AzTrials
AzTrials

Stage III Colon CancerPhase 2/3CIRCULATE-USNCT05174169

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

A Phase 2/3 study testing Signatera test, mFOLFOX6 3-6 month and CAPOX 3 month in people with Stage III Colon Cancer, run by NRG Oncology at 1,085 sites in 3 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Stage III Colon Cancer
What is being tested?
Signatera test, mFOLFOX6 3-6 month and CAPOX 3 month
Could I receive a placebo?
No, everyone receives an active treatment
How many people
1,912 participants
Where
1,085 sitesin 3 countries
Study dates
8 Jul 2022to 10 Mar 2030
Phase
Phase 2/3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • The patient must have an ECOG performance status of 0 or 1.
  • Patients must have histologically/pathologically confirmed Stage IIB, IIC, or Stage III colon adenocarcinoma with R0 resection according to AJCC 8th edition criteria.
  • No radiographic evidence of overt metastatic disease within 45 days prior to Step 1/Study entry (CT with IV contrast or MRI imaging is acceptable and must include chest, abdomen, and pelvis).
  • The distal extent of the tumor must be greater than or equal to 12 cm from the anal verge on colonoscopy or above the peritoneal reflection as documented during surgery or on pathology specimen (i.e., excluding rectal adenocarcinomas warranting treatment with chemoradiation).
  • The patient must have had an en bloc complete gross resection of tumor (curative resection). Patients who have had a two-stage surgical procedure, to first provide a decompressive colostomy and then in a later procedure to have the definitive surgical resection, are eligible.
  • The resected tumor specimen and a blood specimen from patients with Stage IIB, IIC, or Stage III colon cancer must have central testing for ctDNA using the Signatera™ assay by Natera (after Step 1/Study entry and before Step2/Randomization). Patient must have sufficient tissue to meet protocol requirements. This blood specimen for the Signatera assay must be collected after surgery (and recommended at least 14 days post surgery).
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  • Tumor must be documented as microsatellite stable or have intact mismatch repair proteins through CLIA-approved laboratory testing. Patients whose tumors are MSI-H or dMMR are excluded.
  • The treating investigator must deem the patient a candidate for all potential agents used in this trial (5FU, LV, oxaliplatin and irinotecan).
  • The interval between surgery (post-operative Day 7) and Step 1/Study entry must be no more than 60 days. NOTE: Step 1/Study Entry may occur as early as post operative Day 7, but it cannot occur beyond 60 days from the actual date of the patient's surgery.
  • Availability and provision of adequate surgical tumor tissue for molecular diagnostics and confirmatory profiling.
  • Adequate hematologic function within 28 days before Step 1/Study entry defined as follows:
  • Absolute neutrophil count (ANC) must be greater than or equal to 1500/mm3;
  • Participants with benign ethnic neutropenia (BEN): ANC less than 1300 mm3 are eligible.
  • BEN (also known as constitutional neutropenia) is an inherited cause of mild or moderate neutropenia that is not associated with any increased risk for infections or other clinical manifestations. BEN is referred to as ethnic neutropenia because of its increased prevalence in people of African descent and other specific ethnic groups.
  • Platelet count must be greater than or equal to 100,000/mm3; and
  • Hemoglobin must be greater than or equal to 9 g/dL.
  • Adequate hepatic function within 28 days before Step 1/Study entry defined as follows:
  • total bilirubin must be less than or equal to ULN (upper limit of normal) for the lab and
  • alkaline phosphatase must be less than 2.5 x ULN for the lab; and
  • AST and ALT must be less than 2.5 x ULN for the lab.
  • Adequate renal function within 28 days before Step 1/Study entry defined as serum creatinine less than or equal to 1.5 x ULN for the lab or measured or calculated creatinine clearance greater than or equal to 50 mL/min using the Cockroft-Gault formula for patients with creatinine levels greater than 1.5 x ULN for the lab.
  • For Women Creatinine Clearance (mL/min) = (140 - age) x weight (kg) x 0.85 72 x serum creatinine (mg/dL) For Men Creatinine Clearance (mL/min) = (140 - age) x weight (kg) 72 x serum creatinine (mg/dL) NOTE: Adjusted body weight (AdjBW) should be used for patients that have BMI greater than or equal to 28 (less than or equal to 30% above IBW).
  • HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
  • Pregnancy test (urine or serum according to institutional standard) done within 14 days before Step 1/Study entry must be negative (for women of childbearing potential only).
  • Patients receiving a coumarin-derivative anticoagulant must agree to weekly monitoring of INR if they are randomized to Arm 1 or Arm 3 and receive capecitabine.
  • Eligibility Criteria for Cohort A Arm-2 patients on Second Randomization
  • Patient must have developed a ctDNA +ve assay during serial monitoring.
  • Patient's willingness to be re-randomized affirmed.
  • The patient must continue to have an ECOG performance status of 0 or 1.
  • No radiographic evidence of overt metastatic disease.
  • Pregnancy test (urine or serum according to institutional standard) done within 14 days before second randomization must be negative (for women of childbearing potential only).
  • Adequate hematologic function within 28 days before second randomization defined as follows:
  • Absolute neutrophil count (ANC) must be greater than or equal to 1500/mm3;
  • Participants with benign ethnic neutropenia (BEN): ANC less than 1300 mm3 are eligible.
  • BEN (also known as constitutional neutropenia) is an inherited cause of mild or moderate neutropenia that is not associated with any increased risk for infections or other clinical manifestations. BEN is referred to as ethnic neutropenia because of its increased prevalence in people of African descent and other specific ethnic groups.
  • Platelet count must be greater than or equal to 100,000/mm3; and
  • Hemoglobin must be greater than or equal to 9 g/dL.
  • Adequate hepatic function within 28 days before second randomization defined as follows:
  • total bilirubin must be less than or equal to ULN (upper limit of normal) for the lab and
  • alkaline phosphatase must be less than 2.5 x ULN for the lab; and
  • AST and ALT must be less than 2.5 x ULN for the lab.
  • Adequate renal function within 28 days before second randomization defined as serum creatinine less than or equal to 1.5 x ULN for the lab or measured or calculated creatinine clearance greater than or equal to 50 mL/min using the Cockroft-Gault formula for patients with creatinine levels greater than 1.5 x ULN for the lab.
  • For Women Creatinine Clearance (mL/min) = (140 - age) x weight (kg) x 0.85 72 x serum creatinine (mg/dL) For Men Creatinine Clearance (mL/min) = (140 - age) x weight (kg) 72 x serum creatinine (mg/dL)

Who cannot join

  • Colon cancer histology other than adenocarcinoma (i.e., neuroendocrine carcinoma, sarcoma, lymphoma, squamous cell carcinoma, etc.).
  • Pathologic, clinical, or radiologic overt evidence of metastatic disease. This includes isolated, distant, or non-contiguous intra-abdominal metastases, even if resected.
  • Tumor-related bowel perforation.
  • History of prior invasive colon malignancy, regardless of disease-free interval.
  • History of bone marrow or solid organ transplantation (regardless of current immunosuppressive therapy needs). Bone grafts, skin grafts, corneal transplants and organ/tissue donation are not exclusionary.
  • Any prior systemic chemotherapy, targeted therapy, or immunotherapy; or radiation therapy administered as treatment for colorectal cancer (e.g., primary colon adenocarcinomas for which treatment with neoadjuvant chemotherapy and/or radiation is warranted are not permitted). EXCEPTION: one cycle of chemotherapy (regimen per treating physicians' discretion - 5-FU or capecitabine with or without oxaliplatin) is allowed but not required after consent. The optional cycle of chemotherapy should be started greater than or equal to 4 weeks from surgery and while awaiting Step 2 randomization.
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  • Other invasive malignancy within 5 years before Step 1/Study entry. Exceptions are colonic polyps, non-melanoma skin cancer or any carcinoma-in-situ.
  • Synchronous primary rectal and/ or colon cancers.
  • Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better.
  • Sensory or motor neuropathy greater than or equal to grade 2, according to CTCAE v5.0.
  • Blood transfusion within two weeks before collection of blood for central ctDNA testing.
  • Active seizure disorder uncontrolled by medication.
  • Active or chronic infection requiring systemic therapy.
  • Known homozygous DPD (dihydropyrimidine dehydrogenase) deficiency.
  • Patients known to have Gilbert's Syndrome or homozygosity for UGT1A128 polymorphism.
  • Pregnancy or lactation at the time of Step 1/Study entry.
  • Co-morbid illnesses or other concurrent disease that would make the patient inappropriate for entry into this study (i.e., unable to tolerate 6 months of combination chemotherapy or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens or prevent required follow-up).
  • Ineligibility Criteria for Cohort A Arm-2 patients on Second Randomization
  • Pregnancy or lactation at the time of randomization.
  • No longer a candidate for systemic chemotherapy (FOLFOX, CAPOX, and mFOLFIRINOX) in the opinion of the treating investigator.

