Patellofemoral PainSTRIPENCT05403944
Strength or Power Training for Patellofemoral Pain
A study testing Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) in people with Patellofemoral Pain, run by University of Connecticut at 3 sites in United States.
Trial summary
The objective of this study is to compare a novel 6-week strength training rehabilitation incorporating power exercises (STRIPE) program to a standard of care (SOC) program on short-term and long-term pain, subjective function, patellofemoral pain recurrence rates, and secondary outcomes (hip abduction and extension… Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Patellofemoral Pain
- What is being tested?
- Strength Training Rehabilitation Incorporating Power Exercises (STRIPE)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 88 participants
- Where
- 3 sitesUnited States
- Study dates
- 13 Oct 2022to Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Participants to be between the ages of 18-40 years old.
- Insidious onset of symptoms greater than 3 months.
- Worst pain in the previous month of 3/10 with two of the following tasks: prolonged sitting, jumping, squatting, kneeling, running, and stair ambulation.
Who cannot join
- Other forms of anterior knee pain (Osgood-Schlatter, tendon pain, bursitis, etc.).
- History of lower extremity surgery.
- History of patella subluxation, meniscal injury or ligamentous instability.
- History of referred pain from the lumbar spine.
Trial locations and contacts
3 sites in 1 country.
United States3 sites
University of Central Florida
Orlando, Florida, 32816
University of Connecticut
Storrs, Connecticut, 06269
University of Toledo
Toledo, Ohio, 43606
About this study
Official title: Optimizing Clinical Outcomes for Patients With Patellofemoral Pain Using Strength Training Rehabilitation Incorporating Power Exercises
The objective of this study is to compare a novel 6-week strength training rehabilitation incorporating power exercises (STRIPE) program to a standard of care (SOC) program on short-term and long-term pain, subjective function, patellofemoral pain recurrence rates, and secondary outcomes (hip abduction and extension rate of torque development and single-leg squat kinematics). We hypothesize that participants with patellofemoral pain who complete the STRIPE program will have 1) decreased pain, 2) improved subjective function, 3) reduced patellofemoral pain recurrence rates, 4a) improved hip abduction/extension rate of torque development, and 4b) decreased hip adduction and pelvic drop during a single leg squat compared to participants who complete a SOC rehabilitation program.
Read the detailed description
The proposed study will compare strength-based exercises, which is the standard of care (SOC), that target the hip abductors, hip extensors, lumbo-pelvic, and quadriceps muscles, to a strength training program that utilized power-based exercises (Strength Training Rehabilitation Incorporating Power Exercises [STRIPE]). Individuals with patellofemoral pain, both within the military and general population, present with long-term pain, decreased subjective function, and high recurrence rates. Our primary outcomes are to determine intervention success with self-reported knee pain, measured by the visual analog scale, subjective function, measured by the anterior knee pain scale, and recurrence rates. Recent evidence suggests that two in every three individuals with patellofemoral pain report symptoms up to two years after seeking care, therefore we will assess patellofemoral pain recurrence rates for two years. Additionally, the proposed interventions target gluteal muscle function, supporting our selection of secondary outcome variables. We will assess rate of torque development, as power-based exercises are recommended to improve muscle capacity, of both the targeted gluteus medius and gluteus maximus. We will also assess frontal plane kinematics, as the gluteal muscles are responsible for controlling pelvic and hip motion during functional tasks.
- Conditions
- Patellofemoral Pain
- Being tested
- Standard of Care Rehabilitation (SOC), Strength Training Rehabilitation Incorporating Power Exercises (STRIPE)
- Medical subject headings
- Patellofemoral Pain Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standard of Care Rehabilitation (SOC)Behavioural
6 weeks of standard of care rehabilitation will be given designed to target the core, hip, and quadriceps muscles. Each participant will be expected to complete 3 supervised telehealth sessions per week.
