Aging WellNCT05131217
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
A study testing Acute bout of Continuous Moderate Intensity Exercise and Acute bout of High Intensity Interval Training in people with Aging Well, run by University of Virginia at 1 site in United States.
Trial summary
This study will analyze the influence of acute bout exercise intensities (continuous moderate and HIIT) on middle cerebral artery velocity (MCAv) to identify which intensity elicits the greatest increase in CBF in older adults (65+ yrs). Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Aging Well
- What is being tested?
- Acute bout of Continuous Moderate Intensity Exercise and Acute bout of High Intensity Interval Training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 13 participants
- Where
- 1 siteUnited States
- Study dates
- 14 Jan 2022to 1 May 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- 65+ years of age
- Comfortable with experiencing exercise-induced fatigue
- Willingness and ability to comply with scheduled visits and study procedures
- Able to provide consent on their own behalf
- Type 2 Diabetics accepted
Who cannot join
- Competitive athlete (Recreationally active is okay but no more than 3 days/week of structured exercise)
- VO2max below 18 ml/kg/min in men, 15ml/kg/min in women (minimum thresholds for independent living seniors)
- Inability of study staff to acquire signal from the MCA using TCD
- Diagnosis of mild cognitive impairment, Parkinson's Disease, Alzheimer's Disease, multiple sclerosis, or psychiatric illness (unless mild depression or anxiety)
- History of brain damage/stroke/concussions
- Cardiovascular Disease, Pulmonary Disease, or dependence of supplemental O2
Show all 11Show fewer
- Type 2 Diabetics who aren't cleared by the study physician during the first screening visit (HbA1C > 8.5%)
- Neuromuscular or musculoskeletal dysfunctions impairing one from cycling
- Changes in vasoactive medication dose or quantity, recently prior to or during the study time course, or inability to maintain regular timed ingestion of vasoactive medication
- Currently involved in Estrogen or Testosterone Replacement Therapy
- Unable to abstain from food consumption (3hrs), caffeine/alcohol consumption (12hrs), and vigorous exercise (24hrs) prior to experimental procedures
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Virginia; Kinesiology Labs
Charlottesville, Virginia, 22903
About this study
This study will analyze the influence of acute bout exercise intensities (continuous moderate and HIIT) on middle cerebral artery velocity (MCAv) to identify which intensity elicits the greatest increase in CBF in older adults (65+ yrs). Additionally, this study will help verify positive correlations between MCAv and cognitive function. These findings are important in determining the optimal exercise prescription for increased resilience against the age-related cognitive degradation.
Read the detailed description
With an increasingly aging population, it is paramount that we further understand the changes that occur during aging, especially those which contribute to cognitive decline. Evidence shows that cognitive function is closely linked to brain blood flow. When comparing cerebral blood flow (CBF) between old and young individuals, older adults appear to have lower baseline levels of CBF. One of the principle determinants of CBF is CO2. Since exercise results in rises in CO2 production, changes in CBF can be monitored. Older adults appear to have diminished changes in CBF compared to younger individuals during moderate intensity exercise. This then leads to the idea that older adults may need a greater exercise stimulus (i.e. HIIT) to see these changes in CBF. However, the effects of HIIT on CBF in older adults is largely unstudied.
Purpose: To analyze the acute influence of HIIT on middle cerebral artery velocity (MCAv) in older adults, and to verify the positive association between MCAv and cognitive function.
Experimental Design: Recruiting 16 healthy adults age 65 and older. The study will require each participant to report to 4 visits: a screening visit, a control, a moderate intensity exercise bout, and a high intensity exercise bout. The order of the experimental visits will be randomized to each subject, and exercise bouts will be work-matched. During the experimental visits, MCAv, end-tidal CO2, MAP, and HR will be measured continuously. Vascular measures such as pulse wave analysis and pulse wave velocity will be taken pre- and post-exercise. Additionally, blood flow through the internal carotid artery and cognitive measures (n-back test) will be measured and administered pre-exercise, and at 15 mins, 30 mins, and 45 mins post-exercise. A two-way repeated measures ANOVA will be used to determine significant differences for time (pre vs. post measures) x condition (control/moderate/HIIT).
Results: In the process of collecting data.
Implications: If the study is successful in its findings, this could change how exercise is prescribed to older adults. It could also lead to the question regarding if a greater exercise stimulus (i.e. SIT) may be even more beneficial for these individuals.
