Stroke SequelaeNCT05332964
Virtual Reliability System for Visual Spatial Attention Evaluation in Stroke Patients
An observational study of Stroke Sequelae and Neglect, Hemispatial, run by National Taiwan University Hospital at 1 site in Taiwan.
Trial summary
The researchers designed a software based on a head-mounted displays for virtual reality (HMD-VR) to evaluate the reaction time to stimuli presented at right or left visual field. Read more about this study
- Who is it for?
- Ages 20 years and olderHealthy volunteers can take part
- Conditions the study is for
- Stroke Sequelae, Neglect, Hemispatial
- How many people
- 1 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Mar 2025to 31 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: outpatient and inpatient rehabilitation unit in a medical center
Who may be able to join
- aged at least 20 years old
- diagnosed with stroke involving unilateral MCA and ACA territory
- with unilateral upper limb with normal function
- neurologically and medically stable.
- 1) healthy adults, age-matched to stroke patients
Who cannot join
- with history of neurological or psychiatric conditions other than stroke;
- significant cognitive or speech problems that cause difficulties to cooperate with testing;
- significant visual problems (such as color blindness, visual loss, cataract, glaucoma or other major eye condition)
- upper limb musculoskeletal disorders to cause difficulties to use the keyboard or controller;
- history of seizure, vestibular dysfunction or vertigo
- can't tolerate HMD-VR
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Application of a Virtual Reliability System in the Evaluation of the Visual Spatial Attention in Stroke Patients
The researchers designed a software based on a head-mounted displays for virtual reality (HMD-VR) to evaluate the reaction time to stimuli presented at right or left visual field. The study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left each) and 100 age-matched healthy controls. The participants will conduct a simple reaction time task in VR, with stimuli designated in the left or right hemi-field. The stroke patients will also received traditional tests for hemi-neglect. Test-retest reliability of the assessment will be conducted in a subset of the control group. The stroke patients will be followed in 3-4 weeks.
Read the detailed description
The researchers designed a software based on a head-mounted displays for virtual reality (HMD-VR) to evaluate the reaction time to stimuli presented at right or left visual field. The study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left hemisphere each) and 100 age-matched healthy controls. The participants will conduct a simple reaction time task in VR, with stimuli designated in the left or right hemi-field. The stroke patients will also receive traditional tests for hemi-neglect. The researchers will also collect the demographic data, cognition function and daily activity function. Test-retest reliability of the assessment will be conducted in a subset of the control group. The stroke patients will be followed in 3-4 weeks. The researchers will compare the results of a traditional hemi-neglect tests and VR-based tests and their changes in two occasions.
- Conditions
- Stroke Sequelae, Neglect, Hemispatial
- Keywords
- attention, hemineglect, virtual reality, reaction time
- Medical subject headings
- Perceptual Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| stroke (right) | stroke patient with lesions at right hemisphere | |
| stroke (left) | stroke patient with lesions at left hemisphere | |
| control | age-matched group for the stroke patients |
What is being measured
The primary outcome is the main question the study is designed to answer.
reaction time
reaction time to the stimuli presented in the right or left hemi-field with VR software
Measured: 4 weeks
hemineglect tests
Paper-based behavior inattention test (BIT)
Measured: 4 weeks
Secondary outcomes (3)
ADL
activities of daily living function evaluated by barthel index
Measured: 4 weeks
cognition
using Montreal Cognitive Assessment (MoCA)
Measured: 4 weeks
cybersickness
using Simulator Sickness Questionnaire (SSQ)
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Apr 2022
- Study start1 Mar 2025
- Primary completion31 Dec 2025
- Study completion31 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stroke SequelaeStudies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 1 participants (actual)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Huey-Wen Liang, MD, Principal investigator, National Taiwan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05332964
- Sponsor's protocol ID
- 202104030RINC
- Status last verified
- Feb 2025
- First submitted
- 11 Apr 2022
- Last updated
- 24 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Application of a Virtual Reliability System in the Evaluation of the Visual Spatial Attention in Stroke Patients
- ClinicalTrials.gov ID
- NCT05332964
- Acronym / sponsor ID
- 202104030RINC
- Conditions
- Stroke Sequelae, Neglect, Hemispatial
- Keywords
- attention, hemineglect, virtual reality, reaction time
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 1 participants (actual)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Study start
- 1 Mar 2025 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- 31 Dec 2025 (actual)
- First posted
- 18 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The researchers designed a software based on a head-mounted displays for virtual reality (HMD-VR) to evaluate the reaction time to stimuli presented at right or left visual field. The study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left each) and 100 age-matched healthy controls. The participants will conduct a simple reaction time task in VR, with stimuli designated in the left or right hemi-field. The stroke patients will also received traditional tests for hemi-neglect. Test-retest reliability of the assessment will be conducted in a subset of the control group. The stroke patients will be followed in 3-4 weeks.
Detailed description
The researchers designed a software based on a head-mounted displays for virtual reality (HMD-VR) to evaluate the reaction time to stimuli presented at right or left visual field. The study will recruit 100 stroke patients with hemisphere lesions (50 patients for right and left hemisphere each) and 100 age-matched healthy controls. The participants will conduct a simple reaction time task in VR, with stimuli designated in the left or right hemi-field. The stroke patients will also receive traditional tests for hemi-neglect. The researchers will also collect the demographic data, cognition function and daily activity function. Test-retest reliability of the assessment will be conducted in a subset of the control group. The stroke patients will be followed in 3-4 weeks. The researchers will compare the results of a traditional hemi-neglect tests and VR-based tests and their changes in two occasions.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| stroke (right) | – | –stroke patient with lesions at right hemisphere |
| stroke (left) | – | –stroke patient with lesions at left hemisphere |
| control | – | –age-matched group for the stroke patients |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- outpatient and inpatient rehabilitation unit in a medical center
Key inclusion criteria (5 listed)
- aged at least 20 years old
- diagnosed with stroke involving unilateral MCA and ACA territory
- with unilateral upper limb with normal function
- neurologically and medically stable.
- 1) healthy adults, age-matched to stroke patients
Key exclusion criteria (6 listed)
- with history of neurological or psychiatric conditions other than stroke;
- significant cognitive or speech problems that cause difficulties to cooperate with testing;
- significant visual problems (such as color blindness, visual loss, cataract, glaucoma or other major eye condition)
- upper limb musculoskeletal disorders to cause difficulties to use the keyboard or controller;
- history of seizure, vestibular dysfunction or vertigo
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
reaction time
Time frame: 4 weeks
reaction time to the stimuli presented in the right or left hemi-field with VR software
hemineglect tests
Time frame: 4 weeks
Paper-based behavior inattention test (BIT)
3 secondary outcomes
ADL
Time frame: 4 weeks
cognition
Time frame: 4 weeks
cybersickness
Time frame: 1 day
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Huey-Wen Liang, MD principal investigator
National Taiwan University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stroke Sequelae and Neglect, Hemispatial, run by National Taiwan University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
reaction time (time frame: 4 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2026.