Disinfection By-productsNCT05172752
A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia
A study testing Citizen Scientist Training Program and Stakeholder Consultation Core Program in people with Disinfection By-products, run by Anna Hoover at 1 site in United States.
Trial summary
Appalachian Kentuckians in Martin and Letcher Counties are grappling with a health-threatening drinking water crisis arising from exposures to disinfection by-products (DBPs). DBPs include trihalomethanes (THMs), haloacetic acids (HAAs), chlorate, and other compounds that have been associated with a variety of adverse… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Disinfection By-products
- What is being tested?
- Citizen Scientist Training Program and Stakeholder Consultation Core Program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteUnited States
- Study dates
- 25 Feb 2022to Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Located in Martin or Letcher County water districts
- At least 18 years old
- Able to read/speak in English
Who cannot join
- Located outside of Martin or Letcher County water districts
Trial locations and contacts
1 site in 1 country.
About this study
Appalachian Kentuckians in Martin and Letcher Counties are grappling with a health-threatening drinking water crisis arising from exposures to disinfection by-products (DBPs). DBPs include trihalomethanes (THMs), haloacetic acids (HAAs), chlorate, and other compounds that have been associated with a variety of adverse health effects, including increased risk of bladder cancer and cardiovascular birth defects. This study implements a multi-stakeholder, multi-method approach to improve understanding of, characterize spatial and temporal variations in, and reduce exposure to DBPs in these Appalachian Kentucky counties.
- Conditions
- Disinfection By-products
- Being tested
- Citizen Scientist Training Program, Stakeholder Consultation Core Program
- Keywords
- Community-engaged, Appalachia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Citizen Scientist Training ProgramOther
Citizen Scientist Training Program Participants is a three year training and in-home sampling program for disinfection byproducts. Participants will be trained and assessed based on their experience in the training program.
Stakeholder Consultation Core ProgramOther
Stakeholder Consultation Core Program Participants is a five year assessments where participants will participate in quarterly meetings and deliberative activities related to disinfection byproducts. Participants will be assessed based on their experience in the program.
| Study group | Role | What they receive |
|---|---|---|
| Citizen Science Training | Other | Study participants in this condition will participate in training and in-home sampling for disinfection by-products. Receives: Other: Citizen Scientist Training Program |
| Stakeholder Consultation Core Membership | Other | Study participants in this condition will participate in quarterly meetings and deliberative activities of the project's Stakeholder Consultation Core. Receives: Other: Stakeholder Consultation Core Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Environmental Health Literacy (EHL) - Knowledge
Study participants will complete pre-/post-surveys of disinfection byproducts-related knowledge. Participants will answer 21 questions with multiple choice or fill in the blank response options that will be assessed for correctness/completeness.
Measured: Baseline, 5-years
Change in Environmental Health Literacy (EHL) - Attitudes/Behaviors
Study participants will complete pre-/post-surveys of disinfection byproducts-related attitudes. Participants will answer 9 questions related attitudes/behaviors with a five-point Likert scale, ranging from Strongly Disagree to Strongly Agree, where Strongly Agree indicates a greater likelihood for the behavior/more positive attitude.
Measured: Baseline, 5-years
Change in participant network density
The proportion of direct ties within the network as compared to the number of possible ties as measured by an unbounded social media analysis.
Measured: Baseline, 5-years
Change in participant centrality
The influence of each individual within the network (i.e., betweenness and degree centrality) as measured by an unbounded social media analysis.
Measured: Baseline, 5-years
Change in participant reciprocity
The number of reciprocal ties, which is the extent to which individuals within the network recognize each other as valued resources/collaborators as measured by an unbounded social media analysis.
