Muscle StrengthNCT05229367
Mode Specific Effects of Isokinetic Training of Hamstring on Hamstring to Quadriceps Ratio
A study testing Eccentric isokinetic training and Concentric isokinetic training in people with Muscle Strength, run by King Saud University at 1 site in Saudi Arabia.
Trial summary
Mode specificity of eccentric and concentric isokinetic training have been examined in previous studies but with conflicting results. The present study aimed to examine the mode-specific effects of eccentric and concentric isokinetic training of hamstring muscle at slow angular velocity on eccentric peak torque of… Read more about this study
- Who is it for?
- Ages 18 to 28 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Strength
- What is being tested?
- Eccentric isokinetic training and Concentric isokinetic training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 28 Apr 2021to 14 Oct 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 28 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy young males
- Age between 18 to 27
- Recreationally active who used to engage regularly in 1-5 hours of physical activity per week
Who cannot join
- Individual presently indulged in strength training of knee.
- Individuals with any kind of injury around the knee, hip, ankle, foot
- Unconsolidated fractures around the knee. • Stress fractures
- Subjects with the acute phase of trauma, which may interfere with the exercise regime
- Subjects with cardio-respiratory problems and other medical problems like diabetes, asthma, etc.
- Subjects with tendinitis and other inflammatory conditions.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Mode-specific Effects of Concentric and Eccentric Isokinetic Training of Hamstring Muscle at Slow Angular Velocity on Functional Hamstrings-to-quadriceps Ratio
Mode specificity of eccentric and concentric isokinetic training have been examined in previous studies but with conflicting results. The present study aimed to examine the mode-specific effects of eccentric and concentric isokinetic training of hamstring muscle at slow angular velocity on eccentric peak torque of hamstring (PTecc), concentric peak torque of quadriceps (PTcon), acceleration time of hamstring (AThams) and quadriceps (ATquad), deceleration time of hamstring (DThams) and quadriceps (DTquad), time to peak torque of hamstring (TPThams) and quadriceps (TPTquad), and functional Hamstring-to-Quadriceps ratio (PTecc/PTcon).
Read the detailed description
Several studies in past have tried to examine the mode specificity of concentric and eccentric training of different muscles and at different angular velocities i.e. whether concentric training will increase the concentric strength only or both concentric and eccentric strength and whether eccentric training will increase eccentric strength only or both eccentric and concentric strength.
Since conflicting reports are available regarding mode specificity of eccentric and concentric isokinetic training therefore one study was needed that can examine the mode specificity of these training in hamstring muscles at slow angular velocity. The present study aimed to examine the mode-specific effects of six weeks of isokinetic concentric and eccentric training of the hamstring muscle at slow angular velocity on the PTecc/PTcon, AT, DT, and TPT.
- Conditions
- Muscle Strength
- Being tested
- Eccentric isokinetic training, Concentric isokinetic training
- Keywords
- Isokinetic training, peak torque, acceleration time, deceleration time, time to peak torque, Hamstring-to-Quadriceps ratio
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Eccentric isokinetic trainingOther
Eccentric exercises of the hamstring muscles were performed with the use of an isokinetic dynamometer device.
Concentric isokinetic trainingOther
Concentric exercises of the hamstring muscles were performed with the use of an isokinetic dynamometer device.
| Study group | Role | What they receive |
|---|---|---|
| Eccentric isokinetic group | Experimental | In this group, eccentric isokinetic training of hamstring muscle was performed. Receives: Other: Eccentric isokinetic training |
| Concentric isokinetic group | Active comparator | In this group, concentric isokinetic training of hamstring muscle was performed. Receives: Other: Concentric isokinetic training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Functional Hamstring-to-quadriceps ratio (PTecc:PTcon)
This ratio was calculated using eccentric peak of hamstring and concentric peak torque of quadriceps muscle
Measured: 6 weeks
Secondary outcomes (6)
Acceleration time of hamstring (AThams)
Time required by hamstring muscle to reach desired velocity was noted.
Measured: 6 weeks
Acceleration time of quadriceps
Time required by quadriceps muscle to reach desired velocity was noted.
Measured: 6 weeks
Deceleration time of hamstring (DThams)
Time required by hamstring muscle to reach zero velocity from target velocity, was noted.
Measured: 6 weeks
Deceleration time of quadriceps
Time required by quadriceps muscle to reach zero velocity from target velocity to, was noted.
Measured: 6 weeks
Time to peak torque of hamstring
Time required by hamstring muscle to reach peak torque was noted.
Measured: 6 weeks
Time to peak torque of quadriceps
Time required by quadriceps muscle to reach peak torque was noted.
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Feb 2022
- Study start28 Apr 2021
- Primary completion13 Sep 2021
- Study completion14 Oct 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Muscle StrengthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly divided into two groups.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- King Saud University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Masood Khan, King Saud University
- Investigators
- Masood Khan, M.P.Th, Principal investigator, King Saud University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05229367
- Sponsor's protocol ID
- RRC-2021-11
- Status last verified
- Feb 2022
- First submitted
- 27 Jan 2022
- Last updated
- 24 Feb 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Sharma KN, Quddus N, Hameed UA, Khan SA, Kumari A, Alghadir AH, Khan M. Mode-specific effects of concentric and eccentric isokinetic training of the hamstring muscle at slow angular velocity on the functional hamstrings-to-quadriceps ratio-a randomized trial. PeerJ. 2022 Sep 29;10:e13842. doi: 10.7717/peerj.13842. eCollection 2022.
