Autism Spectrum DisorderNCT05193500
Study 3 Learning Verbs and Pronouns
A study testing Verbs and Pronouns in people with Autism Spectrum Disorder, run by New York University at 2 sites in United States.
Trial summary
The goal of this research is to explore abilities to learn word meanings from overheard speech in children with ASD (and, as a control, typically developing children). Specific Aim 3 (Experiment 3): Determine whether children with ASD can learn verbs and pronouns by overhearing. Read more about this study
- Who is it for?
- Ages 24 to 71 monthsHealthy volunteers can take part
- Conditions the study is for
- Autism Spectrum Disorder
- What is being tested?
- Verbs and Pronouns
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 179 participants
- Where
- 2 sitesUnited States
- Study dates
- 1 Aug 2022to 5 Jan 2025
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 24 to 71 months
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- children with or without a diagnosis of ASD between 24 to 71 months of age
Who cannot join
- native language is not English
- born premature (< 36 weeks)
- has uncorrected hearing or vision impairments
- has developmental disorders or medical conditions other than ASD that affect language or cognition (excepting psychiatric conditions often comorbid with ASD such as ADHD)
- has a history of photosensitive epileptic seizures
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Emerson College
Boston, Massachusetts, 02116
New York University
New York, New York, 10012
About this study
The goal of this research is to explore abilities to learn word meanings from overheard speech in children with ASD (and, as a control, typically developing children).
Specific Aim 3 (Experiment 3): Determine whether children with ASD can learn verbs and pronouns by overhearing. Most prior work on learning from overheard speech has focused on learning nouns that label objects. This experiment extends this work to study other kinds of words.
- Conditions
- Autism Spectrum Disorder
- Being tested
- Verbs, Pronouns
- Medical subject headings
- Autism Spectrum Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
VerbsBehavioural
New verbs are introduced that are personally relevant to the child or neutral.
PronounsBehavioural
Pronouns are used that directly refer to the child or are neutral.
| Study group | Role | What they receive |
|---|---|---|
| Verbs | Experimental | Children hear a novel verb in an experimental context that is personally relevant to them (e.g., addressed, of interest) or neutral. Receives: Behavioral: Verbs |
| Pronouns | Experimental | Children hear a pronoun in an experimental context that is personally relevant to them (e.g., addressed, of interest) or neutral. Receives: Behavioral: Pronouns |
What is being measured
The primary outcome is the main question the study is designed to answer.
Object Preference for Verbs
Proportion of Time During Which Children's Eye Gaze is Directed Toward the Target Object in the Window from 1.0-2.5 Seconds after the Test Question
Measured: During test phase of the experimental session (within 3 seconds after the learning phase); 1.0-2.5 seconds after the test question
Object Selection for Pronouns
Proportion of trials on which children select the correct object that matches the pronoun
Measured: During test phase of the experimental session (within approx. 5 seconds of being asked the test question)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jan 2022
- Study start1 Aug 2022
- Primary completion5 Jan 2025
- Study completion5 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for Autism Spectrum DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 179 participants (actual)
Sponsor and investigators
- Lead sponsor
- New York University
- Sponsor type
- University, hospital or other
- Collaborators
- Emerson College
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05193500
- Sponsor's protocol ID
- 280523
- Status last verified
- Nov 2024
- First submitted
- 3 Jan 2022
- Last updated
- 30 Mar 2025
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study 3 Learning Verbs and Pronouns
- ClinicalTrials.gov ID
- NCT05193500
- Acronym / sponsor ID
- 280523
- Conditions
- Autism Spectrum Disorder
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 179 participants (actual)
- Lead sponsor
- New York UniversityUniversity, hospital or other
- Collaborators
- Emerson College
- Study start
- 1 Aug 2022 (actual)
- Primary completion
- 5 Jan 2025 (actual)
- Study completion
- 5 Jan 2025 (actual)
- First posted
- 18 Jan 2022 (actual)
- Results
- Posted 30 Mar 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this research is to explore abilities to learn word meanings from overheard speech in children with ASD (and, as a control, typically developing children).
Specific Aim 3 (Experiment 3): Determine whether children with ASD can learn verbs and pronouns by overhearing. Most prior work on learning from overheard speech has focused on learning nouns that label objects. This experiment extends this work to study other kinds of words.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Verbs | Experimental | Behavioral: VerbsChildren hear a novel verb in an experimental context that is personally relevant to them (e.g., addressed, of interest) or neutral. |
| Pronouns | Experimental | Behavioral: PronounsChildren hear a pronoun in an experimental context that is personally relevant to them (e.g., addressed, of interest) or neutral. |
Who may qualify
- Ages
- 24 to 71 months
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (1 listed)
- children with or without a diagnosis of ASD between 24 to 71 months of age
Key exclusion criteria (5 listed)
- native language is not English
- born premature (< 36 weeks)
- has uncorrected hearing or vision impairments
- has developmental disorders or medical conditions other than ASD that affect language or cognition (excepting psychiatric conditions often comorbid with ASD such as ADHD)
- has a history of photosensitive epileptic seizures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| VerbsNew verbs are introduced that are personally relevant to the child or neutral. | Behavioural | Verbs |
| PronounsPronouns are used that directly refer to the child or are neutral. | Behavioural | Pronouns |
Primary outcome
Object Preference for Verbs
Time frame: During test phase of the experimental session (within 3 seconds after the learning phase); 1.0-2.5 seconds after the test question
Proportion of Time During Which Children's Eye Gaze is Directed Toward the Target Object in the Window from 1.0-2.5 Seconds after the Test Question
Object Selection for Pronouns
Time frame: During test phase of the experimental session (within approx. 5 seconds of being asked the test question)
Proportion of trials on which children select the correct object that matches the pronoun
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2025.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Verbs and Pronouns in people with Autism Spectrum Disorder, run by New York University at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 30 Mar 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Object Preference for Verbs (time frame: During test phase of the experimental session (within 3 seconds after the learning phase); 1.0-2.5 seconds after the test question). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2025.