Heart Failure With Preserved Ejection FractionNeuHFRecoverNCT05338437
NMES in HF Patients to Improve Functional Recovery Following Hospitalization
A study testing Neuromuscular electrical stimulation in people with Heart Failure With Preserved Ejection Fraction, run by University of Vermont Medical Center at 1 site in United States.
Trial summary
The goal of this research study is to understand whether an at-home exercise program started after hospitalization for HFpEF, and continuing for 4 weeks following discharge from the hospital, can preserve or improve physical function. Read more about this study
- Who is it for?
- Ages 50 to 90 years
- Conditions the study is for
- Heart Failure With Preserved Ejection Fraction
- What is being tested?
- Neuromuscular electrical stimulation
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 8 participants
- Where
- 1 siteUnited States
- Study dates
- 7 Feb 2022to 30 Sep 2023
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 50-90 years of age
- clinical diagnosis of HF being actively managed during hospitalization
- live within 30 miles of the medical center
- able to perform informed consent
Who cannot join
- rheumatoid arthritis or other inflammatory/autoimmune disease
- cancer, excluding non-melanoma skin cancer or low-grade prostate cancer
- severe dementia/alzheimer's disease
- exercise limiting peripheral vascular disease
- neuromuscular disease or neuromuscular dysfunction associated with cerebrovascular event
- body mass index ≥40 kg/m2
- lower extremity blood clot or implantable cardioverter-defibrillator or pacemaker
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Vermont Medical Center
Burlington, Vermont, 05405
About this study
Official title: Neuromuscular Electrical Stimulation in Heart Failure Patients to Improve Functional Recovery Following Hospitalization (NeuHF-Recover)
The goal of this research study is to understand whether an at-home exercise program started after hospitalization for HFpEF, and continuing for 4 weeks following discharge from the hospital, can preserve or improve physical function.
Read the detailed description
Heart failure is the leading cause of hospitalization among adults in the US with patients with preserved ejection fraction (HFpEF) comprising half of those admissions. Many patients exhibit chronic fatigue, exercise intolerance and an inability to perform activities of daily living, which is exacerbated by hospitalization. The goal of this research study is to understand whether an at-home exercise program started soon after hospitalization and continuing for 4 weeks following discharge can improve functional recovery in HFpEF patients. Volunteers will be randomly assigned to receive neuromuscular electrical stimulation (NMES) of their quadriceps muscles or not to receive NMES (control group). Volunteers will be evaluated during hospitalization and 4 weeks following discharge. Assessments will include measurements of physical function by 6 minute walk test and the Short Physical Performance Battery, as well as assessment of subjective physical functional capacity and quality of life using the Medical Outcomes Short form 36 and Kansas City Cardiomyopathy questionnaire.
- Being tested
- Neuromuscular electrical stimulation
- Keywords
- HF, rehabilitation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neuromuscular electrical stimulationDevice
Bilateral quadriceps muscle stimulation
| Study group | Role | What they receive |
|---|---|---|
| Neuromuscular electrical stimulation | Experimental | Neuromuscular electrical stimulation of the quadriceps. 45 minutes, 5 days per week Receives: Device: Neuromuscular electrical stimulation |
| Control | No intervention | No treatment control |
What is being measured
The primary outcome is the main question the study is designed to answer.
6 Minute Walk Distance (6MW)
6 MW was developed to assess cardiopulmonary fitness in patients with lung and cardiac disease, and has been validated in heart failure patients. It assesses the distance that a patient can walk in 6 minutes time around a standard course.
Measured: Change from Hospital Discharge (Within 1 day) to 4-weeks post-discharge
Secondary outcomes (40)
Short Physical Performance Battery
Short Physical Performance Battery is composed of three tasks assessing balance, gait speed, and ability to stand from a chair. Units on a scale for each domain range from of 0-4 for a total score of 0 to 12, with a higher score indicating better physical function.
Measured: Change from Hospital Discharge (Within 1 day) to 4-weeks post-discharge
Katz Index of Independence in Activities of Daily Living
The Katz Index of Independence in Activities of Daily Living, commonly referred to as the Katz ADL, is the most appropriate instrument to assess functional status as a measurement of the client's ability to perform activities of daily living independently. Clinicians typically use the tool to detect problems in performing activities of daily living and to plan care accordingly. The Index ranks adequacy of performance in the six functions of bathing, dressing, toileting, transferring, continence, and feeding. Clients are scored yes/no for independence in each of the six functions. A score of 6 indicates full function, 4 indicates moderate impairment, and 2 or less indicates severe functional impairment.
