COVID-19NCT05381675
Short Term Results of Tele-Rehabilitation
A study testing Tele-rehabillitation and Prescribed Exercise Program in people with COVID-19 and Dyspnea, run by Harran University at 1 site in Turkey (Türkiye).
Trial summary
Most people who have coronavirus disease (COVID-19) recover completely without any sequelae. However, some patients continue to experience symptoms of COVID-19 even though their tests turn negative. This clinical spectrum that occurs after acute infection is called the post-COVID syndrome (PCS). Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- What is being tested?
- Tele-rehabillitation and Prescribed Exercise Program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 20 May 2022to 1 Aug 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Being between the ages of 18-75,
- Being in stable medical condition, conscious and cooperative,
- Having had COVID and continuing symptoms
- Volunteering to participate in the study,
- Own a device that can be connected online independently or with support from family members.
Who cannot join
- SpO2 < 92%,
- Hypotension (Systolic Blood Pressure < 90 mmHg or Diastolic Blood Pressure < 60mmHg)
- Having chronic respiratory disease (COPD, Asthma, etc.)
- Having a stroke or neurodegenerative disease.
- Not being willing to participate in the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Short Term Outcomes of Tele-Rehabilitation in Patients With Post-Covid Syndrome
Most people who have coronavirus disease (COVID-19) recover completely without any sequelae. However, some patients continue to experience symptoms of COVID-19 even though their tests turn negative. This clinical spectrum that occurs after acute infection is called the post-COVID syndrome (PCS). Dyspnea, pain, decreased exercise capacity, limitations in activities of daily living, poor sleep quality, anxiety and depression are common symptoms in PCS. The aim of our study is to examine the effect of tele-rehabilitation-based exercise program on dyspnea, pain, functional capacity, sleep quality, anxiety and depression in individuals with PCS.
- Being tested
- Tele-rehabillitation, Prescribed Exercise Program
- Keywords
- Tele-rehabilitation, COVID-19
- Medical subject headings
- COVID-19, Dyspnea
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tele-rehabillitationOther
Tele-rehabilitation program will be performed by physiotherapist two times a week for six consecutive weeks. Program including the following exercises:
Breathing exercises Aerobic exercises Flexibility Strengthening exercises
Prescribed Exercise ProgramOther
The prescribed exercise program will be performed two times a week for six consecutive weeks. Program including the following exercises:
Breathing exercises Aerobic exercises Flexibility Strengthening exercises
| Study group | Role | What they receive |
|---|---|---|
| Intervention | Experimental | Participants will receive a supervised tele-rehabilitation program 2 days a week for 6 weeks. Receives: Other: Tele-rehabillitation |
| Control | Other | Participants will receive the same rehabilitation program as prescribed. Receives: Other: Prescribed Exercise Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from the baseline to the 6th week in mMRC (Modified Medical Research Council) Dyspnoea Scale
The mMRC Dyspnoea Scale is used to assess the degree of baseline functional disability due to dyspnoea
Measured: Baseline and 6th week
Secondary outcomes (4)
Change from the baseline to the 6th week in NPRS
The Numerical Rating Scale (NPRS-11) is an 11-point scale for self-report of pain. It is the most commonly used unidimensional pain scale. The respondent selects a whole number (integers 0-10) that best reflects the intensity (or other quality if requested of his/her pain.
Measured: Baseline and 6th week
Change from the baseline to the 6th week in the 5 times sit to stand test (5XSST)
The 5XSST scoring is based on the amount of time (to the nearest decimal in seconds) a patient is able to transfer from a seated to a standing position and back to sitting five times. The equipment need in performing 5XSST test includes: Stopwatch and standard height chair with straight back.
Measured: Baseline and 6th week
Change from the baseline to the 6th week in the Hospital Anxiety and Depression Scale
The Hospital Anxiety and Depression Scale (HADS) was devised to measure anxiety and depression in a general medical population of patients. The questionnaire comprises seven questions for anxiety and seven questions for depression, and takes 2-5min to complete. Although the anxiety and depression questions are interspersed within the questionnaire, it is vital that these are scored separately.
Measured: Baseline and 6th week
Change from the baseline to the 6th week in the The Pittsburgh Sleep Quality Index
The Pittsburgh Sleep Quality Index (PSQI) is a measure of self-reported sleep quality and sleep disturbance. Scoring Using a four-point, Likert-type scale, respondents indicate how frequently they exhibit certain sleep behaviors (0 = "few," 1 = "some- times," 2 = "often," and 3 = "almost always"). The PSQI takes about 10 minutes to complete and it doesn't involve any procedures or interventions.
