AsthmaNCT05330637
Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.
An observational study of Asthma and Allergic Rhinitis, run by Shanghai Jiao Tong University School of Medicine at 1 site in China.
Trial summary
To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya. Read more about this study
- Who is it for?
- Ages 3 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Asthma, Allergic Rhinitis, Chronic Obstructive Pulmonary Disease(COPD)
- What is being tested?
- Climate and environment in Sanya
- How many people
- 800 participants
- Where
- 1 siteChina
- Study dates
- 3 Mar 2022to 30 Apr 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 3 to 80 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: 1. 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atypical dermatitis from northeast China. 2. 3-12 years-old children with asthma, allergic rhinitis, atypical dermatitisin in Sanya.
Who may be able to join
- 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atopic dermatitis from northern China;
- 3-12 years-old children in Sanya;
- Agree to participate this study.
Who cannot join
- Disagree to participate this study;
- Having other respiratory diseases which can influence airflow, such as lung cancer, tuberculosis, pneumonia, bronchiectasis, etc;
- Inability to understand the study procedures or inability/reluctance to answer questionnaire judged by the investigator.
Trial locations and contacts
1 site in 1 country.
China1 site, 1 recruiting
- Recruiting
Sanya Women and Children's Hospital, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University
Sanya, Hainan
Haidao Guan, BD, 86-0898-88360093, 269941951@qq.com
Shijian Liu, Ph.D
About this study
Official title: Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.
To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.
Read the detailed description
The study is an observational research, which will recruit the community migratory old people and children at school using cluster sampling in Sanya by Sanya Maternal and Child Health Care Hospital (Sanya Women and Children's Hospital). Sanya Central Hospital(Hainan Third People's Hospital) and People's Hospital of Sanya will assist to diagnose old people disease. The data of climate and environment will be obtained from Sanya Meteorological Administration and Sanya Municipal Ecology and Environment Bureau.
- The primary purpose is to investigate the influence of the unique tropical climate and environmental factors on the migratory old people with diseases such as asthma, allergic rhinitis, COPD or atopic dermatitis in Sanya from northern China, and to provide scientific evidence for publicity of the tourism and the health care industry.
- The secondary purpose is to investigate prevalence and risk factors of asthma, allergic rhinitis and atopic dermatitis among children in Sanya, which will provide a base for prevention and control strategies.
- The third purpose is to retrospectively analyze the influence of climate and environmental factors in Sanya on children with asthma, allergic rhinitis and atopic dermatitis in the past decade, and a comparative analysis of the incidence on children in Sanya and Shanghai.
- Conditions
- Asthma, Allergic Rhinitis, Chronic Obstructive Pulmonary Disease(COPD), Atopic Dermatitis, Eczema, Urticaria
- Being tested
- Climate and environment in Sanya
- Keywords
- Asthma, Allergic Rhinitis, Climatotherapy, Chronic Obstructive Pulmonary Disease(COPD), Atopic Dermatitis, Climate, Environment
- Medical subject headings
- Asthma, Rhinitis, Allergic, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic, Eczema, Urticaria, Bronchitis, Emphysema
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Climate and environment in SanyaOther
Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.
| Study group | Role | What they receive |
|---|---|---|
| Migratory old people with asthma from northern China in Sanya | Migratory old people with asthma from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. Receives: Other: Climate and environment in Sanya | |
| Migratory old people with allergic rhinitis from northern China in Sanya | Migratory old people with allergic rhinitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. Receives: Other: Climate and environment in Sanya | |
| Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya | Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. Receives: Other: Climate and environment in Sanya | |
| Migratory old people with atopic dermatitis from northern China in Sanya | Migratory old people with atopic dermatitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. Receives: Other: Climate and environment in Sanya | |
| Children with asthma in Sanya | Children with asthma have being exposure to tropical climate and environment in Sanya for years. Receives: Other: Climate and environment in Sanya | |
| Children with allergic rhinitis in Sanya | Children with allergic rhinitis have being exposure to tropical climate and environment in Sanya for years. Receives: Other: Climate and environment in Sanya | |
| Children with atopic dermatitis in Sanya | Children with atopic dermatitis have being exposure to tropical climate and environment in Sanya for years. Receives: Other: Climate and environment in Sanya | |
| Children with eczema in Sanya | Children with eczema have being exposure to tropical climate and environment in Sanya for years. Receives: Other: Climate and environment in Sanya | |
| Children with urticaria in Sanya | Children with urticaria have being exposure to tropical climate and environment in Sanya for years. Receives: Other: Climate and environment in Sanya | |
| Migratory old people with eczema from northern China in Sanya | Migratory old people with eczema from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. Receives: Other: Climate and environment in Sanya | |
| Migratory old people with urticaria from northern China in Sanya | Migratory old people with urticaria from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. Receives: Other: Climate and environment in Sanya |
What is being measured
The primary outcome is the main question the study is designed to answer.