- Conditions
- Aging Well
- Being tested
- Acute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, Control
- Keywords
- MCAv, Working Memory, Cognition, Exercise Intensity, Cerebral Blood Flow, HIIT
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Acute bout of Continuous Moderate Intensity ExerciseOther
In this experimental intervention subjects will cycle continuously at moderate intensity (VO2 corresponding to lactate threshold) until a 200 kcal equivalent energy expenditure is reached.
Acute bout of High Intensity Interval TrainingOther
Also called HIIT
In this experimental invention subjects will alternate between 1 minute of high intensity cycling (watts corresponding to 85% VO2peak) and 1 minute of low intensity cycling (watts corresponding to 35-40% VO2peak) until a 200 kcal equivalent energy expenditure is reached.
ControlOther
Also called Rest
In this intervention placebo, subjects will lay down on a flat, soft surface for 30 minutes in a dimly light room. They will not be allowed to use any electronic devices or read during this time to avoid potentially influencing continuous data recording.
| Study group | Role | What they receive |
|---|---|---|
| Acute bout of Continuous Moderate Intensity Exercise | Experimental | Not described Receives: Other: Acute bout of Continuous Moderate Intensity Exercise |
| Acute bout of High Intensity Interval Training (HIIT) | Experimental | Not described Receives: Other: Acute bout of High Intensity Interval Training |
| Control | Experimental | Not described Receives: Other: Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Middle Cerebral Artery Velocity (MCAv)
Blood flow velocity measured in the Middle Cerebral Artery via Transcranial Doppler probe secured to the right temporal window.
Measured: Measured continuously over the course of each experimental session (i.e. 2-3 hours)
Secondary outcomes (3)
Working Memory
Measured via n-back test (2-back); Subject's will be presented a sequence of letters (25 of them from a base set of 15 letters) one-by-one and will have 3 seconds to indicate whether the letter they see currently matches the letter from 2 frames ago. If there is no match, then they do not need to respond.They will complete three rounds each with a different sequence. Accuracy score (%) = correct inputs/# of stimuli, averaged across 3 blocks.
Measured: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Internal Carotid Artery (ICA) Diameter
Measured via Ultrasound; diameter will be measured as the peak of the pulse wave
Measured: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Internal Carotid Artery (ICA) Pulse Velocity
Measured via Ultrasound; velocity will be assessed at the peak of each pulse wave
Measured: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Nov 2021
- Study start14 Jan 2022
- Primary completion1 May 2023
- Study completion1 May 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (35)Papers the sponsor has linked to this study.
- Other trials for Aging WellStudies of the same condition, open and under way.
- More trials run by University of VirginiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This is a repeated measures cross-over design, in which all subjects will complete all acute exercise intensity conditions: HIIT, continuous moderate intensity at lactate threshold (LT), and rest (control). The order of the acute treatment bouts will be randomized for each subject over three experimental visits (not counting the screening visit).
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 13 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Virginia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jason Allen, University of Virginia
- Investigators
- Jason Allen, PhD, Principal investigator, University of Virginia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05131217
- Sponsor's protocol ID
- HSR200454
- Status last verified
- Nov 2023
- First submitted
- 11 Nov 2021
- Last updated
- 29 Nov 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Thudium M, Heinze I, Ellerkmann RK, Hilbert T. Cerebral Function and Perfusion during Cardiopulmonary Bypass: A Plea for a Multimodal Monitoring Approach. Heart Surg Forum. 2018 Jan 31;21(1):E028-E035. doi: 10.1532/hsf.1894.
PubMed 29485961Shoemaker LN, Wilson LC, Lucas SJE, Machado L, Thomas KN, Cotter JD. Swimming-related effects on cerebrovascular and cognitive function. Physiol Rep. 2019 Oct;7(20):e14247. doi: 10.14814/phy2.14247.
PubMed 31637867Alexandrov AV, Sloan MA, Wong LK, Douville C, Razumovsky AY, Koroshetz WJ, Kaps M, Tegeler CH; American Society of Neuroimaging Practice Guidelines Committee. Practice standards for transcranial Doppler ultrasound: part I--test performance. J Neuroimaging. 2007 Jan;17(1):11-8. doi: 10.1111/j.1552-6569.2006.00088.x.
PubMed 17238867Burley CV, Francis ST, Whittaker AC, Mullinger KJ, Lucas SJE. Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults. Brain Behav. 2021 Jul;11(7):e02126. doi: 10.1002/brb3.2126. Epub 2021 May 25.
