AcupunctureNCT05261919
Relationship Between Acupuncture Needling Direction and Electric Current
A study testing Acupuncture manipulation in people with Acupuncture and Electricity; Effects, run by Chang Gung Memorial Hospital at 1 site in Taiwan.
Trial summary
This study applies a semiconductor analyzer to investigate the effects of acupuncture manipulation. Read more about this study
- Who is it for?
- Ages 20 years and olderHealthy volunteers can take part
- Conditions the study is for
- Acupuncture, Electricity; Effects
- What is being tested?
- Acupuncture manipulation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Jan 2020to 31 Dec 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- at least 20 years old
- agree to the informed consent
Who cannot join
- under 20 years old
- pregnant or breast-feeding women
- those with an empty stomach before the study
- a tendency toward bleeding with thrombocytopenia or history of platelets < 20000 or a user of an anti-platelet drug.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Meridian Study on the Response Current Affected by Acupuncture Needling Direction
This study applies a semiconductor analyzer to investigate the effects of acupuncture manipulation.
Read the detailed description
Acupuncture manipulation with needling direction is important for the therapeutic effect based on traditional Chinese medicine theory. However, research usually focuses on the therapeutic effects on the acupoints and acupuncture time rather than on the manipulation method. This study applies a semiconductor analyzer to investigate the effects of acupuncture manipulation.
30 healthy participants were recruited in the study. This study employed an Agilent B1500A semiconductor analyzer to investigate the electric characteristics of meridians under directional supplementation and draining manipulation. We measured the electric current of meridians under different manipulation, and compared the difference between supplementation and draining manipulation in healthy individuals.
- Conditions
- Acupuncture, Electricity; Effects
- Being tested
- Acupuncture manipulation
- Keywords
- Acupuncture, Directional manipulation, Electricity, Meridian theory, Traditional Chinese medicine, Supplementation, Draining
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Acupuncture manipulationProcedure or surgery
Also called Directional manipulation
The investigator used directional supplementation and draining manipulation. The supplementation manipulation is defined as the angle of needle insertion to skin as 45 degrees with the needle tip in the same direction as the meridian. While the draining manipulation is defined as the angle of needle insertion at 45 degrees with the needle tip direction opposite to that of the meridian.
| Study group | Role | What they receive |
|---|---|---|
| acupuncture with manipulation group | Experimental | 30 participant were recruited in this study. All the participants received acupuncture at the acupoints (HT7、HT3、SI5、SI8、BL57、BL40、KI3、KI10) and were measured by an Agilent B1500A semiconductor analyzer.
The investigator perform acupuncture with supplementation manipulation first, followed by a measurement of the electrical characteristics using Agilent B1500A. The investigator remove the acupuncture and then perform acupuncture with draining manipulation, followed by measurements. After one meridian measurements were completed, the investigator removed the needle and proceeded to the next meridian to repeat the same procedure. Receives: Procedure: Acupuncture manipulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
The electric current
Agilent B1500A is a device that can measure the electric current after acupuncture manipulation. The investigators measure the electric current after intervention of supplementation manipulation and draining manipulation respectively.
Measured: through study completion, an average of 90 minutes
The voltage
Agilent B1500A is a device that can measure the voltage after acupuncture manipulation. The investigators measure the voltage after intervention of supplementation manipulation and draining manipulation respectively.
Measured: through study completion, an average of 90 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Mar 2022
- Study start1 Jan 2020
- Primary completion10 Mar 2020
- Study completion31 Dec 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for AcupunctureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- All the participants were in one group and received acupuncture manipulation. The investigator used directional supplementation and draining manipulation. The investigator perform acupuncture with supplementation manipulation first, followed by a measurement of the electrical characteristics using Agilent B1500A. The investigator remove the acupuncture and then perform acupuncture with draining manipulation, followed by measurements. After one meridian measurements were completed, the investigator removed the needle and proceeded to the next meridian to repeat the same procedure. The supplementation manipulation is defined as the angle of needle insertion to skin as 45 degrees with the needle tip in the same direction as the meridian. While the draining manipulation is defined as the angle of needle insertion at 45 degrees with the needle tip direction opposite to that of the meridian. The acupoints were HT7、HT3、SI5、SI8、BL57、BL40、KI3、KI10 in this study.
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chang Gung Memorial Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Yu-Chiang Hung, Professor, Principal investigator, Chang Gung Memorial Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05261919
- Sponsor's protocol ID
- 201901601A3
- Status last verified
- Jan 2020
- First submitted
- 14 Feb 2022
- Last updated
- 2 Mar 2022
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Hung YC, Chen WC, Chang TC, Zheng HX, Liu YW, Tan YF, Lin SK, Lu YH, Hu WL, Tsai TM. Meridian study on the response current affected by electrical pulse and acupuncture. Nanoscale Res Lett. 2020 Jul 10;15(1):146. doi: 10.1186/s11671-020-03373-2.
PubMed 32651748Ifrim Chen F, Antochi AD, Barbilian AG. Acupuncture and the retrospect of its modern research. Rom J Morphol Embryol. 2019;60(2):411-418.
PubMed 31658313Zhang WB, Wang GJ, Fuxe K. Classic and Modern Meridian Studies: A Review of Low Hydraulic Resistance Channels along Meridians and Their Relevance for Therapeutic Effects in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2015;2015:410979. doi: 10.1155/2015/410979. Epub 2015 Mar 2.
PubMed 25821487Lin CH, Tan YF, Tseng ST, Chen WC, Kuo CW, Wu CC, Tsai TM, Hu WL, Chang TC, Hung YC. Meridian study on the response current affected by acupuncture needling direction. Medicine (Baltimore). 2022 Sep 2;101(35):e30338. doi: 10.1097/MD.0000000000030338.
