Pain, PostoperativeNCT05331261
The Effect of Post-Surgery Exercise in Patients With Total Knee Replacement Surgery
A study testing Total diz replacement ameliyatı in people with Pain, Postoperative, run by Alev Keskin at 2 sites in Turkey (Türkiye).
Trial summary
postoperative pain; It is acute pain that begins with surgical trauma and decreases during tissue healing. Although it is predictable and treatable, it still seems to be an important problem today. Read more about this study
- Who is it for?
- Ages 18 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Pain, Postoperative
- What is being tested?
- Total diz replacement ameliyatı
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 55 participants
- Where
- 2 sitesTurkey (Türkiye)
- Study dates
- 20 Apr 2022to 28 May 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- be over the age of 18,
- Being able to speak Turkish,
- Does not have any barriers in communication, understanding and comprehension,
- Not having visual and hearing impairment,
- Not taking pain medication 60 minutes before or 30 minutes after the intervention,
- Volunteering to participate in the research,
Who cannot join
- -
Trial locations and contacts
2 sites in 1 country.
Turkey (Türkiye)2 sites
Çukurova Üniversitesi
Adana, Sarıçam
Çukurova Üniversitesi
Adana, University
About this study
postoperative pain; It is acute pain that begins with surgical trauma and decreases during tissue healing. Although it is predictable and treatable, it still seems to be an important problem today. Many researchers in the literature have reported that approximately 50-70% of patients receive inadequate pain treatment after surgery, and many patients complain of moderate or severe pain. Poor control of postoperative pain may cause deep venous thrombosis and delayed wound healing, increased hospital stay, and delayed return to daily life activities. This may negatively affect the quality of life and recovery of patients Therefore, there is a need for methods that increase pain control, such as non-pharmacological methods, to accelerate postoperative recovery. Nurses in postoperative pain management; they help control pain with non-pharmacological methods such as breathing exercises, positioning, relaxation techniques, massage, listening to music, hot application, cold application, and distraction.
Read the detailed description
This study was designed as a quasi-experimental study to examine the effect of breathing exercise on pain in patients undergoing Total Knee Replacement surgery. This exercise is utterly simple, takes almost no time, requires no equipment and can be done anywhere. Although you can do the exercise in any position, sit with your back straight while learning the exercise. Place the tip of your tongue against the ridge of tissue just behind your upper front teeth, and keep it there through the entire exercise. You will be exhaling through your mouth around your tongue; try pursing your lips slightly if this seems awkward.
- Exhale completely through your mouth, making a whoosh sound.
- Close your mouth and inhale quietly through your nose to a mental count of four.
- Hold your breath for a count of seven.
- Exhale completely through your mouth, making a whoosh sound to a count of eight.
- This is one breath. Now inhale again and repeat the cycle three more times for a total of four breaths.
This study was designed as a quasi-experimental study to examine the effect of breathing exercise on pain in patients undergoing Total Knee Replacement surgery. Note that you always inhale quietly through your nose and exhale audibly through your mouth. The tip of your tongue stays in position the whole time. Exhalation takes twice as long as inhalation. The absolute time you spend on each phase is not important; the ratio of 4:7:8 is important. If you have trouble holding your breath, speed the exercise up but keep to the ratio of 4:7:8 for the three phases. With practice you can slow it all down and get used to inhaling and exhaling more and more deeply.
This exercise is a natural tranquilizer for the nervous system. Unlike tranquilizing drugs, which are often effective when you first take them but then lose their power over time, this exercise is subtle when you first try it but gains in power with repetition and practice. Do it at least twice a day. You cannot do it too frequently. Do not do more than four breaths at one time for the first month of practice. Later, if you wish, you can extend it to eight breaths. If you feel a little lightheaded when you first breathe this way, do not be concerned; it will pass.
- Conditions
- Pain, Postoperative
- Being tested
- Total diz replacement ameliyatı
- Keywords
- Ameliyat sonrası ağrıdan nefes egzersizleri.
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Total diz replacement ameliyatıProcedure or surgery
Breath exercises
| Study group | Role | What they receive |
|---|---|---|
| The Effect of 4-7-8 Breathing Technique on Pain | Experimental | Impact of the 4-7-8 Breathing Technique on Postoperative Pain Following Total Knee Arthroplasty Receives: Procedure: Total diz replacement ameliyatı |
What is being measured
The primary outcome is the main question the study is designed to answer.
NRS Scale
NRS is a unidimensional scale that uses 11 numbers (from 0 to 10) to measure pain intensity.32 The patient is asked to choose the number that best reflects their pain intensity (0=no pain at all, 10= the worst pain).
