site 4292

    Cherkasy, Cherkasy Oblast, 18000

  • Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283)

    Cherkasy, Cherkasy Oblast, 18009

  • Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 4284)

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76000

  • Municipal Non-commercial Enterprise "Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018

  • Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306)

    Kharkiv, Kharkiv Oblast, 61000

  • Communal non-profit enterprise "City Clinical Hospital # 27" of Kharkiv City Council ( Site 4262)

    Kharkiv, Kharkiv Oblast, 61000

  • L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti

    Kharkiv, Kharkiv Oblast, 61039

  • Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278)

    Kharkiv, Kharkiv Oblast, 61176

  • Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra

    Khmelnytskyi, Khmelnytskyi Oblast, 29001

  • Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain

    Kiev, Kyiv Oblast, 03049

  • Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 4257)

    Kiev, Kyiv Oblast, 04050

  • Medbud Clinic ( Site 4265)

    Kyiv, Kyivska Oblast, 03037

  • State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259)

    Kyiv, Kyivska Oblast, 03680

  • Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307)

    Kyiv, 01103

  • MNE " Kyiv City Clinical Emergency Hospital" of Kyiv Regional Council (KCSA) ( Site 4256)

    Kyiv, 02166

  • State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a

    Kyiv, 03151

  • State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site

    Kyiv, 03680

  • Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255)

    Lutsk, Volyn Oblast, 43024

  • Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42

    Odesa, Odesa Oblast, 65025

  • Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un

    Uzhhorod, Zakarpattia Oblast, 88000

  • Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274)

    Vinnytsia, Vinnytsia Oblast, 21029

  • Communal Non-profit Enterprise "City Hospital #6" Zaporizhzhia City Counci-Therapy department ( Site

    Zaporizhia, Zaporizhzhia Oblast, 69035

  • Communal nonprofit enterprise "City Hospital #9" of Zaporizhzhia City Council ( Site 4251)

    Zaporizhia, Zaporizhzhia Oblast, 69065

  • Communal Enterprise "Hospital #1" of Zhytomyr City Council-Advisory and Treatment department of Sci

    Zhytomyr, Zhytomyr Oblast, 10002

Other trials in Ukraine

Mexico23 sites

  • Hospital General de Acapulco ( Site 2469)

    Acapulco de Juárez, Guerrero, 39901

  • Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473)

    Aguascalientes, 20230

  • Medivest Centro de Investigación Integral ( Site 2460)

    Chihuahua City, Chihuahua, 31203

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468)

    Ciudad Madero, Tamaulipas, 89440

  • Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466)

    Guadalajara, Jalisco, 44150

  • Cardiocent de Guadalajara S.C. ( Site 2464)

    Guadalajara, Jalisco, 44160

  • Instituto Jalisciense de Metabolismo SC ( Site 2467)

    Guadalajara, Jalisco, 44670

  • Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463)

    Mazatlán, Sinaloa, 82113

  • Medical Care and Research SA de CV ( Site 2461)

    Mérida, Yucatán, 97070

  • HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA ( Site 2478)

    Mexico City, Mexico City, 06720

  • Centro de Imagen y Tecnología en Intervención Cardiovascular ( Site 2477)

    Mexico City, Mexico City, 10400

  • Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454)

    Mexico City, Mexico City, 14080

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474)

    Mexico City, Mexico City, 14080

  • Unidad biomedica avanzada monterrey ( Site 2462)

    Monterrey, Nuevo León, 64460

  • Oaxaca Site Management Organization ( Site 2459)

    Oaxaca City, 68000

  • Centro de Investigacion Clinica de Oaxaca ( Site 2457)

    Oaxaca City, 68020

  • Grupo Ollin Care ( Site 2476)

    Pachuca, Hidalgo, 42000

  • Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453)

    San Luis Potosí City, San Luis Potosí, 78200

  • Unidad Médica para la Salud Integral ( Site 2472)

    San Nicolás de los Garza, Nuevo León, 66465

  • Centro de Investigacion Cardiovascular y Metabólica ( Site 2465)

    Tijuana, Estado de Baja California, 22500

  • CIMAB SA de CV ( Site 2456)

    Torreón, Coahuila, 27000

  • Consultorio de Medicina Especilizada del Sector Privado ( Site 2455)

    Xalapa, Veracruz, 91193

  • Hospital Angeles Xalapa ( Site 2451)

    Xalapa, Veracruz, 91193

Other trials in Mexico

Canada21 sites

  • Heritage Medical Research Clinic ( Site 0679)

    Calgary, Alberta, T2N 4Z6

  • Cambridge Cardiac Care Centre ( Site 0658)

    Cambridge, Ontario, N1R 6V6

  • University Of Alberta Hospital ( Site 0669)

    Edmonton, Alberta, T6G 2B7

  • NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664)

    Halifax, Nova Scotia, B3H 3A7

  • Hôpital de la Cité-de-la-Santé ( Site 0673)

    Laval, Quebec, H7M 3L9

  • G A Research Associates ( Site 0652)

    Moncton, New Brunswick, E1G 1A7

  • Institut de Cardiologie de Montreal ( Site 0661)

    Montreal, Quebec, H1T 1C8

  • Montreal General Hospital ( Site 0653)

    Montreal, Quebec, H3G 1A4

  • PACE Cardiology ( Site 0675)

    Newmarket, Ontario, L3Y 2P6

  • North York Diagnostic and Cardiac Centre ( Site 0682)

    North York, Ontario, M6B 3H7

  • Oakville Cardiovascular Research LP ( Site 0657)

    Oakville, Ontario, L6K 3W7

  • Private Practice - Dr. James Cha ( Site 0655)

    Oshawa, Ontario, L1J 2K1

  • Kawartha Cardiology Clinical Trials ( Site 0654)

    Peterborough, Ontario, K9J 0B2

  • Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668)

    Saint-Jérôme, Quebec, J7Z 2V4

  • Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer

    Sherbrooke, Quebec, J1H 5N4

  • Hopital Pierre-Le Gardeur ( Site 0674)

