Orthodontic Tooth MovementNCT05414019

Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics

A study testing Mini-screw, Utility arch and Nitinol reverse curve wire in people with Orthodontic Tooth Movement and Intrusion of Tooth, run by Al-Azhar University at 1 site in Egypt.

Enrolling by invitation

Enrolling by invitation. The study team selects and invites participants, usually from an existing group of patients.

Sites and contacts

Official record

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Trial summary

Evaluation of root resorption following different mandibular incisors intrusive mechanics : A randomized clinical trial Read more about this study

Who is it for?: Ages 12 to 16 yearsHealthy volunteers can take part
Conditions the study is for: Orthodontic Tooth Movement, Intrusion of Tooth, Resorption, Root
What is being tested?: Mini-screw, Utility arch and Nitinol reverse curve wire
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 21 participants
Where: 1 siteEgypt
Study dates: 15 May 2025to Jan 2026
Phase: Interventional
Are there results?: Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 12 to 16 years
All sexes
Healthy volunteers accepted
Child

Who may be able to join

Patient will be included in this study if has:
An age range between 12 and 16 years.
Deep overbite with excessive curve of Spee of more than 5mm
Over erupted lower incisors.
Permanent teeth are all present (except for third molar).
No previous orthodontic treatment.
No indications or symptoms of periodontal disease in the past or present, as determined by clinical and radiographic examination

Who cannot join

Patients who needed surgery to fix skeletal problems.
Any previous trauma or root canal therapy
Missing lower incisor.
Patients with congenital dentoskeletal disorders

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Egypt1 site

Al Azhar University
Cairo

Other trials in Egypt

About this study

Official title: Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics : A Randomized Clinical Trial

Evaluation of root resorption following different mandibular incisors intrusive mechanics : A randomized clinical trial

Conditions: Orthodontic Tooth Movement, Intrusion of Tooth, Resorption, Root
Being tested: Mini-screw, Utility arch, Nitinol reverse curve wire
Keywords: Intrusion, Root resorption, Cone beam computed tomography, Utility Arch, Nitinol reverse curve wire, Miniscrew, Mandibular incisors
Medical subject headings: Root Resorption

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Mini-screwOther
7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine.
Utility archOther
7 patients will receive an intrusive force delivered by intrusive utility arch.
Nitinol reverse curve wireOther
7 patients will receive an intrusive force delivered by Nitinol reverse curve wire

Study groups in NCT05414019
Study group	Role	What they receive
Mini-screw	Active comparator	7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine. Receives: Other: Mini-screw
Utility arch	Active comparator	7 patients will receive an intrusive force delivered by intrusive utility arch. Receives: Other: Utility arch
Nitinol reverse curve wire	Active comparator	7 patients will receive an intrusive force delivered by Nitinol reverse curve wire. Receives: Other: Nitinol reverse curve wire

What is being measured

The primary outcome is the main question the study is designed to answer.

Linear amount of root resorption
Cone beam computed tomography linear measurements
Measured: Change in Linear Root resorption at 6 months
Volumetric amount of root resorption
Cone beam computed tomography volumetric measurements
Measured: Change in Volumetric Root resorption at 6 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

15 May 2025Jan 2026

First posted10 Jun 2022
Study start15 May 2025 (estimated)
Primary completionJan 2026 (estimated)
Study completionJan 2026 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (9)Papers the sponsor has linked to this study.
Other trials for Orthodontic Tooth MovementStudies of the same condition, open and under way.
More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Basic science
Allocation: Randomised
Intervention model: Parallel groups
Model description: The total sample of patients will be randomly divided into three equal groups: Miniscrew: 7 patients will receive an intrusive force delivered by elastics from 2 miniscrews between mandibular lateral incisor and mandibular canine. Utility arch: 7 patients will receive an intrusive force delivered by intrusive utility arch. Nitinol reverse curve wire: 7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.
Masking: None (open label)
Enrolment: 21 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT05414019
Sponsor's protocol ID: 799/2234
Status last verified: Apr 2025
First submitted: 29 May 2022
Last updated: 25 Apr 2025
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No