Measured: Baseline and 6th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 May 2022
- Study start20 May 2022
- Primary completion20 May 2023
- Study completion1 Aug 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for COVID-19Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Harran University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zeynal Yasacı, Harran University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05381675
- Sponsor's protocol ID
- İntervention
- Status last verified
- Aug 2023
- First submitted
- 15 May 2022
- Last updated
- 29 Aug 2023
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Yasaci Z, Mustafaoglu R, Ozgur O, Kuveloglu B, Esen Y, Ozmen O, Yalcinkaya EY. Virtual recovery: efficacy of telerehabilitation on dyspnea, pain, and functional capacity in post-COVID-19 syndrome. Ir J Med Sci. 2025 Apr;194(2):631-640. doi: 10.1007/s11845-025-03899-3. Epub 2025 Feb 8.
PubMed 39920519
Study at a glance
From the registry record, last updated by the sponsor on 29 Aug 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Short Term Outcomes of Tele-Rehabilitation in Patients With Post-Covid Syndrome
- ClinicalTrials.gov ID
- NCT05381675
- Acronym / sponsor ID
- İntervention
- Keywords
- Tele-rehabilitation, COVID-19
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Harran UniversityUniversity, hospital or other
- Study start
- 20 May 2022 (actual)
- Primary completion
- 20 May 2023 (actual)
- Study completion
- 1 Aug 2023 (actual)
- First posted
- 19 May 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Most people who have coronavirus disease (COVID-19) recover completely without any sequelae. However, some patients continue to experience symptoms of COVID-19 even though their tests turn negative. This clinical spectrum that occurs after acute infection is called the post-COVID syndrome (PCS). Dyspnea, pain, decreased exercise capacity, limitations in activities of daily living, poor sleep quality, anxiety and depression are common symptoms in PCS. The aim of our study is to examine the effect of tele-rehabilitation-based exercise program on dyspnea, pain, functional capacity, sleep quality, anxiety and depression in individuals with PCS.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention | Experimental | Other: Tele-rehabillitationParticipants will receive a supervised tele-rehabilitation program 2 days a week for 6 weeks. |
| Control | Other | Other: Prescribed Exercise ProgramParticipants will receive the same rehabilitation program as prescribed. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Being between the ages of 18-75,
- Being in stable medical condition, conscious and cooperative,
- Having had COVID and continuing symptoms
- Volunteering to participate in the study,
- Own a device that can be connected online independently or with support from family members.
Key exclusion criteria (5 listed)
- SpO2 < 92%,
- Hypotension (Systolic Blood Pressure < 90 mmHg or Diastolic Blood Pressure < 60mmHg)
- Having chronic respiratory disease (COPD, Asthma, etc.)
- Having a stroke or neurodegenerative disease.
- Not being willing to participate in the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Tele-rehabillitationTele-rehabilitation program will be performed by physiotherapist two times a week for six consecutive weeks. Program including the following exercises: Breathing exercises Aerobic exercises Flexibility Strengthening exercises | Other | Intervention |
| Prescribed Exercise ProgramThe prescribed exercise program will be performed two times a week for six consecutive weeks. Program including the following exercises: Breathing exercises Aerobic exercises Flexibility Strengthening exercises | Other | Control |
Primary outcome
Change from the baseline to the 6th week in mMRC (Modified Medical Research Council) Dyspnoea Scale
Time frame: Baseline and 6th week
The mMRC Dyspnoea Scale is used to assess the degree of baseline functional disability due to dyspnoea
4 secondary outcomes
Change from the baseline to the 6th week in NPRS
Time frame: Baseline and 6th week
Change from the baseline to the 6th week in the 5 times sit to stand test (5XSST)
Time frame: Baseline and 6th week
Change from the baseline to the 6th week in the Hospital Anxiety and Depression Scale
Time frame: Baseline and 6th week
Change from the baseline to the 6th week in the The Pittsburgh Sleep Quality Index
Time frame: Baseline and 6th week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Aug 2023.
- Derived from this study: PubMed 39920519Yasaci Z, Mustafaoglu R, Ozgur O, Kuveloglu B, Esen Y, Ozmen O, Yalcinkaya EY. Virtual recovery: efficacy of telerehabilitation on dyspnea, pain, and functional capacity in post-COVID-19 syndrome. Ir J Med Sci. 2025 Apr;194(2):631-640. doi: 10.1007/s11845-025-03899-3. Epub 2025 Feb 8.
Related trials for COVID-19
Not yet recruitingPhase 1
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Post-Acute COVID-19 Syndrome
Active, not recruitingPhase 1
A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults
COVID-19
Active, not recruiting
Intervention to Address Disparate Mental Health Consequences of COVID-19 Pandemic on Latinx and African Newcomers
Mental Health Issue, Mental Health Disorder
Recruiting
Home-Based Exercise Tele-Rehabilitation After COVID-19
Post SARS-CoV2 (COVID-19)
Not yet recruitingPhase 1
A Safety, Reactogenicity and Immunogenicity Trial of RVX-sCPD9 Booster Intranasal COVID-19 Vaccine
COVID -19
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Tele-rehabillitation and Prescribed Exercise Program in people with COVID-19 and Dyspnea, run by Harran University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Aug 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from the baseline to the 6th week in mMRC (Modified Medical Research Council) Dyspnoea Scale (time frame: Baseline and 6th week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05381675, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Aug 2023.