    Terrebonne, Quebec, J6V 2H2

  • Corcare-Corcare Cardiovascular Research ( Site 0660)

    Toronto, Ontario, M1B 5N1

  • Medicus MFC Research Clinic ( Site 0676)

    Toronto, Ontario, M4P 1E4

  • Diex Recherche Trois-Rivieres ( Site 0677)

    Trois-Rivières, Quebec, G9A 4P3

  • Victoria Heart Institute Foundation ( Site 0680)

    Victoria, British Columbia, V8R 1B2

  • St. Boniface General Hospital ( Site 0667)

    Winnipeg, Manitoba, R2H 2A6

Other trials in Canada

Germany21 sites

  • Praxis Rankestrasse ( Site 1461)

    Berlin, 10789

  • Klinikum Coburg ( Site 1464)

    Coburg, Bavaria

  • St. Vinzenz-Hospital-Cardiology ( Site 1455)

    Cologne, North Rhine-Westphalia, 50733

  • Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468)

    Dresden, Saxony, 01067

  • Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien ( Site 1477)

    Dresden, Saxony, 01277

  • Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469)

    Dresden, Saxony, 01307

  • Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462)

    Erfurt, Thuringia, 99097

  • ClinPhenomics CVC GmbH ( Site 1457)

    Frankfurt am Main, Hesse, 60596

  • Klinikum Frankfurt Höchst ( Site 1463)

    Frankfurt am Main, Hesse, 65929

  • Universitätsmedizin Greifswald ( Site 1470)

    Greifswald, Mecklenburg-Vorpommern, 17475

  • Cardiologicum Hamburg ( Site 1467)

    Hamburg, 22041

  • Medizinische Hochschule Hannover ( Site 1476)

    Hanover, Lower Saxony, 30625

  • Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475)

    Heidelberg, Baden-Wurttemberg, 69120

  • Asklepios Klinik Langen ( Site 1473)

    Langen, Hesse, 63225

  • Klinikum Leverkusen ( Site 1453)

    Leverkusen, North Rhine-Westphalia, 51375

  • Klinikum Ludwigshafen ( Site 1456)

    Ludwigshafen am Rhein, Rhineland-Palatinate, 67063

  • Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454)

    Mönchengladbach, North Rhine-Westphalia, 41063

  • Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452)

    Neuwied, Rhineland-Palatinate, 56564

  • Kardiologische Gemeinschaftspraxis ( Site 1460)

    Nuremberg, Bavaria, 90402

  • Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459)

    Siegen, North Rhine-Westphalia, 57072

  • Universitaetsklinikum Wuerzburg ( Site 1458)

    Würzburg, Bavaria, 97080

Other trials in Germany

United Kingdom20 sites

  • Ulster Hospital ( Site 4185)

    Belfast, Lisburn And Castlereagh, BT16 1RH

  • Craigavon Area Hospital ( Site 4162)

    Belfast, Northern Ireland, BT63 5QQ

  • Layton Medical Centre ( Site 4184)

    Blackpool, Lancashire, FY3 7EN

  • Blackpool Victoria Hospital ( Site 4161)

    Blackpool, FY3 8NR

  • Princess of Wales Hospital ( Site 4178)

    Bridgend, Wales, CF31 1RQ

  • Chesterfield Royal Hospital ( Site 4159)

    Calow Chesterfield, Derbyshire, S44 5BL

  • Cumberland Infirmary ( Site 4174)

    Carlisle, Cumbria, CA2 7HY

  • University Hospital Coventry & Warwickshire-Research & Development ( Site 4170)

    Coventry, CV2 2DX

  • Carmel Medical Practice ( Site 4152)

    Darlington, England, DL3 7RD

  • Russells Hall Hospital ( Site 4153)

    Dudley, England, DY1 2HQ

  • Ninewells Hospital and Medical School-Cardiology ( Site 4164)

    Dundee, Dundee City, DD1 9SY

  • King's College Hospital-Cardiac Research Department ( Site 4154)

    London, England, SE5 9RS

  • St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156)

    London, England, SW17 0QT

  • William Harvey Heart Centre ( Site 4169)

    London, London, City of, EC1M 5PZ

  • Prince Charles Hospital ( Site 4171)

    Merthyr Tydfil, Great Britain, CF47 9DT

  • The Adam Practice ( Site 4180)

    Poole, BH16 5PW

  • University Hospital of North Tees ( Site 4172)

    Stockton-on-Tees, TS19 8PE

  • Walsall Manor Hospital ( Site 4179)

    West Midlands, Walsall, WS2 9PS

  • West Cumberland Hospital ( Site 4176)

    Whitehaven, Cumbria, CA28 8JG

  • Worcestershire Royal Hospital-Cardiology Research Department ( Site 4181)

    Worcester, Worcestershire, WR5 1DD

Other trials in United Kingdom

Russia19 sites

  • Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265)

    Ivanovo, Ivanovo Oblast, 153012

  • Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307)

    Kazan', Tatarstan, Respublika, 420101

  • Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281)

    Krasnodar, Krasnodarskiy Kray, 350086

  • State budgetary Healthcare Institution of the city of Moscow "V. V. Vinogradov City Clinical Hospita

    Moscow, Moscow, 117292

  • Omsk Regional Clinical Health Service Number 9 ( Site 3296)

    Omsk, Omsk Oblast, 644018

  • Perm Regional Hospital for War Veterans ( Site 3272)

    Perm, Permskiy Kray, 614990

  • Rostov State Medical University ( Site 3259)

    Rostov-on-Don, Rostov Oblast, 344022

  • Rostov-on-Don City Emergency Hospital ( Site 3271)

    Rostov-on-Don, Rostov Oblast, 344068

  • Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260)

    Ryazan, Ryazan Oblast, 390005

  • First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257)

    Saint Petersburg, Leningradskaya Oblast', 197022

  • First Pavlov State Medical University of Saint Petersburg ( Site 3288)