Measured: Bir dakika
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Apr 2022
- Study start20 Apr 2022
- Primary completion2 May 2023
- Study completion28 May 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pain, PostoperativeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 55 participants (actual)
Sponsor and investigators
- Lead sponsor
- Alev Keskin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Alev Keskin, Cukurova University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05331261
- Sponsor's protocol ID
- ARKeskin
- Status last verified
- Sep 2026
- First submitted
- 10 Apr 2022
- Last updated
- 21 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Post-Surgery Exercise in Patients With Total Knee Replacement Surgery
- ClinicalTrials.gov ID
- NCT05331261
- Acronym / sponsor ID
- ARKeskin
- Conditions
- Pain, Postoperative
- Keywords
- Ameliyat sonrası ağrıdan nefes egzersizleri.
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 55 participants (actual)
- Lead sponsor
- Alev KeskinUniversity, hospital or other
- Study start
- 20 Apr 2022 (actual)
- Primary completion
- 2 May 2023 (actual)
- Study completion
- 28 May 2023 (actual)
- First posted
- 15 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
postoperative pain; It is acute pain that begins with surgical trauma and decreases during tissue healing. Although it is predictable and treatable, it still seems to be an important problem today. Many researchers in the literature have reported that approximately 50-70% of patients receive inadequate pain treatment after surgery, and many patients complain of moderate or severe pain. Poor control of postoperative pain may cause deep venous thrombosis and delayed wound healing, increased hospital stay, and delayed return to daily life activities. This may negatively affect the quality of life and recovery of patients Therefore, there is a need for methods that increase pain control, such as non-pharmacological methods, to accelerate postoperative recovery. Nurses in postoperative pain management; they help control pain with non-pharmacological methods such as breathing exercises, positioning, relaxation techniques, massage, listening to music, hot application, cold application, and distraction.
Detailed description
This study was designed as a quasi-experimental study to examine the effect of breathing exercise on pain in patients undergoing Total Knee Replacement surgery. This exercise is utterly simple, takes almost no time, requires no equipment and can be done anywhere. Although you can do the exercise in any position, sit with your back straight while learning the exercise. Place the tip of your tongue against the ridge of tissue just behind your upper front teeth, and keep it there through the entire exercise. You will be exhaling through your mouth around your tongue; try pursing your lips slightly if this seems awkward.
- Exhale completely through your mouth, making a whoosh sound.
- Close your mouth and inhale quietly through your nose to a mental count of four.
- Hold your breath for a count of seven.
- Exhale completely through your mouth, making a whoosh sound to a count of eight.
- This is one breath. Now inhale again and repeat the cycle three more times for a total of four breaths.
This study was designed as a quasi-experimental study to examine the effect of breathing exercise on pain in patients undergoing Total Knee Replacement surgery. Note that you always inhale quietly through your nose and exhale audibly through your mouth. The tip of your tongue stays in position the whole time. Exhalation takes twice as long as inhalation. The absolute time you spend on each phase is not important; the ratio of 4:7:8 is important. If you have trouble holding your breath, speed the exercise up but keep to the ratio of 4:7:8 for the three phases. With practice you can slow it all down and get used to inhaling and exhaling more and more deeply.
This exercise is a natural tranquilizer for the nervous system. Unlike tranquilizing drugs, which are often effective when you first take them but then lose their power over time, this exercise is subtle when you first try it but gains in power with repetition and practice. Do it at least twice a day. You cannot do it too frequently. Do not do more than four breaths at one time for the first month of practice. Later, if you wish, you can extend it to eight breaths. If you feel a little lightheaded when you first breathe this way, do not be concerned; it will pass.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| The Effect of 4-7-8 Breathing Technique on Pain | Experimental | Procedure: Total diz replacement ameliyatıImpact of the 4-7-8 Breathing Technique on Postoperative Pain Following Total Knee Arthroplasty |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- be over the age of 18,
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Total diz replacement ameliyatıBreath exercises | Procedure or surgery | The Effect of 4-7-8 Breathing Technique on Pain |
Primary outcome
NRS Scale
Time frame: Bir dakika
NRS is a unidimensional scale that uses 11 numbers (from 0 to 10) to measure pain intensity.32 The patient is asked to choose the number that best reflects their pain intensity (0=no pain at all, 10= the worst pain).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Total diz replacement ameliyatı in people with Pain, Postoperative, run by Alev Keskin at 2 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
NRS Scale (time frame: Bir dakika). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026; AzTrials last refreshed its copy on 6 Nov 2026.