Cancer, BreastNCT05114005
Tango for Neuropathy Among Breast Cancer Survivors
A study testing Rhythmic Auditory Stimulation and Evidence-Based Exercise in people with Cancer, Breast and Neuropathy, run by Ohio State University Comprehensive Cancer Center at 1 site in United States.
Trial summary
Group dance classes have been found to improve markers of quality of life and physical health (i.e., balance) among some populations engaged in rehabilitation, such as the elderly and individuals with Parkinson Disease. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Cancer, Breast, Neuropathy
- What is being tested?
- Rhythmic Auditory Stimulation and Evidence-Based Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Aug 2021to 15 Apr 2024
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Breast cancer survivor stage I-III
- Symptomatic for neuropathy
- postural control outside 70% CI for adults who are middle-aged without neurotrauma
- having completed taxane-based chemotherapy treatment at least 3 months ago;
- able to understand and comply with directions associated with testing and study treatments.
Who cannot join
- Pre-existing vestibular deficit;
- poorly controlled diabetes (hgA1C > 8);
- non-ambulatory or lower extremity amputation (assistive devices allowed);
- use of cytotoxic or immunotherapy during study (endocrine therapy allowed);
- participation in physical therapy during the study;
- contraindication to participate in Tango due to orthopedic issue (e.g., herniated vertebral disc);
Trial locations and contacts
1 site in 1 country.
United States1 site
Stephanie Spielman Comprehensive Breast Center
Columbus, Ohio, 43212
About this study
Official title: Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects (DAANCE)
Group dance classes have been found to improve markers of quality of life and physical health (i.e., balance) among some populations engaged in rehabilitation, such as the elderly and individuals with Parkinson Disease. However, such interventions have yet to be studied among cancer survivors despite the relevance of quality of life and physical health within cancer survivorship. Group dance classes are a promising avenue in that they deliver activity-based medicine in a social context, thus potentially improving physical as well as psychosocial aspects of health. To further this avenue of inquiry, we propose to study the effect of dance-based interventions for cancer survivors.
Read the detailed description
Participants will be randomized (1:1) to one of two activity intervention arms: Argentine Tango dance or home exercise. Information about neuropathy symptoms, motion, falls incidence, and participant feedback about the interventions will be collected.
Aim1: To evaluate change in postural control over 16 sessions of Tango (exp) vs HEX (control) (n=26 per group) as primary endpoint. As secondary measures, to assess: balance function (i.e., TUG) and patient-reported outcomes (PROs) (i.e., symptoms, pain, fatigue, mood, quality of life) monthly including 1 month post-intervention completion; postural control and symptoms within-session; and falls incidence weekly for 6 months following intervention completion. Hypothesis: At primary endpoint, participants in the experimental group will show more improvement than participants in the control group in measures sensitive to neuropathy disease state (i.e., sway variability and area).
Aim2: To evaluate change in gait variability after 16 sessions of Tango (exp) vs HEX (control) (n=26 per group; 1:1 randomization). As secondary measures, to analyze local and orbital dynamic stability (pre, post, and 1mo post-intervention), PROs (monthly), and falls incidence (weekly) following intervention completion. Hypothesis: At primary endpoint, participants in the experimental group will show more improvement than participants in the control group in measures of gait variability (i.e., stride-to-stride variability in speed).
- Conditions
- Cancer, Breast, Neuropathy
- Being tested
- Rhythmic Auditory Stimulation, Evidence-Based Exercise
- Medical subject headings
- Breast Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Rhythmic Auditory StimulationBehavioural
Rhythmically-entrained sensorimotor activity.