    Saint Petersburg, Sankt-Peterburg, 197022

  • Almazov National Medical Research Centre ( Site 3320)

    Saint Petersburg, Sankt-Peterburg, 197341

  • Pokrovskaya Municipal Hospital ( Site 3252)

    Saint Petersburg, Sankt-Peterburg, 199106

  • Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251)

    Saint Petersburg, Sankt-Peterburg, 199106

  • Astarta Clinic ( Site 3276)

    Saint Petersburg, Sankt-Peterburg, 199226

  • Institute for Medical Research ( Site 3316)

    Saint Petersburg, 196084

  • Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254)

    Saratov, Saratov Oblast, 410054

  • City Hospital No. 4 ( Site 3269)

    Sochi, Krasnodarskiy Kray, 354057

  • Volgograd State Medical University ( Site 3258)

    Volgograd, Volgograd Oblast, 400131

Other trials in Russia

Hungary17 sites

  • DRC Gyógyszervizsgáló Központ ( Site 1869)

    Balatonfüred, Veszprém megye, 8230

  • Private Practice - Dr. Lakatos Ferenc ( Site 1854)

    Békéscsaba, Bekes County, 5600

  • Szent Rókus Kórház ( Site 1858)

    Budapest, 1085

  • Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1851)

    Budapest, 1096

  • Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855)

    Budapest, 1122

  • Óbudai Egészségügyi Centrum ( Site 1861)

    Budapest, 1932

  • Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Cardiology ( Site 1878)

    Gyula, Bekes County, 5700

  • Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873)

    Kecskemét, Bács-Kiskun county, 6000

  • Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852)

    Kistarcsa, Pest County, 2143

  • TaNa Med ( Site 1866)

    Mosonmagyaróvár, Győr-Moson-Sopron, 9200

  • Medifarma 98 Kft-Outpatient Clinic ( Site 1859)

    Nyíregyháza, 4400

  • CoroMed ( Site 1867)

    Pécs, Baranya, 7623

  • Pécsi Tudományegyetem Klinikai Központ ( Site 1865)

    Pécs, Baranya, 7624

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874)

    Szeged, Csongrád megye, 6725

  • CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877)

    Székesfehérvár, Szekesfehervar, 8000

  • Tolna Megyei Balassa János Kórház ( Site 1868)

    Szekszárd, Szekszard, 7100

  • OEC Clinical Research - Zalaegerszeg ( Site 1864)

    Zalaegerszeg, 8900

Other trials in Hungary

Poland15 sites

  • NZOZ Centrum Medyczne KERmed ( Site 3066)

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231

  • Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062)

    Chrzanów, Lesser Poland Voivodeship, 32-500

  • Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman

    Gdynia, Pomeranian Voivodeship, 81-157

  • Polsko-Amerykańskie Kliniki Serca ( Site 3077)

    Kędzierzyn-Koźle, Opole Voivodeship, 47-200

  • Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061)

    Krakow, Lesser Poland Voivodeship, 31-216

  • Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070)

    Legnica, Lower Silesian Voivodeship, 59-220

  • NZOZ Twoja Przychodnia ( Site 3051)

    Lublin, Lublin Voivodeship, 20-857

  • SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071)

    Puławy, Lublin Voivodeship, 24-100

  • Centrum Medyczne Medyk ( Site 3065)

    Rzeszów, Podkarpackie Voivodeship, 35-055

  • Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073)

    Sokółka, Podlaskie Voivodeship, 16-100

  • Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site

    Tarnów, Lesser Poland Voivodeship, 33-100

  • Praktyka Lekarska Lidia Pawlowicz ( Site 3053)

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100

  • Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100

  • ETG Warszawa ( Site 3052)

    Warsaw, Masovian Voivodeship, 02-793

  • Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057)

    Wrocaw, Lower Silesian Voivodeship, 50-556

Other trials in Poland

Italy14 sites

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151)

    Bergamo, 24127

  • IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158)

    Bologna, 40138

  • Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154)

    Brescia, 25123

  • Azienda Ospedaliero Universitaria S.Anna ( Site 2152)

    Cona, Emilia-Romagna, 44124

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161)

    Milan, Lombardy, 20122

  • Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153)

    Milan, Lombardy, 20138

  • ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159)

    Milan, Milano, 20162

  • Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157)

    Pavia, 27100

  • University of Perugia ( Site 2164)

    Perugia, 06132

  • Policlinico Umberto I ( Site 2166)

    Rome, Lazio, 00161

  • IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156)

    Rome, Roma, 00163

  • ospedale le scotte ( Site 2163)

    Siena, Tuscany, 53100

  • Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165)

    Torino, 10126

  • Cattinara Hospital-Cardiovascular Department ( Site 2162)

    Trieste, Friuli Venezia Giulia, 34149

Other trials in Italy

South Africa14 sites

  • Tiervlei Trial Centre ( Site 3461)

    Bellville, Cape Town, Western Cape, 7530

  • Universitas Private Hospital-Cardiology Research ( Site 3453)

    Bloemfontein, Free State, 9321

  • TREAD Research ( Site 3451)

    Cape Town, Western Cape, 7500

  • Professor Ntsekhe Cardiology Clinic ( Site 3454)

    Cape Town, Western Cape, 7925

  • Enhancing Care Foundation ( Site 3456)

    Durban, KwaZulu-Natal, 4001

  • Excellentis Clinical Trial Consultants ( Site 3464)

    George, Western Cape, 6529

  • Lenasia Clinical Trial Centre - Johannesburg ( Site 3470)

    Johannesburg, Gauteng, 1821

  • Netcare Sunninghill Hospital ( Site 3457)

    Johannesburg, Gauteng, 2196

  • Midrand Medical Centre ( Site 3466)

    Midrand, Gauteng, 1685

  • Paarl Research Centre ( Site 3468)

    Paarl, Western Cape, 7646

  • University of Pretoria - Faculty of Health Sciences-CRU ( Site 3462)

    Pretoria, Gauteng, 0001

  • Clinical Trial Systems ( Site 3452)

