ExerciseNCT05311202
The Effect of Acute Resistance Exercise on Inhibitory Control
A study testing low-volume moderate-intensity group, moderate-volume moderate-intensity group and high-volume moderate-intensity group in people with Exercise and Cognitive Function, run by National Taiwan Normal University at 1 site in Taiwan.
Trial summary
The current study is a five-arm, single bout program aiming to assess the effects of training volume and intensity of acute resistance exercise on inhibitory control on neurocognitive function with respect to event-related potential in adults aged 20 - 26 years. Read more about this study
- Who is it for?
- Ages 20 to 26 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise, Cognitive Function
- What is being tested?
- low-volume moderate-intensity group, moderate-volume moderate-intensity group and high-volume moderate-intensity group
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 175 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Apr 2022to 31 Dec 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 26 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- The dominant hand is right-handed
- 18.5 < BMI < 26
- Can cooperate with fingertip blood collection
- No color blindness and epilepsy
- Not taking medications that affect brain function
- Irregular exercise (more than 150 minutes per week for 3 months)
Who cannot join
- The participants who do not meet the inclusion or The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) Criteria.
Trial locations and contacts
1 site in 1 country.
Taiwan1 site, 1 recruiting
- Recruiting
National Taiwan Normal University
Taipei, 106
Yan-Ho Lo, Master, 0903679058, yanholo@hotmail.com
Yan-Ho Lo, Master
About this study
Official title: The Effect of Training Volume and Intensity of Acute Resistance Exercise on Inhibitory Control: An Event-Related Potential Study
The current study is a five-arm, single bout program aiming to assess the effects of training volume and intensity of acute resistance exercise on inhibitory control on neurocognitive function with respect to event-related potential in adults aged 20 - 26 years.
Read the detailed description
The current study is expected that 175 healthy adults will be recruited and randomly assigned to control group, low volume-moderate intensity, moderate volume-moderate intensity, high volume-moderate intensity, or moderate volume-low intensity group, with 35 participants in each group. Participants will be required to conduct two experiments. The first was the familiarity experiment, which consisted of the experiment description, the familiarity test, and the 6 Repetition Maximum (RM) test. The process lasted about 3 hours. The exercise group was given a warm-up exercise before the intervention, followed by resistance exercise, including Bench Press, Rowing, Deadlift, and Squat, all completed on the Smith machine. After the exercise, the group was given a cool down, while the control group was given 30 minutes of reading. Before and after the intervention, Stroop, event-related potential and fingertip blood lactate were measured, and another fingertip blood lactate was measured 10 minutes after the intervention, which lasted about 3 hours.
- Conditions
- Exercise, Cognitive Function
- Being tested
- low-volume moderate-intensity group, moderate-volume moderate-intensity group, high-volume moderate-intensity group, moderate-volume low-intensity group, Control group
- Keywords
- Acute resistance exercise, Inhibitory control, Training volume, Intensity, Event-related potential
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
low-volume moderate-intensity groupBehavioural
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 20 minutes of two sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down
moderate-volume moderate-intensity groupBehavioural
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 30 minutes of three sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down
high-volume moderate-intensity groupBehavioural
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 40 minutes of four sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down
moderate-volume low-intensity groupBehavioural
The interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 35 minutes of four sets of low intensity resistance exercise with 20 repetitions; (3) 5 minutes of cool down
Control groupBehavioural
Reading a book related to cognitive function \& exercise for 40 minutes
| Study group | Role | What they receive |
|---|---|---|
| low-volume moderate-intensity group | Experimental | Participants will attend the trainer-supervised resistance exercise program for 30 minutes Receives: Behavioral: low-volume moderate-intensity group |
| moderate-volume moderate-intensity group | Experimental | Participants will attend the trainer-supervised resistance exercise program for 40 minutes Receives: Behavioral: moderate-volume moderate-intensity group |
| high-volume moderate-intensity group | Experimental | Participants will attend the trainer-supervised resistance exercise program for 50 minutes Receives: Behavioral: high-volume moderate-intensity group |
| moderate-volume low-intensity group | Experimental | Participants will attend the trainer-supervised resistance exercise program for 45 minutes Receives: Behavioral: moderate-volume low-intensity group |
| Control group | Experimental | Reading for 40 minutes Receives: Behavioral: Control group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes In Inhibitory Control
The computerized Stroop test will be administrated to assess participants' inhibitory function, and the changes in Emotional Stroop test performance (i.e., response time and accuracy) before (pre-test) and after (post-test) intervention will be examined.
