Endodontic DiseaseNCT05267249
Revascularisation of Autotransplanted Teeth
An observational study of Endodontic Disease and Pulp Canal Obliteration, run by Medical University of Graz at 1 site in Austria.
Trial summary
Retrospective Analysis of a Study cohort that experienced autotransplantation of mature teeth with simultaneous root end resection Note: The study was registered on Clinicaltrials.gov after termination of study. Read more about this study
- Who is it for?
- Ages 12 to 70 years
- Conditions the study is for
- Endodontic Disease, Pulp Canal Obliteration
- How many people
- 16 participants
- Where
- 1 siteAustria
- Study dates
- 6 Aug 2021to 15 Feb 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 70 years
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients who underwent Autotransplantation of mature teeth with simultaneous apicoectomy between July 2017 and July 2020
Who may be able to join
- Male and female consenting and judicious young people and adults
- Written consent of the participant and, if applicable, of the legal guardian after education
- Planned tooth transplantation with advanced or completed root growth
Who cannot join
- Contraindications for magnetic resonance imaging (MRI): (pronounced metal restorations, running orthodontics with metal, fixed appliance in the target jaw)
- Current or past antiresorptive therapy with bisphosphonates
- Further anamnestic general or local risk situation, among others: Anti-angiogenic therapy, History of local radiation therapy, severe coagulation disorder, unadjusted diabetes mellitus, malignant diseases
- Acute gingivitis or advanced periodontitis
- Participation in an ongoing drug trial (various drugs may distort the result, such as bisphosphonates, cortisone, chemotherapeutics, angiogenesis inhibitors)
- heavy smokers (> 10 per day)
Show all 13Show fewer
- Acute or chronic infections (osteomyelitis) at the surgical site
- metabolic diseases (diabetes, hyperparathyroidism, osteomalacia)
- Severe kidney dysfunction, severe liver disease
- Patients with high-dose corticosteroid therapy
- prolonged corticosteroid or radiotherapy in the oral cavity
- autoimmune diseases
- Pregnant or breastfeeding women
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Revascularisation of Autotransplanted Teeth - Retrospective Analysis of a Novel Technique
Retrospective Analysis of a Study cohort that experienced autotransplantation of mature teeth with simultaneous root end resection
Note: The study was registered on Clinicaltrials.gov after termination of study.
- Conditions
- Endodontic Disease, Pulp Canal Obliteration
- Keywords
- Autotransplantation, Apicoectomy, Revascularisation
- Medical subject headings
- Dental Pulp Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Autotransplantation | Autotransplantation and apicoectomy of mature teeth |
What is being measured
The primary outcome is the main question the study is designed to answer.
Survival
Tooth survival
Measured: 1 year
Secondary outcomes (1)
Revascularisation
Occurrence of Revascularisation
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Mar 2022
- Study start6 Aug 2021
- Primary completion1 Feb 2022
- Study completion15 Feb 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Endodontic DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Medical University of Graz
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Petra Rugani, DDS, Principal investigator, Medical University of Graz
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05267249
- Sponsor's protocol ID
- ResectTX
- Status last verified
- Mar 2026
- First submitted
- 23 Feb 2022
- Last updated
- 20 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Available upon reasonable request
Publications
Jakse N, Ruckenstuhl M, Rugani P, Kirnbauer B, Sokolowski A, Ebeleseder K. Influence of Extraoral Apicoectomy on Revascularization of an Autotransplanted Tooth: A Case Report. J Endod. 2018 Aug;44(8):1298-1302. doi: 10.1016/j.joen.2018.04.016. Epub 2018 Jun 20.
PubMed 29935869
Study at a glance
From the registry record, last updated by the sponsor on 20 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Revascularisation of Autotransplanted Teeth - Retrospective Analysis of a Novel Technique
- ClinicalTrials.gov ID
- NCT05267249
- Acronym / sponsor ID
- ResectTX
- Conditions
- Endodontic Disease, Pulp Canal Obliteration
- Keywords
- Autotransplantation, Apicoectomy, Revascularisation
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Medical University of GrazUniversity, hospital or other
- Study start
- 6 Aug 2021 (actual)
- Primary completion
- 1 Feb 2022 (actual)
- Study completion
- 15 Feb 2022 (actual)
- First posted
- 4 Mar 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Retrospective Analysis of a Study cohort that experienced autotransplantation of mature teeth with simultaneous root end resection
Note: The study was registered on Clinicaltrials.gov after termination of study.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Autotransplantation | – | –Autotransplantation and apicoectomy of mature teeth |
Who may qualify
- Ages
- 12 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients who underwent Autotransplantation of mature teeth with simultaneous apicoectomy between July 2017 and July 2020
Key inclusion criteria (3 listed)
- Male and female consenting and judicious young people and adults
- Written consent of the participant and, if applicable, of the legal guardian after education
- Planned tooth transplantation with advanced or completed root growth
Key exclusion criteria (13 listed)
- Contraindications for magnetic resonance imaging (MRI): (pronounced metal restorations, running orthodontics with metal, fixed appliance in the target jaw)
- Current or past antiresorptive therapy with bisphosphonates
- Further anamnestic general or local risk situation, among others: Anti-angiogenic therapy, History of local radiation therapy, severe coagulation disorder, unadjusted diabetes mellitus, malignant diseases
- Acute gingivitis or advanced periodontitis
- Participation in an ongoing drug trial (various drugs may distort the result, such as bisphosphonates, cortisone, chemotherapeutics, angiogenesis inhibitors)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Survival
Time frame: 1 year
Tooth survival
1 secondary outcome
Revascularisation
Time frame: 1 year
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Mar 2026.
- Background: PubMed 29935869Jakse N, Ruckenstuhl M, Rugani P, Kirnbauer B, Sokolowski A, Ebeleseder K. Influence of Extraoral Apicoectomy on Revascularization of an Autotransplanted Tooth: A Case Report. J Endod. 2018 Aug;44(8):1298-1302. doi: 10.1016/j.joen.2018.04.016. Epub 2018 Jun 20.
- Individual participant dataSharing planned: Undecided. Available upon reasonable request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Petra Rugani, DDS principal investigator
Medical University of Graz
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Endodontic Disease and Pulp Canal Obliteration, run by Medical University of Graz at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Survival (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05267249, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Mar 2026.