    Pretoria, Gauteng, 0186

  • Jongaie Research ( Site 3469)

    Pretoria West, Gauteng, 0183

  • Chris Hani Baragwanath Academic Hospital ( Site 3455)

    Soweto, Gauteng, 2013

Other trials in South Africa

Denmark13 sites

  • Aarhus Universitetshospital, Skejby ( Site 1160)

    Aarhus, Central Jutland, 8200

  • Rigshospitalet-Cardiology ( Site 1161)

    Copenhagen, Capital Region, 2100

  • Amager Hospital ( Site 1163)

    Copenhagen, Capital Region, 2300

  • Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154)

    Esbjerg, Region Syddanmark, 6700

  • Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158)

    Hellerup, Capital Region, 2900

  • Nordsjællands Hospital - Hillerød ( Site 1159)

    Hillerød, Capital Region, 3400

  • Sygehus Vendsyssel Hjoerring ( Site 1164)

    Hjørring, North Denmark, 9800

  • Holbæk Sygehus-Cardiology ( Site 1152)

    Holbæk, Region Sjælland, 4300

  • Hvidovre Hospital-259 ( Site 1151)

    Hvidovre, Capital Region, 2650

  • Roskilde Sygehus ( Site 1162)

    Roskilde, Region Sjælland, 4000

  • Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153)

    Slagelse, Region Sjælland, 4200

  • Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156)

    Svendborg, Region Syddanmark, 5700

  • Regionshospitalet Viborg ( Site 1166)

    Viborg, Central Jutland, 8800

Other trials in Denmark

Turkey (Türkiye)13 sites

  • Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058)

    Afyonkarahisar, 03200

  • Hacettepe Universitesi ( Site 4061)

    Ankara, 06230

  • Ankara Bilkent Şehir Hastanesi-cardiology ( Site 4053)

    Ankara, 06800

  • Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064)

    Antalya, 07100

  • Ege University Medicine of Faculty-Cardilogy Department ( Site 4054)

    Bornova, İzmir, 35100

  • Eskisehir Osmangazi University-Cardiology ( Site 4052)

    Eskişehir, 26480

  • Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit

    Istanbul, 34098

  • Başkent Üniversitesi Istanbul Hastanesi ( Site 4057)

    Istanbul, 34662

  • Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063)

    Istanbul, 34668

  • Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055)

    Izmir, 35340

  • Medical Park zmir Hastanesi-cardiology ( Site 4059)

    Izmir, 35510

  • Kocaeli Üniversitesi-Cardiology ( Site 4060)

    Kocaeli, 41380

  • Mersin University ( Site 4056)

    Mersin, 33343

Other trials in Turkey (Türkiye)

Chile12 sites

  • IC La Serena Research ( Site 0769)

    La Serena, Coquimbo Region, 1720430

  • Clinica Alemana Osorno ( Site 0768)

    Osorno, Los Lagos Region, 5311089

  • Enroll SpA ( Site 0755)

    Santiago, Region M. de Santiago, 7500587

  • Clinica Dermacross ( Site 0760)

    Santiago, Region M. de Santiago, 7640881

  • Espacio Eme ( Site 0762)

    Santiago, Region M. de Santiago, 7770086

  • Hospital y CRS El Pino ( Site 0763)

    Santiago, Region M. de Santiago, 8053095

  • Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754)

    Santiago, Region M. de Santiago, 8330111

  • Clínica Ensenada ( Site 0753)

    Santiago, Region M. de Santiago, 8380465

  • Cardio Sur ( Site 0756)

    Santiago, Region M. de Santiago, 8910259

  • Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752)

    Temuco, Araucania, 4780000

  • Clinical Research Chile SpA ( Site 0761)

    Valdivia, Los Ríos Region, 5110683

  • ONCOCENTRO APYS ( Site 0770)

    Viña del Mar, Valparaiso, 2520598

Other trials in Chile

Colombia12 sites

  • Clinica de la Costa S.A.S. ( Site 0954)

    Barranquilla, Atlántico, 080020

  • Corazon IPS ( Site 0964)

    Barranquilla, Atlántico, 080020

  • IPS Centro Científico Asistencial S.A.S ( Site 0952)

    Barranquilla, Atlántico, 080020

  • Instituto Del Corazón De Bucaramanga ( Site 0960)

    Bucaramanga, Santander Department, 680002

  • Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962)

    Cali, Valle del Cauca Department, 760032

  • Centro de Investigaciones Clinicas SAS ( Site 0957)

    Cali, Valle del Cauca Department, 760036

  • Clínica Imbanaco S.A.S ( Site 0963)

    Cali, Valle del Cauca Department

  • IPS Médicos Internistas de Caldas ( Site 0959)

    Manizales, Caldas Department, 170004

  • Fundación Centro de Investigación Clínica CIC ( Site 0955)

    Medellín, Antioquia, 050021

  • Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951)

    Medellín, Antioquia, 050034

  • Rodrigo Botero S.A.S ( Site 0953)

    Medellín, Antioquia, 50030

  • Fundación Cardiovascular de Colombia ( Site 0961)

    Piedecuesta, Santander Department, 681017

Other trials in Colombia

Spain12 sites

  • CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666)

    A Coruña, La Coruna, 15006

  • Hospital Germans Trias i Pujol ( Site 3664)

    Badalona, Barcelona, 08916

  • Hospital Quiron Barcelona ( Site 3655)

    Barcelona, Catalonia, 08023

  • Parc de Salut Mar - Hospital del Mar ( Site 3663)

    Barcelona, 08003

  • Hospital Universitari Vall d'Hebron ( Site 3659)

    Barcelona, 08035

  • Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM

    L'Hospitalet de Llobregat, Catalonia, 08907

  • Hospital Universitario Ramón y Cajal ( Site 3662)

    Madrid, Madrid, Comunidad de, 28034

  • Hospital Clinico San Carlos-Cardiology ( Site 3661)

    Madrid, 28040

  • Hospital Universitario La Paz ( Site 3665)

    Madrid, 28046

  • CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651)

