COVID-19 PneumoniaNCT05238623
Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19
An observational study of COVID-19 Pneumonia and Post-acute COVID-19 Syndrome, run by Jan-Christoph Lewejohann at 1 site in Germany.
Trial summary
Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- COVID-19 Pneumonia, Post-acute COVID-19 Syndrome, Electric Impedance
- What is being tested?
- additional EIT Measurement
- How many people
- 50 participants
- Where
- 1 siteGermany
- Study dates
- 1 Oct 2025to 31 Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: All patients presenting to the post-COVID-19 outpatient clinic are screened.
Who may be able to join
- all patients undergoing a Chest CT due to suspected post-acute-Covid-19-syndrome
- >18 years
- informed consent.
Who cannot join
- trauma patients and patients with unstable spinal injuries or fractures
- patients with an BMI over 50
- patients with uncontrolled body movements
- Patients with a pacemaker
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19 Symptoms
Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.
Read the detailed description
Prospective non-interventional, monocentric observational study on imbalances in regional lung ventilation compared to chest CT in post-acute-Covid-19. The aim is to verify the agreement between computerized tomography derived imaging variables and electrical impedance tomography in detecting lung ventilation imbalances. The primary study objective is to match CT morphological changes in regional ventilation in post-acute-COVID-19 patients and/or changes in lung function examination, with changes that can be visualized by electroimpedance tomography.
- Being tested
- additional EIT Measurement
- Keywords
- Electric Impedance, CT, Tomography, regional ventilation, post-acute-COVID-19 syndrome, post-COVID-19, EIT, electroimpedance tomography, long-COVID
- Medical subject headings
- Post-Acute COVID-19 Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
additional EIT MeasurementDiagnostic test
Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement. The lunghealthy Patients in the control group only receive a EIT.
| Study group | Role | What they receive |
|---|---|---|
| Control cohort | lung-healthy volunteers get a EIT measurement | |
| Case cohort | Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement Receives: Diagnostic Test: additional EIT Measurement |
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation between tomography and electroimpedance tomography
The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography.
Measured: until May 2022
Secondary outcomes (1)
Correlation between lung function testing and electroimpedance tomography
Measured: until May 2022
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Feb 2022
- Study start1 Oct 2025 (estimated)
- Primary completion30 Jun 2026 (estimated)
- Study completion31 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for COVID-19 PneumoniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Jan-Christoph Lewejohann
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Jan-Christoph Lewejohann, Jena University Hospital
- Investigators
- Phillip A Reuken, Dr., Study director, Jena University Hospital, Klinik für Innere Medizin IV
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05238623
- Sponsor's protocol ID
- KIM-IV-EIT03
- Status last verified
- Sep 2025
- First submitted
- 8 Feb 2022
- Last updated
- 25 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19 Symptoms
- ClinicalTrials.gov ID
- NCT05238623
- Acronym / sponsor ID
- KIM-IV-EIT03
- Keywords
- Electric Impedance, CT, Tomography, regional ventilation, post-acute-COVID-19 syndrome, post-COVID-19, EIT, electroimpedance tomography
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Jan-Christoph LewejohannUniversity, hospital or other
- Study start
- 1 Oct 2025 (estimated)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 31 Mar 2027 (estimated)
- First posted
- 14 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.
Detailed description
Prospective non-interventional, monocentric observational study on imbalances in regional lung ventilation compared to chest CT in post-acute-Covid-19. The aim is to verify the agreement between computerized tomography derived imaging variables and electrical impedance tomography in detecting lung ventilation imbalances. The primary study objective is to match CT morphological changes in regional ventilation in post-acute-COVID-19 patients and/or changes in lung function examination, with changes that can be visualized by electroimpedance tomography.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control cohort | – | –lung-healthy volunteers get a EIT measurement |
| Case cohort | – | Diagnostic Test: additional EIT MeasurementPatients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- All patients presenting to the post-COVID-19 outpatient clinic are screened.
Key inclusion criteria (3 listed)
- all patients undergoing a Chest CT due to suspected post-acute-Covid-19-syndrome
- >18 years
- informed consent.
Key exclusion criteria (4 listed)
- trauma patients and patients with unstable spinal injuries or fractures
- patients with an BMI over 50
- patients with uncontrolled body movements
- Patients with a pacemaker
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| additional EIT MeasurementPatients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement. The lunghealthy Patients in the control group only receive a EIT. | Diagnostic test | Case cohort |
Primary outcome
Correlation between tomography and electroimpedance tomography
Time frame: until May 2022
The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography.
1 secondary outcome
Correlation between lung function testing and electroimpedance tomography
Time frame: until May 2022
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2025.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Phillip A Reuken, Dr. study director
Jena University Hospital, Klinik für Innere Medizin IV
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of COVID-19 Pneumonia and Post-acute COVID-19 Syndrome, run by Jan-Christoph Lewejohann at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 25 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jan-Christoph Lewejohann, Dr. (+49 3641 9 32 20 13, jan-christoph.lewejohann@med.uni-jena.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation between tomography and electroimpedance tomography (time frame: until May 2022). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2025.