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Out-of-hospital Cardiac ArrestG-CARNCT05142124

German Cardiac Arrest Registry

An observational study of Out-of-hospital Cardiac Arrest, run by Leipzig Heart Science gGmbH at 25 sites in Germany.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Out-of-hospital Cardiac Arrest
How many people
400 participants
Where
25 sitesGermany
Study dates
21 Jul 2021to 30 Jun 2027
How long will I take part?
12 Months
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: patients with out-of-hospital cardiac arrest with assumed cardiovacular cause

Who may be able to join

  • patients with out-of-hospital cardiac arrest with assumed cardiovascular cause

Who cannot join

  • rejection of register participation by patient or legal representative

Trial locations and contacts

25 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Janine Pöss, Dr. contact

+49 341 865 ext. 1428

janine.poess@medizin.uni-leipzig.de

Holger Thiele, Prof. contact

+49 341 865 ext. 1428

holger.thiele@medizin.uni-leipzig.de

25 sites in 1 country

Germany25 sites, 22 recruiting

  • SLK-Kliniken Heilbronn - Klinikum am Plattenwald

    Bad Friedrichshall, 74177

    Thomas Dengler, MD, Prof. Dr.

    Recruiting

  • CHARITE - Universitätsmedizin Berlin - Campus Virchow Klinikum

    Berlin, State of Berlin, 13353

    Active, not recruiting

  • Charité Universitätsmedizin Berlin - Deutsches Herzzentrum Berlin

    Berlin, 12203

    Wulf Knie, MD

    Recruiting

  • Universitätsklinikum Bonn

    Bonn

    Sebastian Zimmer, Prof. Dr.

    Philip R Goody, Dr.

    Recruiting

  • Bremer Institut für Herz- und Kreislaufforschung am Klinikum Links der Weser

    Bremen, 28277

    Harm Wienbergen, Prof.

    Recruiting

  • Herzzentrum der Universität zu Köln

    Cologne, 50937

    Roman Pflister, Prof.

    Recruiting

  • Herzzentrum Dresden GmbH

    Dresden, 01307

    Active, not recruiting

  • Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie

    Düsseldorf, 40225

    Malte Kelm, Prof.

    Ralf Westenfeld, PD Dr.

    Recruiting

  • Elisabeth Krankenhaus Essen - Klinik für Akut- und Notfallmedizin

    Essen, 45138

    Ingo Voigt, Dr.

    Recruiting

  • Klinikum Frankfurt Höchst

    Frankfurt, 65929

    Daniel Bock, Dr.

    Recruiting

  • Universitätsklinikum Halle (Saale)

    Halle, 06120

    Daniel Sedding, Prof. Dr.

    Jochen Dutzmann, Dr.

    Recruiting

  • Universitäres Herz- und Gefäßzentrum Hamburg

    Hamburg, 20246

    Christoph Sinning, PD Dr.

    Recruiting

  • Asklepios Klinik St- Georg Hamburg

    Hamburg

    Eike P Tigges, Dr.

    Recruiting

  • SLK-Kliniken Heilbronn - Klinikum am Gesundbrunnen

    Heilbronn, 74078

    Marcus Hennersdorf, MD, Prof. Dr.

    Recruiting

  • Universitätsklinikum des Saarlandes

    Homburg

    Andreas Link, Prof.

    Recruiting

  • Heart Center Leipzig at University of Leipzig, Department of Internal Medicine/Cardiology

    Leipzig, 04289

    Janine Pöss, Dr., +49 341 865 ext. 1428, janine.poess@medizin.uni-leipzig.de

    Holger Thiele, Prof., holger.thiele@medizin.uni-leipzig.de

    Recruiting

  • Herzzentrum Lübeck

    Lübeck

    Tobias Graf, Dr.

    Recruiting

  • Klinikum der Stadt Ludwigshafen gGmbH

    Ludwigshafen, 67063

    Uwe Zeymer, Prof.

    Recruiting

  • Universitätsklinikum Mannheim

    Mannheim, 68167

    Ibrahim Akin, Prof. Dr. med.

    Recruiting

  • Klinikum der Universität München

    München, 81377

    Clemens Scherer, MD

    Recruiting

  • Marienhaus Klinikum Hetzelstift

    Neustadt, 67434

    Patrick Swojanowsky, Dr.

    Recruiting

  • Hegau-Bodensee Klinikum

    Singen, 78224

    Stephan Richter, MD

    Recruiting

  • Hegau-Bodensee-Klinikum Singen

    Singen, 78224

    Stephan Richter, MD

    Not yet recruiting

  • Schwarzwald-Baar Klinikum VS

    Villingen-Schwenningen, 78052

    Sebastian Ewen, MD

    Recruiting

  • Dr. Horst Schmidt Kliniken

    Wiesbaden

    Active, not recruiting

Other trials in Germany

About this study

In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.