The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China.
The asthma, COPD, allergic rhinitis or atopic dermatitis will be diagnosed and assessed through history of diseases and questionnaire..
Measured: 3 year
Secondary outcomes (7)
Asthma control of migratory old people with asthma.
Quality of life is assessed through questionnaires of "Asthma Control Questionnaire (ACQ) ".
Measured: 1-3 year
Asthma life quality of migratory old people with asthma.
Quality of life is assessed through questionnaires of "Asthma Quality of Life Questionnaire (AQLQ)".
Measured: 1-3 year
Lung function of migratory old people with asthma or COPD.
Lung function is assessed through simple lung function test using spirometry.
Measured: 1-3 year
The respiratory function of migratory old people with COPD.
Lung function is assessed through Saint George Respiratory Questionnaire (SGRQ).
Measured: 1-3 year
Allergens will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
Veinal blood was extracted to detect allergens.
Measured: 1-3 year
Inflammatory factors will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
Inflammatory factors such as esophageal granulocytes and eosinophils will be detected to assess inflammatory status of the migratory old people.
Measured: 1-3 year
The change of asthma incidence rate in migratory old people .
Diagnosis and severity grading of asthma is based on the "American Thoracic Society" or the "National Heart, Lung, and Blood Institute guidelines."
Measured: 1-3 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Apr 2022
- Study start3 Mar 2022
- Primary completion31 Dec 2023 (estimated)
- Study completion30 Apr 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (14)Papers the sponsor has linked to this study.
- Other trials for AsthmaStudies of the same condition, open and under way.
- More trials run by Shanghai Jiao Tong University School of MedicineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 800 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Shanghai Jiao Tong University School of Medicine
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Shijian Liu, Ph.D, Principal investigator, Shanghai Children's Medicial Center affiliated Shanghai Jiao Tong University School of Medicine
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05330637
- Sponsor's protocol ID
- SYFYIRB2022009
- Status last verified
- Sep 2023
- First submitted
- 18 Mar 2022
- Last updated
- 11 Sep 2023
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Xu G, Wu S, Wang C, Wang R, Shi Z, Xu Y, Ye X, Song Y, Wang Q, Zhou Y, Li W, Ding L, Wan C, Yao W, Guo Y, Xiao F, Lu Y, Peng X, Zhang B, Xiao D, Wang Z, Chen Z, Bu X, Zhang H, Zhang X, An L, Zhang S, Zhu J, Cao Z, Zhan Q, Yang Y, Liang L, Tong X, Dai H, Cao B, Wu T, Chung KF, He J, Wang C; China Pulmonary Health (CPH) Study Group. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019 Aug 3;394(10196):407-418. doi: 10.1016/S0140-6736(19)31147-X. Epub 2019 Jun 20.
PubMed 31230828Xie L, Liu Z, Hao S, Wu Q, Sun L, Luo H, Yu R, Li X, Wu X, Li S. Assessment of knowledge, attitude, and practice towards pulmonary rehabilitation among COPD patients: A multicenter and cross-sectional survey in China. Respir Med. 2020 Nov-Dec;174:106198. doi: 10.1016/j.rmed.2020.106198. Epub 2020 Oct 20.
PubMed 33120194Zhu B, Wang Y, Ming J, Chen W, Zhang L. Disease burden of COPD in China: a systematic review. Int J Chron Obstruct Pulmon Dis. 2018 Apr 27;13:1353-1364. doi: 10.2147/COPD.S161555. eCollection 2018.
PubMed 29731623Ding Y, Xu J, Yao J, Chen Y, He P, Ouyang Y, Niu H, Tian Z, Sun P. The analyses of risk factors for COPD in the Li ethnic group in Hainan, People's Republic of China. Int J Chron Obstruct Pulmon Dis. 2015 Nov 30;10:2593-600. doi: 10.2147/COPD.S86402. eCollection 2015.
PubMed 26664107Garcia-Almaraz R, Reyes-Noriega N, Del-Rio-Navarro BE, Berber A, Navarrete-Rodriguez EM, Ellwood P, Garcia Marcos Alvarez L; GAN Phase I group. Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I. World Allergy Organ J. 2020 Dec 5;14(1):100492. doi: 10.1016/j.waojou.2020.100492. eCollection 2021 Jan.