PubMed 34032379Fan JL, Nogueira RC, Brassard P, Rickards CA, Page M, Nasr N, Tzeng YC. Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke. J Cereb Blood Flow Metab. 2022 Mar;42(3):454-470. doi: 10.1177/0271678X211033732. Epub 2021 Jul 26.
PubMed 34304623Klein T, Sanders M, Wollseiffen P, Carnahan H, Abeln V, Askew CD, Claassen JA, Schneider S. Transient cerebral blood flow responses during microgravity. Life Sci Space Res (Amst). 2020 May;25:66-71. doi: 10.1016/j.lssr.2020.03.003. Epub 2020 Mar 19.
PubMed 32414494Loe H, Rognmo O, Saltin B, Wisloff U. Aerobic capacity reference data in 3816 healthy men and women 20-90 years. PLoS One. 2013 May 15;8(5):e64319. doi: 10.1371/journal.pone.0064319. Print 2013.
PubMed 23691196Ogoh S, Ainslie PN. Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol (1985). 2009 Nov;107(5):1370-80. doi: 10.1152/japplphysiol.00573.2009. Epub 2009 Sep 3.
PubMed 19729591Settakis G, Lengyel A, Molnar C, Bereczki D, Csiba L, Fulesdi B. Transcranial Doppler study of the cerebral hemodynamic changes during breath-holding and hyperventilation tests. J Neuroimaging. 2002 Jul;12(3):252-8.
PubMed 12116744Shephard RJ. Maximal oxygen intake and independence in old age. Br J Sports Med. 2009 May;43(5):342-6. doi: 10.1136/bjsm.2007.044800. Epub 2008 Apr 10.
PubMed 18403414Jones-Muhammad M, Warrington JP. Redefining the cerebral autoregulatory range of blood pressures: Not as wide as previously reported. Physiol Rep. 2021 Sep;9(17):e15006. doi: 10.14814/phy2.15006.
PubMed 34435458Keating CJ, Parraga Montilla JA, Latorre Roman PA, Moreno Del Castillo R. Comparison of High-Intensity Interval Training to Moderate-Intensity Continuous Training in Older Adults: A Systematic Review. J Aging Phys Act. 2020 Apr 16;28(5):798-807. doi: 10.1123/japa.2019-0111. Print 2020 Oct 1.
PubMed 32303000Smith KJ, Ainslie PN. Regulation of cerebral blood flow and metabolism during exercise. Exp Physiol. 2017 Nov 1;102(11):1356-1371. doi: 10.1113/EP086249. Epub 2017 Sep 30.
PubMed 28786150Calverley TA, Ogoh S, Marley CJ, Steggall M, Marchi N, Brassard P, Lucas SJE, Cotter JD, Roig M, Ainslie PN, Wisloff U, Bailey DM. HIITing the brain with exercise: mechanisms, consequences and practical recommendations. J Physiol. 2020 Jul;598(13):2513-2530. doi: 10.1113/JP275021. Epub 2020 Jun 1.
PubMed 32347544Ogoh S, Tsukamoto H, Hirasawa A, Hasegawa H, Hirose N, Hashimoto T. The effect of changes in cerebral blood flow on cognitive function during exercise. Physiol Rep. 2014 Sep 28;2(9):e12163. doi: 10.14814/phy2.12163. Print 2014 Sep 1.
PubMed 25263210
Study at a glance
From the registry record, last updated by the sponsor on 29 Nov 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
- ClinicalTrials.gov ID
- NCT05131217
- Acronym / sponsor ID
- HSR200454
- Conditions
- Aging Well
- Keywords
- MCAv, Working Memory, Cognition, Exercise Intensity, Cerebral Blood Flow, HIIT
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 13 participants (actual)
- Lead sponsor
- University of VirginiaUniversity, hospital or other
- Study start
- 14 Jan 2022 (actual)
- Primary completion
- 1 May 2023 (actual)
- Study completion
- 1 May 2023 (actual)
- First posted
- 23 Nov 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will analyze the influence of acute bout exercise intensities (continuous moderate and HIIT) on middle cerebral artery velocity (MCAv) to identify which intensity elicits the greatest increase in CBF in older adults (65+ yrs). Additionally, this study will help verify positive correlations between MCAv and cognitive function. These findings are important in determining the optimal exercise prescription for increased resilience against the age-related cognitive degradation.