Keywords
Out-of-hospital Cardiac Arrest, OHCA, resuscitation, cardiac arrest center, acute care medicine, intensive care, post-resuscitation care
Medical subject headings
Out-of-Hospital Cardiac Arrest

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. In hospital mortality

    Measured: until discharge, an average of 2 weeks

Secondary outcomes (15)

  1. Length of ICU stay

    Measured: until discharge, an average of 2 weeks

  2. Length of hospital stay

    Measured: until discharge, an average of 2 weeks

  3. Mortality

    Measured: Day 30

  4. Mortality

    Measured: Month 6

  5. European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)

    five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'

    Measured: Month 6

  6. Post Traumatic Stress Syndrome

    PTSS-14

    Measured: Month 6

  7. Reintegration

    Reintegration to Normal Living Index

    Measured: Month 6

  8. Hospital Anxiety and Depression Scale (HADS)

    score 0-21; higher value show more severe depression

    Measured: Month 6

  9. Mini Montreal Cognitive Assessment (MoCA)

    score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction

    Measured: Month 6

  10. Mini Montreal Cognitive Assessment (MoCA)

    score 0-15; 11 or higher is normal, 10 or less indicate cognitive dysfunction

    Measured: Month 12

  11. Mortality

    Measured: Month 12

  12. European Quality of Life 5 Dimensions 5 Level Version (EQ-5D)

    five levels in each dimension are worded as (1) 'not /no problems', (2) 'slight problems', (3) 'moderate problems', (4) 'severe problems', and (5) 'unable to'

    Measured: Month 12

  13. Post Traumatic Stress Syndrome (PTSS-14)

    scor 14-98; higher value indicate more post traumatic stress

    Measured: Month 12

  14. Reintegration

    Reintegration to Normal Living Index

    Measured: Month 12

  15. Hospital Anxiety and Depression Scale (HADS)

    score 0-21; higher value indicate more severe depression

    Measured: Month 12

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Dec 2021
  2. Study start21 Jul 2021
  3. Primary completion31 Dec 2026 (estimated)
  4. Study completion30 Jun 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Case only
Time perspective
Prospective
Enrolment
400 participants (estimated)
Target duration
12 Months
IDs, dates and publications
ClinicalTrials.gov ID
NCT05142124
Sponsor's protocol ID
2020-0396
Acronym
G-CAR
Status last verified
Feb 2026
First submitted
8 Nov 2021
Last updated
12 Feb 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Rossberg M, Heerklotz H, Hosler N, Ouarrak T, Desch S, Thiele H, Zeymer U, Tigges E, Voigt I, Michels G, Voss F, Apfelbacher C, Freund A, Ewen S, Fleischmann-Struzek C, Sinning C, Poss J; G-CAR Investigators. Cognition, Quality of Life, and Psychological Outcomes in Out-of-Hospital Cardiac Arrest Survivors - Results from the German Cardiac Arrest Registry (G-CAR). Resuscitation. 2026 Aug 24:111277. doi: 10.1016/j.resuscitation.2026.111277. Online ahead of print.

    PubMed 42637214

  • Poss J, Sinning C, Rossberg M, Hosler N, Ouarrak T, Bottiger BW, Ewen S, Wienbergen H, Voss F, Dutzmann J, Tigges E, Voigt I, Freund A, Desch S, Michels G, Thiele H, Zeymer U; G-CAR Investigators. German Cardiac Arrest Registry (G-CAR)-results of the pilot phase. Clin Res Cardiol. 2025 Oct;114(10):1270-1279. doi: 10.1007/s00392-024-02468-5. Epub 2024 Jun 13.

    PubMed 38869632

  • Poss J, Sinning C, Schreiner I, Apfelbacher C, Drewitz KP, Hosler N, Schneider S, Pieske B, Bottiger BW, Ewen S, Wienbergen H, Kelm M, Bock D, Graf T, Adler C, Dutzmann J, Knie W, Orban M, Zeymer U, Michels G, Thiele H; G-CAR Investigators. German Cardiac Arrest Registry: rationale and design of G-CAR. Clin Res Cardiol. 2023 Apr;112(4):455-463. doi: 10.1007/s00392-022-02044-9. Epub 2022 Jun 21.

    PubMed 35729429

Questions about this trial

What is this clinical trial studying?

An observational study of Out-of-hospital Cardiac Arrest, run by Leipzig Heart Science gGmbH at 25 sites in Germany.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 12 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 25 sites in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Janine Pöss, Dr. (+49 341 865 ext. 1428, janine.poess@medizin.uni-leipzig.de), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

In hospital mortality (time frame: until discharge, an average of 2 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05142124, which also lists 3 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Feb 2026.

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