PubMed 34659624Pesce G, Bugiani M, Marcon A, Marchetti P, Carosso A, Accordini S, Antonicelli L, Cogliani E, Pirina P, Pocetta G, Spinelli F, Villani S, de Marco R. Geo-climatic heterogeneity in self-reported asthma, allergic rhinitis and chronic bronchitis in Italy. Sci Total Environ. 2016 Feb 15;544:645-52. doi: 10.1016/j.scitotenv.2015.12.015. Epub 2015 Dec 10.
PubMed 26674694Zanolin ME, Pattaro C, Corsico A, Bugiani M, Carrozzi L, Casali L, Dallari R, Ferrari M, Marinoni A, Migliore E, Olivieri M, Pirina P, Verlato G, Villani S, Marco R; ISAYA Study Group. The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: results from the Italian study of asthma in young adults. Allergy. 2004 Mar;59(3):306-14. doi: 10.1046/j.1398-9995.2003.00391.x.
PubMed 14982513Weiland SK, Husing A, Strachan DP, Rzehak P, Pearce N; ISAAC Phase One Study Group. Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med. 2004 Jul;61(7):609-15. doi: 10.1136/oem.2002.006809.
PubMed 15208377Wang X, Zhuang Y, Chen Y, Wang H, Wang X. Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China. Allergy Asthma Clin Immunol. 2021 Mar 9;17(1):27. doi: 10.1186/s13223-021-00532-7.
PubMed 33750462Su N, Lin J, Chen P, Li J, Wu C, Yin K, Liu C, Chen Y, Zhou X, Yuan Y, Huang X. Evaluation of asthma control and patient's perception of asthma: findings and analysis of a nationwide questionnaire-based survey in China. J Asthma. 2013 Oct;50(8):861-70. doi: 10.3109/02770903.2013.808346.
PubMed 23713625Li J, Sun B, Huang Y, Lin X, Zhao D, Tan G, Wu J, Zhao H, Cao L, Zhong N; China Alliance of Research on Respiratory Allergic Disease. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China. Allergy. 2009 Jul;64(7):1083-92. doi: 10.1111/j.1398-9995.2009.01967.x. Epub 2009 Feb 11.
PubMed 19210346Donaldson GC, Wedzicha JA. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2014 Oct 6;9:1101-10. doi: 10.2147/COPD.S54475. eCollection 2014.
PubMed 25336941Kantor R, Silverberg JI. Environmental risk factors and their role in the management of atopic dermatitis. Expert Rev Clin Immunol. 2017 Jan;13(1):15-26. doi: 10.1080/1744666X.2016.1212660. Epub 2016 Jul 28.
PubMed 27417220Wang X, Li LF, Zhao DY, Shen YW. Prevalence and Clinical Features of Atopic Dermatitis in China. Biomed Res Int. 2016;2016:2568301. doi: 10.1155/2016/2568301. Epub 2016 Nov 13.
PubMed 27957490
Study at a glance
From the registry record, last updated by the sponsor on 11 Sep 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.
- ClinicalTrials.gov ID
- NCT05330637
- Acronym / sponsor ID
- SYFYIRB2022009
- Conditions
- Asthma, Allergic Rhinitis, Chronic Obstructive Pulmonary Disease(COPD), Atopic Dermatitis, Eczema, Urticaria
- Keywords
- Asthma, Allergic Rhinitis, Climatotherapy, Chronic Obstructive Pulmonary Disease(COPD), Atopic Dermatitis, Climate, Environment
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 800 participants (estimated)
- Lead sponsor
- Shanghai Jiao Tong University School of MedicineUniversity, hospital or other
- Study start
- 3 Mar 2022 (actual)
- Primary completion
- 31 Dec 2023 (estimated)
- Study completion
- 30 Apr 2025 (estimated)
- First posted
- 15 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.
Detailed description
The study is an observational research, which will recruit the community migratory old people and children at school using cluster sampling in Sanya by Sanya Maternal and Child Health Care Hospital (Sanya Women and Children's Hospital). Sanya Central Hospital(Hainan Third People's Hospital) and People's Hospital of Sanya will assist to diagnose old people disease. The data of climate and environment will be obtained from Sanya Meteorological Administration and Sanya Municipal Ecology and Environment Bureau.
- The primary purpose is to investigate the influence of the unique tropical climate and environmental factors on the migratory old people with diseases such as asthma, allergic rhinitis, COPD or atopic dermatitis in Sanya from northern China, and to provide scientific evidence for publicity of the tourism and the health care industry.
- The secondary purpose is to investigate prevalence and risk factors of asthma, allergic rhinitis and atopic dermatitis among children in Sanya, which will provide a base for prevention and control strategies.
