FatigueNCT05121272
Fatigability and Cognitive Demand With Aging
A study testing cognitive task in people with Fatigue, run by University of Oklahoma at 1 site in United States.
Trial summary
This study will determine the influence of a cognitive task performed during fatiguing contractions. Read more about this study
- Who is it for?
- Ages 18 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Fatigue
- What is being tested?
- cognitive task
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 11 Oct 2021to 27 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy individuals aged between 18-35 and 65-90
Who cannot join
- Metal implants or joint replacement. neuromuscular disease
Trial locations and contacts
1 site in 1 country.
About this study
This study will determine the influence of a cognitive task performed during fatiguing contractions.
Read the detailed description
Individuals will participate in one familiarization session followed by 3 randomized experimental sessions (crossover design).
- Conditions
- Fatigue
- Being tested
- cognitive task
- Keywords
- sex difference, aging
- Medical subject headings
- Fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
cognitive taskBehavioural
cognitive task
| Study group | Role | What they receive |
|---|---|---|
| young men | Experimental | Individuals will participate in 1 familiarization and 3 test sessions Receives: Behavioral: cognitive task |
| young women | Experimental | Individuals will participate in 1 familiarization and 3 test sessions Receives: Behavioral: cognitive task |
| older men | Experimental | Individuals will participate in 1 familiarization and 3 test sessions Receives: Behavioral: cognitive task |
| older women | Experimental | Individuals will participate in 1 familiarization and 3 test sessions Receives: Behavioral: cognitive task |
What is being measured
The primary outcome is the main question the study is designed to answer.
force
Change in force of the arm muscles will be evaluated with a custom made device during each test session
Measured: Each session will take approximately 2-3 hours (total of 4 test sessions)
anxiety levels
changes in anxiety levels quantified with a questionnaire
Measured: Each session will take approximately 2-3 hours (total of 4 test sessions
arterial pressure
changes in arterial pressure will be quantified with a non-invasive device (finometer)
Measured: Each session will take approximately 2-3 hours (total of 4 test sessions
fatigue
changes in fatigue will be assessed with questionnaires
Measured: Each session will take approximately 2-3 hours (total of 4 test sessions
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Nov 2021
- Study start11 Oct 2021
- Primary completion15 Aug 2025
- Study completion27 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for FatigueStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Oklahoma
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Hugo Pereira, PhD, Principal investigator, University of Oklahoma
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05121272
- Sponsor's protocol ID
- 13406P
- Status last verified
- Apr 2026
- First submitted
- 3 Sep 2021
- Last updated
- 1 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Fatigability and Cognitive Demand With Aging
- ClinicalTrials.gov ID
- NCT05121272
- Acronym / sponsor ID
- 13406P
- Conditions
- Fatigue
- Keywords
- sex difference, aging
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- University of OklahomaUniversity, hospital or other
- Study start
- 11 Oct 2021 (actual)
- Primary completion
- 15 Aug 2025 (actual)
- Study completion
- 27 Apr 2026 (actual)
- First posted
- 16 Nov 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will determine the influence of a cognitive task performed during fatiguing contractions.
Detailed description
Individuals will participate in one familiarization session followed by 3 randomized experimental sessions (crossover design).
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Single blind (participant)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| young men | Experimental | Behavioral: cognitive taskIndividuals will participate in 1 familiarization and 3 test sessions |
| young women | Experimental | Behavioral: cognitive taskIndividuals will participate in 1 familiarization and 3 test sessions |
| older men | Experimental | Behavioral: cognitive taskIndividuals will participate in 1 familiarization and 3 test sessions |
| older women | Experimental | Behavioral: cognitive taskIndividuals will participate in 1 familiarization and 3 test sessions |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Healthy individuals aged between 18-35 and 65-90
Key exclusion criteria (1 listed)
- Metal implants or joint replacement. neuromuscular disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| cognitive taskcognitive task | Behavioural | older men, older women, young men, young women |
Primary outcome
force
Time frame: Each session will take approximately 2-3 hours (total of 4 test sessions)
Change in force of the arm muscles will be evaluated with a custom made device during each test session
anxiety levels
Time frame: Each session will take approximately 2-3 hours (total of 4 test sessions
changes in anxiety levels quantified with a questionnaire
arterial pressure
Time frame: Each session will take approximately 2-3 hours (total of 4 test sessions
changes in arterial pressure will be quantified with a non-invasive device (finometer)
fatigue
Time frame: Each session will take approximately 2-3 hours (total of 4 test sessions
changes in fatigue will be assessed with questionnaires
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 May 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hugo Pereira, PhD principal investigator
University of Oklahoma
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing cognitive task in people with Fatigue, run by University of Oklahoma at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
force (time frame: Each session will take approximately 2-3 hours (total of 4 test sessions)). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 May 2026.