Borderline Personality DisorderNCT05358925
Psychoeducational Videos and Digital Assessments for BPD
A study testing Psychoeducational Videos, Neuropsychological Feedback and Non-BPD-related Educational Videos in people with Borderline Personality Disorder, run by Mclean Hospital at 1 site in United States.
Trial summary
In this study, 100 adults who were recently diagnosed with borderline personality disorder (BPD) will be randomized to either receive educational videos about BPD or educational videos about other topics. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Borderline Personality Disorder
- What is being tested?
- Psychoeducational Videos, Neuropsychological Feedback and Non-BPD-related Educational Videos
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 83 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jun 2023to 1 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- reliable access to a smartphone with a data plan for the duration of the study
- ability to speak and understand English
- age 18 years or older
- diagnosis of BPD within the past 6 months
- awake and able to complete EMA surveys between 9:00am and 9:00pm on most days
- located within the United States
Who cannot join
- cognitive disability that impedes ability to participate in the study
- current psychiatric symptoms that interfere with the individual's ability to provide consent or complete the research procedures (e.g., acute mania, acute psychosis, eating disorder threatening medical stability).
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Online Psychoeducational Videos and Digital Assessments as a Method for Broadening Access to Care for Borderline Personality Disorder
In this study, 100 adults who were recently diagnosed with borderline personality disorder (BPD) will be randomized to either receive educational videos about BPD or educational videos about other topics. All participants in both conditions will complete daily surveys about their emotions and social interactions, and they will respond to surveys and complete cognitive tests at 4 different time points. Some participants will receive feedback about their cognitive test performance, and others will not. The investigators are interested in learning about how accurate education about BPD and enhanced knowledge about cognitive abilities might help people manage their BPD symptoms. The investigators expect that participants who received psychoeducation about BPD will have lower levels of BPD and depressive symptoms than other participants, and that participants who received feedback on their cognitive tests will also have lower symptoms.
Read the detailed description
In this study, 100 adults who were diagnosed with BPD within the past three months will be randomly assigned to receive psychoeducational videos (4-10 minutes each) about the development, symptoms, naturalistic trajectory, and treatment of BPD (2/3 of participants) or matched-length videos about non-BPD, health-related topics (1/3 of participants). One video will be delivered every business day for two weeks. Participants will respond to 5-minute surveys on their recent social interactions, their feelings of threat, connectedness, and aloneness, and will complete a 1-minute version of the Continuous Performance Test (CPT) and Digit Symbol Matching Test, every day for 30 days. Participants will complete additional full-length surveys and cognitive tests at 4 time points: baseline (Day 1), Time 2 (day 15), Time 3 (Day 30), and Follow-up (day 60). The primary outcome is BPD symptom severity, and the secondary outcome is depressive symptom severity. The investigators expect that BPD-focused psychoeducation and personalized neuropsychological feedback will each lead to separate, measurable reductions in BPD and depressive symptom severity. The investigators also expect that the relationship between psychoeducation and symptom reduction will be mediated by increased knowledge about BPD, and that the relationship between neuropsychological feedback and symptom reduction will be mediated by increased cognitive control.
- Conditions
- Borderline Personality Disorder
- Being tested
- Psychoeducational Videos, Neuropsychological Feedback, Non-BPD-related Educational Videos
- Keywords
- borderline personality disorder, ecological momentary assessment, psychoeducation, neuropsychological feedback, symptom tracking
- Medical subject headings
- Borderline Personality Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Psychoeducational VideosOther
A total of ten videos will be delivered daily Monday-Friday over approximately 2 weeks (days 1-15). The videos will each feature a mental health professional who is an expert in BPD explaining the topic in relatable language that can be understood by the general public. Each video will be approximately 4-10 minutes long, for a total of ~72 minutes of video. Videos will be shared via a hyperlink in a text message.
The psychoeducational videos will cover the following topics: symptoms, basic factors about BPD, the naturalistic long term course of BPD, prevalence of BPD and its common comorbid disorders, key principles for recovery, available psychotherapeutic treatment options for BPD, common factors amongst treatments, medications, the interpersonal hypersensitivity model of BPD, and a review of the top 10 tips.