Detailed description
With an increasingly aging population, it is paramount that we further understand the changes that occur during aging, especially those which contribute to cognitive decline. Evidence shows that cognitive function is closely linked to brain blood flow. When comparing cerebral blood flow (CBF) between old and young individuals, older adults appear to have lower baseline levels of CBF. One of the principle determinants of CBF is CO2. Since exercise results in rises in CO2 production, changes in CBF can be monitored. Older adults appear to have diminished changes in CBF compared to younger individuals during moderate intensity exercise. This then leads to the idea that older adults may need a greater exercise stimulus (i.e. HIIT) to see these changes in CBF. However, the effects of HIIT on CBF in older adults is largely unstudied.
Purpose: To analyze the acute influence of HIIT on middle cerebral artery velocity (MCAv) in older adults, and to verify the positive association between MCAv and cognitive function.
Experimental Design: Recruiting 16 healthy adults age 65 and older. The study will require each participant to report to 4 visits: a screening visit, a control, a moderate intensity exercise bout, and a high intensity exercise bout. The order of the experimental visits will be randomized to each subject, and exercise bouts will be work-matched. During the experimental visits, MCAv, end-tidal CO2, MAP, and HR will be measured continuously. Vascular measures such as pulse wave analysis and pulse wave velocity will be taken pre- and post-exercise. Additionally, blood flow through the internal carotid artery and cognitive measures (n-back test) will be measured and administered pre-exercise, and at 15 mins, 30 mins, and 45 mins post-exercise. A two-way repeated measures ANOVA will be used to determine significant differences for time (pre vs. post measures) x condition (control/moderate/HIIT).
Results: In the process of collecting data.
Implications: If the study is successful in its findings, this could change how exercise is prescribed to older adults. It could also lead to the question regarding if a greater exercise stimulus (i.e. SIT) may be even more beneficial for these individuals.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- This is a repeated measures cross-over design, in which all subjects will complete all acute exercise intensity conditions: HIIT, continuous moderate intensity at lactate threshold (LT), and rest (control). The order of the acute treatment bouts will be randomized for each subject over three experimental visits (not counting the screening visit).
| Arm | Type | Receives |
|---|---|---|
| Acute bout of Continuous Moderate Intensity Exercise | Experimental | Other: Acute bout of Continuous Moderate Intensity Exercise |
| Acute bout of High Intensity Interval Training (HIIT) | Experimental | Other: Acute bout of High Intensity Interval Training |
| Control | Experimental | Other: Control |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (5 listed)
- 65+ years of age
- Comfortable with experiencing exercise-induced fatigue
- Willingness and ability to comply with scheduled visits and study procedures
- Able to provide consent on their own behalf
- Type 2 Diabetics accepted
Key exclusion criteria (11 listed)
- Competitive athlete (Recreationally active is okay but no more than 3 days/week of structured exercise)
- VO2max below 18 ml/kg/min in men, 15ml/kg/min in women (minimum thresholds for independent living seniors)
- Inability of study staff to acquire signal from the MCA using TCD
- Diagnosis of mild cognitive impairment, Parkinson's Disease, Alzheimer's Disease, multiple sclerosis, or psychiatric illness (unless mild depression or anxiety)
- History of brain damage/stroke/concussions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Acute bout of Continuous Moderate Intensity ExerciseIn this experimental intervention subjects will cycle continuously at moderate intensity (VO2 corresponding to lactate threshold) until a 200 kcal equivalent energy expenditure is reached. | Other | Acute bout of Continuous Moderate Intensity Exercise |
| Acute bout of High Intensity Interval TrainingAlso: HIITIn this experimental invention subjects will alternate between 1 minute of high intensity cycling (watts corresponding to 85% VO2peak) and 1 minute of low intensity cycling (watts corresponding to 35-40% VO2peak) until a 200 kcal equivalent energy expenditure is reached. | Other | Acute bout of High Intensity Interval Training (HIIT) |
| ControlAlso: RestIn this intervention placebo, subjects will lay down on a flat, soft surface for 30 minutes in a dimly light room. They will not be allowed to use any electronic devices or read during this time to avoid potentially influencing continuous data recording. | Other | Control |
Primary outcome
Middle Cerebral Artery Velocity (MCAv)
Time frame: Measured continuously over the course of each experimental session (i.e. 2-3 hours)
Blood flow velocity measured in the Middle Cerebral Artery via Transcranial Doppler probe secured to the right temporal window.