    Santiago de Compostela, La Coruna, 15706

  • Hospital Universitario Virgen de Valme ( Site 3654)

    Seville, 41014

  • HOSPITAL CLINICO DE VALENCIA ( Site 3656)

    Valencia, Valenciana, Comunitat, 46010

Other trials in Spain

Czechia11 sites

  • Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058)

    Brno, Brno-mesto, 625 00

  • Vojenská Nemocnice Brno-Internal department ( Site 1055)

    Brno, Brno-mesto, 636 00

  • MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057)

    Brno, South Moravian, 602 00

  • Fakultni Nemocnice u sv. Anny v Brne-I. interni kardioangiologicka klinika ( Site 1066)

    Brno, South Moravian, 60200

  • KardioBusak s.r.o. ( Site 1051)

    Louny, 44001

  • Klinika Dr. Pirka ( Site 1065)

    Mladá Boleslav, Mlada Boleslav, 293 01

  • Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052)

    Prague, Praha 4, 14021

  • Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054)

    Prague, Praha 6, 169 02

  • Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059)

    Prague, 12808

  • Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063)

    Slaný, Central Bohemia, 274 01

  • KIGE ( Site 1060)

    Znojmo, 66902

Other trials in Czechia

France11 sites

  • CHD Vendee ( Site 1361)

    La Roche-sur-Yon, Vendee, 85000

  • Centre Hospitalier Louis Pasteur ( Site 1360)

    Le Coudray, Eure-et-Loir, 28630

  • Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356)

    Le Kremlin-Bicêtre, Paris, 94270

  • Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1364)

    Lyon, Rhone, 69677

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur-Service cardiologie ( Site 1353)

    Nice, Alpes-Maritimes, 06000

  • Pitie Salpetriere University Hospital ( Site 1363)

    Paris, Île-de-France Region, 75013

  • CHU Bordeaux Haut-Leveque ( Site 1362)

    Pessac, Aquitaine, 33600

  • CHU Charles Nicolle ( Site 1354)

    Rouen, Haute-Normandie, 76031

  • Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352)

    Toulon, Provence-Alpes-Côte d'Azur Region, 83100

  • CHU Rangueil-Cardiology ( Site 1351)

    Toulouse, Haute-Garonne, 31059

  • Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé

    Vandœuvre-lès-Nancy, Lorraine, 54511

Other trials in France

Greece11 sites

  • University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551)

    Alexanroupolis, Evros, 681 00

  • General Hospital of Athens Hippokratio ( Site 1552)

    Athens, Attica, 115 27

  • Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559)

    Athens, Attica, 115 28

  • General Hospital of Athens "G. Gennimatas"-General Hospital of Athens "G.Gennimatas" ( Site 1561)

    Athens, Attica, 11527

  • Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553)

    Athens, Attica, 142 33

  • ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556)

    Chaïdári, Attica, 124 62

  • University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554)

    Ioannina, West Greece, 455 00

  • University General Hospital of Larissa ( Site 1555)

    Larissa, Thessaly, 411 10

  • Hygeia Hospital-6th cardiology clinic ( Site 1560)

    Marousi, Attica, 151 23

  • AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558)

    Thessaloniki, 546 36

  • European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557)

    Thessaloniki, 57001

Other trials in Greece

Brazil10 sites

  • Centro de Pesquisa Clinica do Coracao ( Site 0561)

    Acaraju, Sergipe, 49055-530

  • Instituto de Pesquisa clinica de Campinas ( Site 0551)

    Campinas, São Paulo, 13060-080

  • PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555)

    Curitiba, Paraná

  • Hospital de Messejana Dr Carlos Alberto Studart Gomes ( Site 0560)

    Fortaleza, Ceará, 60864-190

  • Universidade Federal de Goias-Serviço de Cardiologia ( Site 0553)

    Goiânia, Goiás, 74605-020

  • Hospital Mae de Deus ( Site 0564)

    Porto Alegre, Rio Grande do Sul, 90880-480

  • CAPED Centro Avancado Pesquisa e Diagnostica ( Site 0552)

    Ribeirão Preto, São Paulo, 14026-900

  • Hospital de Clínicas de Ribeirão Preto ( Site 0559)

    Ribeirão Preto, São Paulo, 14048900

  • Hospital Pro-Cardiaco ( Site 0556)

    Rio de Janeiro, 22280-003

  • Incor - Instituto do Coracao ( Site 0557)

    São Paulo, 05403-900

Other trials in Brazil

Israel10 sites

  • Assuta Ashdod Medical Center-Cardiology ( Site 2063)

    Ashdod, 7747629

  • Hillel Yaffe Medical Center-Heart Institute ( Site 2058)

    Hadera, 3810101

  • Rambam Health Care Campus-Cardiology ( Site 2053)

    Haifa, 3109601

  • Shaare Zedek Medical Center-Cardiology ( Site 2055)

    Jerusalem, 9013102

  • Hadassah Medical Center-Heart Institute ( Site 2062)

    Jerusalem, 9112001

  • Galilee Medical Center-Cardiology ( Site 2051)

    Nahariya, 2210001

  • Rabin Medical Center-Cardiology - CHF ( Site 2052)

    Petah Tikva, 49100

  • Sheba Medical Center-Leviev Heart Center ( Site 2064)

    Ramat Gan, 5262100

  • Kaplan Medical Center-Heart Institution ( Site 2054)

    Rehovot, 7610001

  • Yitzhak Shamir Medical Center-Cardiology ( Site 2060)

    Ẕerifin, 609300

Other trials in Israel

Peru9 sites

  • Hospital Alberto Sabogal Sologuren ( Site 2851)

    Bellavista, Qallaw, 07011

  • Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2855)

    Jesús María, Lima, 15072

  • Clínica Vesalio-Cardiology ( Site 2854)

    Lima, 15036

  • Clínica Javier Prado ( Site 2853)

    Lima, 15046

  • Clínica El Golf-Cardiologia ( Site 2857)

    Lima, 15076

  • Clínica Providencia ( Site 2856)