Evidence-Based ExerciseBehavioural
This program consists of information on neuropathy and fall prevention combined with a schedule of 1 hour training (i.e., endurance, resistance, and sensorimotor) performed 2x per week
| Study group | Role | What they receive |
|---|---|---|
| Tango | Experimental | The intervention will consist of 16 Argentine Tango (Tango) sessions, adapted for neurorehabilitation per Hackney and Earhart (2010). Delivered over 8 weeks at a frequency of 2x per week and duration of 1 hour per session, this program teaches the basics steps of partnered Tango dance. Receives: Behavioral: Rhythmic Auditory Stimulation |
| Home Exercise (HEX) | Active comparator | The control group will consist of an evidence-based, structured home exercise program (HEX) based on the 8 week intervention described by Zimmer et al (2018) and recommended by physical therapists specializing in BC within our organization. This program consists of information on neuropathy and fall prevention combined with a schedule of 1 hour training (i.e., endurance, resistance, and sensorimotor) performed 2x per week Receives: Behavioral: Evidence-Based Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postural Control (Variability)
root-mean square of the center of pressure (COP)
Measured: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
Intrinsic Motivation
Intrinsic motivation will be measured using a subscale of the Intrinsic Motivation Inventory (IMI). The 6 item Interest/Enjoyment subscale of the IMI represents intrinsic motivation in an activity just performed as a possible score of 6 to 36 with 6 = most; 18 = neutral; 36 = least interesting/enjoyable. Specific items queried include whether the activity just performed was: enjoyable, enjoyed, boring (reverse order), interesting, fun, and able to hold the participant's attention.
Measured: Assessed at week 4, week 8, and week 12
Secondary outcomes (19)
Postural Control (Ellipse Area)
95% ellipse area of the COP
Measured: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
Postural Control (Velocity)
velocity of COP
Measured: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
Postural Control (Complexity)
sample entropy of the center of pressure (COP). Sample entropy is a non-linear COP measure that determines the irregularity of a time-series. Sample entropy of the resultant COP position will be calculated using the increment calculation method (SEI) with constant values applied of m = 3 and r = 0.3. Entropy of postural responses represents the automatic complexity of neuromotor control that is available to an individual. Sample entropy scores won't go below 0 or above 2, and higher values indicate better complexity in postural response
Measured: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
Postural Control (Variability) at Tango Sessions
root-mean square of the center of pressure (COP). The mean will be taken of all beginning of session data points together and all end of session data points together. Lower numbers indicate better neuromotor health.
Measured: at the beginning and at the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Postural Control (Ellipse Area) at Tango Sessions
95% ellipse area of the COP. The mean will be taken of all beginning of session data points together and all end of session data points together. Lower numbers indicate better neuromotor health.
Measured: at the beginning and at the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Postural Control (Velocity) at Tango Sessions
velocity of COP. The mean will be taken of all beginning of session data points together and all end of session data points together. Lower numbers indicate better neuromotor health.
Measured: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Postural Control (Complexity) at Tango Sessions
sample entropy of the center of pressure (COP). Sample entropy is a non-linear COP measure that determines the irregularity of a time-series. Sample entropy of the resultant COP position will be calculated using the increment calculation method (SEI) with constant values applied of m = 3 and r = 0.3. Entropy of postural responses represents the automatic complexity of neuromotor control that is available to an individual. Sample entropy scores won't go below 0 or above 2, and higher values indicate better complexity in postural responseThe mean will be taken of all beginning of session data points together and all end of session data points together
Measured: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Clinical Measure of Balance Function
The Timed Up-and-Go test, or TUG, (<2 min to administer) is a timed test of a person's ability to stand from a chair, walk 10 feet, turn around, and return to sitting with shorter times indicating better functional balance.
Measured: At baseline, week 4 of intervention, and at 4 week follow-up post intervention, up to 12 weeks
Neuropathy Symptoms Score at Tango Sessions
European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire, Chemotherapy-Induced Peripheral Neuropathy (CIPN 20): is a validated instrument for longitudinal evaluation of neuropathy symptoms induced by chemotherapy. This is a 20-item patient reported questionnaire. It is easy to use and filled out by patients themselves. Scores range between 1 to 10 with higher scores indicating greater chemotherapy-induced peripheral neuropathy (CIPN) severity. The mean will be taken of all beginning of session data points together and all end of session data points together
Measured: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Neuropathy Symptoms Score
European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire, Chemotherapy-Induced Peripheral Neuropathy (CIPN 20): is a validated instrument for longitudinal evaluation of neuropathy symptoms induced by chemotherapy. This is a 20-item patient reported questionnaire. It is easy to use and filled out by patients themselves. Scores range between 1 to 10 with higher scores indicating greater chemotherapy-induced peripheral neuropathy (CIPN) severity.