Strength Training Rehabilitation Incorporating Power Exercises (STRIPE)Behavioural
6 weeks of STRIPE rehabilitation will be given designed to target the core, hip, and quadriceps muscles. Each participant will be expected to complete 3 supervised telehealth sessions per week.
| Study group | Role | What they receive |
|---|---|---|
| Standard of Care (SOC) | Active comparator | The SOC rehabilitation group will complete three strength sessions a week. All participants will be provided an educational pamphlet and exercises will be divided into four components - hip abductors, hip extensors, core, and quadriceps muscles. The load magnitude for exercises will be between 60-70% of their 1 repetition max (1RM), with 3 sets of 12 repetitions and a 2-3-minute rest between sets. Time under tension will be prescribed as slow to moderate, with a 2-second concentric phase and 2-second eccentric phase for each exercise. Hip abductor, hip extensor, and core exercises will be initiated during week 1 and continued for the 6-week intervention, while quadriceps focused exercises will be introduced in weeks 3-6. Receives: Behavioral: Standard of Care Rehabilitation (SOC) |
| Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) | Experimental | Those in the STRIPE group will complete two power and one strength training sessions a week. All participants will be provided an educational pamphlet and exercises will be divided into four components - hip abductors, hip extensors, core, and quadriceps muscles. The load magnitude will be greater than 60% of the 1RM, with the goal of continually loading against heavy resistance. Participants will complete 4 sets of 6 repetitions, with 3-5 minutes of rest between sets. Time under tension will be prescribed as <1 second for the concentric phase and 1 second for the eccentric phase of the exercise. The strength training sessions will adhere to same parameters as the SOC. Hip abductor, hip extensor, and core exercises will be initiated during week 1 and continued for the 6-week intervention, while quadriceps focused exercises will be introduced in weeks 3-6. Receives: Behavioral: Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in knee pain.
Data are presented as knee pain, assessed on the visual analog scale in centimeters, resulting in a score of 0-10, with 0 representing no pain and 10 being worst pain imaginable. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in self-reported knee function.
Data are presented as self-reported knee function, assessed by the anterior knee pain scale.
The scale ranged between 0-100, with 0 indicating complete disability and 100 indicating no disability. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Patellofemoral pain recurrence
The number of patients who report symptoms of patellofemoral pain
Measured: 6 months post intervention, 12-months post intervention, 18-months post intervention, and 24-months post intervention
Change in hip rate of torque development
Hip abduction and extension rate of torque development will be assessed with a handheld dynamometer. Data are reported as linear, with higher scores representing a faster ability to develop hip muscle force. Group means and standard deviations will be reported.
Measured: Immediately after the intervention.
Change in hip adduction during a single leg squat
Data are presented as a degree, with a higher number representing a higher amount of hip adduction. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in pelvic drop during a single leg squat
Data are presented as a degree, with a higher number representing a higher amount of pelvic drop. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Secondary outcomes (5)
Change in psychological factors
Psychological factors will be measures with the PROMIS-10, a 10-item general self-reported questionnaire that assess general domains related to physical, mental, and social health, in addition to perceived quality of life. PROMIS-10 scores are standardized to the general population using a "T-Score", which is a score of 50 points and a standard deviation of 10-points. Higher scores on the PROMIS-10 indicate a healthier patient. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in cognitive factors
Cognitive factors will be assessed with the Fear-Avoidance Belief Questionnaire (FABQ), a dimension specific questionnaire. The FABQ contains two subscales - physical activity section that includes six-items, while the work section includes ten-items. The physical activity subscale score range between 0-24 and the work subscale is scored between 0-42. Higher scores identifying greater fear avoidance beliefs for both physical activity and work subscales. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in coping strategy
Coping strategies will be assessed with the Pain Self-Efficacy Questionnaire (PSEQ), a dimension specific questionnaire. The PSEQ is a ten-item, dimension specific questionnaire that assesses how confident participants are with performing activities while experiencing pain. Each item is rated on a scale ranging from 0 ("not at all confident") to 6 ("completely confident"). The PSEQ score ranges between 0-60, with a higher score representing higher confidence to function with pain. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in physical activity
Physical activity will be quantified with the International Physical Activity Questionnaire - Short Form (IPAQ-SF), a dimension specific questionnaire. The IPAQ-SF is a 4-item short form that measures physical activity from the previous 7-days. Questions include the number of days per week the participant engaged in vigorous activities, moderate activities, walking, and sitting, with a follow-up question for each asking for duration of time for each task. Group means and standard deviations will be reported.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in self-reported knee function
The Knee Injury and Osteoarthritis Outcome Scale (KOOS) and the PFP subscale (KOOS-PF) will provide region and disease specific data throughout the study. The KOOS measures five separate dimensions; pain, symptoms, activities of daily living function, sports and recreational function, and quality of life. Each of the five domains are scored on a scale between 0-100, with lower scores representing greater impairments in self-reported function. The KOOS-PF subscale is an 11-item region specific questionnaire, ranging from 0-100, with greater scores also reflecting greater function.