Measured: 30 minutes each before & after intervention
Changes In Neuroelectrical Activities: Event-Related Potential Recording and Analysis
The continuous electroencephalogram (EEG) activity of each participant will be recorded throughout the entire Stroop task using a Neuroscan Quick-Cap, with 32 Ag/AgCl electrodes arranged following the international 10-20 system (NeuroScan Inc., El Paso, TX, USA). Changes in the neuroelectrical activities before and after the intervention will be examined. The time windows for each ERP component will be determined based on a visual inspection of the averaged grand waveform.
Measured: 30 minutes each before & after intervention
Secondary outcomes (6)
Changes In Positive & Negative Affect
The changes in the Positive \& Negative affect after pre-and post-test will be assessed by The Positive and Negative Affect Schedule (PANAS) questionnaire, which is made up of two 10-item scales that assess both positive and negative emotions. Each item is scored on a scale of 1 (not at all) to 5 (very much).
Measured: 5 minutes after pre-test and post-test of Stroop test
Muscular Fitness Measurements (1RM)-Deadlift
The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 10-20% for lower body exercises. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. The 1RM will be caculated by the results of 6-RM protocol.
Measured: 2 hours on the first day
Muscular Fitness Measurements (1RM)-Bench Press
The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 5-10%. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. 1RM will be caculated by the results of 6-RM protocol.
Measured: 2 hours on the first day
Muscular Fitness Measurements (1RM)-Squat
The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 10-20% for. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. 1RM will be caculated by the results of 6-RM protocol.
Measured: 2 hours on the first day
Muscular Fitness Measurements (1RM)-Rowing
The greatest weight an individual is capable of lifting for one repetition (1RM) will be examined using the 6-RM assessment according to the American College of Sports Medicine (ACSM) protocol. There were multiple steps in the resistance exercise assessment process. Warming up at a low intensity for 1 minute will be followed by a 1-minute rest break. For the first set of exercises, each person's workload (lbs) will be increased by 5-10%. Participants will be told to do 10 repetitions followed by a 2-minute rest break during this step. Following that, a steadily increasing load will be applied until the load can only be completed less than 6 repetitions. The numbers of set will be limited to the minimum 1set to maximum 4sets. 1RM will be caculated by the results of 6-RM protocol.
Measured: 2 hours on the first day
Changes In Concentration Of Blood Lactate
Fingertip Blood samples will be collected using Lactate Analyzer in three times point: before the pre-test of cognitive test, after the intervention and before the post-test of cognitive test, and analysed the change in concentration of blood lactate between the three time points.
Measured: 2 minutes of each time point (Before the pre-test of cognitive test, after the intervention and before the post-test of cognitive test)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Apr 2022
- Study start1 Apr 2022
- Primary completion30 Sep 2022 (estimated)
- Study completion31 Dec 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 175 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan Normal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yu-Kai Chang, National Taiwan Normal University
- Investigators
- Yu-Kai Chang, Ph.D., Principal investigator, Department of Physical Education and Sport Sciences, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05311202
- Sponsor's protocol ID
- PACNL_202201HM012
- Status last verified
- May 2022
- First submitted
- 16 Mar 2022
- Last updated
- 13 May 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Chen YC, Lo YH, Hung CS, Cheng YT, Li RH, Chen FT, Chang YK. Acute effects of resistance exercise intensity and repetition at a predetermined volume on inhibitory control: a randomized controlled trial. Front Sports Act Living. 2025 Mar 13;7:1551624. doi: 10.3389/fspor.2025.1551624. eCollection 2025.
PubMed 40181929
Study at a glance
From the registry record, last updated by the sponsor on 13 May 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Training Volume and Intensity of Acute Resistance Exercise on Inhibitory Control: An Event-Related Potential Study
- ClinicalTrials.gov ID
- NCT05311202
- Acronym / sponsor ID
- PACNL_202201HM012
- Conditions
- Exercise, Cognitive Function
- Keywords
- Acute resistance exercise, Inhibitory control, Training volume, Intensity, Event-related potential
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 175 participants (estimated)
- Lead sponsor
- National Taiwan Normal UniversityUniversity, hospital or other
- Study start
- 1 Apr 2022 (actual)
- Primary completion
- 30 Sep 2022 (estimated)
- Study completion
- 31 Dec 2022 (estimated)
- First posted
- 5 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The current study is a five-arm, single bout program aiming to assess the effects of training volume and intensity of acute resistance exercise on inhibitory control on neurocognitive function with respect to event-related potential in adults aged 20 - 26 years.