Neuropsychological FeedbackOther
In the second phase of the study, participants randomized to the Feedback condition will receive an email with a personalized summary of their symptom endorsement and neuropsychological performance. The feedback will include the relevant scores or sub-scores for each cognitive test (CPT, RMET, BEST, DST) from the first two time points. For each score and sub-score, there will be a description of the cognitive domain that the metric assesses (e.g., attention span in the CPT). The investigators will tailor the feedback to each participant's scores. The investigators may adjust the format or wording of the feedback based on participant responses (i.e., if a participant alerts the investigators that some wording is unclear or confusing). The investigators may also alter the feedback if they learn new information about the relevance or interpretability of these cognitive tests, as this is a growing field of research.
Non-BPD-related Educational VideosOther
The non-BPD-related educational videos will be matched in length and frequency to the BPD-related videos. These videos will discuss aspects of mental and physical health that are not related to BPD. Examples may include: nutrition and healthy eating, coping, self-compassion and self-care, stress and anxiety, depression, and healthy sleep habits.
| Study group | Role | What they receive |
|---|---|---|
| BPD Videos and Feedback | Experimental | Ten daily 4-10 minute psychoeducational videos about BPD and personalized feedback about performance on neuropsychological tasks. Receives: Other: Psychoeducational Videos; Other: Neuropsychological Feedback |
| BPD Videos and No Feedback | Experimental | Ten daily 4-10 minute psychoeducational videos about BPD. Receives: Other: Psychoeducational Videos |
| Non-BPD Videos and No Feedback | Sham comparator | Ten daily 4-10 minute educational videos about health-related topics other than BPD. Receives: Other: Non-BPD-related Educational Videos |
What is being measured
The primary outcome is the main question the study is designed to answer.
Borderline Symptom List 23 (BSL-23)
Change (increase or decrease) in BSL-23 mean score (average score across all 23 items) at time 2, time 3, and follow-up, as compared to baseline. Minimum score = 0, maximum score = 4. A higher score indicates more severe BPD symptoms.
Measured: Baseline (day 1), Time 2 (day 15), Time 3 (day 30), Follow-Up (day 60)
Secondary outcomes (1)
Patient Health Questionnaire (PHQ-9)
Change (increase or decrease) in PHQ-9 total score at time 2, time 3, and follow-up, as compared to baseline. Minimum score = 0, maximum score = 27. A higher score indicates more severe depressive symptoms.
Measured: Baseline (day 1), Time 2 (day 15), Time 3 (day 30), Follow-Up (day 60)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 May 2022
- Study start1 Jun 2023
- Primary completion20 Aug 2024
- Study completion1 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Borderline Personality DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Model description
- This study includes two randomization branching points: (1) BPD-related videos vs. non-BPD-related videos, and (2) receive neuropsychological feedback vs. not. At branching point (1), 2/3 of participants will be directed to the BPD-video condition, and 1/3 to the non-BPD-video condition. Only the participants in the BPD-video condition will be randomized to receive feedback or not (1/2 each condition). No non-BPD-video participants will receive feedback.
- Masking
- None (open label)
- Enrolment
- 83 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mclean Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Brain & Behavior Research Foundation
- Responsible party
- Principal investigator, Lois W. Choi-Kain, MD, Mclean Hospital
- Investigators
- Lois W Choi-Kain, MD, Principal investigator, Mclean Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05358925
- Sponsor's protocol ID
- 2022P000892
- Other IDs
- 30053
- Status last verified
- Dec 2025
- First submitted
- 28 Apr 2022
- Last updated
- 6 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Choi-Kain LW, Crisp DJ, Mermin S, Murray GE, Jurist JB, Masland SR, Mosby M, Germine LT, Ren B. Online psychoeducation and assessment for borderline personality disorder as a first step of care: A pilot study assessing safety, feasibility, and mechanisms of change. PLoS One. 2026 Aug 19;21(8):e0353836. doi: 10.1371/journal.pone.0353836. eCollection 2026.