Trial locations and contacts

1,085 sites in 3 countries. Contact the study team or a site near you to ask about taking part.

Judy Langer contact

412-339-5300

langerj@nrgoncology.org

Langer contact

340 sites in 3 countries

United States300 sites, 257 recruiting

  • Hawaii Cancer Care - Westridge

    ‘Aiea, Hawaii, 96701

    Site Public Contact, 808-539-2273, info@hawaiicancercare.com

    Jared D. Acoba

    Recruiting

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, 96701

    Site Public Contact, 808-486-6000

    Jared D. Acoba

    Recruiting

  • The Queen's Medical Center - West Oahu

    ‘Ewa Beach, Hawaii, 96706

    Site Public Contact, rohta@queens.org

    Jared D. Acoba

    Recruiting

  • Abbeville General Hospital

    Abbeville, Louisiana, 70510

    Site Public Contact, 337-898-6413

    Augusto C. Ochoa

    Recruiting

  • UM Upper Chesapeake Hematology and Oncology - Aberdeen

    Aberdeen, Maryland, 21001

    Site Public Contact, 443-643-1029, nfadrwoski@umm.edu

    Ashkan Bahrani

    Recruiting

  • Avera Cancer Institute-Aberdeen

    Aberdeen, South Dakota, 57401

    Site Public Contact, 605-622-8700, oncregulatory@avera.org

    Heidi A. McKean

    Recruiting

  • Summa Health System - Akron Campus

    Akron, Ohio, 44304

    Site Public Contact, 330-375-4221, cancerresearch@summahealth.org

    Bradley T. Clifford

    Recruiting

  • Cleveland Clinic Akron General

    Akron, Ohio, 44307

    Site Public Contact, 866-223-8100, CancerAnswer@ccf.org

    Judy Peih-Ying Tsai

    Recruiting

  • Phoebe Putney Memorial Hospital

    Albany, Georgia, 31701

    Site Public Contact, 229-312-0405, ga_cares@augusta.edu

    Anand P. Jillella

    Recruiting

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106

    Site Public Contact, 505-925-0348, HSC-ClinicalTrialInfo@salud.unm.edu

    Alissa Greenbaum

    Recruiting

  • Presbyterian Kaseman Hospital

    Albuquerque, New Mexico, 87110

    Site Public Contact, 505-559-6113, WBurman@phs.org

    Alissa Greenbaum

    Recruiting

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania, 18103

    Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org

    Tareq Al baghdadi

    Recruiting

  • Aultman Alliance Community Hospital

    Alliance, Ohio, 44601

    Site Public Contact, 330-363-1250

    Raza A. Khan

    Recruiting

  • AdventHealth Altamonte

    Altamonte Springs, Florida, 32701

    Site Public Contact, 407-303-2200

    Mohamedtaki A. Tejani

    Recruiting

  • OSF Saint Anthony's Health Center

    Alton, Illinois, 62002

    Site Public Contact, 618-463-5623

    Jay W. Carlson

    Recruiting

  • UPMC Altoona

    Altoona, Pennsylvania, 16601

    Site Public Contact, 412-339-5294, Roster@nrgoncology.org

    Anwaar Saeed

    Recruiting

  • The Don and Sybil Harrington Cancer Center

    Amarillo, Texas, 79106

    Site Public Contact, 806-212-1985, Gina.Cravey@bsahs.org

    Anita Ravipati

    Recruiting

  • American Fork Hospital / Huntsman Intermountain Cancer Center

    American Fork, Utah, 84003

    Site Public Contact, 801-855-4100, officeofresearch@imail.org

    Ramya Thota

    Recruiting

  • Mary Greeley Medical Center

    Ames, Iowa, 50010

    Site Public Contact, 515-956-4132

    Joseph J. Merchant

    Recruiting

  • McFarland Clinic - Ames

    Ames, Iowa, 50010

    Site Public Contact, 515-239-4734, ksoder@mcfarlandclinic.com

    Joseph J. Merchant

    Recruiting

  • Community Hospital of Anaconda

    Anaconda, Montana, 59711

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Kaiser Permanente-Anaheim

    Anaheim, California, 92806

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Gary L. Buchschacher

    Recruiting

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa, 50023

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan, 48106

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan, 48109

    Site Public Contact, 800-865-1125, CancerAnswerLine@med.umich.edu

    John C. Krauss

    Recruiting

  • Aspirus Cancer Care-Antigo-Volm Cancer Center

    Antigo, Wisconsin, 54409

    Site Public Contact, 715-623-9869, Juli.Alford@aspirus.org

    Andrew J. Huang

    Recruiting

  • Kaiser Permanente-Deer Valley Medical Center

    Antioch, California, 94531

    Site Public Contact, 877-642-4691, Kpoct@kp.org

    Tatjana Kolevska

    Recruiting

  • ThedaCare Regional Cancer Center

    Appleton, Wisconsin, 54911

    Site Public Contact, 920-364-3604, ResearchDept@thedacare.org

    Matthias Weiss

    Recruiting

  • Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton

    Appleton, Wisconsin, 54915

    Site Public Contact, AWRI.inquiry@ascension.org

    Shannon Offerman

    Recruiting

  • Mission Hope Medical Oncology - Arroyo Grande

    Arroyo Grande, California, 93420

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • PCR Oncology

    Arroyo Grande, California, 93420

    Site Public Contact, 702-384-0013, research@sncrf.org

    Khawaja S. Jahangir

    Recruiting

  • Duluth Clinic Ashland

    Ashland, Wisconsin, 54806

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • University Cancer and Blood Center LLC

