Injuries Related WorkMN RETAINNCT05216016
Minnesota RETAIN Phase 2 (Sub-study)
A study testing RETAIN Program in people with Injuries Related Work and Illness Related Work, run by Mayo Clinic at 1 site in United States.
Trial summary
MN RETAIN Phase 2 Sub-study is a non-randomized trial to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Injuries Related Work, Illness Related Work, Disability
- What is being tested?
- RETAIN Program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 3,414 participants
- Where
- 1 siteUnited States
- Study dates
- 23 Dec 2021to 16 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- > 18-years-old
- MN Resident
- Works in MN
- Employed at the time of enrollment
- Within 6 months of last day of work
- Meets one of the following:
Show all 13Show fewer
- Provider work restrictions of unable to work for at least 4 weeks
- Per healthcare team anticipated to be unable to work for at least 4 weeks
- Employer's inability to accommodate current work restrictions
- Meets one of the following:
- Diagnosis of a work related or personal injury or illness that impacts employment
- Invasive procedure (e.g., surgery) anticipated within the next 4-weeks that impacts employment
- Documentation of work restrictions (i.e., written note/form documentation in electronic medical record prior to enrollment)
Who cannot join
- Legal representation/litigation at the time of enrollment related to a workers' compensation medical condition
- Does not have the capacity to give appropriate informed consent
- Employed by a RETAIN healthcare recipient or subrecipient with an existing return to work program for employees (i.e., Mayo Clinic employees)
- Workers' compensation recipients that have a qualified rehabilitation consultant (QRC) or a disability case manager (DCM)
- Pending application OR Receiving Social Security Disability Insurance (SSDI) or Supplemental Security Income (SSI)
- Self-Employed
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Minnesota Retaining Employment and Talent After Injury/Illness Network Phase 2 RETAIN
MN RETAIN Phase 2 Sub-study is a non-randomized trial to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. The program is funded by US Department of Labor (US DOL) and sponsored jointly with the US Social Security Administration. There will be collaboration between partners to implement best practices in early intervention to support injured or ill employees in stay-at-work and return-to-work. MN RETAIN involves a partnership between Mayo Clinic and MN Department of Employment and Economic Development (DEED), MN Department of Labor and Industry (DLI), MN Department of Health (MDH), Workforce Development, Inc. (WDI), and the Governor's Workforce Development Board. MN DEED serves as the main recipient and administrator of the funding within the state with Mayo Clinic, DLI, and WDI, as subrecipients of the grant.
(Effective Date: 12/23/2021-05/16/2024) MN RETAIN Phase 2 : This study is a randomized control trial (RCT) to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. The program is funded by US Department of Labor (US DOL) and sponsored jointly with the US Social Security Administration. There will be collaboration between partners to implement best practices in early intervention to support injured or ill employees in stay-at-work and return-to-work. MN RETAIN involves a partnership between Mayo Clinic and MN Department of Employment and Economic Development (DEED), MN Department of Labor and Industry (DLI), MN Department of Health (MDH), Workforce Development, Inc. (WDI), and the Governor's Workforce Development Board. MN DEED serves as the main recipient and administrator of the funding within the state with Mayo Clinic, DLI, and WDI, as subrecipients of the grant. During this Phase: additional collaborators: Mathematica Policy Research
- Conditions
- Injuries Related Work, Illness Related Work, Disability
- Being tested
- RETAIN Program
- Keywords
- RETAIN, Minnesota RETAIN, MN RETAIN, Illness Recovery, Injury Recovery, Out of work help, Work placement assistance, Job help, Work Help, Help keeping my job, Stay at work, Return to work
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RETAIN ProgramOther
Facilitates early intervention strategies to support workers in staying-at or returning-to-work (SAW/RTW) after injury or illness and preventing unnecessary disability. This is done by incorporating a Return-to-Work Case Manager as a member of the healthcare clinical team who acts as a liaison for the patient and assists in coordination of referrals between healthcare and Workforce Development services. Return-to-Work Case Managers will interact with treating providers of Minnesota RETAIN intervention group participants to ensure functionally based work restrictions are documented and shared with the patient's employer.
| Study group | Role | What they receive |
|---|---|---|
| Control Group | No intervention | Individuals will receive a handout with additional job related services; e.g. Job Accommodation Network. |
| Intervention Group | Experimental | Individuals will be assigned a dedicated Minnesota RETAIN Return-to-Work Case Manager. Intervention group participants will be referred for additional career and workforce development resources when needed. Receives: Other: RETAIN Program |
| Sub Study Group | Experimental | Individuals will be assigned a dedicated Minnesota RETAIN Return-to-Work Case Manager. Intervention group participants will be referred for additional career and workforce development resources when needed. Receives: Other: RETAIN Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Workers to maintain employment
Total number of workers employed at the time of program completion and who have maintained employment 12 months after enrollment.
Measured: 12 months
Reduction on work disability at 1 years
Total number of enrollees that applied for SSDI or SSI during any of the 1 year after enrollment.
Measured: 1 year
Reduction in long term work disability
Total number of enrollees that applied for SSDI or SSI during any of the 5 year after enrollment.