PubMed 36107585
Study at a glance
From the registry record, last updated by the sponsor on 2 Mar 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Meridian Study on the Response Current Affected by Acupuncture Needling Direction
- ClinicalTrials.gov ID
- NCT05261919
- Acronym / sponsor ID
- 201901601A3
- Conditions
- Acupuncture, Electricity; Effects
- Keywords
- Acupuncture, Directional manipulation, Electricity, Meridian theory, Traditional Chinese medicine, Supplementation, Draining
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Chang Gung Memorial HospitalUniversity, hospital or other
- Study start
- 1 Jan 2020 (actual)
- Primary completion
- 10 Mar 2020 (actual)
- Study completion
- 31 Dec 2020 (actual)
- First posted
- 2 Mar 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study applies a semiconductor analyzer to investigate the effects of acupuncture manipulation.
Detailed description
Acupuncture manipulation with needling direction is important for the therapeutic effect based on traditional Chinese medicine theory. However, research usually focuses on the therapeutic effects on the acupoints and acupuncture time rather than on the manipulation method. This study applies a semiconductor analyzer to investigate the effects of acupuncture manipulation.
30 healthy participants were recruited in the study. This study employed an Agilent B1500A semiconductor analyzer to investigate the electric characteristics of meridians under directional supplementation and draining manipulation. We measured the electric current of meridians under different manipulation, and compared the difference between supplementation and draining manipulation in healthy individuals.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- All the participants were in one group and received acupuncture manipulation. The investigator used directional supplementation and draining manipulation. The investigator perform acupuncture with supplementation manipulation first, followed by a measurement of the electrical characteristics using Agilent B1500A. The investigator remove the acupuncture and then perform acupuncture with draining manipulation, followed by measurements. After one meridian measurements were completed, the investigator removed the needle and proceeded to the next meridian to repeat the same procedure. The supplementation manipulation is defined as the angle of needle insertion to skin as 45 degrees with the needle tip in the same direction as the meridian. While the draining manipulation is defined as the angle of needle insertion at 45 degrees with the needle tip direction opposite to that of the meridian. The acupoints were HT7、HT3、SI5、SI8、BL57、BL40、KI3、KI10 in this study.
| Arm | Type | Receives |
|---|---|---|
| acupuncture with manipulation group | Experimental | Procedure: Acupuncture manipulation30 participant were recruited in this study. All the participants received acupuncture at the acupoints (HT7、HT3、SI5、SI8、BL57、BL40、KI3、KI10) and were measured by an Agilent B1500A semiconductor analyzer. The investigator perform acupuncture with supplementation manipulation first, followed by a measurement of the electrical characteristics using Agilent B1500A. The investigator remove the acupuncture and then perform acupuncture with draining manipulation, followed by measurements. After one meridian measurements were completed, the investigator removed the needle and proceeded to the next meridian to repeat the same procedure. |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- at least 20 years old
- agree to the informed consent
Key exclusion criteria (4 listed)
- under 20 years old
- pregnant or breast-feeding women
- those with an empty stomach before the study
- a tendency toward bleeding with thrombocytopenia or history of platelets < 20000 or a user of an anti-platelet drug.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Acupuncture manipulationAlso: Directional manipulationThe investigator used directional supplementation and draining manipulation. The supplementation manipulation is defined as the angle of needle insertion to skin as 45 degrees with the needle tip in the same direction as the meridian. While the draining manipulation is defined as the angle of needle insertion at 45 degrees with the needle tip direction opposite to that of the meridian. | Procedure or surgery | acupuncture with manipulation group |
Primary outcome
The electric current
Time frame: through study completion, an average of 90 minutes
Agilent B1500A is a device that can measure the electric current after acupuncture manipulation. The investigators measure the electric current after intervention of supplementation manipulation and draining manipulation respectively.
The voltage
Time frame: through study completion, an average of 90 minutes
Agilent B1500A is a device that can measure the voltage after acupuncture manipulation. The investigators measure the voltage after intervention of supplementation manipulation and draining manipulation respectively.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Mar 2022.
- Background: PubMed 32651748Hung YC, Chen WC, Chang TC, Zheng HX, Liu YW, Tan YF, Lin SK, Lu YH, Hu WL, Tsai TM. Meridian study on the response current affected by electrical pulse and acupuncture. Nanoscale Res Lett. 2020 Jul 10;15(1):146. doi: 10.1186/s11671-020-03373-2.
- Background: PubMed 31658313Ifrim Chen F, Antochi AD, Barbilian AG. Acupuncture and the retrospect of its modern research. Rom J Morphol Embryol. 2019;60(2):411-418.
- Background: PubMed 25821487Zhang WB, Wang GJ, Fuxe K. Classic and Modern Meridian Studies: A Review of Low Hydraulic Resistance Channels along Meridians and Their Relevance for Therapeutic Effects in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2015;2015:410979. doi: 10.1155/2015/410979. Epub 2015 Mar 2.
- Derived from this study: PubMed 36107585Lin CH, Tan YF, Tseng ST, Chen WC, Kuo CW, Wu CC, Tsai TM, Hu WL, Chang TC, Hung YC. Meridian study on the response current affected by acupuncture needling direction. Medicine (Baltimore). 2022 Sep 2;101(35):e30338. doi: 10.1097/MD.0000000000030338.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yu-Chiang Hung, Professor principal investigator
Chang Gung Memorial Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acupuncture manipulation in people with Acupuncture and Electricity; Effects, run by Chang Gung Memorial Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Mar 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The electric current (time frame: through study completion, an average of 90 minutes). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05261919, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Mar 2022.