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Lawton Instrumental Activities of Daily Living (IADL) Scale
The Lawton Instrumental Activities of Daily Living Scale (IADL) is an appropriate instrument to assess independent living skills. These skills are considered more complex than the basic activities of daily living as measured by the Katz Index of ADLs. The instrument is most useful for identifying how a person is functioning at the present time, and to identify improvement or deterioration over time. There are eight domains of function measured with the Lawton IADL scale. Women are scored on all 8 areas of function; historically, for men, the areas of food preparation, housekeeping, laundering have been excluded. Since men regularly complete food preparation, housekeeping, and laundering tasks, they were scored in all 8 domains as well.
Clients are scored according to their highest level of functioning in that category. A summary score ranges from 0 (low function, dependent) to 8 (high function, independent) for women and men.
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36
The Medical Outcomes Short Form 36 is a questionnaire that assesses self-reported health and physical functional status. There are 36 questions that reflect eight sub-domains of health included in this questionnaire. Scores for each domain represent weighted sums of the questions in each sub-domain. Each scale is directly transformed into a 0-100 scale on the assumption that each question carries equal weight. This measure represents the total computed score across all sub-domains. Lower scores represent worse overall health, while higher scores represent better health.
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 1
Responses to Q1. In general, would you say your health is:
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 2
Responses to Q2. Compared to one year ago, how would you rate your health in general now?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3a
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3a. Vigorous activities, such as running, lifting heavy objects, participating in strenuous sports.
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3b
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3b. Moderate activities, such as moving a table, pushing a vacuum cleaner, bowling, or playing golf.
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3c
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3c. Lifting or carrying groceries.
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3d
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3d. Climbing several flights ofstairs
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3e
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3e. Climbing one flight of stairs
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3f
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3f. Bending, kneeling, or stooping
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3g
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3g. Walking more than a mile
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3h
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3h. Walking several blocks
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3i
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3i. Walking one block
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3j
The following items are about activities you might do during a typical day. Does your health now limit you in these activities? If so, how much? Responses to Q3j. Bathing or dressing yourself
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4a
During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Responses to Q4a. Cut down the amount of time you spent on work or other activities
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4b
During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Responses to Q4b. Accomplished less than you would like
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4c
During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Responses to Q4c. Were limited in the kind of work or other activities
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4d
During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health? Responses to Q4d. Had difficulty performing the work or other activities (for example, it took extra effort)
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 5a
During the past 4weeks, have you had any of he following problems with your work or other regular daily activities as a result of any emotional problems (such as feeling depressed or anxious)? Responses to Q5a. Cut down the amount of time you spent on work or other activities
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 5b
During the past 4weeks, have you had any of he following problems with your work or other regular daily activities as a result of any emotional problems (such as feeling depressed or anxious)? Responses to Q5b. Accomplished less than you would like
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 5c
During the past 4weeks, have you had any of he following problems with your work or other regular daily activities as a result of any emotional problems (such as feeling depressed or anxious)? Responses to Q5c. Didn't do work or other activities as carefully as usual
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 6
Responses to Q6. During the past 4weeks, to what extent has your physical health or emotional problems interfered with your normal social activities with family, friends, neighbors or groups?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 7
Responses to Q7. How much bodily pain have you had during the past four weeks?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 8
Responses to Q8. During the past 4weeks, how much did pain interfere with your normal work (including both work outside the home and housework)?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9a
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9a. Did you feel full of pep?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9b
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9b. Have you been a very nervous person?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9c
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9c. Have you felt so down in the dumps that nothing could cheer you up?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9d
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9d. Have you felt calm and peaceful?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9e
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9e. Did you have a lot of energy?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9f
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9f. Have you felt down hearted and blue?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9g
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9g. Did you feel worn out?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9h
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9h. Have you been a happy person?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9i
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9i. Did you feel tired?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9j
These questions are about how you feel and how things have been with you during the past 4weeks. For each question, please give the one answer that comes closest to the way you have been feeling. How much of the time during the past 4weeks...
Responses to Q9j. During the past 4weeks, how much of the time has your physical health or emotional problems interfered with your social activities (like visiting with friends, relatives, etc.)?