PubMed 36196400
Study at a glance
From the registry record, last updated by the sponsor on 24 Feb 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Mode-specific Effects of Concentric and Eccentric Isokinetic Training of Hamstring Muscle at Slow Angular Velocity on Functional Hamstrings-to-quadriceps Ratio
- ClinicalTrials.gov ID
- NCT05229367
- Acronym / sponsor ID
- RRC-2021-11
- Conditions
- Muscle Strength
- Keywords
- Isokinetic training, peak torque, acceleration time, deceleration time, time to peak torque, Hamstring-to-Quadriceps ratio
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- King Saud UniversityUniversity, hospital or other
- Study start
- 28 Apr 2021 (actual)
- Primary completion
- 13 Sep 2021 (actual)
- Study completion
- 14 Oct 2021 (actual)
- First posted
- 8 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Mode specificity of eccentric and concentric isokinetic training have been examined in previous studies but with conflicting results. The present study aimed to examine the mode-specific effects of eccentric and concentric isokinetic training of hamstring muscle at slow angular velocity on eccentric peak torque of hamstring (PTecc), concentric peak torque of quadriceps (PTcon), acceleration time of hamstring (AThams) and quadriceps (ATquad), deceleration time of hamstring (DThams) and quadriceps (DTquad), time to peak torque of hamstring (TPThams) and quadriceps (TPTquad), and functional Hamstring-to-Quadriceps ratio (PTecc/PTcon).
Detailed description
Several studies in past have tried to examine the mode specificity of concentric and eccentric training of different muscles and at different angular velocities i.e. whether concentric training will increase the concentric strength only or both concentric and eccentric strength and whether eccentric training will increase eccentric strength only or both eccentric and concentric strength.
Since conflicting reports are available regarding mode specificity of eccentric and concentric isokinetic training therefore one study was needed that can examine the mode specificity of these training in hamstring muscles at slow angular velocity. The present study aimed to examine the mode-specific effects of six weeks of isokinetic concentric and eccentric training of the hamstring muscle at slow angular velocity on the PTecc/PTcon, AT, DT, and TPT.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants were randomly divided into two groups.
| Arm | Type | Receives |
|---|---|---|
| Eccentric isokinetic group | Experimental | Other: Eccentric isokinetic trainingIn this group, eccentric isokinetic training of hamstring muscle was performed. |
| Concentric isokinetic group | Active comparator | Other: Concentric isokinetic trainingIn this group, concentric isokinetic training of hamstring muscle was performed. |
Who may qualify
- Ages
- 18 to 28 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Healthy young males
- Age between 18 to 27
- Recreationally active who used to engage regularly in 1-5 hours of physical activity per week
Key exclusion criteria (6 listed)
- Individual presently indulged in strength training of knee.
- Individuals with any kind of injury around the knee, hip, ankle, foot
- Unconsolidated fractures around the knee. • Stress fractures
- Subjects with the acute phase of trauma, which may interfere with the exercise regime
- Subjects with cardio-respiratory problems and other medical problems like diabetes, asthma, etc.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Eccentric isokinetic trainingEccentric exercises of the hamstring muscles were performed with the use of an isokinetic dynamometer device. | Other | Eccentric isokinetic group |
| Concentric isokinetic trainingConcentric exercises of the hamstring muscles were performed with the use of an isokinetic dynamometer device. | Other | Concentric isokinetic group |
Primary outcome
Functional Hamstring-to-quadriceps ratio (PTecc:PTcon)
Time frame: 6 weeks
This ratio was calculated using eccentric peak of hamstring and concentric peak torque of quadriceps muscle
6 secondary outcomes
Acceleration time of hamstring (AThams)
Time frame: 6 weeks
Acceleration time of quadriceps
Time frame: 6 weeks
Deceleration time of hamstring (DThams)
Time frame: 6 weeks
Deceleration time of quadriceps
Time frame: 6 weeks
Time to peak torque of hamstring
Time frame: 6 weeks
Time to peak torque of quadriceps
Time frame: 6 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Feb 2022.
- Derived from this study: PubMed 36196400Sharma KN, Quddus N, Hameed UA, Khan SA, Kumari A, Alghadir AH, Khan M. Mode-specific effects of concentric and eccentric isokinetic training of the hamstring muscle at slow angular velocity on the functional hamstrings-to-quadriceps ratio-a randomized trial. PeerJ. 2022 Sep 29;10:e13842. doi: 10.7717/peerj.13842. eCollection 2022.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Masood Khan, M.P.Th principal investigator
King Saud University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Eccentric isokinetic training and Concentric isokinetic training in people with Muscle Strength, run by King Saud University at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Feb 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Functional Hamstring-to-quadriceps ratio (PTecc:PTcon) (time frame: 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05229367, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2022.