Measured: Baseline, 5-years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Dec 2021
- Study start25 Feb 2022
- Primary completionOct 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Disinfection By-productsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Anna Hoover
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute of Environmental Health Sciences (NIEHS)
- Responsible party
- Sponsor-investigator, Anna Hoover, University of Kentucky
- Investigators
- Anna Hoover, PhD, Principal investigator, University of Kentucky
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05172752
- Sponsor's protocol ID
- 62921
- Other IDs
- 1R01ES032396-01
- Status last verified
- Oct 2026
- First submitted
- 25 Oct 2021
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A University-Community Partnership to Reduce Exposure to Disinfection Byproducts In Appalachia
- ClinicalTrials.gov ID
- NCT05172752
- Acronym / sponsor ID
- 62921
- Conditions
- Disinfection By-products
- Keywords
- Community-engaged, Appalachia
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Anna HooverUniversity, hospital or other
- Collaborators
- National Institute of Environmental Health Sciences (NIEHS)
- Study start
- 25 Feb 2022 (actual)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 29 Dec 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Appalachian Kentuckians in Martin and Letcher Counties are grappling with a health-threatening drinking water crisis arising from exposures to disinfection by-products (DBPs). DBPs include trihalomethanes (THMs), haloacetic acids (HAAs), chlorate, and other compounds that have been associated with a variety of adverse health effects, including increased risk of bladder cancer and cardiovascular birth defects. This study implements a multi-stakeholder, multi-method approach to improve understanding of, characterize spatial and temporal variations in, and reduce exposure to DBPs in these Appalachian Kentucky counties.
Study design
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Citizen Science Training | Other | Other: Citizen Scientist Training ProgramStudy participants in this condition will participate in training and in-home sampling for disinfection by-products. |
| Stakeholder Consultation Core Membership | Other | Other: Stakeholder Consultation Core ProgramStudy participants in this condition will participate in quarterly meetings and deliberative activities of the project's Stakeholder Consultation Core. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Located in Martin or Letcher County water districts
- At least 18 years old
- Able to read/speak in English
Key exclusion criteria (1 listed)
- Located outside of Martin or Letcher County water districts
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Citizen Scientist Training ProgramCitizen Scientist Training Program Participants is a three year training and in-home sampling program for disinfection byproducts. Participants will be trained and assessed based on their experience in the training program. | Other | Citizen Science Training |
| Stakeholder Consultation Core ProgramStakeholder Consultation Core Program Participants is a five year assessments where participants will participate in quarterly meetings and deliberative activities related to disinfection byproducts. Participants will be assessed based on their experience in the program. | Other | Stakeholder Consultation Core Membership |
Primary outcome
Change in Environmental Health Literacy (EHL) - Knowledge
Time frame: Baseline, 5-years
Study participants will complete pre-/post-surveys of disinfection byproducts-related knowledge. Participants will answer 21 questions with multiple choice or fill in the blank response options that will be assessed for correctness/completeness.
Change in Environmental Health Literacy (EHL) - Attitudes/Behaviors
Time frame: Baseline, 5-years
Study participants will complete pre-/post-surveys of disinfection byproducts-related attitudes. Participants will answer 9 questions related attitudes/behaviors with a five-point Likert scale, ranging from Strongly Disagree to Strongly Agree, where Strongly Agree indicates a greater likelihood for the behavior/more positive attitude.
Change in participant network density
Time frame: Baseline, 5-years
The proportion of direct ties within the network as compared to the number of possible ties as measured by an unbounded social media analysis.
Change in participant centrality
Time frame: Baseline, 5-years
The influence of each individual within the network (i.e., betweenness and degree centrality) as measured by an unbounded social media analysis.
Change in participant reciprocity
Time frame: Baseline, 5-years
The number of reciprocal ties, which is the extent to which individuals within the network recognize each other as valued resources/collaborators as measured by an unbounded social media analysis.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anna Hoover, PhD principal investigator
University of Kentucky
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Citizen Scientist Training Program and Stakeholder Consultation Core Program in people with Disinfection By-products, run by Anna Hoover at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Environmental Health Literacy (EHL) - Knowledge (time frame: Baseline, 5-years). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.