AgingNAANCT05120713
Noradrenergic Activity and Attention
An observational study of Aging, run by University of Southern California at 1 site in United States.
Trial summary
Older adults demonstrate increased distractibility by task-irrelevant information which contributes to general cognitive impairment. However, it is yet unclear how changes in noradrenergic activity during aging influences attentional control. Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging
- How many people
- 140 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Nov 2021to 20 Nov 2023
- Phase
- Observational
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Young adults will be recruited from the student population at the University of Southern California. Older adults will be recruited from a volunteer registry.
Who may be able to join
- Fluent in English
- Aged between 18-35 or 50-80
- Have normal or corrected-to-normal vision and hearing, and normal color vision
- Have a mobile phone and email address
Who cannot join
- Non-English speakers
- Currently practicing any relaxation, meditation, or breathing technique for more than an hour per week
- Have participated in studies measuring attentional capture in the past year
- Experiencing symptoms of dementia
Trial locations and contacts
1 site in 1 country.
United States1 site
USC Leonard Davis School of Gerontology
Los Angeles, California, 90089
About this study
Official title: The Influence of Noradrenergic Activity on Attentional Control in Younger and Older Adults
Older adults demonstrate increased distractibility by task-irrelevant information which contributes to general cognitive impairment. However, it is yet unclear how changes in noradrenergic activity during aging influences attentional control. In the current study, tonic noradrenergic activity will be increased or decreased to investigate its behavioral and neural effects on attentional control.
- Conditions
- Aging
- Keywords
- attention, arousal
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Young Adults | Young Adults aged 18-35 | |
| Older Adults | Older Adults aged 50-80 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker
The oculomotor suppression effect is a lower likelihood that salient display items will be the target of the initial eye movement in a visual search task compared to nonsalient display items. This effect is calculated from the percentage of first saccades toward a non-target stimuli subtracted by the percentage of first saccades toward the distractor stimuli. Greater % of first saccades toward the target would demonstrate better goal-directed attentional control and greater % of first saccades toward the distractor would demonstrate increased distractibility. Thus, a greater oculomotor suppression effect would demonstrate an increased ability to inhibit salient information that is irrelevant to the task.
Measured: Calculated once at the end of the 1 day experiment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Nov 2021
- Study start1 Nov 2021
- Primary completion20 Nov 2023
- Study completion20 Nov 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for AgingStudies of the same condition, open and under way.
- More trials run by University of Southern CaliforniaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 140 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Southern California
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mara Mather, University of Southern California
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05120713
- Sponsor's protocol ID
- UP-21-00711
- Acronym
- NAA
- Status last verified
- Sep 2024
- First submitted
- 13 Oct 2021
- Last updated
- 19 Sep 2024
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: At the conclusion of the study, data in de-identified form will be shared using the Open Science Framework and/or OpenNeuro Databases which are free and open platforms for sharing and archiving scientific data.
Study at a glance
From the registry record, last updated by the sponsor on 19 Sep 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Influence of Noradrenergic Activity on Attentional Control in Younger and Older Adults
- ClinicalTrials.gov ID
- NCT05120713
- Acronym / sponsor ID
- NAA / UP-21-00711
- Conditions
- Aging
- Keywords
- attention, arousal
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 140 participants (actual)
- Lead sponsor
- University of Southern CaliforniaUniversity, hospital or other
- Study start
- 1 Nov 2021 (actual)
- Primary completion
- 20 Nov 2023 (actual)
- Study completion
- 20 Nov 2023 (actual)
- First posted
- 15 Nov 2021 (actual)
- Results
- Posted 19 Sep 2024
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Older adults demonstrate increased distractibility by task-irrelevant information which contributes to general cognitive impairment. However, it is yet unclear how changes in noradrenergic activity during aging influences attentional control. In the current study, tonic noradrenergic activity will be increased or decreased to investigate its behavioral and neural effects on attentional control.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Young Adults | – | –Young Adults aged 18-35 |
| Older Adults | – | –Older Adults aged 50-80 |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Young adults will be recruited from the student population at the University of Southern California. Older adults will be recruited from a volunteer registry.
Key inclusion criteria (4 listed)
- Fluent in English
- Aged between 18-35 or 50-80
- Have normal or corrected-to-normal vision and hearing, and normal color vision
- Have a mobile phone and email address
Key exclusion criteria (4 listed)
- Non-English speakers
- Currently practicing any relaxation, meditation, or breathing technique for more than an hour per week
- Have participated in studies measuring attentional capture in the past year
- Experiencing symptoms of dementia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker
Time frame: Calculated once at the end of the 1 day experiment
The oculomotor suppression effect is a lower likelihood that salient display items will be the target of the initial eye movement in a visual search task compared to nonsalient display items. This effect is calculated from the percentage of first saccades toward a non-target stimuli subtracted by the percentage of first saccades toward the distractor stimuli. Greater % of first saccades toward the target would demonstrate better goal-directed attentional control and greater % of first saccades toward the distractor would demonstrate increased distractibility. Thus, a greater oculomotor suppression effect would demonstrate an increased ability to inhibit salient information that is irrelevant to the task.
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2024.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Individual participant dataSharing planned: Yes. At the conclusion of the study, data in de-identified form will be shared using the Open Science Framework and/or OpenNeuro Databases which are free and open platforms for sharing and archiving scientific data.
Related trials for Aging
RecruitingObservational study
PET Imaging in the Baltimore Longitudinal Study of Aging (BLSA)
Aging
Not yet recruiting
Effects of Cannabidiol on Memory and Attention in Adults Aged 60-70: A Pilot Study
Healthy Aging, Cognition
RecruitingPhase 2
Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin
Alzheimer's Disease
Active, not recruitingObservational study
MCR Syndrome in Quebec : Results From NuAge Study
Motoric Cognitive Risk Syndrome, Aging Disorder
Active, not recruitingObservational study
Passive Limb Movement: A Tool to Assess Vascular Health and Guide Rehabilitation
Aging, Cardiovascular Disease
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Aging, run by University of Southern California at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Sep 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 19 Sep 2024). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker (time frame: Calculated once at the end of the 1 day experiment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2024.