Measured: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Jun 2022
- Study start13 Oct 2022
- Primary completion15 Dec 2026 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Patellofemoral PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 88 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Connecticut
- Sponsor type
- University, hospital or other
- Collaborators
- University of Central Florida, University of Toledo
- Responsible party
- Principal investigator, Neal Glaviano, University of Connecticut
- Investigators
- Neal Glaviano, PhD, Principal investigator, University of Connecticut
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05403944
- Sponsor's protocol ID
- HR22-0038
- Other IDs
- OR210126
- Acronym
- STRIPE
- Status last verified
- Apr 2026
- First submitted
- 31 May 2022
- Last updated
- 17 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IPD data will be available on request after manuscript has been published.
Publications
Glaviano NR, Mangum LC, Bazett-Jones DM, DiStefano LJ, Toland MD, Boling M. Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) for individuals with patellofemoral pain: a randomised controlled trial protocol. BMJ Open Sport Exerc Med. 2023 Jan 17;9(1):e001482. doi: 10.1136/bmjsem-2022-001482. eCollection 2023.
PubMed 36684710
Study at a glance
From the registry record, last updated by the sponsor on 17 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Optimizing Clinical Outcomes for Patients With Patellofemoral Pain Using Strength Training Rehabilitation Incorporating Power Exercises
- ClinicalTrials.gov ID
- NCT05403944
- Acronym / sponsor ID
- STRIPE / HR22-0038
- Conditions
- Patellofemoral Pain
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 88 participants (estimated)
- Lead sponsor
- University of ConnecticutUniversity, hospital or other
- Collaborators
- University of Central Florida, University of Toledo
- Study start
- 13 Oct 2022 (actual)
- Primary completion
- 15 Dec 2026 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 3 Jun 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study is to compare a novel 6-week strength training rehabilitation incorporating power exercises (STRIPE) program to a standard of care (SOC) program on short-term and long-term pain, subjective function, patellofemoral pain recurrence rates, and secondary outcomes (hip abduction and extension rate of torque development and single-leg squat kinematics). We hypothesize that participants with patellofemoral pain who complete the STRIPE program will have 1) decreased pain, 2) improved subjective function, 3) reduced patellofemoral pain recurrence rates, 4a) improved hip abduction/extension rate of torque development, and 4b) decreased hip adduction and pelvic drop during a single leg squat compared to participants who complete a SOC rehabilitation program.
Detailed description
The proposed study will compare strength-based exercises, which is the standard of care (SOC), that target the hip abductors, hip extensors, lumbo-pelvic, and quadriceps muscles, to a strength training program that utilized power-based exercises (Strength Training Rehabilitation Incorporating Power Exercises [STRIPE]). Individuals with patellofemoral pain, both within the military and general population, present with long-term pain, decreased subjective function, and high recurrence rates. Our primary outcomes are to determine intervention success with self-reported knee pain, measured by the visual analog scale, subjective function, measured by the anterior knee pain scale, and recurrence rates. Recent evidence suggests that two in every three individuals with patellofemoral pain report symptoms up to two years after seeking care, therefore we will assess patellofemoral pain recurrence rates for two years. Additionally, the proposed interventions target gluteal muscle function, supporting our selection of secondary outcome variables. We will assess rate of torque development, as power-based exercises are recommended to improve muscle capacity, of both the targeted gluteus medius and gluteus maximus. We will also assess frontal plane kinematics, as the gluteal muscles are responsible for controlling pelvic and hip motion during functional tasks.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Standard of Care (SOC) | Active comparator | Behavioral: Standard of Care Rehabilitation (SOC)The SOC rehabilitation group will complete three strength sessions a week. All participants will be provided an educational pamphlet and exercises will be divided into four components - hip abductors, hip extensors, core, and quadriceps muscles. The load magnitude for exercises will be between 60-70% of their 1 repetition max (1RM), with 3 sets of 12 repetitions and a 2-3-minute rest between sets. Time under tension will be prescribed as slow to moderate, with a 2-second concentric phase and 2-second eccentric phase for each exercise. Hip abductor, hip extensor, and core exercises will be initiated during week 1 and continued for the 6-week intervention, while quadriceps focused exercises will be introduced in weeks 3-6. |
| Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) | Experimental | Behavioral: Strength Training Rehabilitation Incorporating Power Exercises (STRIPE)Those in the STRIPE group will complete two power and one strength training sessions a week. All participants will be provided an educational pamphlet and exercises will be divided into four components - hip abductors, hip extensors, core, and quadriceps muscles. The load magnitude will be greater than 60% of the 1RM, with the goal of continually loading against heavy resistance. Participants will complete 4 sets of 6 repetitions, with 3-5 minutes of rest between sets. Time under tension will be prescribed as <1 second for the concentric phase and 1 second for the eccentric phase of the exercise. The strength training sessions will adhere to same parameters as the SOC. Hip abductor, hip extensor, and core exercises will be initiated during week 1 and continued for the 6-week intervention, while quadriceps focused exercises will be introduced in weeks 3-6. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Participants to be between the ages of 18-40 years old.