    Lima, 15088

  • Hospital Cayetano Heredia-Servicio de cardiologia ( Site 2852)

    Lima, Lima 31

  • Clínica Belén ( Site 2858)

    Piura, 20000

  • Centro de investigacion Clínica Trujillo-Medical specialties ( Site 2860)

    Trujillo, La Libertad, 13001

Other trials in Peru

South Korea9 sites

  • Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556)

    Anyang-si, Kyonggi-do, 14068

  • Pusan National University Hospital-Internal Medicine ( Site 3553)

    Busan, Pusan-Kwangyokshi, 49241

  • Chungbuk National University Hospital-Internal medicine ( Site 3551)

    Cheongju-si, North Chungcheong, 28644

  • Chonnam National University Hospital ( Site 3558)

    Gwangju, Kwangju-Kwangyokshi, 61469

  • Chungnam national university hospital ( Site 3554)

    Junggu, Taejon-Kwangyokshi, 35015

  • Gachon University Gil Medical Center ( Site 3559)

    Namdong-gu, Incheon, 21565

  • Seoul National University Hospital ( Site 3557)

    Seoul, 03080

  • Severance Hospital, Yonsei University Health System ( Site 3552)

    Seoul, 03722

  • Yonsei University-Wonju Severance Christian Hospital ( Site 3555)

    Wŏnju, Kang-won-do, 26426

Other trials in South Korea

Sweden9 sites

  • Falu Lasarett-Dep of Cardiology ( Site 3756)

    Falun, Dalarna County, 791 31

  • Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753)

    Gothenburg, Västra Götaland County, 413 45

  • Clemenstorgets Hjartmottagning ( Site 3755)

    Lund, Skåne County, 22221

  • Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754)

    Örebro, Örebro County, 701 85

  • Skellefteå Lasarett-Research unit, floor 5 ( Site 3760)

    Skellefteå, Västerbotten County, 931 86

  • Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759)

    Solna, Stockholm County, 171 64

  • Aleris Specialistvård Sabbatsberg ( Site 3762)

    Stockholm, Stockholm County, 113 61

  • Akardo Med Site ( Site 3763)

    Stockholm, Stockholm County, 117 27

  • Västmanlands Sjukhus Västerås ( Site 3757)

    Västerås, Västmanland County, 72189

Other trials in Sweden

Malaysia8 sites

  • Hospital Sultanah Bahiyah-Department of Cardiology ( Site 2355)

    Alor Star, Kedah, 05460

  • Hospital Queen Elizabeth II ( Site 2359)

    Kota Kinabalu, Sabah, 88300

  • Sarawak Heart Centre ( Site 2352)

    Kota Samarahan, Sarawak, 94300

  • Hospital Sultanah Nur Zahirah-Jabatan Perubatan ( Site 2360)

    Kuala Terengganu, Terengganu, 20400

  • Hospital Tengku Ampuan Afzan ( Site 2353)

    Kuantan, Pahang, 25100

  • Hospital Universiti Sains Malaysia-Medical Department ( Site 2357)

    Kubang Kerian, Kelantan, 16150

  • University Malaya Medical Centre ( Site 2351)

    Lembah Pantai, Kuala Lumpur, 59100

  • UiTM Sungai Buloh Campus ( Site 2354)

    Sungai Buloh, Selangor, 47000

Other trials in Malaysia

Argentina7 sites

  • Centro Médico Viamonte-Clinical Research ( Site 4361)

    Buenos Aires, Buenos Aires F.D., C1120AAC

  • CEDIC ( Site 4363)

    CABA, Buenos Aires, C1060ABN

  • Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 4352)

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1027AAP

  • DIM Clínica Privada ( Site 4359)

    Ramos Mejía, Buenos Aires, B1704ETD

  • Fundacion Estudios Clinicos ( Site 4356)

    Rosario, Santa Fe Province, S2000DEJ

  • Centro de Investigaciones Clinicas del Litoral ( Site 4354)

    Santa Fe, 3000

  • Instituto de Investigaciones Clinicas Zarate ( Site 4360)

    Zárate, Buenos Aires, B2800DGH

Other trials in Argentina

New Zealand7 sites

  • North Shore Hospital-Cardiology Research ( Site 2656)

    Auckland, 0622

  • Auckland City Hospital ( Site 2659)

    Auckland, 1023

  • Middlemore Clinical Trials ( Site 2658)

    Auckland, 2025

  • Christchurch Heart Institute ( Site 2651)

    Christchurch, Canterbury, 8011

  • Dunedin Hospital-Cardiology Department ( Site 2653)

    Dunedin, Otago, 9016

  • Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654)

    Hamilton, Waikato Region, 3204

  • Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652)

    Lower Hutt, Wellington Region, 5010

Other trials in New Zealand

Australia6 sites

  • Royal Adelaide Hospital-Cardiology ( Site 0456)

    Adelaide, South Australia, 5000

  • Flinders Medical Centre-Cardiology Research ( Site 0455)

    Bedford Park, South Australia, 5042

  • Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453)

    Brisbane, Queensland, 4029

  • The Prince Charles Hospital-Cardiology Research Centre ( Site 0451)

    Brisbane, Queensland, 4032

  • Core Research Group ( Site 0452)

    Brisbane, Queensland, 4064

  • St. John of God Subiaco Hospital ( Site 0457)

    Subiaco, Western Australia, 6008

Other trials in Australia

Taiwan6 sites

  • Changhua Christian Hospital ( Site 3857)

    Changhua County, Changhua, 50006

  • Mackay Memorial Hospital-Hsinchu ( Site 3852)

    Hsinchu, Hsinchu, 300

  • Kaohsiung Medical University Hospital ( Site 3856)

    Kaohsiung City, 807

  • Taichung Veterans General Hospital ( Site 3855)

    Taichung, 407

  • Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851)

    Taipei, 11217

  • Chang Gung Medical Foundation-Linkou Branch ( Site 3854)