Detailed description
The current study is expected that 175 healthy adults will be recruited and randomly assigned to control group, low volume-moderate intensity, moderate volume-moderate intensity, high volume-moderate intensity, or moderate volume-low intensity group, with 35 participants in each group. Participants will be required to conduct two experiments. The first was the familiarity experiment, which consisted of the experiment description, the familiarity test, and the 6 Repetition Maximum (RM) test. The process lasted about 3 hours. The exercise group was given a warm-up exercise before the intervention, followed by resistance exercise, including Bench Press, Rowing, Deadlift, and Squat, all completed on the Smith machine. After the exercise, the group was given a cool down, while the control group was given 30 minutes of reading. Before and after the intervention, Stroop, event-related potential and fingertip blood lactate were measured, and another fingertip blood lactate was measured 10 minutes after the intervention, which lasted about 3 hours.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| low-volume moderate-intensity group | Experimental | Behavioral: low-volume moderate-intensity groupParticipants will attend the trainer-supervised resistance exercise program for 30 minutes |
| moderate-volume moderate-intensity group | Experimental | Behavioral: moderate-volume moderate-intensity groupParticipants will attend the trainer-supervised resistance exercise program for 40 minutes |
| high-volume moderate-intensity group | Experimental | Behavioral: high-volume moderate-intensity groupParticipants will attend the trainer-supervised resistance exercise program for 50 minutes |
| moderate-volume low-intensity group | Experimental | Behavioral: moderate-volume low-intensity groupParticipants will attend the trainer-supervised resistance exercise program for 45 minutes |
| Control group | Experimental | Behavioral: Control groupReading for 40 minutes |
Who may qualify
- Ages
- 20 to 26 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- The dominant hand is right-handed
- 18.5 < BMI < 26
- Can cooperate with fingertip blood collection
- No color blindness and epilepsy
- Not taking medications that affect brain function
Key exclusion criteria (1 listed)
- The participants who do not meet the inclusion or The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) Criteria.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| low-volume moderate-intensity groupThe interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 20 minutes of two sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down | Behavioural | low-volume moderate-intensity group |
| moderate-volume moderate-intensity groupThe interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 30 minutes of three sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down | Behavioural | moderate-volume moderate-intensity group |
| high-volume moderate-intensity groupThe interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 40 minutes of four sets of moderate intensity resistance exercise with 10 repetitions; (3) 5 minutes of cool down | Behavioural | high-volume moderate-intensity group |
| moderate-volume low-intensity groupThe interventional program will include (1) 5 minutes of warm-up and aerobic exercise from light to moderate intensity; (2) 35 minutes of four sets of low intensity resistance exercise with 20 repetitions; (3) 5 minutes of cool down | Behavioural | moderate-volume low-intensity group |
| Control groupReading a book related to cognitive function \& exercise for 40 minutes | Behavioural | Control group |
Primary outcome
Changes In Inhibitory Control
Time frame: 30 minutes each before & after intervention
The computerized Stroop test will be administrated to assess participants' inhibitory function, and the changes in Emotional Stroop test performance (i.e., response time and accuracy) before (pre-test) and after (post-test) intervention will be examined.
Changes In Neuroelectrical Activities: Event-Related Potential Recording and Analysis
Time frame: 30 minutes each before & after intervention
The continuous electroencephalogram (EEG) activity of each participant will be recorded throughout the entire Stroop task using a Neuroscan Quick-Cap, with 32 Ag/AgCl electrodes arranged following the international 10-20 system (NeuroScan Inc., El Paso, TX, USA). Changes in the neuroelectrical activities before and after the intervention will be examined. The time windows for each ERP component will be determined based on a visual inspection of the averaged grand waveform.
6 secondary outcomes
Changes In Positive & Negative Affect
Time frame: 5 minutes after pre-test and post-test of Stroop test
Muscular Fitness Measurements (1RM)-Deadlift
Time frame: 2 hours on the first day
Muscular Fitness Measurements (1RM)-Bench Press
Time frame: 2 hours on the first day
Muscular Fitness Measurements (1RM)-Squat
Time frame: 2 hours on the first day
Muscular Fitness Measurements (1RM)-Rowing
Time frame: 2 hours on the first day
Changes In Concentration Of Blood Lactate
Time frame: 2 minutes of each time point (Before the pre-test of cognitive test, after the intervention and before the post-test of cognitive test)
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 May 2022.
- Derived from this study: PubMed 40181929Chen YC, Lo YH, Hung CS, Cheng YT, Li RH, Chen FT, Chang YK. Acute effects of resistance exercise intensity and repetition at a predetermined volume on inhibitory control: a randomized controlled trial. Front Sports Act Living. 2025 Mar 13;7:1551624. doi: 10.3389/fspor.2025.1551624. eCollection 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yu-Kai Chang, Ph.D. principal investigator
Department of Physical Education and Sport Sciences, National Taiwan Normal University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing low-volume moderate-intensity group, moderate-volume moderate-intensity group and high-volume moderate-intensity group in people with Exercise and Cognitive Function, run by National Taiwan Normal University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 13 May 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Yu-Kai Chang, Ph.D (+886277493220, yukaichangnew@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes In Inhibitory Control (time frame: 30 minutes each before & after intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05311202, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 May 2022.