    Athens, Georgia, 30607

    Site Public Contact, research@universitycancer.com

    Anand P. Jillella

    Recruiting

  • Piedmont Hospital

    Atlanta, Georgia, 30309

    Active, not recruiting

  • Northside Hospital

    Atlanta, Georgia, 30342

    Site Public Contact, 404-303-3355, ClinicalTrials@northside.com

    Aldemar Montero

    Recruiting

  • Sutter Auburn Faith Hospital

    Auburn, California, 95602

    Site Public Contact, clinicalresearch@sutterhealth.org

    Jorge A. Garcia-Young

    Recruiting

  • Sutter Cancer Centers Radiation Oncology Services-Auburn

    Auburn, California, 95603

    Site Public Contact, clinicalresearch@sutterhealth.org

    Jorge A. Garcia-Young

    Recruiting

  • Harold Alfond Center for Cancer Care

    Augusta, Maine, 04330

    Site Public Contact, 207-626-4855

    Na Liu

    Recruiting

  • UCHealth University of Colorado Hospital

    Aurora, Colorado, 80045

    Site Public Contact, 720-848-0650

    Christopher H. Lieu

    Recruiting

  • Rush-Copley Medical Center

    Aurora, Illinois, 60504

    Suspended

  • Advocate Outpatient Center - Aurora

    Aurora, Illinois, 60506

    Site Public Contact, ncorp@aah.org

    Antony Ruggeri

    Recruiting

  • Dell Seton Medical Center at The University of Texas

    Austin, Texas, 78701

    Site Public Contact, 512-324-7991

    Om N. Pandey

    Recruiting

  • University of Texas at Austin

    Austin, Texas, 78712

    Site Public Contact, 512-232-1543, irb@austin.utexas.edu

    Om N. Pandey

    Recruiting

  • Avon - Richard E Jacobs Health Center

    Avon, Ohio, 44011

    Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

    Kanika Nair

    Recruiting

  • UH Seidman Cancer Center at UH Avon Health Center

    Avon, Ohio, 44011

    Suspended

  • AIS Cancer Center at San Joaquin Community Hospital

    Bakersfield, California, 93301

    Site Public Contact, 661-323-4673

    Ricardo Salas

    Recruiting

  • Kaiser Permanente-Baldwin Park

    Baldwin Park, California, 91706

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Gary L. Buchschacher

    Recruiting

  • Mercy Oncology and Hematology - Clayton-Clarkson

    Ballwin, Missouri, 63011

    Site Public Contact, 888-446-3729

    Jay W. Carlson

    Recruiting

  • Greater Baltimore Medical Center

    Baltimore, Maryland, 21204

    Site Public Contact, 443-849-3706

    Gang Chen

    Recruiting

  • Sinai Hospital of Baltimore

    Baltimore, Maryland, 21215

    Site Public Contact, 410-601-9083

    Pallavi P. Kumar

    Recruiting

  • Saint Agnes Hospital

    Baltimore, Maryland, 21229

    Site Public Contact, 410-368-2910

    Carole B. Miller

    Recruiting

  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute

    Baltimore, Maryland, 21237

    Site Public Contact, 443-777-7364

    Benjamin A. Weinberg

    Recruiting

  • MedStar Good Samaritan Hospital

    Baltimore, Maryland, 21239

    Site Public Contact, 410-261-8151, Barbara.rector@medstar.net

    Benjamin A. Weinberg

    Recruiting

  • Kaiser Permanente-Woodlawn Medical Center

    Baltimore, Maryland, 21244

    Site Public Contact, 240-632-4285, Charmaine.A.Mckie@kp.org

    James Liu

    Recruiting

  • Summa Health System - Barberton Campus

    Barberton, Ohio, 44203

    Site Public Contact, 330-375-4221, cancerresearch@summahealth.org

    Bradley T. Clifford

    Recruiting

  • CommonSpirit Saint Joseph Hospital - Bardstown

    Bardstown, Kentucky, 40004

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Advocate Good Shepherd Hospital

    Barrington, Illinois, 60010

    Site Public Contact, 847-842-4847

    Antony Ruggeri

    Recruiting

  • LSU Health Baton Rouge-North Clinic

    Baton Rouge, Louisiana, 70805

    Site Public Contact, 225-765-7659, research@ololrmc.com

    Marshall P. Stagg

    Recruiting

  • Our Lady of the Lake Physician Group

    Baton Rouge, Louisiana, 70808

    Site Public Contact, 225-765-7659, research@ololrmc.com

    Marshall P. Stagg

    Recruiting

  • Medical Center of Baton Rouge

    Baton Rouge, Louisiana, 70816

    Site Public Contact, 225-761-5346, Camille.Beck@Ochsner.org

    Lingling Du

    Recruiting

  • Ochsner High Grove

    Baton Rouge, Louisiana, 70836

    Site Public Contact, 225-761-5346, Camielle.beck@ochsner.org

    Lingling Du

    Recruiting

  • Bronson Battle Creek

    Battle Creek, Michigan, 49017

    Site Public Contact, 616-391-1230, crcwm-regulatory@crcwm.org

    Kathleen Y. Butler

    Recruiting

  • UHHS-Chagrin Highlands Medical Center

    Beachwood, Ohio, 44122

    Suspended

  • UPMC-Heritage Valley Health System Beaver

    Beaver, Pennsylvania, 15009

    Site Public Contact, 412-389-5208, haneydl@upmc.edu

    Anwaar Saeed

    Recruiting

  • Indu and Raj Soin Medical Center

    Beavercreek, Ohio, 45431

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Howard M. Gross

    Recruiting

  • UM Upper Chesapeake Medical Center

    Bel Air, Maryland, 21014

    Site Public Contact, 443-643-3010

    Ashkan Bahrani

    Recruiting

  • FHCC Overlake

    Bellevue, Washington, 98004

    Site Public Contact, 425-454-2148

    Nancy Y. Cui

    Recruiting

  • Kaiser Permanente-Bellflower

    Bellflower, California, 90706

    Site Public Contact, 800-398-3996, clinical.trials@kp.org

    Gary L. Buchschacher

    Recruiting

  • Strecker Cancer Center-Belpre

    Belpre, Ohio, 45714

    Site Public Contact, 614-488-2745, Jeffh@columbusccop.org

    Aruna C. Gowda

    Recruiting

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601

    Site Public Contact, 218-333-5000, OncologyClinicalTrialsFargo@sanfordhealth.org

    Daniel Almquist

    Recruiting

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California, 94704

    Site Public Contact, clinicalresearch@sutterhealth.org

    Jorge A. Garcia-Young

    Recruiting

  • Summit Medical Group

    Berkeley Heights, New Jersey, 07922

    Suspended

  • ThedaCare Cancer Care - Berlin

    Berlin, Wisconsin, 54923

    Site Public Contact, 920-364-3605, ResearchDept@thedacare.org

    Matthias Weiss

    Recruiting

  • Central Vermont Medical Center/National Life Cancer Treatment

    Berlin Corners, Vermont, 05602

    Site Public Contact, 802-225-5400

    Jeremy Dressler

    Recruiting

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania, 18017

    Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org

    Tareq Al baghdadi

    Recruiting

  • University of Iowa Healthcare Cancer Services Quad Cities

    Bettendorf, Iowa, 52722

    Site Public Contact, 563-355-7733, katherine-daprile@uiowa.edu

    Saima Sharif

    Recruiting

  • Beverly Hospital

    Beverly, Massachusetts, 01915

    Site Public Contact, 978-922-3000 ext. 2405

    Karl J. D'Silva

    Recruiting

  • Tower Cancer Research Foundation

    Beverly Hills, California, 90211

    Site Public Contact, towercancerresearch@toweroncology.com

    Jun Gong

    Recruiting

  • MaineHealth Maine Medical Center - Biddeford

    Biddeford, Maine, 04005

    Suspended

  • Billings Clinic Cancer Center

    Billings, Montana, 59101

    Site Public Contact, 800-996-2663, research@billingsclinic.org

    John M. Schallenkamp

    Recruiting

  • Saint Vincent Frontier Cancer Center

    Billings, Montana, 59102

    Site Public Contact, 800-648-6274

    Ramya Thota

    Recruiting

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233

    Active, not recruiting

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501

    Site Public Contact, 701-323-5760, OncologyClinicalTrialsFargo@sanfordhealth.org

    Daniel Almquist

    Recruiting

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Saint Elizabeth Boardman Hospital

    Boardman, Ohio, 44512

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Howard M. Gross

    Recruiting

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina, 29316

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, 83706

    Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712

    Site Public Contact, 208-381-2774, eslinget@slhs.org

    Dan S. Zuckerman

    Recruiting

  • Central Care Cancer Center - Bolivar

    Bolivar, Missouri, 65613

    Site Public Contact, 913-948-5588, aroland@kccop.org

    Jay W. Carlson

    Recruiting

  • McFarland Clinic - Boone

    Boone, Iowa, 50036

    Suspended

  • Tufts Medical Center

    Boston, Massachusetts, 02111

    Site Public Contact, 617-636-5000, ContactUsCancerCenter@TuftsMedicalCenter.org

    Jacob M. Elkon

    Recruiting

  • Boston Medical Center

    Boston, Massachusetts, 02118

    Active, not recruiting

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Essentia Health Saint Joseph's Medical Center

