Locked-In Syndrome；Pulmonary Arteriovenous MalformationNCT05348902
Locked-in Syndrome Caused by Pulmonary Arteriovenous Malformation: A Case Report
An observational study of Locked-In Syndrome；Pulmonary Arteriovenous Malformation, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
Trial summary
In this case, we report a case of atresia syndrome (LIS), a serious neurological disease caused by pulmonary arteriovenous fistula (PAVM). We present a previously healthy middle-aged woman who developed atresia syndrome after severe pontine infarction due to basilar artery occlusion due to undiagnosed arteriovenous… Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Locked-In Syndrome；Pulmonary Arteriovenous Malformation
- What is being tested?
- In this study, only cases were collected and reported without any intervention or adverse reactions
- How many people
- 1 participants
- Where
- 1 siteChina
- Study dates
- 1 Oct 2021to 2 Jun 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: A patient with locked-in syndrome
Who may be able to join
- A case of Locked-in syndrome due to pulmonary arteriovenous malformation
Who cannot join
- Patients or family members objected to the study
Trial locations and contacts
1 site in 1 country.
China1 site, 1 recruiting
- Recruiting
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou
hao wang, master, +86 15968891667, 2519160@zju.edu.cn
le zhang, master, +86 13616511229, 2319053@zju.edu.cn
About this study
In this case, we report a case of atresia syndrome (LIS), a serious neurological disease caused by pulmonary arteriovenous fistula (PAVM). We present a previously healthy middle-aged woman who developed atresia syndrome after severe pontine infarction due to basilar artery occlusion due to undiagnosed arteriovenous malformation. This report reviewed the medical history, post-admission examination and related literature, and concluded that PAVM should be considered as the cause of implicit stroke, especially in young patients with right-to-left shunt, and should be actively treated.
- Being tested
- In this study, only cases were collected and reported without any intervention or adverse reactions
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
In this study, only cases were collected and reported without any intervention or adverse reactionsOther
In this study, only cases were collected and reported without any intervention or adverse reactions
What is being measured
The primary outcome is the main question the study is designed to answer.
Locked-in syndrome caused by pulmonary arteriovenous malformation . Check list report
A recommendation is made for the treatment and prognosis of patients with severe atresia caused by arteriovenous fistula.
Measured: 1month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Apr 2022
- Study start1 Oct 2021
- Primary completion2 Jun 2022 (estimated)
- Study completion2 Jun 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Locked-In Syndrome；Pulmonary Arteriovenous MalformationStudies of the same condition, open and under way.
- More trials run by Second Affiliated Hospital, Zhejiang University, School of MedicineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Retrospective
- Enrolment
- 1 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05348902
- Sponsor's protocol ID
- 2022-0138
- Status last verified
- Oct 2021
- First submitted
- 10 Apr 2022
- Last updated
- 27 Apr 2022
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Apr 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Locked-in Syndrome Caused by Pulmonary Arteriovenous Malformation: A Case Report
- ClinicalTrials.gov ID
- NCT05348902
- Acronym / sponsor ID
- 2022-0138
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 1 participants (estimated)
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of MedicineUniversity, hospital or other
- Study start
- 1 Oct 2021 (actual)
- Primary completion
- 2 Jun 2022 (estimated)
- Study completion
- 2 Jun 2022 (estimated)
- First posted
- 27 Apr 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this case, we report a case of atresia syndrome (LIS), a serious neurological disease caused by pulmonary arteriovenous fistula (PAVM). We present a previously healthy middle-aged woman who developed atresia syndrome after severe pontine infarction due to basilar artery occlusion due to undiagnosed arteriovenous malformation. This report reviewed the medical history, post-admission examination and related literature, and concluded that PAVM should be considered as the cause of implicit stroke, especially in young patients with right-to-left shunt, and should be actively treated.
Study design
- Observational model
- Case-control
- Time perspective
- Retrospective
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- A patient with locked-in syndrome
Key inclusion criteria (1 listed)
- A case of Locked-in syndrome due to pulmonary arteriovenous malformation
Key exclusion criteria (1 listed)
- Patients or family members objected to the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| In this study, only cases were collected and reported without any intervention or adverse reactionsIn this study, only cases were collected and reported without any intervention or adverse reactions | Other | – |
Primary outcome
Locked-in syndrome caused by pulmonary arteriovenous malformation . Check list report
Time frame: 1month
A recommendation is made for the treatment and prognosis of patients with severe atresia caused by arteriovenous fistula.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Apr 2022.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Locked-In Syndrome；Pulmonary Arteriovenous Malformation, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 27 Apr 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact hao wang, master (+8615968891667, 2519160@zju.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Locked-in syndrome caused by pulmonary arteriovenous malformation . Check list report (time frame: 1month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Apr 2022.