Measured: At week 8 of intervention and at 4-week follow-up post intervention
Brief Pain Inventory Short Form at Tango Sessions
The Brief Pain Inventory Short Form (BPI) is a validated instrument used to evaluate pain symptoms and functional capacity "right now" using a single item visual analog scale (VAS) on which participants will rate how much pain they are in "right now" on a scale of 1 to 10 (10 being high the worst pain imaginable). The mean will be taken of all beginning of session data points together and all end of session data points together
Measured: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Brief Pain Inventory Short Form
The Brief Pain Inventory Short Form (BPI) is a validated instrument used to evaluate pain symptoms and functional capacity "right now" using a single item visual analog scale (VAS) on which participants will rate how much pain they are in "right now" on a scale of 1 to 10 (10 being high the worst pain imaginable).
Measured: At week 8 of intervention and at 4-week follow-up post intervention
Cancer-Related Fatigue (BFI Scores) at Tango Sessions
The Brief Fatigue Inventory (BFI) is used to rapidly assess the severity and impact of cancer-related fatigue "right now" using a single item visual analog scale (VAS) on which participants will rate how much fatigue they feel "right now" on a scale of 1 to 10 (10 being high the worst fatigue imaginable). The mean will be taken of all beginning of session data points together and all end of session data points together
Measured: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Cancer-Related Fatigue
The Brief Fatigue Inventory (BFI) is used to rapidly assess the severity and impact of cancer-related fatigue "right now" using a single item visual analog scale (VAS) on which participants will rate how much fatigue they feel "right now" on a scale of 1 to 10 (10 being high the worst fatigue imaginable).
Measured: At week 8 and at 4-week follow-up visit post intervention
Number of Falls
the number of falls or near falls that the participant remembers experiencing in the month prior to enrollment in the study will be assessed. All reported falls will be totaled and reported by arm.
Measured: once at the point of study enrollment
Number of Falls
the number of falls or near falls experienced by the participant since last evaluation/intervention session. All reported falls throughout the intervention time period will be totaled and reported by arm.
Measured: at the beginning of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Number of Falls
the number of falls or near falls experienced by the participant in the 6 months post-intervention. All reported falls throughout the follow-up time period will be totaled and reported by arm
Measured: 6 months post-intervention
Change in Dual-task Function
Dual task function was measured using the Timed-Up-and-Go motor task while counting backward by 3 s (TUGCog), a validated clinical test of dual-task function for which lower values indicate better performance. To perform this test, participants completed the Timed-Up-and Go (TUG) test commonly used in clinical practice wherein individuals stand from a chair with arms, walk 3 meters, turn around, and return to sitting as fast as safely possible (i.e. motor task) while counting out loud and backward by 3 s (i.e. cognitive task). The test is completed 3 times, with rest allowed between trials. Time in seconds per trial is averaged to produce the TUGCog score per timepoint.
Measured: Assessed at baseline, 4 weeks, 8 weeks, and 12 weeks
Adherence
Adherence is measured by the number of enrollees who participated through each time point of the study
Measured: Assessed at baseline, 4 weeks, 8 weeks, and 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Nov 2021
- Study start15 Aug 2021
- Primary completion15 Apr 2024
- Study completion15 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Cancer, BreastStudies of the same condition, open and under way.