    Taoyuan, 333

Other trials in Taiwan

Austria5 sites

  • Krankenhaus St. Josef Braunau ( Site 0354)

    Braunau am Inn, Upper Austria, 5280

  • Medizinische Universität Graz-Department of Cardiology ( Site 0351)

    Graz, Styria, 8036

  • Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv

    Salzburg, 5020

  • Imed19-privat ( Site 0353)

    Vienna, State of Vienna, A-1190

  • Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep

    Vienna, 1210

Other trials in Austria

Puerto Rico5 sites

  • Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151)

    Bayamón, 00961

  • Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156)

    Humacao, 00791

  • Research and Cardiovascular Corp. ( Site 3152)

    Ponce, 00717

  • Caparra Internal Medicine ( Site 3155)

    Rio Grande, 00745

  • VA Caribbean Healthcare System ( Site 3157)

    San Juan, 00921-3201

Other trials in Puerto Rico

Hong Kong4 sites

  • Grantham Hospital ( Site 1753)

    Aberdeen, 999077

  • Queen Mary Hospital-Medicine - Cardiology ( Site 1752)

    Hksar

  • Princess Margaret Hospital ( Site 1755)

    Hong Kong

  • Prince of Wales Hospital ( Site 1751)

    Shatin, NT

Other trials in Hong Kong

Singapore4 sites

  • National Heart Centre Singapore ( Site 3351)

    Singapore, Central Singapore, 169609

  • Tan Tock Seng Hospital ( Site 3353)

    Singapore, Central Singapore, 308433

  • Changi General Hospital ( Site 3356)

    Singapore, South East, 529889

  • National University Heart Centre, Singapore-Department of Cardiology ( Site 3355)

    Singapore, South West, 119074

Other trials in Singapore

Guatemala3 sites

  • Unidad De Diagnostico Cardiologico ( Site 1652)

    Guatemala City, 01001

  • Clinica Medica ( Site 1651)

    Guatemala City, 01010

  • Unidad De Diagnostico Cardiologico ( Site 1654)

    Guatemala City

Other trials in Guatemala

Ireland2 sites

  • St. James's Hospital-Cardiology ( Site 1951)

    Dublin, D08 E9P6

  • St. Michael's Hospital ( Site 1955)

    Dún Laoghaire, Dublin, A96 D628

Other trials in Ireland

About this study

Official title: A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults With Chronic Heart Failure With Reduced Ejection Fraction

The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV) diuretics. The primary hypothesis is that vericiguat is superior to placebo in reducing the risk of cardiovascular death or heart failure hospitalization.

Being tested
Vericiguat, Placebo

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • VericiguatDrug

    Also called MK-1242, BAY 1021189

    2.5, 5.0, or 10.0 mg orally once daily

  • PlaceboDrug

    0 mg matching placebo for 2.5 mg, 5 mg, and 10 mg of vericiguat

Study groups in NCT05093933
Study groupRoleWhat they receive
VericiguatExperimentalParticipants receive a starting dose of 2.5 mg of vericiguat taken orally once daily. The vericiguat dose will be titrated to 5 mg and to 10 mg.
Receives: Drug: Vericiguat
PlaceboPlacebo comparatorParticipants receive a starting matching placebo to vericiguat dose of 2.5 mg taken orally once daily. The matching placebo dose will be sham titrated to 5 mg and to 10 mg.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Occurrence of Composite Endpoint of Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization: Participants With an Event Per 100 Patient-Years

    The time to first occurrence of the composite endpoint of CV death or HF hospitalization was defined as the time from randomization to the first event of CV death or HF hospitalization. Randomized participants without a HF hospitalization or CV death event at the time of analysis were censored at the last available information, when the protocol pre-specified number of total CV death events was achieved (primary completion analysis data cutoff), or the date of their non-CV death, whichever occurred first. Events were confirmed by a clinical events committee (CEC). Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with a CV death or HF hospitalization event per 100 patient-years at risk is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

Secondary outcomes (11)

  1. Time to CV Death: Participants With an Event Per 100 Patient-Years

    Time to CV death was defined as the time from randomization to CV death. Randomized participants without a CV death at the time of analysis were censored at their last available information, when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), or the date of their non-CV death, whichever occurred first. CV deaths were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with a CV death event per 100 patient-years at risk is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  2. Time to First Occurrence of HF Hospitalization: Participants With an Event Per 100 Patient-Years

    Time to first occurrence of HF hospitalization was defined as the time from randomization to the first event of HF hospitalization. Randomized participants without an HF hospitalization at the time of analysis were censored at their last available information, when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), or the date of their death, whichever occurred first. HF hospitalizations were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with an HF hospitalization event per 100 patient-years at risk is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  3. Time to Total HF Hospitalizations (Including First and Recurrent Events): Total Events Per 100 Patient-Years

    Time to total HF hospitalizations was defined as the time from randomization to all HF hospitalization events, including time to first event and time increments between events. Randomized participants without an HF hospitalization at the time of analysis were censored at their last available information, when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), or the date of their death, whichever occurred first. HF hospitalizations were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of total HF hospitalization events per 100 patient-years at risk is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  4. Time to First Occurrence of Composite Endpoint of All-Cause Mortality or HF Hospitalization: Participants With an Event Per 100 Patient-Years

    The time to first occurrence of the composite endpoint of all-cause mortality or HF hospitalization was defined as the time from randomization to the first event of all-cause mortality or HF hospitalization. Randomized participants without an all-cause mortality or HF hospitalization event at the time of analysis were censored at the last available information or when the protocol pre-specified number of total CV death events is achieved (primary analysis database cutoff), whichever occurred first. Events were confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with an all-cause mortality or HF hospitalization event per 100 patient-years at risk is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  5. Time to All-Cause Mortality: Participants With an Event Per 100 Patient-Years

