General AnesthesiaNCT05239234
Ultrasonographic Predictors of Hypotension After Induction
An observational study of General Anesthesia and Hypotension on Induction, run by Antalya Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
The purpose of the study is to evaluate the predictive value of the inferior vena cava collapsibility index and caval aorta index for detecting hypotension after induction of general anesthesia. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- General Anesthesia, Hypotension on Induction
- What is being tested?
- Inferior vena cava-Aorta diameter index
- How many people
- 100 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 2 Mar 2022to 12 Nov 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: patients who scheduled for elective non-cardiac surgery under general anesthesia
Who may be able to join
- patients more than 18 years of age
- American Society of Anesthesiologists' (ASA) physical status 1 or 2
Who cannot join
- BMI more than 30 kg/m²
- Use of angiotensin converting enzyme inhibitors
- pregnancy,
- emergency operations
- baseline arterial systolic blood pressure less than 90 mmHg
- mean arterial blood pressure less than 70 mmHg
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Antalya Training and Researching Hospital
Antalya
About this study
Official title: Pre-operative Ultrasonographic Evaluation of Inferior Vena Cava Collapsibility Index and Caval Aorta Index to Predict Hypotension After Induction of General Anesthesia
The purpose of the study is to evaluate the predictive value of the inferior vena cava collapsibility index and caval aorta index for detecting hypotension after induction of general anesthesia.
Read the detailed description
Since cardiovascular depressant and vasodilatory effects of anesthetic agents, patients may be at risk of hypotension after induction of general anesthesia. Previous studies reported that, for evaluating volume status, some ultrasonographic measurements such as inferior vena cava collapsibility index (IVCCI) could be used. Also some studies stated that measurement of aorta diameter index (IVC : Ao index) is reliable to predict hypotension after induction of spinal anesthesia. At the study, the investigators aimed to investigate the predictive values of the inferior vena cava collapsibility index and caval aorta index under ultrasound guidance in predicting post-induction hypotension in patients under general anesthesia.
- Conditions
- General Anesthesia, Hypotension on Induction
- Being tested
- Inferior vena cava-Aorta diameter index
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Inferior vena cava-Aorta diameter indexOther
Also called Inferior vena cava collapsibility index
Before the induction of general anesthesia, inferior vena cava-Aorta diameter index and inferior vena cava collapsibility index will be measured.
What is being measured
The primary outcome is the main question the study is designed to answer.
Diagnostic value of IVCCI to detect post-induction hypotension assessed by Receiver operating characteristic (ROC) curve analysis.
Measurement of inferior vena cava collapsibility index.
Measured: 20 minutes
Diagnostic value of IVC : Ao index to detect post-induction hypotension assessed by ROC curve analysis.
Measurement of inferior vena cava-Aorta diameter index.
Measured: 20 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Feb 2022
- Study start2 Mar 2022
- Primary completion9 Nov 2022
- Study completion12 Nov 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for General AnesthesiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Antalya Training and Research Hospital
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Enes Eskin, M.D., Principal investigator, Antalya Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05239234
- Sponsor's protocol ID
- AntalyaTRH55
- Status last verified
- Jan 2022
- First submitted
- 19 Jan 2022
- Last updated
- 28 Nov 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Eskin E, Kavakli AS, Eskin FP, Karaveli A, Eroglu S, Sahin T. Preoperative Ultrasonographic Assessment of Caval-Aortic Index and Inferior Vena Cava Collapsibility Index for Predicting Postinduction Hypotension During General Anesthesia: A Prospective Observational Study. J Cardiothorac Vasc Anesth. 2026 Oct;40(10):3183-3192. doi: 10.1053/j.jvca.2026.06.028. Epub 2026 Jun 22.
PubMed 42493316
Study at a glance
From the registry record, last updated by the sponsor on 28 Nov 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pre-operative Ultrasonographic Evaluation of Inferior Vena Cava Collapsibility Index and Caval Aorta Index to Predict Hypotension After Induction of General Anesthesia
- ClinicalTrials.gov ID
- NCT05239234
- Acronym / sponsor ID
- AntalyaTRH55
- Conditions
- General Anesthesia, Hypotension on Induction
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Antalya Training and Research HospitalOther government
- Study start
- 2 Mar 2022 (actual)
- Primary completion
- 9 Nov 2022 (actual)
- Study completion
- 12 Nov 2022 (actual)
- First posted
- 14 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the study is to evaluate the predictive value of the inferior vena cava collapsibility index and caval aorta index for detecting hypotension after induction of general anesthesia.
Detailed description
Since cardiovascular depressant and vasodilatory effects of anesthetic agents, patients may be at risk of hypotension after induction of general anesthesia. Previous studies reported that, for evaluating volume status, some ultrasonographic measurements such as inferior vena cava collapsibility index (IVCCI) could be used. Also some studies stated that measurement of aorta diameter index (IVC : Ao index) is reliable to predict hypotension after induction of spinal anesthesia. At the study, the investigators aimed to investigate the predictive values of the inferior vena cava collapsibility index and caval aorta index under ultrasound guidance in predicting post-induction hypotension in patients under general anesthesia.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- patients who scheduled for elective non-cardiac surgery under general anesthesia
Key inclusion criteria (2 listed)
- patients more than 18 years of age
- American Society of Anesthesiologists' (ASA) physical status 1 or 2
Key exclusion criteria (6 listed)
- BMI more than 30 kg/m²
- Use of angiotensin converting enzyme inhibitors
- pregnancy,
- emergency operations
- baseline arterial systolic blood pressure less than 90 mmHg
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Inferior vena cava-Aorta diameter indexAlso: Inferior vena cava collapsibility indexBefore the induction of general anesthesia, inferior vena cava-Aorta diameter index and inferior vena cava collapsibility index will be measured. | Other | – |
Primary outcome
Diagnostic value of IVCCI to detect post-induction hypotension assessed by Receiver operating characteristic (ROC) curve analysis.
Time frame: 20 minutes
Measurement of inferior vena cava collapsibility index.
Diagnostic value of IVC : Ao index to detect post-induction hypotension assessed by ROC curve analysis.
Time frame: 20 minutes
Measurement of inferior vena cava-Aorta diameter index.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Nov 2022.
- Derived from this study: PubMed 42493316Eskin E, Kavakli AS, Eskin FP, Karaveli A, Eroglu S, Sahin T. Preoperative Ultrasonographic Assessment of Caval-Aortic Index and Inferior Vena Cava Collapsibility Index for Predicting Postinduction Hypotension During General Anesthesia: A Prospective Observational Study. J Cardiothorac Vasc Anesth. 2026 Oct;40(10):3183-3192. doi: 10.1053/j.jvca.2026.06.028. Epub 2026 Jun 22.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Enes Eskin, M.D. principal investigator
Antalya Training and Research Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of General Anesthesia and Hypotension on Induction, run by Antalya Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Nov 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diagnostic value of IVCCI to detect post-induction hypotension assessed by Receiver operating characteristic (ROC) curve analysis. (time frame: 20 minutes). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05239234, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Nov 2022.