- More trials run by Ohio State University Comprehensive Cancer CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Principal investigator, Lise Worthen-Chaudhari, Ohio State University Comprehensive Cancer Center
- Investigators
- Lise Worthen-Chaudhari, PhD, MFA, Principal investigator, Ohio State University Comprehensive Cancer Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05114005
- Sponsor's protocol ID
- 2015C0090
- Other IDs
- NCI-2018-00310, R21AG068831, OSU-15047
- Status last verified
- Aug 2025
- First submitted
- 20 Sep 2021
- Last updated
- 15 Sep 2025
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Hackney ME, Earhart GM. Recommendations for Implementing Tango Classes for Persons with Parkinson Disease. Am J Dance Ther. 2010 Jun;32(1):41-52. doi: 10.1007/s10465-010-9086-y.
PubMed 30369677Zimmer P, Trebing S, Timmers-Trebing U, Schenk A, Paust R, Bloch W, Rudolph R, Streckmann F, Baumann FT. Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support Care Cancer. 2018 Feb;26(2):615-624. doi: 10.1007/s00520-017-3875-5. Epub 2017 Sep 30.
PubMed 28963591Worthen-Chaudhari L, Schnell P, Bland C, Lantis K, Wilder J, Hock K, Alwan A, Hawke A, Bader G, Davenport AP, Gatti-Mays ME, Johnson KC, Quiroga DM, Sardesai SD, Stover DG, Wesolowski R, Williams NO, Crasta JE, Hackney ME, Lustberg MB. Effect of tango versus exercise on chemotherapy-induced neuropathy after breast cancer treatment: a Phase II randomized controlled trial. Res Sq [Preprint]. 2026 Aug 5:rs.3.rs-10168428. doi: 10.21203/rs.3.rs-10168428/v1.
PubMed 42620214Worthen-Chaudhari L, Schnell PM, Hackney ME, Lustberg MB. Partnered dance evokes greater intrinsic motivation than home exercise as therapeutic activity for chemotherapy-induced deficits: secondary results of a randomized, controlled clinical trial. Front Psychol. 2024 Jun 19;15:1383143. doi: 10.3389/fpsyg.2024.1383143. eCollection 2024.
PubMed 38962217Lantis K, Schnell P, Bland CR, Wilder J, Hock K, Vargo C, Glover NA, Hackney ME, Lustberg MB, Worthen-Chaudhari L. Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trial and preliminary baseline data. Trials. 2023 Sep 1;24(1):564. doi: 10.1186/s13063-023-07554-z.
PubMed 37658464Lantis KD, Schne P, Bland CR, Wilder J, Hock K, Glover NA, Hackney ME, Lustberg MB, Worthen-Chaudhari L. Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trail and preliminary baseline data. Res Sq [Preprint]. 2023 Jun 29:rs.3.rs-2988661. doi: 10.21203/rs.3.rs-2988661/v1.
PubMed 37461666
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects (DAANCE)
- ClinicalTrials.gov ID
- NCT05114005
- Acronym / sponsor ID
- 2015C0090
- Conditions
- Cancer, Breast, Neuropathy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Ohio State University Comprehensive Cancer CenterUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- 15 Aug 2021 (actual)
- Primary completion
- 15 Apr 2024 (actual)
- Study completion
- 15 Apr 2024 (actual)
- First posted
- 9 Nov 2021 (actual)
- Results
- Posted 15 Sep 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Group dance classes have been found to improve markers of quality of life and physical health (i.e., balance) among some populations engaged in rehabilitation, such as the elderly and individuals with Parkinson Disease. However, such interventions have yet to be studied among cancer survivors despite the relevance of quality of life and physical health within cancer survivorship. Group dance classes are a promising avenue in that they deliver activity-based medicine in a social context, thus potentially improving physical as well as psychosocial aspects of health. To further this avenue of inquiry, we propose to study the effect of dance-based interventions for cancer survivors.
Detailed description
Participants will be randomized (1:1) to one of two activity intervention arms: Argentine Tango dance or home exercise. Information about neuropathy symptoms, motion, falls incidence, and participant feedback about the interventions will be collected.
