IVFIVF-RegsitryNCT05125497
Natural Cycle, Minimal Stimulation and Conventional IVF: a Registry-based Study
An observational study of IVF, run by Universitätsklinik fur Frauenheilkunde, Inselspital Bern at 1 site in Switzerland.
Trial summary
International prospective registry-based study of different types of In Vitro Fertilisation (IVF) and their outcome. Read more about this study
- Who is it for?
- Any age, women only
- Conditions the study is for
- IVF
- What is being tested?
- In Vitro Fertilisation (IVF)
- Type of treatment
- Surgery or procedure
- How many people
- 3,000 participants
- Where
- 1 siteSwitzerland
- Study dates
- 1 Jan 2022to 31 Mar 2023
- How long will I take part?
- 1 Year
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Women only
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients aiming to do In Vitro Fertilisation with fresh embryo transfer
Who may be able to join
None listed.
Who cannot join
- Medical freezing
- Social freezing
- thawed cycles
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Natural Cycle, Minimal Stimulation and Conventional IVF: a Registry-based Comparison of the IVF Treatments, Their Efficacy and Pregnancy Outcomes
International prospective registry-based study of different types of In Vitro Fertilisation (IVF) and their outcome.
Read the detailed description
One year of prospective collection of descriptive In-Vitro-Fertilisation data. The data will be collected in 13 In-Vitro-Fertilisation-centres
- Conditions
- IVF
- Being tested
- In Vitro Fertilisation (IVF)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
In Vitro Fertilisation (IVF)Procedure or surgery
Natural Cycle In Vitro Fertilisation (IVF): without hormonal stimulation Conventional In Vitro Fertilisation (IVF): conventional hormonal stimulation Minimal Stimulation In Vitro Fertilisation (IVF): low dose of hormonal stimulation will be applied
| Study group | Role | What they receive |
|---|---|---|
| In Vitro Fertilisation (IVF)-Patients | Patients aim to do In-Vitro-Fertilisation (IVF) Receives: Procedure: In Vitro Fertilisation (IVF) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Implantation rate
pregnancy rate per transferred embryo
Measured: 1 year
Secondary outcomes (4)
Number of oocytes
Number of retrieved oocytes per protocol
Measured: 1 Year
Clinical pregnancy rate
Pregnancy rate per transfer
Measured: 1 year
Pregnancy outcome
Pregnancy complications including preeclampsia
Measured: 1 year
In Vitro Fertilisation complications rates
miscarriage
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Nov 2021
- Study start1 Jan 2022
- Primary completion31 Mar 2023
- Study completion31 Mar 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for IVFStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 3,000 participants (actual)
- Target duration
- 1 Year
Sponsor and investigators
- Lead sponsor
- Universitätsklinik fur Frauenheilkunde, Inselspital Bern
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Magaton Isotta, Universitätsklinik fur Frauenheilkunde, Inselspital Bern
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05125497
- Sponsor's protocol ID
- 2021-01689 (BASEC-ID)
- Other IDs
- LB1562_NC-IVF, Study Number 4949
- Acronym
- IVF-Regsitry
- Status last verified
- May 2023
- First submitted
- 3 Nov 2021
- Last updated
- 15 May 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Magaton IM, Siercks I, Nordin M, Popovici RM, Boogen EM, Eisenhardt S, Reeka N, Lanowski JS, Roumet M, von Wolff M. Oocyte and zygote development potential in minimal stimulation, natural cycle and conventionally stimulated IVF: an international multi-centre retrospective cohort study. J Assist Reprod Genet. 2025 Jul;42(7):2331-2340. doi: 10.1007/s10815-025-03508-3. Epub 2025 May 28.
PubMed 40434705
Study at a glance
From the registry record, last updated by the sponsor on 15 May 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Natural Cycle, Minimal Stimulation and Conventional IVF: a Registry-based Comparison of the IVF Treatments, Their Efficacy and Pregnancy Outcomes
- ClinicalTrials.gov ID
- NCT05125497
- Acronym / sponsor ID
- IVF-Regsitry / 2021-01689 (BASEC-ID)
- Conditions
- IVF
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 3,000 participants (actual)
- Lead sponsor
- Universitätsklinik fur Frauenheilkunde, Inselspital BernUniversity, hospital or other
- Study start
- 1 Jan 2022 (actual)
- Primary completion
- 31 Mar 2023 (actual)
- Study completion
- 31 Mar 2023 (actual)
- First posted
- 18 Nov 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
International prospective registry-based study of different types of In Vitro Fertilisation (IVF) and their outcome.
Detailed description
One year of prospective collection of descriptive In-Vitro-Fertilisation data. The data will be collected in 13 In-Vitro-Fertilisation-centres
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Year
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| In Vitro Fertilisation (IVF)-Patients | – | Procedure: In Vitro Fertilisation (IVF)Patients aim to do In-Vitro-Fertilisation (IVF) |
Who may qualify
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients aiming to do In Vitro Fertilisation with fresh embryo transfer
Key inclusion criteria (0 listed)
Key exclusion criteria (3 listed)
- Medical freezing
- Social freezing
- thawed cycles
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| In Vitro Fertilisation (IVF)Natural Cycle In Vitro Fertilisation (IVF): without hormonal stimulation Conventional In Vitro Fertilisation (IVF): conventional hormonal stimulation Minimal Stimulation In Vitro Fertilisation (IVF): low dose of hormonal stimulation will be applied | Procedure or surgery | In Vitro Fertilisation (IVF)-Patients |
Primary outcome
Implantation rate
Time frame: 1 year
pregnancy rate per transferred embryo
4 secondary outcomes
Number of oocytes
Time frame: 1 Year
Clinical pregnancy rate
Time frame: 1 year
Pregnancy outcome
Time frame: 1 year
In Vitro Fertilisation complications rates
Time frame: 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 May 2023.
- Derived from this study: PubMed 40434705Magaton IM, Siercks I, Nordin M, Popovici RM, Boogen EM, Eisenhardt S, Reeka N, Lanowski JS, Roumet M, von Wolff M. Oocyte and zygote development potential in minimal stimulation, natural cycle and conventionally stimulated IVF: an international multi-centre retrospective cohort study. J Assist Reprod Genet. 2025 Jul;42(7):2331-2340. doi: 10.1007/s10815-025-03508-3. Epub 2025 May 28.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of IVF, run by Universitätsklinik fur Frauenheilkunde, Inselspital Bern at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 May 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Implantation rate (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05125497, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 May 2023.