    Time to all-cause mortality was defined as the time from randomization to all-cause mortality. Randomized participants without an all-cause mortality event at the time of analysis were censored at their last available information or when the protocol pre-specified number of total CV death events was achieved (primary analysis database cutoff), whichever occurred first. All-cause mortality was confirmed by a CEC. Protocol-specified final analyses are reported here with a primary completion data cutoff. Time-to-event methodology was used to evaluate the results and the number of participants with an all-cause mortality event per 100 patient-years at risk is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  6. Percentage of Participants Who Experienced One or More Selected Nonserious Adverse Events (NSAEs)

    An adverse event (AE) is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. Selected NSAEs are defined as nonserious AEs that meet any of the following criteria: AEs that lead to study intervention dose modification or discontinuation, AEs that lead to withdrawal from the study, or Coronavirus Disease 2019 (COVID-19) disease-related AEs. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more selected NSAEs is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  7. Percentage of Participants Who Experienced One or More Serious Adverse Events (SAEs)

    An SAE is defined as any untoward medical occurrence that, at any dose, results in death, is life threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly or birth defect, or other important medical events as determined by the investigator. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more SAEs is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  8. Percentage of Participants Who Experienced One or More Events of Clinical Interest (ECIs)

    ECIs were determined and reported based on the clinical judgment of the investigator. As pre-specified in the protocol, ECIs included the following: 1) Events of potential drug-induced liver injury (DILI), defined as an elevated aspartate aminotransferase or alanine aminotransferase laboratory value that is greater than or equal to 3X the upper limit of normal (ULN) and an elevated total bilirubin laboratory value that is greater than or equal to 2X the ULN and, at the same time, an alkaline phosphatase laboratory value that is less than 2X the ULN, 2) Events associated with symptomatic hypotension, or 3) Events associated with anemia, regardless of etiology. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more ECIs is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  9. Percentage of Participants Who Experienced One or More Potential DILI ECIs

    Potential DILI ECIs were determined and reported based on the clinical judgment of the investigator. Potential DILI ECIs were defined as an elevated aspartate aminotransferase or alanine aminotransferase laboratory value that is greater than or equal to 3X the ULN and an elevated total bilirubin laboratory value that is greater than or equal to 2X the ULN and, at the same time, an alkaline phosphatase laboratory value that is less than 2X the ULN. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more potential DILI ECIs is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  10. Percentage of Participants Who Experienced One or More Symptomatic Hypotension ECIs

    Symptomatic hypotension ECIs were determined and reported based on the clinical judgment of the investigator. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more symptomatic hypotension ECIs is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

  11. Percentage of Participants Who Experienced One or More Anemia ECIs

    Anemia ECIs were determined and reported based on the clinical judgment of the investigator, regardless of etiology. Protocol-specified final analyses are reported here with a primary completion data cutoff. The percentage of participants who experienced one or more anemia ECIs is presented.

    Measured: Up to approximately 36 months (from randomization to the primary completion data cutoff)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted26 Oct 2021
  2. Study start2 Nov 2021
  3. Primary completion20 Nov 2024
  4. Study completion5 Feb 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
6,106 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05093933
Sponsor's protocol ID
1242-035
Other IDs
MK-1242-035, 2022-500881-80-00, U1111-1278-5066, 2020-005941-18
Acronym
VICTOR
Status last verified
Dec 2025
First submitted
18 Oct 2021
Last updated
19 Dec 2025
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

Publications

  • Butler J, Usman MS, Anstrom KJ, Blaustein RO, Bonaca MP, Ezekowitz JA, Freitas C, Lam CSP, Lewis EF, Lindenfeld J, McMullan CJ, Mentz RJ, O'Connor C, Rosano GMC, Saldarriaga CI, Senni M, Udelson J, Voors AA, Zannad F. Soluble guanylate cyclase stimulators in patients with heart failure with reduced ejection fraction across the risk spectrum. Eur J Heart Fail. 2022 Nov;24(11):2029-2036. doi: 10.1002/ejhf.2720. Epub 2022 Nov 16.

    PubMed 36250238

  • Reddy YNV, Butler J, Anstrom KJ, Blaustein RO, Bonaca MP, Corda S, Ezekowitz JA, Lam CSP, Lewis EF, Lindenfeld J, McMullan CJ, Mentz RJ, O'Connor C, Patel M, Ponikowski P, Rosano GMC, Saldarriaga CI, Senni M, Udelson J, Voors AA, Zannad F. Vericiguat Global Study in Participants with Chronic Heart Failure: Design of the VICTOR trial. Eur J Heart Fail. 2025 Feb;27(2):209-218. doi: 10.1002/ejhf.3501. Epub 2024 Oct 30.

    PubMed 39473305

  • Butler J, McMullan CJ, Anstrom KJ, Barash I, Bonaca MP, Borentain M, Corda S, Ezekowitz JA, Felker GM, Gates D, Lam CSP, Lewis EF, Lindenfeld J, Mentz RJ, O'Connor CM, Ponikowski P, Reddy YNV, Rosano GMC, Saldarriaga C, Senni M, She L, Teixeira PP, Udelson J, Urbinati A, Vlajnic V, Voors AA, Xing A, Patel MJ, Zannad F; VICTOR Study Group. Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet. 2025 Sep 27;406(10510):1341-1350. doi: 10.1016/S0140-6736(25)01665-4. Epub 2025 Aug 30.

    PubMed 40897189

  • Khan MS, Grayburn PA, Butler J. Cardiac reverse remodelling with vericiguat: Victory or no victory? Eur J Heart Fail. 2023 Jul;25(7):1022-1024. doi: 10.1002/ejhf.2883. Epub 2023 May 25. No abstract available.

    PubMed 37191077

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Vericiguat in people with Chronic Heart Failure With Reduced Ejection Fraction, run by Merck Sharp & Dohme LLC at 519 sites in 36 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 19 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 519 sites in United States, China, Ukraine, Mexico, Canada and 31 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 19 Dec 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Occurrence of Composite Endpoint of Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization: Participants With an Event Per 100 Patient-Years (time frame: Up to approximately 36 months (from randomization to the primary completion data cutoff)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05093933, which also lists 4 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Dec 2025.

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