Aim1: To evaluate change in postural control over 16 sessions of Tango (exp) vs HEX (control) (n=26 per group) as primary endpoint. As secondary measures, to assess: balance function (i.e., TUG) and patient-reported outcomes (PROs) (i.e., symptoms, pain, fatigue, mood, quality of life) monthly including 1 month post-intervention completion; postural control and symptoms within-session; and falls incidence weekly for 6 months following intervention completion. Hypothesis: At primary endpoint, participants in the experimental group will show more improvement than participants in the control group in measures sensitive to neuropathy disease state (i.e., sway variability and area).
Aim2: To evaluate change in gait variability after 16 sessions of Tango (exp) vs HEX (control) (n=26 per group; 1:1 randomization). As secondary measures, to analyze local and orbital dynamic stability (pre, post, and 1mo post-intervention), PROs (monthly), and falls incidence (weekly) following intervention completion. Hypothesis: At primary endpoint, participants in the experimental group will show more improvement than participants in the control group in measures of gait variability (i.e., stride-to-stride variability in speed).
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Tango | Experimental | Behavioral: Rhythmic Auditory StimulationThe intervention will consist of 16 Argentine Tango (Tango) sessions, adapted for neurorehabilitation per Hackney and Earhart (2010). Delivered over 8 weeks at a frequency of 2x per week and duration of 1 hour per session, this program teaches the basics steps of partnered Tango dance. |
| Home Exercise (HEX) | Active comparator | Behavioral: Evidence-Based ExerciseThe control group will consist of an evidence-based, structured home exercise program (HEX) based on the 8 week intervention described by Zimmer et al (2018) and recommended by physical therapists specializing in BC within our organization. This program consists of information on neuropathy and fall prevention combined with a schedule of 1 hour training (i.e., endurance, resistance, and sensorimotor) performed 2x per week |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Breast cancer survivor stage I-III
- Symptomatic for neuropathy
- postural control outside 70% CI for adults who are middle-aged without neurotrauma
- having completed taxane-based chemotherapy treatment at least 3 months ago;
- able to understand and comply with directions associated with testing and study treatments.
Key exclusion criteria (6 listed)
- Pre-existing vestibular deficit;
- poorly controlled diabetes (hgA1C > 8);
- non-ambulatory or lower extremity amputation (assistive devices allowed);
- use of cytotoxic or immunotherapy during study (endocrine therapy allowed);
- participation in physical therapy during the study;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Rhythmic Auditory StimulationRhythmically-entrained sensorimotor activity. | Behavioural | Tango |
| Evidence-Based ExerciseThis program consists of information on neuropathy and fall prevention combined with a schedule of 1 hour training (i.e., endurance, resistance, and sensorimotor) performed 2x per week | Behavioural | Home Exercise (HEX) |
Primary outcome
Postural Control (Variability)
Time frame: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
root-mean square of the center of pressure (COP)
Intrinsic Motivation
Time frame: Assessed at week 4, week 8, and week 12
Intrinsic motivation will be measured using a subscale of the Intrinsic Motivation Inventory (IMI). The 6 item Interest/Enjoyment subscale of the IMI represents intrinsic motivation in an activity just performed as a possible score of 6 to 36 with 6 = most; 18 = neutral; 36 = least interesting/enjoyable. Specific items queried include whether the activity just performed was: enjoyable, enjoyed, boring (reverse order), interesting, fun, and able to hold the participant's attention.