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10a
How TRUE or FALSE is each of the following statements for you:
Responses to Q10a. I seem to get sick a little easier than other people
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10b
How TRUE or FALSE is each of the following statements for you:
Responses to Q10b. I am as healthy as anybody I know
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10c
How TRUE or FALSE is each of the following statements for you:
Responses to Q10c. I expect my health to get worse
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10d
How TRUE or FALSE is each of the following statements for you:
Responses to Q10d. My health is excellent
Measured: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Apr 2022
- Study start7 Feb 2022
- Primary completion30 Sep 2023
- Study completion30 Sep 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for Heart Failure With Preserved Ejection FractionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 8 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Vermont Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sherrie Khadanga, University of Vermont Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05338437
- Sponsor's protocol ID
- STUDY00001757
- Acronym
- NeuHFRecover
- Status last verified
- Apr 2025
- First submitted
- 21 Mar 2022
- Last updated
- 10 Jun 2026
- Results posted
- Yes, on ClinicalTrials.gov
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neuromuscular Electrical Stimulation in Heart Failure Patients to Improve Functional Recovery Following Hospitalization (NeuHF-Recover)
- ClinicalTrials.gov ID
- NCT05338437
- Acronym / sponsor ID
- NeuHFRecover / STUDY00001757
- Keywords
- HF, rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 8 participants (actual)
- Lead sponsor
- University of Vermont Medical CenterUniversity, hospital or other
- Study start
- 7 Feb 2022 (actual)
- Primary completion
- 30 Sep 2023 (actual)
- Study completion
- 30 Sep 2023 (actual)
- First posted
- 21 Apr 2022 (actual)
- Results
- Posted 10 Jun 2026
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this research study is to understand whether an at-home exercise program started after hospitalization for HFpEF, and continuing for 4 weeks following discharge from the hospital, can preserve or improve physical function.
Detailed description
Heart failure is the leading cause of hospitalization among adults in the US with patients with preserved ejection fraction (HFpEF) comprising half of those admissions. Many patients exhibit chronic fatigue, exercise intolerance and an inability to perform activities of daily living, which is exacerbated by hospitalization. The goal of this research study is to understand whether an at-home exercise program started soon after hospitalization and continuing for 4 weeks following discharge can improve functional recovery in HFpEF patients. Volunteers will be randomly assigned to receive neuromuscular electrical stimulation (NMES) of their quadriceps muscles or not to receive NMES (control group). Volunteers will be evaluated during hospitalization and 4 weeks following discharge. Assessments will include measurements of physical function by 6 minute walk test and the Short Physical Performance Battery, as well as assessment of subjective physical functional capacity and quality of life using the Medical Outcomes Short form 36 and Kansas City Cardiomyopathy questionnaire.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Neuromuscular electrical stimulation | Experimental | Device: Neuromuscular electrical stimulationNeuromuscular electrical stimulation of the quadriceps. 45 minutes, 5 days per week |
| Control | No intervention | –No treatment control |
Who may qualify
- Ages
- 50 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- 50-90 years of age
- clinical diagnosis of HF being actively managed during hospitalization
- live within 30 miles of the medical center
- able to perform informed consent
Key exclusion criteria (7 listed)
- rheumatoid arthritis or other inflammatory/autoimmune disease
- cancer, excluding non-melanoma skin cancer or low-grade prostate cancer
- severe dementia/alzheimer's disease
- exercise limiting peripheral vascular disease
- neuromuscular disease or neuromuscular dysfunction associated with cerebrovascular event
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neuromuscular electrical stimulationBilateral quadriceps muscle stimulation | Device | Neuromuscular electrical stimulation |
Primary outcome
6 Minute Walk Distance (6MW)
Time frame: Change from Hospital Discharge (Within 1 day) to 4-weeks post-discharge
6 MW was developed to assess cardiopulmonary fitness in patients with lung and cardiac disease, and has been validated in heart failure patients. It assesses the distance that a patient can walk in 6 minutes time around a standard course.
40 secondary outcomes
Short Physical Performance Battery
Time frame: Change from Hospital Discharge (Within 1 day) to 4-weeks post-discharge
Katz Index of Independence in Activities of Daily Living
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Lawton Instrumental Activities of Daily Living (IADL) Scale
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 1
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 2
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3a
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3b
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3c
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3d
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3e
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3f
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3g
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3h
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3i
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 3j
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4a
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4b
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4c
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 4d
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 5a
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 5b
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 5c
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 6
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 7
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 8
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9a
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9b
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9c
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9d
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9e
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9f
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9g
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9h
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9i
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 9j
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10a
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10b
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10c
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Medical Outcomes Short Form 36 Question 10d
Time frame: Hospital discharge (Within 1 day) and 4-weeks post-discharge
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jun 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neuromuscular electrical stimulation in people with Heart Failure With Preserved Ejection Fraction, run by University of Vermont Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 10 Jun 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
6 Minute Walk Distance (6MW) (time frame: Change from Hospital Discharge (Within 1 day) to 4-weeks post-discharge). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jun 2026.