Measured: 5 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jan 2022
- Study start23 Dec 2021
- Primary completion16 May 2026
- Study completion16 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Injuries Related WorkStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 3,414 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Collaborators
- Minnesota Department of Employment and Economic Development, Minnesota Department of Labor and Industry, Minnesota Department of Health, Workforce Development, Inc., United States Department of Labor, Social Security Administration, The United States
- Responsible party
- Principal investigator, Laura E. Breeher, Mayo Clinic
- Investigators
- Laura Breeher, MD, MPH, Principal investigator, Mayo ClinicClayton Cowl, MD,MS, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05216016
- Sponsor's protocol ID
- 21-006979
- Other IDs
- OD-36365-21-75-4-27
- Acronym
- MN RETAIN
- Status last verified
- May 2026
- First submitted
- 18 Jan 2022
- Last updated
- 27 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Minnesota Retaining Employment and Talent After Injury/Illness Network Phase 2 RETAIN
- ClinicalTrials.gov ID
- NCT05216016
- Acronym / sponsor ID
- MN RETAIN / 21-006979
- Conditions
- Injuries Related Work, Illness Related Work, Disability
- Keywords
- RETAIN, Minnesota RETAIN, MN RETAIN, Illness Recovery, Injury Recovery, Out of work help, Work placement assistance, Job help
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 3,414 participants (actual)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Collaborators
- Minnesota Department of Employment and Economic Development, Minnesota Department of Labor and Industry, Minnesota Department of Health, Workforce Development, Inc., United States Department of Labor, Social Security Administration, The United States
- Study start
- 23 Dec 2021 (actual)
- Primary completion
- 16 May 2026 (actual)
- Study completion
- 16 May 2026 (actual)
- First posted
- 31 Jan 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
MN RETAIN Phase 2 Sub-study is a non-randomized trial to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. The program is funded by US Department of Labor (US DOL) and sponsored jointly with the US Social Security Administration. There will be collaboration between partners to implement best practices in early intervention to support injured or ill employees in stay-at-work and return-to-work. MN RETAIN involves a partnership between Mayo Clinic and MN Department of Employment and Economic Development (DEED), MN Department of Labor and Industry (DLI), MN Department of Health (MDH), Workforce Development, Inc. (WDI), and the Governor's Workforce Development Board. MN DEED serves as the main recipient and administrator of the funding within the state with Mayo Clinic, DLI, and WDI, as subrecipients of the grant.
(Effective Date: 12/23/2021-05/16/2024) MN RETAIN Phase 2 : This study is a randomized control trial (RCT) to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. The program is funded by US Department of Labor (US DOL) and sponsored jointly with the US Social Security Administration. There will be collaboration between partners to implement best practices in early intervention to support injured or ill employees in stay-at-work and return-to-work. MN RETAIN involves a partnership between Mayo Clinic and MN Department of Employment and Economic Development (DEED), MN Department of Labor and Industry (DLI), MN Department of Health (MDH), Workforce Development, Inc. (WDI), and the Governor's Workforce Development Board. MN DEED serves as the main recipient and administrator of the funding within the state with Mayo Clinic, DLI, and WDI, as subrecipients of the grant. During this Phase: additional collaborators: Mathematica Policy Research
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Control Group | No intervention | –Individuals will receive a handout with additional job related services; e.g. Job Accommodation Network. |
| Intervention Group | Experimental | Other: RETAIN ProgramIndividuals will be assigned a dedicated Minnesota RETAIN Return-to-Work Case Manager. Intervention group participants will be referred for additional career and workforce development resources when needed. |
| Sub Study Group | Experimental | Other: RETAIN ProgramIndividuals will be assigned a dedicated Minnesota RETAIN Return-to-Work Case Manager. Intervention group participants will be referred for additional career and workforce development resources when needed. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (13 listed)
- > 18-years-old
- MN Resident
- Works in MN
- Employed at the time of enrollment
- Within 6 months of last day of work
Key exclusion criteria (6 listed)
- Legal representation/litigation at the time of enrollment related to a workers' compensation medical condition
- Does not have the capacity to give appropriate informed consent
- Employed by a RETAIN healthcare recipient or subrecipient with an existing return to work program for employees (i.e., Mayo Clinic employees)
- Workers' compensation recipients that have a qualified rehabilitation consultant (QRC) or a disability case manager (DCM)
- Pending application OR Receiving Social Security Disability Insurance (SSDI) or Supplemental Security Income (SSI)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| RETAIN ProgramFacilitates early intervention strategies to support workers in staying-at or returning-to-work (SAW/RTW) after injury or illness and preventing unnecessary disability. This is done by incorporating a Return-to-Work Case Manager as a member of the healthcare clinical team who acts as a liaison for the patient and assists in coordination of referrals between healthcare and Workforce Development services. Return-to-Work Case Managers will interact with treating providers of Minnesota RETAIN intervention group participants to ensure functionally based work restrictions are documented and shared with the patient's employer. | Other | Intervention Group, Sub Study Group |
Primary outcome
Workers to maintain employment
Time frame: 12 months
Total number of workers employed at the time of program completion and who have maintained employment 12 months after enrollment.
Reduction on work disability at 1 years
Time frame: 1 year
Total number of enrollees that applied for SSDI or SSI during any of the 1 year after enrollment.
Reduction in long term work disability
Time frame: 5 years
Total number of enrollees that applied for SSDI or SSI during any of the 5 year after enrollment.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Laura Breeher, MD, MPH principal investigator
Mayo Clinic
Clayton Cowl, MD,MS principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing RETAIN Program in people with Injuries Related Work and Illness Related Work, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Workers to maintain employment (time frame: 12 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2026.