3 secondary outcomes
Working Memory
Time frame: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Internal Carotid Artery (ICA) Diameter
Time frame: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Internal Carotid Artery (ICA) Pulse Velocity
Time frame: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Nov 2023.
- Background: PubMed 29485961Thudium M, Heinze I, Ellerkmann RK, Hilbert T. Cerebral Function and Perfusion during Cardiopulmonary Bypass: A Plea for a Multimodal Monitoring Approach. Heart Surg Forum. 2018 Jan 31;21(1):E028-E035. doi: 10.1532/hsf.1894.
- Background: PubMed 31637867Shoemaker LN, Wilson LC, Lucas SJE, Machado L, Thomas KN, Cotter JD. Swimming-related effects on cerebrovascular and cognitive function. Physiol Rep. 2019 Oct;7(20):e14247. doi: 10.14814/phy2.14247.
- Background: PubMed 17238867Alexandrov AV, Sloan MA, Wong LK, Douville C, Razumovsky AY, Koroshetz WJ, Kaps M, Tegeler CH; American Society of Neuroimaging Practice Guidelines Committee. Practice standards for transcranial Doppler ultrasound: part I--test performance. J Neuroimaging. 2007 Jan;17(1):11-8. doi: 10.1111/j.1552-6569.2006.00088.x.
- Background: PubMed 34032379Burley CV, Francis ST, Whittaker AC, Mullinger KJ, Lucas SJE. Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults. Brain Behav. 2021 Jul;11(7):e02126. doi: 10.1002/brb3.2126. Epub 2021 May 25.
- Background: PubMed 34304623Fan JL, Nogueira RC, Brassard P, Rickards CA, Page M, Nasr N, Tzeng YC. Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke. J Cereb Blood Flow Metab. 2022 Mar;42(3):454-470. doi: 10.1177/0271678X211033732. Epub 2021 Jul 26.
- Background: PubMed 32414494Klein T, Sanders M, Wollseiffen P, Carnahan H, Abeln V, Askew CD, Claassen JA, Schneider S. Transient cerebral blood flow responses during microgravity. Life Sci Space Res (Amst). 2020 May;25:66-71. doi: 10.1016/j.lssr.2020.03.003. Epub 2020 Mar 19.
- Background: PubMed 23691196Loe H, Rognmo O, Saltin B, Wisloff U. Aerobic capacity reference data in 3816 healthy men and women 20-90 years. PLoS One. 2013 May 15;8(5):e64319. doi: 10.1371/journal.pone.0064319. Print 2013.
- Background: PubMed 19729591Ogoh S, Ainslie PN. Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol (1985). 2009 Nov;107(5):1370-80. doi: 10.1152/japplphysiol.00573.2009. Epub 2009 Sep 3.
- Background: PubMed 12116744Settakis G, Lengyel A, Molnar C, Bereczki D, Csiba L, Fulesdi B. Transcranial Doppler study of the cerebral hemodynamic changes during breath-holding and hyperventilation tests. J Neuroimaging. 2002 Jul;12(3):252-8.
- Background: PubMed 18403414Shephard RJ. Maximal oxygen intake and independence in old age. Br J Sports Med. 2009 May;43(5):342-6. doi: 10.1136/bjsm.2007.044800. Epub 2008 Apr 10.
- Background: PubMed 34435458Jones-Muhammad M, Warrington JP. Redefining the cerebral autoregulatory range of blood pressures: Not as wide as previously reported. Physiol Rep. 2021 Sep;9(17):e15006. doi: 10.14814/phy2.15006.
- Background: PubMed 32303000Keating CJ, Parraga Montilla JA, Latorre Roman PA, Moreno Del Castillo R. Comparison of High-Intensity Interval Training to Moderate-Intensity Continuous Training in Older Adults: A Systematic Review. J Aging Phys Act. 2020 Apr 16;28(5):798-807. doi: 10.1123/japa.2019-0111. Print 2020 Oct 1.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jason Allen, PhD principal investigator
University of Virginia
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acute bout of Continuous Moderate Intensity Exercise and Acute bout of High Intensity Interval Training in people with Aging Well, run by University of Virginia at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Nov 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Middle Cerebral Artery Velocity (MCAv) (time frame: Measured continuously over the course of each experimental session (i.e. 2-3 hours)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05131217, which also lists 35 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Nov 2023.