RecoveryNCT05220371
Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage
A study testing Collagen and Concurrent training in people with Recovery, run by University of Vienna at 1 site in Austria.
Trial summary
The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects. Read more about this study
- Who is it for?
- Ages 18 to 40 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Recovery
- What is being tested?
- Collagen and Concurrent training
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 50 participants
- Where
- 1 siteAustria
- Study dates
- 28 Jan 2022to 30 Jun 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- No subjective symptoms during physical exertion
- Stable weight and dietary behaviour
- Body Mass Index (BMI) between 18.5 and 24.9
- No extensive strength/endurance sports so far (less than 3 h/week)
- No complaints during strenuous physical activity
Who cannot join
- Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
- Intolerance/aversion to animal protein
- Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest
- Presence of insulin-dependent diabetes mellitus
- Liver and/or kidney disease that precludes a high protein load
- Collagen supplementation or regular intake of other dietary supplements in the last 6 months.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage
The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.
- Conditions
- Recovery
- Being tested
- Collagen, Concurrent training
- Keywords
- Collagen peptides, Concurrent training, Ultrasound, MVC, RFD
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CollagenDietary supplement
Participants ingest 15 grams of either specific collagen peptides or Placebo daily
Concurrent trainingOther
Both arms undergo a 12-week trainingintervention 3x/week
| Study group | Role | What they receive |
|---|---|---|
| Collagen | Experimental | 15g of collagen peptides ingested daily Receives: Dietary Supplement: Collagen; Other: Concurrent training |
| Placebo | Placebo comparator | 15g of Placebo ingested daily Receives: Other: Concurrent training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in maximal voluntary contraction (MVC)
Measured by isokinetic dynamometer
Measured: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in rate of force development (RFD)
Measured by isokinetic dynamometer
Measured: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in countermovement jump height (CMJ)
Measured by force plate
Measured: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in subjective pain score
Measured by visual analogue scale
Measured: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in Achilles tendon cross-sectional area
Measured by ultrasound
Measured: Baseline and after 12 weeks
Change in Vastus Lateralis fibre length
Measured by ultrasound
Measured: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Change in collagen related blood markers
Measured by blood analysis
Measured: Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)
Change in Achilles tendon echo intensity
Measured by ultrasound
Measured: Baseline and after 12 weeks
Change in Vastus Lateralis echo intensity
Measured by ultrasound
Measured: Baseline and after 12 weeks
Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)
Measured by bioelectrical impedance analysis
Measured: Baseline and after 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Feb 2022
- Study start28 Jan 2022
- Primary completion30 Jun 2023
- Study completion30 Jun 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for RecoveryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Vienna
- Sponsor type
- University, hospital or other
- Collaborators
- Collagen Research Institute
- Responsible party
- Principal investigator, Daniel König, University of Vienna
- Investigators
- Daniel Koenig, Prof. Dr., Principal investigator, University of Vienna, Institute of Sport Science
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05220371
- Sponsor's protocol ID
- 00765
- Status last verified
- Aug 2023
- First submitted
- 28 Jan 2022
- Last updated
- 28 Aug 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides - a randomized controlled trial. Front Nutr. 2024 Mar 25;11:1384112. doi: 10.3389/fnut.2024.1384112. eCollection 2024.
PubMed 38590831Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Influence of specific collagen peptides and 12-week concurrent training on recovery-related biomechanical characteristics following exercise-induced muscle damage-A randomized controlled trial. Front Nutr. 2023 Nov 16;10:1266056. doi: 10.3389/fnut.2023.1266056. eCollection 2023.
PubMed 38035363
Study at a glance
From the registry record, last updated by the sponsor on 28 Aug 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage
- ClinicalTrials.gov ID
- NCT05220371
- Acronym / sponsor ID
- 00765
- Conditions
- Recovery
- Keywords
- Collagen peptides, Concurrent training, Ultrasound, MVC, RFD
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- University of ViennaUniversity, hospital or other
- Collaborators
- Collagen Research Institute
- Study start
- 28 Jan 2022 (actual)
- Primary completion
- 30 Jun 2023 (actual)
- Study completion
- 30 Jun 2023 (actual)
- First posted
- 2 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Collagen | Experimental | Dietary Supplement: Collagen, Other: Concurrent training15g of collagen peptides ingested daily |
| Placebo | Placebo comparator | Other: Concurrent training15g of Placebo ingested daily |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- No subjective symptoms during physical exertion
- Stable weight and dietary behaviour
- Body Mass Index (BMI) between 18.5 and 24.9
- No extensive strength/endurance sports so far (less than 3 h/week)
- No complaints during strenuous physical activity
Key exclusion criteria (6 listed)
- Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
- Intolerance/aversion to animal protein
- Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest
- Presence of insulin-dependent diabetes mellitus
- Liver and/or kidney disease that precludes a high protein load
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CollagenParticipants ingest 15 grams of either specific collagen peptides or Placebo daily | Dietary supplement | Collagen |
| Concurrent trainingBoth arms undergo a 12-week trainingintervention 3x/week | Other | Collagen, Placebo |
Primary outcome
Change in maximal voluntary contraction (MVC)
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by isokinetic dynamometer
Change in rate of force development (RFD)
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by isokinetic dynamometer
Change in countermovement jump height (CMJ)
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by force plate
Change in subjective pain score
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by visual analogue scale
Change in Achilles tendon cross-sectional area
Time frame: Baseline and after 12 weeks
Measured by ultrasound
Change in Vastus Lateralis fibre length
Time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by ultrasound
Change in collagen related blood markers
Time frame: Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)
Measured by blood analysis
Change in Achilles tendon echo intensity
Time frame: Baseline and after 12 weeks
Measured by ultrasound
Change in Vastus Lateralis echo intensity
Time frame: Baseline and after 12 weeks
Measured by ultrasound
Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)
Time frame: Baseline and after 12 weeks
Measured by bioelectrical impedance analysis
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Aug 2023.
- Derived from this study: PubMed 38590831Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides - a randomized controlled trial. Front Nutr. 2024 Mar 25;11:1384112. doi: 10.3389/fnut.2024.1384112. eCollection 2024.
- Derived from this study: PubMed 38035363Bischof K, Stafilidis S, Bundschuh L, Oesser S, Baca A, Konig D. Influence of specific collagen peptides and 12-week concurrent training on recovery-related biomechanical characteristics following exercise-induced muscle damage-A randomized controlled trial. Front Nutr. 2023 Nov 16;10:1266056. doi: 10.3389/fnut.2023.1266056. eCollection 2023.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Daniel Koenig, Prof. Dr. principal investigator
University of Vienna, Institute of Sport Science
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Collagen and Concurrent training in people with Recovery, run by University of Vienna at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Aug 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in maximal voluntary contraction (MVC) (time frame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05220371, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Aug 2023.