19 secondary outcomes
Postural Control (Ellipse Area)
Time frame: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
Postural Control (Velocity)
Time frame: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
Postural Control (Complexity)
Time frame: At baseline, week 8 of intervention, and at 4 week follow-up post intervention
Postural Control (Variability) at Tango Sessions
Time frame: at the beginning and at the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Postural Control (Ellipse Area) at Tango Sessions
Time frame: at the beginning and at the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Postural Control (Velocity) at Tango Sessions
Time frame: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Postural Control (Complexity) at Tango Sessions
Time frame: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Clinical Measure of Balance Function
Time frame: At baseline, week 4 of intervention, and at 4 week follow-up post intervention, up to 12 weeks
Neuropathy Symptoms Score at Tango Sessions
Time frame: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Neuropathy Symptoms Score
Time frame: At week 8 of intervention and at 4-week follow-up post intervention
Brief Pain Inventory Short Form at Tango Sessions
Time frame: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Brief Pain Inventory Short Form
Time frame: At week 8 of intervention and at 4-week follow-up post intervention
Cancer-Related Fatigue (BFI Scores) at Tango Sessions
Time frame: at the beginning and the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Cancer-Related Fatigue
Time frame: At week 8 and at 4-week follow-up visit post intervention
Number of Falls
Time frame: once at the point of study enrollment
Number of Falls
Time frame: at the beginning of each assessment or intervention session for up to 20 sessions, up to 8 weeks
Number of Falls
Time frame: 6 months post-intervention
Change in Dual-task Function
Time frame: Assessed at baseline, 4 weeks, 8 weeks, and 12 weeks
Adherence
Time frame: Assessed at baseline, 4 weeks, 8 weeks, and 12 weeks
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2025.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Background: PubMed 30369677Hackney ME, Earhart GM. Recommendations for Implementing Tango Classes for Persons with Parkinson Disease. Am J Dance Ther. 2010 Jun;32(1):41-52. doi: 10.1007/s10465-010-9086-y.
- Background: PubMed 28963591Zimmer P, Trebing S, Timmers-Trebing U, Schenk A, Paust R, Bloch W, Rudolph R, Streckmann F, Baumann FT. Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support Care Cancer. 2018 Feb;26(2):615-624. doi: 10.1007/s00520-017-3875-5. Epub 2017 Sep 30.
- Derived from this study: PubMed 42620214Worthen-Chaudhari L, Schnell P, Bland C, Lantis K, Wilder J, Hock K, Alwan A, Hawke A, Bader G, Davenport AP, Gatti-Mays ME, Johnson KC, Quiroga DM, Sardesai SD, Stover DG, Wesolowski R, Williams NO, Crasta JE, Hackney ME, Lustberg MB. Effect of tango versus exercise on chemotherapy-induced neuropathy after breast cancer treatment: a Phase II randomized controlled trial. Res Sq [Preprint]. 2026 Aug 5:rs.3.rs-10168428. doi: 10.21203/rs.3.rs-10168428/v1.
- Derived from this study: PubMed 38962217Worthen-Chaudhari L, Schnell PM, Hackney ME, Lustberg MB. Partnered dance evokes greater intrinsic motivation than home exercise as therapeutic activity for chemotherapy-induced deficits: secondary results of a randomized, controlled clinical trial. Front Psychol. 2024 Jun 19;15:1383143. doi: 10.3389/fpsyg.2024.1383143. eCollection 2024.
- Derived from this study: PubMed 37658464Lantis K, Schnell P, Bland CR, Wilder J, Hock K, Vargo C, Glover NA, Hackney ME, Lustberg MB, Worthen-Chaudhari L. Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trial and preliminary baseline data. Trials. 2023 Sep 1;24(1):564. doi: 10.1186/s13063-023-07554-z.
- Derived from this study: PubMed 37461666Lantis KD, Schne P, Bland CR, Wilder J, Hock K, Glover NA, Hackney ME, Lustberg MB, Worthen-Chaudhari L. Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trail and preliminary baseline data. Res Sq [Preprint]. 2023 Jun 29:rs.3.rs-2988661. doi: 10.21203/rs.3.rs-2988661/v1.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Lise Worthen-Chaudhari, PhD, MFA principal investigator
Ohio State University Comprehensive Cancer Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Rhythmic Auditory Stimulation and Evidence-Based Exercise in people with Cancer, Breast and Neuropathy, run by Ohio State University Comprehensive Cancer Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 15 Sep 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postural Control (Variability) (time frame: At baseline, week 8 of intervention, and at 4 week follow-up post intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05114005, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2025.