- The third purpose is to retrospectively analyze the influence of climate and environmental factors in Sanya on children with asthma, allergic rhinitis and atopic dermatitis in the past decade, and a comparative analysis of the incidence on children in Sanya and Shanghai.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 11
| Arm | Type | Receives |
|---|---|---|
| Migratory old people with asthma from northern China in Sanya | – | Other: Climate and environment in SanyaMigratory old people with asthma from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| Migratory old people with allergic rhinitis from northern China in Sanya | – | Other: Climate and environment in SanyaMigratory old people with allergic rhinitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya | – | Other: Climate and environment in SanyaMigratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| Migratory old people with atopic dermatitis from northern China in Sanya | – | Other: Climate and environment in SanyaMigratory old people with atopic dermatitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| Children with asthma in Sanya | – | Other: Climate and environment in SanyaChildren with asthma have being exposure to tropical climate and environment in Sanya for years. |
| Children with allergic rhinitis in Sanya | – | Other: Climate and environment in SanyaChildren with allergic rhinitis have being exposure to tropical climate and environment in Sanya for years. |
| Children with atopic dermatitis in Sanya | – | Other: Climate and environment in SanyaChildren with atopic dermatitis have being exposure to tropical climate and environment in Sanya for years. |
| Children with eczema in Sanya | – | Other: Climate and environment in SanyaChildren with eczema have being exposure to tropical climate and environment in Sanya for years. |
| Children with urticaria in Sanya | – | Other: Climate and environment in SanyaChildren with urticaria have being exposure to tropical climate and environment in Sanya for years. |
| Migratory old people with eczema from northern China in Sanya | – | Other: Climate and environment in SanyaMigratory old people with eczema from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
| Migratory old people with urticaria from northern China in Sanya | – | Other: Climate and environment in SanyaMigratory old people with urticaria from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months. |
Who may qualify
- Ages
- 3 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- 1. 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atypical dermatitis from northeast China. 2. 3-12 years-old children with asthma, allergic rhinitis, atypical dermatitisin in Sanya.
Key inclusion criteria (3 listed)
- 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atopic dermatitis from northern China;
- 3-12 years-old children in Sanya;
- Agree to participate this study.
Key exclusion criteria (3 listed)
- Disagree to participate this study;
- Having other respiratory diseases which can influence airflow, such as lung cancer, tuberculosis, pneumonia, bronchiectasis, etc;
- Inability to understand the study procedures or inability/reluctance to answer questionnaire judged by the investigator.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Climate and environment in SanyaSanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine. | Other | Children with allergic rhinitis in Sanya, Children with asthma in Sanya, Children with atopic dermatitis in Sanya, Children with eczema in Sanya, Children with urticaria in Sanya, Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya, Migratory old people with allergic rhinitis from northern China in Sanya, Migratory old people with asthma from northern China in Sanya, Migratory old people with atopic dermatitis from northern China in Sanya, Migratory old people with eczema from northern China in Sanya, Migratory old people with urticaria from northern China in Sanya |
Primary outcome
The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China.
Time frame: 3 year
The asthma, COPD, allergic rhinitis or atopic dermatitis will be diagnosed and assessed through history of diseases and questionnaire..
7 secondary outcomes
Asthma control of migratory old people with asthma.
Time frame: 1-3 year
Asthma life quality of migratory old people with asthma.
Time frame: 1-3 year
Lung function of migratory old people with asthma or COPD.
Time frame: 1-3 year
The respiratory function of migratory old people with COPD.
Time frame: 1-3 year
Allergens will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
Time frame: 1-3 year
Inflammatory factors will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
Time frame: 1-3 year
The change of asthma incidence rate in migratory old people .
Time frame: 1-3 year
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Sep 2023.
- Results publication: PubMed 31230828Huang K, Yang T, Xu J, Yang L, Zhao J, Zhang X, Bai C, Kang J, Ran P, Shen H, Wen F, Chen Y, Sun T, Shan G, Lin Y, Xu G, Wu S, Wang C, Wang R, Shi Z, Xu Y, Ye X, Song Y, Wang Q, Zhou Y, Li W, Ding L, Wan C, Yao W, Guo Y, Xiao F, Lu Y, Peng X, Zhang B, Xiao D, Wang Z, Chen Z, Bu X, Zhang H, Zhang X, An L, Zhang S, Zhu J, Cao Z, Zhan Q, Yang Y, Liang L, Tong X, Dai H, Cao B, Wu T, Chung KF, He J, Wang C; China Pulmonary Health (CPH) Study Group. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019 Aug 3;394(10196):407-418. doi: 10.1016/S0140-6736(19)31147-X. Epub 2019 Jun 20.