- Insidious onset of symptoms greater than 3 months.
- Worst pain in the previous month of 3/10 with two of the following tasks: prolonged sitting, jumping, squatting, kneeling, running, and stair ambulation.
Key exclusion criteria (4 listed)
- Other forms of anterior knee pain (Osgood-Schlatter, tendon pain, bursitis, etc.).
- History of lower extremity surgery.
- History of patella subluxation, meniscal injury or ligamentous instability.
- History of referred pain from the lumbar spine.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standard of Care Rehabilitation (SOC)6 weeks of standard of care rehabilitation will be given designed to target the core, hip, and quadriceps muscles. Each participant will be expected to complete 3 supervised telehealth sessions per week. | Behavioural | Standard of Care (SOC) |
| Strength Training Rehabilitation Incorporating Power Exercises (STRIPE)6 weeks of STRIPE rehabilitation will be given designed to target the core, hip, and quadriceps muscles. Each participant will be expected to complete 3 supervised telehealth sessions per week. | Behavioural | Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) |
Primary outcome
Change in knee pain.
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Data are presented as knee pain, assessed on the visual analog scale in centimeters, resulting in a score of 0-10, with 0 representing no pain and 10 being worst pain imaginable. Group means and standard deviations will be reported.
Change in self-reported knee function.
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Data are presented as self-reported knee function, assessed by the anterior knee pain scale. The scale ranged between 0-100, with 0 indicating complete disability and 100 indicating no disability. Group means and standard deviations will be reported.
Patellofemoral pain recurrence
Time frame: 6 months post intervention, 12-months post intervention, 18-months post intervention, and 24-months post intervention
The number of patients who report symptoms of patellofemoral pain
Change in hip rate of torque development
Time frame: Immediately after the intervention.
Hip abduction and extension rate of torque development will be assessed with a handheld dynamometer. Data are reported as linear, with higher scores representing a faster ability to develop hip muscle force. Group means and standard deviations will be reported.
Change in hip adduction during a single leg squat
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Data are presented as a degree, with a higher number representing a higher amount of hip adduction. Group means and standard deviations will be reported.
Change in pelvic drop during a single leg squat
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Data are presented as a degree, with a higher number representing a higher amount of pelvic drop. Group means and standard deviations will be reported.
5 secondary outcomes
Change in psychological factors
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in cognitive factors
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in coping strategy
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in physical activity
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Change in self-reported knee function
Time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Apr 2026.
- Derived from this study: PubMed 36684710Glaviano NR, Mangum LC, Bazett-Jones DM, DiStefano LJ, Toland MD, Boling M. Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) for individuals with patellofemoral pain: a randomised controlled trial protocol. BMJ Open Sport Exerc Med. 2023 Jan 17;9(1):e001482. doi: 10.1136/bmjsem-2022-001482. eCollection 2023.
- Individual participant dataSharing planned: No. IPD data will be available on request after manuscript has been published.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Neal Glaviano, PhD principal investigator
University of Connecticut
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Strength Training Rehabilitation Incorporating Power Exercises (STRIPE) in people with Patellofemoral Pain, run by University of Connecticut at 3 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 17 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in knee pain. (time frame: Immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05403944, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Apr 2026.