Anorexia in AdolescenceNCT05235867
Secretin in Refeeding
An observational study of Anorexia in Adolescence, run by University of California, Los Angeles at 1 site in United States.
Trial summary
Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Read more about this study
- Who is it for?
- Ages 13 to 24 years
- Conditions the study is for
- Anorexia in Adolescence
- How many people
- 10 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Feb 2022to 31 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 13 to 24 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Adolescents with restrictive-type anorexia hospitalized for medical nutritional stabilization.
Who may be able to join
- Group 1:
- male and female patients
- age 13-24 years
- diagnosis of restrictive-type anorexia nervosa
- hospitalization for nutritional support
- >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
Show all 12Show fewer
- Group 2:
- male and female patients
- age 13-24 years
- diagnosis of restrictive-type anorexia nervosa
- hospitalization for nutritional support
- <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)
Who cannot join
- 5150 hold
- Anti-depressant, anti-psychotic, or anticonvulsant medications
- Previous hospitalization within the past 6 months
- Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
- Pregnancy
- NG or G-tube feeds after day 2 of hospitalization
- > 10% of nutritional needs from supplemental feeds
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of California, Los Angeles (UCLA)
Los Angeles, California, 90095
Finnegan Mercer, 310-206-7631, fjmercer@mednet.ucla.edu
About this study
Official title: Secretin Levels in Refeeding-induced Polyuria (Cross Section)
Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.
- Conditions
- Anorexia in Adolescence
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| dumpers | * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5) | |
| non-dumpers | * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in secretin
Change in secretin value from pre- to post- meal
Measured: 1 hour
Secondary outcomes (1)
Change in serum bicarbonate
Change in bicarbonate value from pre- to post- meal
Measured: 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Feb 2022
- Study start1 Feb 2022
- Primary completion30 Jun 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anorexia in AdolescenceStudies of the same condition, open and under way.
- More trials run by University of California, Los AngelesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, Los Angeles
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elaine L. Rosen, MD, University of California, Los Angeles
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05235867
- Sponsor's protocol ID
- IRB#21-001489
- Status last verified
- Feb 2026
- First submitted
- 1 Feb 2022
- Last updated
- 12 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Secretin Levels in Refeeding-induced Polyuria (Cross Section)
- ClinicalTrials.gov ID
- NCT05235867
- Acronym / sponsor ID
- IRB#21-001489
- Conditions
- Anorexia in Adolescence
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- University of California, Los AngelesUniversity, hospital or other
- Study start
- 1 Feb 2022 (actual)
- Primary completion
- 30 Jun 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 11 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| dumpers | – | –* male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5) |
| non-dumpers | – | –* male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5) |
Who may qualify
- Ages
- 13 to 24 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Adolescents with restrictive-type anorexia hospitalized for medical nutritional stabilization.
Key inclusion criteria (12 listed)
- Group 1:
- Group 2:
Key exclusion criteria (7 listed)
- 5150 hold
- Anti-depressant, anti-psychotic, or anticonvulsant medications
- Previous hospitalization within the past 6 months
- Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Change in secretin
Time frame: 1 hour
Change in secretin value from pre- to post- meal
1 secondary outcome
Change in serum bicarbonate
Time frame: 1 hour
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Feb 2026.
- Individual participant dataSharing planned: No
Related trials for Anorexia in Adolescence
Recruiting
Adapting Exposure for Adolescent AN
Anorexia Nervosa
Active, not recruitingEarly Phase 1
Naltrexone Neuroimaging in Teens With Eating Disorders
Eating Disorders, Binge Eating
RecruitingPhase 2
Safety, Therapeutic Potential, and Mechanisms of Two Psilocybin Doses, Administered With Psychological Support in Young Adults With Anorexia Nervosa
Anorexia Nervosa
Not yet recruitingObservational study
3-Dimensional Optical Scanning to Assess and Monitor Malnutrition in Eating Disorders (3D-ED) Study
Anorexia in Adolescence, Anorexia Nervosa
Not yet recruitingObservational study
Sleep Quality and Biomarkers in Adolescent Girls With Anorexia Nervosa
Anorexia Nervosa
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Anorexia in Adolescence, run by University of California, Los Angeles at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Misciel Macaraig (310-825-0922, mbmacaraig@mednet.ucla.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in secretin (time frame: 1 hour). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Feb 2026.