- Results publication: PubMed 33120194Xie L, Liu Z, Hao S, Wu Q, Sun L, Luo H, Yu R, Li X, Wu X, Li S. Assessment of knowledge, attitude, and practice towards pulmonary rehabilitation among COPD patients: A multicenter and cross-sectional survey in China. Respir Med. 2020 Nov-Dec;174:106198. doi: 10.1016/j.rmed.2020.106198. Epub 2020 Oct 20.
- Results publication: PubMed 29731623Zhu B, Wang Y, Ming J, Chen W, Zhang L. Disease burden of COPD in China: a systematic review. Int J Chron Obstruct Pulmon Dis. 2018 Apr 27;13:1353-1364. doi: 10.2147/COPD.S161555. eCollection 2018.
- Results publication: PubMed 26664107Ding Y, Xu J, Yao J, Chen Y, He P, Ouyang Y, Niu H, Tian Z, Sun P. The analyses of risk factors for COPD in the Li ethnic group in Hainan, People's Republic of China. Int J Chron Obstruct Pulmon Dis. 2015 Nov 30;10:2593-600. doi: 10.2147/COPD.S86402. eCollection 2015.
- Results publication: PubMed 34659624Garcia-Almaraz R, Reyes-Noriega N, Del-Rio-Navarro BE, Berber A, Navarrete-Rodriguez EM, Ellwood P, Garcia Marcos Alvarez L; GAN Phase I group. Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I. World Allergy Organ J. 2020 Dec 5;14(1):100492. doi: 10.1016/j.waojou.2020.100492. eCollection 2021 Jan.
- Results publication: PubMed 26674694Pesce G, Bugiani M, Marcon A, Marchetti P, Carosso A, Accordini S, Antonicelli L, Cogliani E, Pirina P, Pocetta G, Spinelli F, Villani S, de Marco R. Geo-climatic heterogeneity in self-reported asthma, allergic rhinitis and chronic bronchitis in Italy. Sci Total Environ. 2016 Feb 15;544:645-52. doi: 10.1016/j.scitotenv.2015.12.015. Epub 2015 Dec 10.
- Results publication: PubMed 14982513Zanolin ME, Pattaro C, Corsico A, Bugiani M, Carrozzi L, Casali L, Dallari R, Ferrari M, Marinoni A, Migliore E, Olivieri M, Pirina P, Verlato G, Villani S, Marco R; ISAYA Study Group. The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: results from the Italian study of asthma in young adults. Allergy. 2004 Mar;59(3):306-14. doi: 10.1046/j.1398-9995.2003.00391.x.
- Results publication: PubMed 15208377Weiland SK, Husing A, Strachan DP, Rzehak P, Pearce N; ISAAC Phase One Study Group. Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med. 2004 Jul;61(7):609-15. doi: 10.1136/oem.2002.006809.
- Results publication: PubMed 33750462Wang X, Zhuang Y, Chen Y, Wang H, Wang X. Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China. Allergy Asthma Clin Immunol. 2021 Mar 9;17(1):27. doi: 10.1186/s13223-021-00532-7.
- Results publication: PubMed 23713625Su N, Lin J, Chen P, Li J, Wu C, Yin K, Liu C, Chen Y, Zhou X, Yuan Y, Huang X. Evaluation of asthma control and patient's perception of asthma: findings and analysis of a nationwide questionnaire-based survey in China. J Asthma. 2013 Oct;50(8):861-70. doi: 10.3109/02770903.2013.808346.
- Results publication: PubMed 19210346Li J, Sun B, Huang Y, Lin X, Zhao D, Tan G, Wu J, Zhao H, Cao L, Zhong N; China Alliance of Research on Respiratory Allergic Disease. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China. Allergy. 2009 Jul;64(7):1083-92. doi: 10.1111/j.1398-9995.2009.01967.x. Epub 2009 Feb 11.
- Results publication: PubMed 25336941Donaldson GC, Wedzicha JA. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2014 Oct 6;9:1101-10. doi: 10.2147/COPD.S54475. eCollection 2014.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Shijian Liu, Ph.D principal investigator
Shanghai Children's Medicial Center affiliated Shanghai Jiao Tong University School of Medicine
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Asthma and Allergic Rhinitis, run by Shanghai Jiao Tong University School of Medicine at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 11 Sep 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Shijian Liu, Ph.D (86-21-38087983, liushijian@scmc.com.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China. (time frame: 3 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05330637, which also lists 14 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Sep 2023; AzTrials last refreshed its copy on 7 Nov 2026.