PubMed 42616804Choi-Kain LW, Murray GE, Jurist J, Ren B, Germine L. Online psychoeducation and digital assessments as a first step of treatment for borderline personality disorder: A protocol for a pilot randomized controlled trial. PLoS One. 2023 Dec 7;18(12):e0294331. doi: 10.1371/journal.pone.0294331. eCollection 2023.
PubMed 38060545
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Online Psychoeducational Videos and Digital Assessments as a Method for Broadening Access to Care for Borderline Personality Disorder
- ClinicalTrials.gov ID
- NCT05358925
- Acronym / sponsor ID
- 2022P000892
- Conditions
- Borderline Personality Disorder
- Keywords
- borderline personality disorder, ecological momentary assessment, psychoeducation, neuropsychological feedback, symptom tracking
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 83 participants (actual)
- Lead sponsor
- Mclean HospitalUniversity, hospital or other
- Collaborators
- Brain & Behavior Research Foundation
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 20 Aug 2024 (actual)
- Study completion
- 1 Dec 2025 (actual)
- First posted
- 3 May 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this study, 100 adults who were recently diagnosed with borderline personality disorder (BPD) will be randomized to either receive educational videos about BPD or educational videos about other topics. All participants in both conditions will complete daily surveys about their emotions and social interactions, and they will respond to surveys and complete cognitive tests at 4 different time points. Some participants will receive feedback about their cognitive test performance, and others will not. The investigators are interested in learning about how accurate education about BPD and enhanced knowledge about cognitive abilities might help people manage their BPD symptoms. The investigators expect that participants who received psychoeducation about BPD will have lower levels of BPD and depressive symptoms than other participants, and that participants who received feedback on their cognitive tests will also have lower symptoms.
Detailed description
In this study, 100 adults who were diagnosed with BPD within the past three months will be randomly assigned to receive psychoeducational videos (4-10 minutes each) about the development, symptoms, naturalistic trajectory, and treatment of BPD (2/3 of participants) or matched-length videos about non-BPD, health-related topics (1/3 of participants). One video will be delivered every business day for two weeks. Participants will respond to 5-minute surveys on their recent social interactions, their feelings of threat, connectedness, and aloneness, and will complete a 1-minute version of the Continuous Performance Test (CPT) and Digit Symbol Matching Test, every day for 30 days. Participants will complete additional full-length surveys and cognitive tests at 4 time points: baseline (Day 1), Time 2 (day 15), Time 3 (Day 30), and Follow-up (day 60). The primary outcome is BPD symptom severity, and the secondary outcome is depressive symptom severity. The investigators expect that BPD-focused psychoeducation and personalized neuropsychological feedback will each lead to separate, measurable reductions in BPD and depressive symptom severity. The investigators also expect that the relationship between psychoeducation and symptom reduction will be mediated by increased knowledge about BPD, and that the relationship between neuropsychological feedback and symptom reduction will be mediated by increased cognitive control.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- This study includes two randomization branching points: (1) BPD-related videos vs. non-BPD-related videos, and (2) receive neuropsychological feedback vs. not. At branching point (1), 2/3 of participants will be directed to the BPD-video condition, and 1/3 to the non-BPD-video condition. Only the participants in the BPD-video condition will be randomized to receive feedback or not (1/2 each condition). No non-BPD-video participants will receive feedback.