    Brainerd, Minnesota, 56401

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Cox Cancer Center Branson

    Branson, Missouri, 65616

    Site Public Contact, 417-269-4520

    Jay W. Carlson

    Recruiting

  • United Hospital Center

    Bridgeport, West Virginia, 26330

    Site Public Contact, 304-293-7374, cancertrialsinfo@hsc.wvu.edu

    Nour Daboul

    Recruiting

  • Intermountain Health Platte Valley Hospital

    Brighton, Colorado, 80601

    Site Public Contact, peaksresearch@imail.org

    Ramya Thota

    Recruiting

  • Dana-Farber Cancer Institute at Boston Medical Center - Brighton

    Brighton, Massachusetts, 02135

    Site Public Contact, 617-789-2903

    Alys Malcolm

    Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan, 48114

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan, 48114

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield

    Brookfield, Wisconsin, 53045

    Site Public Contact, AWRI.Inquiry@Ascension.org

    Shannon Offerman

    Recruiting

  • New York-Presbyterian/Brooklyn Methodist Hospital

    Brooklyn, New York, 11215

    Site Public Contact, 718-780-3677, Adg9003@nyp.org

    Uqba Khan

    Recruiting

  • Saint Joseph Regional Cancer Center

    Bryan, Texas, 77802

    Suspended

  • Saint Anne Hospital

    Burien, Washington, 98166

    Suspended

  • Kaiser Permanente-Burke Medical Center

    Burke, Virginia, 22015

    Site Public Contact, 240-632-4285, Charmaine.A.Mckie@kp.org

    James Liu

    Recruiting

  • Mills-Peninsula Medical Center

    Burlingame, California, 94010

    Site Public Contact, clinicalresearch@sutterhealth.org

    Jorge A. Garcia-Young

    Recruiting

  • Lahey Clinic

    Burlington, Massachusetts, 01805

    Site Public Contact, 781-744-3421, lhmc-cancer-clinical-trials@lahey.org

    Karl J. D'Silva

    Recruiting

  • University of Vermont Medical Center

    Burlington, Vermont, 05401

    Site Public Contact, 802-656-4101, rpo@uvm.edu

    Jeremy Dressler

    Recruiting

  • University of Vermont and State Agricultural College

    Burlington, Vermont, 05405

    Site Public Contact, 802-656-8990, rpo@uvm.edu

    Jeremy Dressler

    Recruiting

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin, 53105

    Site Public Contact, 414-302-2304, ncorp@aurora.org

    Antony Ruggeri

    Recruiting

  • Fairview Ridges Hospital

    Burnsville, Minnesota, 55337

    Suspended

  • Minnesota Oncology - Burnsville

    Burnsville, Minnesota, 55337

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    Joleen M. Hubbard

    Recruiting

  • UPMC Hillman Cancer Center at Butler Health System

    Butler, Pennsylvania, 16001

    Site Public Contact, 412-389-5208, haneydl@upmc.edu

    Anwaar Saeed

    Recruiting

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, 83605

    Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Cambridge Medical Center

    Cambridge, Minnesota, 55008

    Suspended

  • Marshall Cancer Center

    Cameron Park, California, 95682

    Site Public Contact, 530-672-7050, cancerservices@marshallmedical.org

    Edward J. Kim

    Recruiting

  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park

    Cameron Park, California, 95682

    Site Public Contact, clinicalresearch@sutterhealth.org

    Jorge A. Garcia-Young

    Recruiting

  • UPMC Camp Hill

    Camp Hill, Pennsylvania, 17011

    Active, not recruiting

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan, 48188

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Trinity Health Medical Center - Canton

    Canton, Michigan, 48188

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Cleveland Clinic Mercy Hospital

    Canton, Ohio, 44708

    Site Public Contact, 888-293-4673

    Mitchell Haut

    Recruiting

  • Aultman Health Foundation

    Canton, Ohio, 44710

    Site Public Contact, 330-363-7274, ClinicalReserachDept@aultman.com

    Raza A. Khan

    Recruiting

  • Mercy Cancer Center - Cape Girardeau

    Cape Girardeau, Missouri, 63703

    Site Public Contact, 888-446-3729

    Jay W. Carlson

    Recruiting

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703

    Site Public Contact, 573-334-2230, sfmc@sfmc.net

    Bryan A. Faller

    Recruiting

  • AtlantiCare Health Park-Cape May Court House

    Cape May Court House, New Jersey, 08210

    Site Public Contact, 609-677-7735

    Devon S. Mckenzie

    Recruiting

  • Memorial Hospital of Carbondale

    Carbondale, Illinois, 62902

    Site Public Contact, 618-457-5200, clinical.research@sih.net

    Bryan A. Faller

    Recruiting

  • Carlisle Regional Cancer Center

    Carlisle, Pennsylvania, 17015

    Site Public Contact, 412-339-5294, Roster@nrgoncology.org

    Anwaar Saeed

    Recruiting

  • Mercy Cancer Center - Carmichael

    Carmichael, California, 95608

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Mercy San Juan Medical Center

    Carmichael, California, 95608

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@commonspirit.org

    Loretta J. Nastoupil

    Recruiting

  • Caro Cancer Center

    Caro, Michigan, 48723

    Suspended

  • Saint Anthony Regional Hospital

    Carroll, Iowa, 51401

    Site Public Contact, 515-689-7658, sbenson@iora.org

    Seema Harichand-Herdt

    Recruiting

  • Carson Tahoe Regional Medical Center

    Carson City, Nevada, 89703

    Site Public Contact, 702-384-0013, research@sncrf.org

    Khawaja S. Jahangir

    Recruiting

  • SIH Cancer Institute

    Carterville, Illinois, 62918

    Site Public Contact, 618-985-3333, clinical.research@sih.net

    Bryan A. Faller

    Recruiting

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321

    Site Public Contact, 309-243-3605, andersonj@illinoiscancercare.com

    Bryan A. Faller

    Recruiting

  • Duke Cancer Center Cary

    Cary, North Carolina, 27518

    Site Public Contact, NCTNStudyTeam@dm.duke.edu

    Aman Opneja

    Recruiting

  • UNC Health Cancer Care Cary

    Cary, North Carolina, 27518

    Site Public Contact, 919-784-2500, CancCtrOncologyClinicalResearch@unchealth.unc.edu

    Ranjit Joseph

    Recruiting

  • Waverly Hematology Oncology

    Cary, North Carolina, 27518

    Site Public Contact, 919-350-1700, TCHILDRESS@wakemed.org

    Vijay Chaudhary

    Recruiting

  • Eden Hospital Medical Center

    Castro Valley, California, 94546

    Site Public Contact, clinicalresearch@sutterhealth.org

    Jorge A. Garcia-Young

    Recruiting

  • Sandra L Maxwell Cancer Center

    Cedar City, Utah, 84720

    Site Public Contact, 435-868-5680, officeofresearch@imail.org

    Ramya Thota

    Recruiting

  • Physicians' Clinic of Iowa PC

    Cedar Rapids, Iowa, 52402

    Site Public Contact, 319-297-2900

    Bharat Jenigiri

    Recruiting

  • Mercy Hospital

    Cedar Rapids, Iowa, 52403

    Site Public Contact, 319-365-4673

    Deborah W. Wilbur

    Recruiting

  • Oncology Associates at Mercy Medical Center

    Cedar Rapids, Iowa, 52403

    Site Public Contact, 319-363-2690

    Deborah W. Wilbur

    Recruiting

  • AdventHealth Celebration

    Celebration, Florida, 34747

    Site Public Contact, 407-303-4120

    Mohamedtaki A. Tejani

    Recruiting

  • Dayton Physicians LLC-Miami Valley South

    Centerville, Ohio, 45459

    Suspended

  • Miami Valley Hospital South

    Centerville, Ohio, 45459

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801

    Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com

    Bryan A. Faller

    Recruiting

  • WellSpan Medical Oncology and Hematology

    Chambersburg, Pennsylvania, 17201

    Site Public Contact, 717-217-6020

    Marianne Spengler

    Recruiting

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599

    Site Public Contact, 877-668-0683, cancerclinicaltrials@med.unc.edu

    Hanna K. Sanoff

    Recruiting

  • Geauga Hospital

    Chardon, Ohio, 44024

    Suspended

  • Roper Hospital

    Charleston, South Carolina, 29401

    Active, not recruiting

  • Charleston Oncology - Roper

    Charleston, South Carolina, 29403

    Active, not recruiting

  • Bon Secours Saint Francis Hospital

    Charleston, South Carolina, 29414

    Active, not recruiting

  • Charleston Oncology - Saint Francis

    Charleston, South Carolina, 29414

    Active, not recruiting

  • Medical University of South Carolina

    Charleston, South Carolina, 29425

    Site Public Contact, 843-792-9321, hcc-clinical-trials@musc.edu

    Toros Dincman

    Recruiting

  • Vandalia Health/CAMC Institute for Academic Medicine

    Charleston, West Virginia, 25304

    Site Public Contact, 304-388-9944, CAMCClinicalTrials@vandaliahealth.org

    Anahat Kaur

    Recruiting

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina, 28203

    Site Public Contact, 800-804-9376

    Kunal C. Kadakia

    Recruiting

  • Atrium Health Pineville/LCI-Pineville

    Charlotte, North Carolina, 28210

    Site Public Contact, 980-442-2000

    Kunal C. Kadakia

    Recruiting

  • Levine Cancer Institute-SouthPark

    Charlotte, North Carolina, 28211

    Site Public Contact, 980-442-2000

    Kunal C. Kadakia

    Recruiting

  • Atrium Health University City/LCI-University

    Charlotte, North Carolina, 28262

    Site Public Contact, 800-804-9376

    Kunal C. Kadakia

    Recruiting

  • Levine Cancer Institute-Ballantyne

    Charlotte, North Carolina, 28277

    Site Public Contact, 800-804-9376

    Kunal C. Kadakia

    Recruiting

  • Minnesota Oncology Hematology PA-Chaska

    Chaska, Minnesota, 55318

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    Joleen M. Hubbard

    Recruiting

  • Chelsea Hospital

    Chelsea, Michigan, 48118

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan, 48118

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Jefferson Cherry Hill Hospital

    Cherry Hill, New Jersey, 08002

    Site Public Contact, 215-600-9151, ONCTrialNow@jefferson.edu

    Steven J. Cohen

    Recruiting

  • Cancer Specialists of Tidewater Limited

    Chesapeake, Virginia, 23320

    Site Public Contact, 757-534-6863, casey.morris@rivhs.com

    Khalid Matin

    Recruiting

  • Mount Sinai Hospital Medical Center

    Chicago, Illinois, 60608

    Site Public Contact, 773-257-5960, suhi@sinai.org

    Pam G. Khosla

    Recruiting

  • Northwestern University

    Chicago, Illinois, 60611

    Site Public Contact, 312-695-1301, cancer@northwestern.edu

    Mary F. Mulcahy

    Recruiting

  • John H Stroger Jr Hospital of Cook County

    Chicago, Illinois, 60612

    Site Public Contact, 312-864-5204

    Deimante M. Tamkus

    Recruiting

  • Rush MD Anderson Cancer Center

    Chicago, Illinois, 60612

    Site Public Contact, 312-226-2371, Cancer_Studies@rush.edu

    Audrey Kam

    Recruiting

  • University of Illinois

    Chicago, Illinois, 60612

    Site Public Contact, 312-355-3046

    Shikha Jain

    Recruiting

  • Swedish Covenant Hospital

    Chicago, Illinois, 60625

    Site Public Contact, 773-878-8200

    Carolina Soto Chervin

    Recruiting

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637

    Site Public Contact, 773-702-8222, cancerclinicaltrials@bsd.uchicago.edu

    Blase N. Polite

    Recruiting

  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois, 60657

    Site Public Contact, 773-296-5360

    Antony Ruggeri

    Recruiting

  • Enloe Medical Center

    Chico, California, 95926

    Site Public Contact, 530-332-4700

    Edward J. Kim

    Recruiting

  • Adena Regional Medical Center

    Chillicothe, Ohio, 45601

    Site Public Contact, 877-779-7585, Jeffh@columbusccop.org

    Aruna C. Gowda

    Recruiting

  • Ascension Calumet Hospital-Chilton

    Chilton, Wisconsin, 53014

    Site Public Contact, AWRI.inquiry@ascension.org

    Shannon Offerman

    Recruiting

  • Marshfield Clinic-Chippewa Center

    Chippewa Falls, Wisconsin, 54729

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Michael Husak

    Recruiting

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219

    Site Public Contact, 513-584-7698, cancer@uchealth.com

    Adam Rojan

    Recruiting

  • Good Samaritan Hospital - Cincinnati

    Cincinnati, Ohio, 45220

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Oncology Hematology Care Inc-Kenwood

    Cincinnati, Ohio, 45236

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Howard M. Gross

    Recruiting

  • Bethesda North Hospital

    Cincinnati, Ohio, 45242

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • TriHealth Cancer Institute-Westside

    Cincinnati, Ohio, 45247

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • TriHealth Cancer Institute-Anderson

    Cincinnati, Ohio, 45255

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Moh'd Khushman

    Recruiting

  • Clackamas Radiation Oncology Center

    Clackamas, Oregon, 97015

    Site Public Contact, 503-215-2614, CanRsrchStudies@providence.org

    Dan S. Zuckerman

    Recruiting

  • Providence Cancer Institute Clackamas Clinic

    Clackamas, Oregon, 97015

    Suspended

  • Hematology Oncology Consultants-Clarkston

    Clarkston, Michigan, 48346

    Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org

    Tareq Al baghdadi

    Recruiting

  • Newland Medical Associates-Clarkston

    Clarkston, Michigan, 48346

    Suspended

  • Morton Plant Hospital

    Clearwater, Florida, 33756

    Site Public Contact, 855-314-8646

    Hassan M. Ebrahim

    Recruiting

  • Case Western Reserve University

    Cleveland, Ohio, 44106

    Suspended

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109

    Active, not recruiting

  • Cleveland Clinic Cancer Center/Fairview Hospital

    Cleveland, Ohio, 44111

    Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

    Kanika Nair

    Recruiting

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195

    Site Public Contact, 866-223-8100, TaussigResearch@ccf.org

    Kanika Nair

    Recruiting

  • MedStar Southern Maryland Hospital Center

    Clinton, Maryland, 20735

    Site Public Contact, 301-877-4673

    Benjamin A. Weinberg

    Recruiting

  • Southeastern Medical Oncology Center-Clinton

    Clinton, North Carolina, 28328

    Site Public Contact, 919-587-9084, jfields@cancersmoc.com

    Samer S. Kasbari

    Recruiting

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325

    Site Public Contact, 515-241-3305

    Richard L. Deming

    Recruiting

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa, 50325

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Kootenai Health - Coeur d'Alene

    Coeur d'Alene, Idaho, 83814

    Site Public Contact, 406-969-6060, mccinfo@mtcancer.org

    John M. Schallenkamp

    Recruiting

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee, 38017

    Site Public Contact, 901-226-1366, BCCclintrials@bmhcc.org

    Sohail A. Minhas

    Recruiting

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, 80907

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado, 80907

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado, 80909

    Site Public Contact, 719-365-2406

    Christopher H. Lieu

    Recruiting

  • Memorial Hospital North

    Colorado Springs, Colorado, 80920

    Site Public Contact, 719-364-6700

    Christopher H. Lieu

    Recruiting

  • Saint Francis Cancer Center

    Colorado Springs, Colorado, 80923

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • MU Health - University Hospital/Ellis Fischel Cancer Center

    Columbia, Missouri, 65212

    Site Public Contact, 573-882-7440

    RuoBing Xue

    Recruiting

  • Baptist Memorial Hospital and Cancer Center-Golden Triangle

    Columbus, Mississippi, 39705

    Site Public Contact, 901-226-1366, BCCclintrials@bmhcc.org

    Sohail A. Minhas

    Recruiting

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210

    Site Public Contact, 800-293-5066, Jamesline@osumc.edu

    Pannaga Malalur

    Recruiting

  • Mount Carmel East Hospital

    Columbus, Ohio, 43213

    Site Public Contact, 614-488-2745, Jeffh@columbusccop.org

    Aruna C. Gowda

    Recruiting

  • Columbus Oncology and Hematology Associates Inc

    Columbus, Ohio, 43214

    Suspended

  • Riverside Methodist Hospital

    Columbus, Ohio, 43214

    Suspended

  • Grant Medical Center

    Columbus, Ohio, 43215

    Suspended

  • The Mark H Zangmeister Center

    Columbus, Ohio, 43219

    Site Public Contact, 614-488-2745, Jeffh@columbusccop.org

    Aruna C. Gowda

    Recruiting

  • Mount Carmel Health Center West

    Columbus, Ohio, 43222

    Site Public Contact, 614-488-2745, Jeffh@columbusccop.org

    Aruna C. Gowda

    Recruiting

  • Doctors Hospital

    Columbus, Ohio, 43228

    Suspended

  • New Hampshire Oncology Hematology PA-Concord

    Concord, New Hampshire, 03301

    Site Public Contact, 603-224-2556

    Gina M. DiVenuti

    Recruiting

  • Atrium Health Cabarrus/LCI-Concord

    Concord, North Carolina, 28025

    Site Public Contact, 800-804-9376

    Kunal C. Kadakia

    Recruiting

  • UT MD Anderson - The Woodlands

    Conroe, Texas, 77384

    Site Public Contact, 866-632-6789, askmdanderson@mdanderson.org

    Nageshwara V. Dasari

    Recruiting

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    Joleen M. Hubbard

    Recruiting

  • Minnesota Oncology - Coon Rapids

    Coon Rapids, Minnesota, 55433

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    Joleen M. Hubbard

    Recruiting

  • Commonwealth Cancer Center-Corbin

    Corbin, Kentucky, 40701

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Alegent Health Mercy Hospital

    Council Bluffs, Iowa, 51503

    Suspended

  • Ochsner Hematology Oncology North Shore - Covington (West Region)