| Arm | Type | Receives |
|---|---|---|
| BPD Videos and Feedback | Experimental | Other: Psychoeducational Videos, Other: Neuropsychological FeedbackTen daily 4-10 minute psychoeducational videos about BPD and personalized feedback about performance on neuropsychological tasks. |
| BPD Videos and No Feedback | Experimental | Other: Psychoeducational VideosTen daily 4-10 minute psychoeducational videos about BPD. |
| Non-BPD Videos and No Feedback | Sham comparator | Other: Non-BPD-related Educational VideosTen daily 4-10 minute educational videos about health-related topics other than BPD. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- reliable access to a smartphone with a data plan for the duration of the study
- ability to speak and understand English
- age 18 years or older
- diagnosis of BPD within the past 6 months
- awake and able to complete EMA surveys between 9:00am and 9:00pm on most days
Key exclusion criteria (2 listed)
- cognitive disability that impedes ability to participate in the study
- current psychiatric symptoms that interfere with the individual's ability to provide consent or complete the research procedures (e.g., acute mania, acute psychosis, eating disorder threatening medical stability).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Psychoeducational VideosA total of ten videos will be delivered daily Monday-Friday over approximately 2 weeks (days 1-15). The videos will each feature a mental health professional who is an expert in BPD explaining the topic in relatable language that can be understood by the general public. Each video will be approximately 4-10 minutes long, for a total of ~72 minutes of video. Videos will be shared via a hyperlink in a text message. The psychoeducational videos will cover the following topics: symptoms, basic factors about BPD, the naturalistic long term course of BPD, prevalence of BPD and its common comorbid disorders, key principles for recovery, available psychotherapeutic treatment options for BPD, common factors amongst treatments, medications, the interpersonal hypersensitivity model of BPD, and a review of the top 10 tips. | Other | BPD Videos and Feedback, BPD Videos and No Feedback |
| Neuropsychological FeedbackIn the second phase of the study, participants randomized to the Feedback condition will receive an email with a personalized summary of their symptom endorsement and neuropsychological performance. The feedback will include the relevant scores or sub-scores for each cognitive test (CPT, RMET, BEST, DST) from the first two time points. For each score and sub-score, there will be a description of the cognitive domain that the metric assesses (e.g., attention span in the CPT). The investigators will tailor the feedback to each participant's scores. The investigators may adjust the format or wording of the feedback based on participant responses (i.e., if a participant alerts the investigators that some wording is unclear or confusing). The investigators may also alter the feedback if they learn new information about the relevance or interpretability of these cognitive tests, as this is a growing field of research. | Other | BPD Videos and Feedback |
| Non-BPD-related Educational VideosThe non-BPD-related educational videos will be matched in length and frequency to the BPD-related videos. These videos will discuss aspects of mental and physical health that are not related to BPD. Examples may include: nutrition and healthy eating, coping, self-compassion and self-care, stress and anxiety, depression, and healthy sleep habits. | Other | Non-BPD Videos and No Feedback |
Primary outcome
Borderline Symptom List 23 (BSL-23)
Time frame: Baseline (day 1), Time 2 (day 15), Time 3 (day 30), Follow-Up (day 60)
Change (increase or decrease) in BSL-23 mean score (average score across all 23 items) at time 2, time 3, and follow-up, as compared to baseline. Minimum score = 0, maximum score = 4. A higher score indicates more severe BPD symptoms.
1 secondary outcome
Patient Health Questionnaire (PHQ-9)
Time frame: Baseline (day 1), Time 2 (day 15), Time 3 (day 30), Follow-Up (day 60)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2026.
- Derived from this study: PubMed 42616804Choi-Kain LW, Crisp DJ, Mermin S, Murray GE, Jurist JB, Masland SR, Mosby M, Germine LT, Ren B. Online psychoeducation and assessment for borderline personality disorder as a first step of care: A pilot study assessing safety, feasibility, and mechanisms of change. PLoS One. 2026 Aug 19;21(8):e0353836. doi: 10.1371/journal.pone.0353836. eCollection 2026.
- Derived from this study: PubMed 38060545Choi-Kain LW, Murray GE, Jurist J, Ren B, Germine L. Online psychoeducation and digital assessments as a first step of treatment for borderline personality disorder: A protocol for a pilot randomized controlled trial. PLoS One. 2023 Dec 7;18(12):e0294331. doi: 10.1371/journal.pone.0294331. eCollection 2023.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Lois W Choi-Kain, MD principal investigator
Mclean Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Psychoeducational Videos, Neuropsychological Feedback and Non-BPD-related Educational Videos in people with Borderline Personality Disorder, run by Mclean Hospital at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Borderline Symptom List 23 (BSL-23) (time frame: Baseline (day 1), Time 2 (day 15), Time 3 (day 30), Follow-Up (day 60)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05358925, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2026.