    Covington, Louisiana, 70433

    Site Public Contact, 985-809-5668, Cheryl.kesler@ochsner.org

    Lingling Du

    Recruiting

  • UPMC Hillman Cancer Center - Passavant - Cranberry

    Cranberry Township, Pennsylvania, 16066

    Site Public Contact, 412-389-5208, haneydl@upmc.edu

    Anwaar Saeed

    Recruiting

  • Greater Regional Medical Center

    Creston, Iowa, 50801

    Suspended

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141

    Site Public Contact, 800-600-3606, info@siteman.wustl.edu

    Moh'd Khushman

    Recruiting

  • Northwest Cancer Center - Crown Point

    Crown Point, Indiana, 46307

    Site Public Contact, 219-836-6879, CancerResearch@powershealth.org

    Suparna Mantha

    Recruiting

  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois, 60014

    Site Public Contact, 630-929-6129, advocateresearch@advocate.com

    Antony Ruggeri

    Recruiting

  • Aurora Saint Luke's South Shore

    Cudahy, Wisconsin, 53110

    Site Public Contact, 414-302-2304, ncorp@aurora.org

    Antony Ruggeri

    Recruiting

  • UPMC Western Maryland

    Cumberland, Maryland, 21502

    Site Public Contact, 240-964-1400

    Anwaar Saeed

    Recruiting

  • Parkland Memorial Hospital

    Dallas, Texas, 75235

    Site Public Contact, 214-590-5582, canceranswerline@UTSouthwestern.edu

    Nilesh Verma

    Recruiting

  • UT Southwestern Simmons Cancer Center - RedBird

    Dallas, Texas, 75237

    Site Public Contact, 214-648-7097, canceranswerline@utsouthwestern.edu

    Nilesh Verma

    Recruiting

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390

    Site Public Contact, 214-648-7097, canceranswerline@UTSouthwestern.edu

    Nilesh Verma

    Recruiting

  • Danbury Hospital

    Danbury, Connecticut, 06810

    Site Public Contact, 833-223-4732

    Wenli Gao

    Recruiting

  • Carle at The Riverfront

    Danville, Illinois, 61832

    Site Public Contact, 800-446-5532, Research@Carle.com

    Suparna Mantha

    Recruiting

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822

    Site Public Contact, 570-271-5251, cancerresearch@geisinger.edu

    Mina Makary

    Recruiting

  • Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis

    Daphne, Alabama, 36526

    Suspended

  • Sutter Davis Hospital

    Davis, California, 95616

    Site Public Contact, NCIclinicaltrials@sutterhealth.org

    Jorge A. Garcia-Young

    Recruiting

  • Miami Valley Hospital

    Dayton, Ohio, 45409

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Premier Blood and Cancer Center

    Dayton, Ohio, 45409

    Site Public Contact, 937-276-8320

    Tarek M. Sabagh

    Recruiting

  • Dayton Physician LLC - Englewood

    Dayton, Ohio, 45415

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Howard M. Gross

    Recruiting

  • Miami Valley Hospital North

    Dayton, Ohio, 45415

    Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org

    Tarek M. Sabagh

    Recruiting

  • Corewell Health Dearborn Hospital

    Dearborn, Michigan, 48124

    Site Public Contact, 248-551-7695

    Andrew A. Muskovitz

    Recruiting

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526

    Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com

    Bryan A. Faller

    Recruiting

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526

    Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com

    Bryan A. Faller

    Recruiting

  • Essentia Health - Deer River Clinic

    Deer River, Minnesota, 56636

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois, 60115

    Site Public Contact, 630-352-5360, Donald.Smith3@nm.org

    Mary F. Mulcahy

    Recruiting

  • Delaware Health Center-Grady Cancer Center

    Delaware, Ohio, 43015

    Suspended

  • Grady Memorial Hospital

    Delaware, Ohio, 43015

    Suspended

  • Denver Health Medical Center

    Denver, Colorado, 80204

    Site Public Contact, 303-777-2663, ccrp@co-cancerresearch.org

    Ankita Tandon

    Recruiting

  • Kaiser Permanente-Franklin

    Denver, Colorado, 80205

    Site Public Contact, 303-817-9295, KPCOIHRClinicalResearch@kp.org

    Matthew J. Eadens

    Recruiting

  • UCHealth - Cherry Creek

    Denver, Colorado, 80206

    Site Public Contact, 412-339-5294, Roster@nrgoncology.org

    Christopher H. Lieu

    Recruiting

  • AdventHealth Porter

    Denver, Colorado, 80210

    Suspended

  • Saint Joseph Hospital - Cancer Centers of Colorado

    Denver, Colorado, 80218

    Site Public Contact, 303-318-3413

    Ramya Thota

    Recruiting

  • Smilow Cancer Hospital-Derby Care Center

    Derby, Connecticut, 06418

    Site Public Contact, 203-785-5702, canceranswers@yale.edu

    Jeremy S. Kortmansky

    Recruiting

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309

    Site Public Contact, 515-241-6727

    Seema Harichand-Herdt

    Recruiting

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa, 50309

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314

    Site Public Contact, 515-241-3305

    Richard L. Deming

    Recruiting

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa, 50314

    Site Public Contact, 515-241-3305

    Seema Harichand-Herdt

    Recruiting

  • Henry Ford Health Saint John Hospital

    Detroit, Michigan, 48236

    Site Public Contact, 313-343-3166, Kkeenan1@hfhs.org

    Tareq Al baghdadi

    Recruiting

  • Essentia Health Saint Mary's - Detroit Lakes Clinic

    Detroit Lakes, Minnesota, 56501

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • Geisinger Cancer Center Dickson City

    Dickson City, Pennsylvania, 18519

    Site Public Contact, 877-204-6081, cancerresearch@geisinger.edu

    Mina Makary

    Recruiting

  • Dillon Health Center/Shaw Cancer Center

    Dillon, Colorado, 80435

    Site Public Contact, 970-470-7170

    Erin Schwab

    Recruiting

  • Illinois CancerCare-Dixon

    Dixon, Illinois, 61021

    Site Public Contact, 815-285-7800

    Bryan A. Faller

    Recruiting

  • Bayhealth Hospital Kent Campus

    Dover, Delaware, 19901

    Active, not recruiting

  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois, 60515

    Site Public Contact, 630-275-1270, Barbara.barhamand@advocatehealth.com

    Antony Ruggeri

    Recruiting

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010

    Site Public Contact, 800-826-4673, becomingapatient@coh.org

    Richard T. Lee

    Recruiting

  • Epic Care-Dublin

    Dublin, California, 94568

    Suspended

  • Kaiser Permanente Dublin

    Dublin, California, 94568

    Site Public Contact, 877-642-4691

    Tatjana Kolevska

    Recruiting

  • Columbus Oncology and Hematology Associates

    Dublin, Ohio, 43016

    Suspended

  • Dublin Methodist Hospital

    Dublin, Ohio, 43016

    Suspended

  • Northside Hospital - Duluth

    Duluth, Georgia, 30096

    Site Public Contact, 404-303-3355, Clinical.trials@northside.com

    Aldemar Montero

    Recruiting

  • Essentia Health Cancer Center

    Duluth, Minnesota, 55805

    Site Public Contact, 218-786-3308, CancerTrials@EssentiaHealth.org

    Bret E. Friday

    Recruiting

  • CommonSpirit Cancer Center Mercy

    Durango, Colorado, 81301

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Mercy Medical Center

    Durango, Colorado, 81301

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Duke University Medical Center

    Durham, North Carolina, 27710

    Site Public Contact, 888-275-3853

    Aman Opneja

    Recruiting

  • Northwest Oncology LLC

    Dyer, Indiana, 46311

    Site Public Contact, 219-924-8178

    Suparna Mantha

    Recruiting

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina, 29640

    Site Public Contact, 864-522-4317, Kim.Williams3@prismahealth.org

    Ki Y. Chung

    Recruiting

  • Henry Ford River District Hospital

    East China Township, Michigan, 48054

    Site Public Contact, 313-343-3166, kforman1@hfhs.org

    Tareq Al baghdadi

    Recruiting

  • Pocono Medical Center

    East Stroudsburg, Pennsylvania, 18301

    Site Public Contact, 610-402-9543, Morgan_M.Horton@lvhn.org

    Tareq Al baghdadi

    Recruiting

  • HSHS Sacred Heart Hospital

    Eau Claire, Wisconsin, 54701

    Active, not recruiting

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701

    Site Public Contact, 800-782-8581, oncology.clinical.trials@marshfieldresearch.org

    Michael Husak

    Recruiting

  • Mayo Clinic Health System-Eau Claire Clinic

    Eau Claire, Wisconsin, 54701

    Active, not recruiting

  • Fairview Southdale Hospital

    Edina, Minnesota, 55435

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    Joleen M. Hubbard

    Recruiting

  • Minnesota Oncology - Edina

    Edina, Minnesota, 55435

    Site Public Contact, 952-993-1517, mmcorc@healthpartners.com

    Joleen M. Hubbard

    Recruiting

  • STCC at DHR Health Institute for Research and Development

    Edinburg, Texas, 78539

    Site Public Contact, 956-362-2390, dhrresearch@dhr-rgv.com

    Jose Cruz

    Recruiting

  • Swedish Cancer Institute-Edmonds

    Edmonds, Washington, 98026

    Site Public Contact, 206-215-2343, PCRC-NCORP@Swedish.org

    Dan S. Zuckerman

    Recruiting

  • Shaw Cancer Center

    Edwards, Colorado, 81632

    Site Public Contact, 970-569-7429

    Erin Schwab

    Recruiting

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401

    Site Public Contact, 800-446-5532, Research@carle.com

    Suparna Mantha

    Recruiting

  • Crossroads Cancer Center

    Effingham, Illinois, 62401

    Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com

    Bryan A. Faller

    Recruiting

  • AtlantiCare Surgery Center

    Egg Harbor, New Jersey, 08234

    Site Public Contact, 609-748-7200

    Devon S. Mckenzie

    Recruiting

  • Advocate Sherman Hospital

    Elgin, Illinois, 60123

    Site Public Contact, 847-429-2907

    Antony Ruggeri

    Recruiting

  • Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus

    Elizabeth, New Jersey, 07207

    Site Public Contact, 908-994-8000

    Howard S. Hochster

    Recruiting

  • Mercy Cancer Center - Elk Grove

    Elk Grove, California, 95758

    Site Public Contact, 720-874-1881, ResearchInstituteInquiries@CommonSpirit.org

    Loretta J. Nastoupil

    Recruiting

  • Elmhurst Memorial Hospital

    Elmhurst, Illinois, 60126

    Site Public Contact, 630-758-5460, Jrohde@emhc.org

    Mohammed S. Azeem

    Recruiting

  • Epic Care Partners in Cancer Care

    Emeryville, California, 94608

    Suspended

  • Saint Elizabeth Hospital

    Enumclaw, Washington, 98022

    Suspended

  • Ephrata Cancer Center

    Ephrata, Pennsylvania, 17522

    Site Public Contact, 717-721-4840

    Marianne Spengler

    Recruiting

  • UPMC Hillman Cancer Center Erie

    Erie, Pennsylvania, 16505

    Site Public Contact, 412-864-7716, ClinicalResearchServices@upmc.edu

    Anwaar Saeed

    Recruiting

  • Saint Vincent Hospital

    Erie, Pennsylvania, 16544

    Site Public Contact, 814-452-5000

    Dulabh K. Monga

    Recruiting

Other trials in United States

Canada31 sites, 29 recruiting

  • Royal Victoria Regional Health Centre

    Barrie, Ontario, L4M 6M2

    Site Public Contact, 705-739-5661

    Coralea Kappel

    Recruiting

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2

    Site Public Contact, 412-339-5294, Roster@nrgoncology.org

    Patricia Tang

    Recruiting

  • Cambridge Memorial Hospital

    Cambridge, Ontario, N1R 3G2

    Site Public Contact, 519-621-2333

    Skander Ghedira

    Recruiting

  • CSSS Champlain-Charles Le Moyne

    Greenfield Park, Quebec, J4V 2H1

    Site Public Contact, 450-466-5065

    Melina Boutin

    Recruiting

  • Juravinski Cancer Centre at Hamilton Health Sciences

    Hamilton, Ontario, L8V 5C2

    Site Public Contact, 905-387-9495

    Shivani Dadwal

    Recruiting

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7

    Site Public Contact, 613-549-6666, cc-clinicaltrials@kgh.kari.net

    Christopher M. Booth

    Recruiting

  • Waterloo Regional Health Network

    Kitchener, Ontario, N2G 1G3

    Site Public Contact, 519-749-4370, research@wrhn.ca

    Anupam Batra

    Recruiting

  • Hotel-Dieu De Levis

    Lévis, Quebec, G6V 3Z1

    Suspended

  • London Regional Cancer Program

    London, Ontario, N6A 4L6

    Site Public Contact, 519-685-8600

    Elena V. Tsvetkova

    Recruiting

  • Markham Stouffville Hospital

    Markham, Ontario, L3P 7P3

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Sam Babak

    Recruiting

  • CIUSSSEMTL-Hopital Maisonneuve-Rosemont

    Montreal, Quebec, H1T 2M4

    Site Public Contact, 514-252-3400 ext. 3329

    Mikael Soucisse

    Recruiting

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2

    Site Public Contact, 514-340-8222 ext. 8248

    Petr Kavan

    Recruiting

  • Hopital Du Sacre-Coeur de Montreal

    Montreal, Quebec, H4J 1C5

    Site Public Contact, 514-338-2172

    Setareh Samimi

    Recruiting

  • Stronach Regional Health Centre at Southlake

    Newmarket, Ontario, L3Y 2P9

    Site Public Contact, 905-895-4521 ext. 6820

    Cynthia Luk

    Recruiting

  • Lakeridge Health Oshawa

    Oshawa, Ontario, L1G 2B9

    Site Public Contact, 905-576-8711 ext. 4258

    Amin Kay

    Recruiting

  • Ottawa Hospital and Cancer Center-General Campus

    Ottawa, Ontario, K1H 8L6

    Site Public Contact, 613-761-4395

    Tina Hsu

    Recruiting

  • BCCA-Cancer Centre for the North

    Prince George, British Columbia, V2M 7E9

    Site Public Contact, 855-775-7300

    Jonathan M. Loree

    Recruiting

  • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

    Québec, Quebec, G1R 2J6

    Site Public Contact, rechclinique@crchuq.ulaval.ca

    Maxime Chenard-Poirier

    Recruiting

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, S4T 7T1

    Site Public Contact, 306-766-2213

    Kimberly M. Hagel

    Recruiting

  • Niagara Health System-Saint Catharines General

    Saint Catharines, Ontario, L2S 0A9

    Site Public Contact, 905-682-6451

    Radhika Yelamanchili

    Recruiting

  • Atlantic Health Sciences Corporation-Saint John Regional Hospital

    Saint John, New Brunswick, E2L 4L2

    Site Public Contact, 506-648-6890

    James Michael

    Recruiting

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4

    Site Public Contact, 306-655-2914

    Shahid Ahmed

    Recruiting

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    Sherbrooke, Quebec, J1H 5N4

    Site Public Contact, 819-820-6480, crcinformation.chus@ssss.gouv.qc.ca

    Frederic Lemay

    Recruiting

  • Doctor H. Bliss Murphy Cancer Centre

    St. John's, Newfoundland and Labrador, A1B 3V6

    Site Public Contact, 709-777-7589

    Angela Hyde

    Recruiting

  • North York General Hospital

    Toronto, Ontario, M2K 1E1

    Site Public Contact, 416-756-6000

    Kathryn A. Towns

    Recruiting

  • Humber River Hospital

    Toronto, Ontario, M3M 0B2

    Site Public Contact, 416-242-1000, research@hrh.ca

    Gautam Sudan

    Recruiting

  • Odette Cancer Centre- Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5

    Site Public Contact, 416-480-5000

    Anthony C. Lott

    Recruiting

  • Saint Michael's Hospital

    Toronto, Ontario, M5B 1W8

    Site Public Contact, 416-864-6060 ext. 7830

    Suneil Khanna

    Recruiting

  • BCCA-Vancouver Cancer Centre

    Vancouver, British Columbia, V5Z 4E6

    Site Public Contact, 888-939-3333

    Jonathan M. Loree

    Recruiting

  • BCCA-Vancouver Island Cancer Centre

    Victoria, British Columbia, V8R 6V5

    Site Public Contact, 604-877-6010

    Georgia Geller

    Recruiting

  • Windsor Regional Cancer Centre

    Windsor, Ontario, N8W 2X3

    Active, not recruiting

Other trials in Canada

Puerto Rico9 sites, 9 recruiting

  • Pan American Center for Oncology Trials LLC - Cayey

    Cayey, 00646

    Site Public Contact, 787-407-3333, info@panoncologytrials.com

    Marcia R. Cruz-Correa

    Recruiting

  • Pan American Center for Oncology Trials LLC - Dorado

    Dorado, 00646

    Site Public Contact, 787-407-3333, info@panoncologytrials.com

    Marcia R. Cruz-Correa

    Recruiting

  • Doctors Cancer Center

    Manati, 00674

    Site Public Contact, 787-621-4397

    Luis J. Santos Reyes

    Recruiting

  • Pan American Center for Oncology Trials LLC

    San Juan, PR, 00680

    Site Public Contact, 888-823-5923, ctsucontact@westat.com

    Marcia R. Cruz-Correa

    Recruiting

  • Pan American Center for Oncology Trials LLC

    San Juan, 00902

    Site Public Contact, 787-407-3333, marcia.cruzcorrea@panoncologytrials.com

    Marcia R. Cruz-Correa

    Recruiting

  • Pan American Center for Oncology Trials LLC - Ciudadela

    San Juan, 00909

    Site Public Contact, 787-407-3333, info@panoncologytrials.com

    Marcia R. Cruz-Correa

    Recruiting

  • Centro Comprensivo de Cancer de UPR

    San Juan, 00927

    Site Public Contact, 412-339-5294, Roster@nrgoncology.org

    Luis J. Santos Reyes

    Recruiting

  • PROncology

    San Juan, 00927

    Site Public Contact, 787-919-7919, info@PRoncology.com

    Luis J. Santos Reyes

    Recruiting

  • San Juan City Hospital

    San Juan, 00936

    Site Public Contact, 787-763-1296

    Luis J. Santos Reyes

    Recruiting

Other trials in Puerto Rico

About this study

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.

Read the detailed description

Currently, there are no biomarkers validated prospectively in randomized studies for resected colon cancer to determine need for adjuvant chemotherapy. However, circulating tumor DNA (ctDNA) shed into the bloodstream represents a highly specific and sensitive approach (especially with serial monitoring) for identifying microscopic or residual tumor cells in colon cancer patients and may outperform traditional clinical and pathological features in prognosticating risk for recurrence. Colon cancer patients who do not have detectable ctDNA (ctDNA-) are at a much lower risk of recurrence and may not need adjuvant chemotherapy. Furthermore, for colon cancer pts with detectable ctDNA (ctDNA+) who are at a very high risk of recurrence, the optimal adjuvant chemotherapy regimen has not been established. We hypothesize that for pts whose colon cancer has been resected, ctDNA status may be used to risk stratify for making decisions about adjuvant chemotherapy.

Being tested
Signatera test, mFOLFOX6 3-6 month, CAPOX 3 month, mFOLFIRINOX, mFOLFOX6 6 month
Keywords
ctDNA positive, ctDNA negative, Adjuvant Chemotherapy, Natera, Signatera, mFOLFOX6, Stage III, CAPOX, mFOLFIRINOX, Oxaliplatin, 5-Fluorouracil (5-FU), Capecitabine, Leucovorin, Irinotecan, Stage II
Medical subject headings
Colonic Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Signatera testDevice

    Central ctDNA testing for all patients

  • mFOLFOX6 3-6 monthDrug

    Oxaliplatin 85 mg/m2 IV + Leucovorin 400mg/m2 IV + 5-Fluorouracil (5-FU) 400mg/m2 bolus + 5-Fluorouracil (5-FU) 2400mg/m2 IV continuous infusion over 46-48 hours (total dose) Day1 every 2 weeks for 6-12 cycles

  • CAPOX 3 monthDrug

    Oxaliplatin 130 mg/m2 IV Day 1 every 3 weeks + Capecitabine 1000 mg/m2 BID by mouth days 1-14 every 3 weeks for 4 cycles

  • mFOLFIRINOXDrug

    Oxaliplatin 85 mg/m2 IV + Leucovorin 400mg/m2 IV + Irinotecan 150 mg/m2 IV continuous infusion (30-90 minutes) + 5-Fluorouracil (5-FU) 2400mg/m2 IV continuous infusion over 46-48 hours (total dose) Day1 every 2 weeks for 12 cycles

  • mFOLFOX6 6 monthDrug

    Oxaliplatin 85 mg/m2 IV + Leucovorin 400mg/m2 IV + 5-Fluorouracil (5-FU) 400mg/m2 bolus + 5-Fluorouracil (5-FU) 2400mg/m2 IV continuous infusion over 46-48 hours (total dose) Day1 every 2 weeks for 12 cycles

  • CAPOX 6 monthDrug

    Oxaliplatin 130 mg/m2 IV Day 1 every 3 weeks + Capecitabine 1000 mg/m2 BID by mouth days 1-14 every 3 weeks for 8 cycles

Study groups in NCT05174169
Study groupRoleWhat they receive
Cohort A - Arm 1 (ctDNA-ve)Active comparatorOxaliplatin 85 mg/m2 IV + Leucovorin 400mg/m2 IV + 5-Fluorouracil (5-FU) 400mg/m2 bolus + 5-Fluorouracil (5-FU) 2400mg/m2 IV continuous infusion over 46-48 hours (total dose) Day1 every 2 weeks for 6-12 cycles OR Oxaliplatin 130 mg/m2 IV Day 1 every 3 weeks + Capecitabine 1000 mg/m2 BID by mouth days 1-14 every 3 weeks for 4 cycles
Receives: Device: Signatera test; Drug: mFOLFOX6 3-6 month; Drug: CAPOX 3 month
Cohort A - Arm 2 (ctDNA-ve)ExperimentalSerial ctDNA monitoring no treatment
Receives: Device: Signatera test
Cohort B - Arm 3 (ctDNA+ve)Active comparatorOxaliplatin 85 mg/m2 IV + Leucovorin 400mg/m2 IV + 5-Fluorouracil (5-FU) 400mg/m2 bolus + 5-Fluorouracil (5-FU) 2400mg/m2 IV continuous infusion over 46-48 hours (total dose) Day1 every 2 weeks for 12 cycles OR Oxaliplatin 130 mg/m2 IV Day 1 every 3 weeks + Capecitabine 1000 mg/m2 BID by mouth days 1-14 every 3 weeks for 8 cycles
Receives: Device: Signatera test; Drug: mFOLFOX6 6 month; Drug: CAPOX 6 month
Cohort B - Arm 4 (ctDNA+ve)ExperimentalOxaliplatin 85 mg/m2 IV + Leucovorin 400mg/m2 IV + Irinotecan 150 mg/m2 IV continuous infusion (30-90 minutes) + 5-Fluorouracil (5-FU) 2400mg/m2 IV continuous infusion over 46-48 hours (total dose) Day1 every 2 weeks for 12 cycles
Receives: Device: Signatera test; Drug: mFOLFIRINOX

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. ctDNA positive status (TTPos)

    TTPos is defined as time from randomization until ctDNA positive event: TTPos events are first ctDNA positive result after randomization for the immediate adjuvant chemo arm (Arm 1), 2nd ctDNA positive result after randomization for the delayed adjuvant chemo (Arm 2) and recurrence without a positive ctDNA result for both arms.

    Measured: Time from randomization to the first TTPos event, a maximum of 3 years

  2. Disease-Free Survival (DFS)

    Time from randomization to first disease-free survival event (recurrence, second primary colorectal cancer or death from any cause).

    Measured: Time from randomization to disease-free survival event, a maximum of 5 years]

Secondary outcomes (4)

  1. Baseline post-surgery ctDNA positivity rate

    percentage of patients with ctDNA positive results post-surgery at study entry.

    Measured: At time of randomization

  2. Overall Survival (OS)

    Time from randomization to death of any cause.

    Measured: Time from randomization to death, a maximum of 5 years.

  3. Recurrence

    Time from randomization to disease recurrence.

    Measured: Time from randomization to disease recurrence, a maximum of 5 years

  4. Compliance with adjuvant chemotherapy

    number of cycles of chemotherapy received.

    Measured: from randomization to the last cycle of chemotherapy, a maximum of 6 months.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted30 Dec 2021
  2. Study start8 Jul 2022
  3. Primary completion10 Mar 2029 (estimated)
  4. Study completion10 Mar 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2/3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
1,912 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05174169
Sponsor's protocol ID
NRG-GI008
Other IDs
U10CA180868, NRG-GI008, NCI-2021-08397
Acronym
CIRCULATE-US
Status last verified
Nov 2026
First submitted
13 Dec 2021
Last updated
4 Nov 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
Yes
Individual data sharing
Yes: NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page.

Questions about this trial

What is this clinical trial studying?

A Phase 2/3 study testing Signatera test, mFOLFOX6 3-6 month and CAPOX 3 month in people with Stage III Colon Cancer, run by NRG Oncology at 1,085 sites in 3 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 43 inclusion and 20 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1,085 sites in United States, Canada, Puerto Rico. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this combined phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Judy Langer (412-339-5300, langerj@nrgoncology.org), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

ctDNA positive status (TTPos) (time frame: Time from randomization to the first TTPos event, a maximum of 3 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05174169.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.

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