Publications

Goel P, Tandon R, Agrawal KK. A comparative study of different intrusion methods and their effect on maxillary incisors. J Oral Biol Craniofac Res. 2014 Sep-Dec;4(3):186-91. doi: 10.1016/j.jobcr.2014.11.007. Epub 2014 Dec 6.
PubMed 25737942
Hamdan AM, Lewis SM, Kelleher KE, Elhady SN, Lindauer SJ. Does overbite reduction affect smile esthetics? Angle Orthod. 2019 Nov;89(6):847-854. doi: 10.2319/030819-177.1. Epub 2019 Jul 15.
PubMed 31306077
Piancino MG, Tortarolo A, Di Benedetto L, Crincoli V, Falla D. Chewing Patterns and Muscular Activation in Deep Bite Malocclusion. J Clin Med. 2022 Mar 19;11(6):1702. doi: 10.3390/jcm11061702.
PubMed 35330027
Nielsen IL. Vertical malocclusions: etiology, development, diagnosis and some aspects of treatment. Angle Orthod. 1991 Winter;61(4):247-60. doi: 10.1043/0003-3219(1991)0612.0.CO;2.
PubMed 1763835
Sonnesen L, Svensson P. Temporomandibular disorders and psychological status in adult patients with a deep bite. Eur J Orthod. 2008 Dec;30(6):621-9. doi: 10.1093/ejo/cjn044. Epub 2008 Aug 5.
PubMed 18684706
Guven BA, Ciger S. Evaluation of the Effect of Fixed Anterior Biteplane Treatment on Temporomandibular Joint in Patients with Deep Bite. Turk J Orthod. 2020 Mar 1;33(1):8-12. doi: 10.5152/TurkJOrthod.2020.19108. eCollection 2020 Mar.
PubMed 32284893
Millett DT, Cunningham SJ, O'Brien KD, Benson PE, de Oliveira CM. Orthodontic treatment for deep bite and retroclined upper front teeth in children. Cochrane Database Syst Rev. 2018 Feb 1;2(2):CD005972. doi: 10.1002/14651858.CD005972.pub4.
PubMed 29390172
Nanda R. The differential diagnosis and treatment of excessive overbite. Dent Clin North Am. 1981 Jan;25(1):69-84. No abstract available.
PubMed 6937401
Burstone CR. Deep overbite correction by intrusion. Am J Orthod. 1977 Jul;72(1):1-22. doi: 10.1016/0002-9416(77)90121-x.
PubMed 267433

Interested in taking part?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See sites and contacts

Enrolling by invitation
Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth Study
Bimaxillary Protrusion, Class II Div 1 Malocclusion
Not yet recruiting
Impact of Various Acceleration Techniques on En-masse Retraction of Maxillary Anterior Teeth
Accelerate Tooth Movement
Active, not recruiting
Treatment of the Mandibular Dental Crowding With and Without Corticotomy Surgery
Dental Research, Orthodontics
Recruiting
Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction
Malocclusions, Canine Retraction
Enrolling by invitation
Evaluation of Corticotomy-Assisted Canine Retraction Rate
Malocclusion, Corticotomy

All Orthodontic Tooth Movement trials

Study at a glance

From the registry record, last updated by the sponsor on 25 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Evaluation of Root Resorption Following Different Mandibular Incisors Intrusive Mechanics : A Randomized Clinical Trial
ClinicalTrials.gov ID: NCT05414019
Acronym / sponsor ID: 799/2234
Conditions: Orthodontic Tooth Movement, Intrusion of Tooth, Resorption, Root
Keywords: Intrusion, Root resorption, Cone beam computed tomography, Utility Arch, Nitinol reverse curve wire, Miniscrew, Mandibular incisors
Study type: Interventional
Recruitment status: Enrolling by invitation
Enrolment: 21 participants (estimated)
Lead sponsor: Al-Azhar UniversityUniversity, hospital or other
Study start: 15 May 2025 (estimated)
Primary completion: Jan 2026 (estimated)
Study completion: Jan 2026 (estimated)
First posted: 10 Jun 2022 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Evaluation of root resorption following different mandibular incisors intrusive mechanics : A randomized clinical trial

Study design

Primary purpose: Basic science
Allocation: Randomised
Intervention model: Parallel groups
Masking: None (open label)
Number of arms: 3
Model description: The total sample of patients will be randomly divided into three equal groups: Miniscrew: 7 patients will receive an intrusive force delivered by elastics from 2 miniscrews between mandibular lateral incisor and mandibular canine. Utility arch: 7 patients will receive an intrusive force delivered by intrusive utility arch. Nitinol reverse curve wire: 7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.

Arm	Type	Receives
Mini-screw	Active comparator	Other: Mini-screw7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine.
Utility arch	Active comparator	Other: Utility arch7 patients will receive an intrusive force delivered by intrusive utility arch.
Nitinol reverse curve wire	Active comparator	Other: Nitinol reverse curve wire7 patients will receive an intrusive force delivered by Nitinol reverse curve wire.

Who may qualify

Ages: 12 to 16 years
Sex: All
Healthy volunteers: Accepted
Age groups: Child

Key inclusion criteria (7 listed)

Patient will be included in this study if has:

Key exclusion criteria (4 listed)

Patients who needed surgery to fix skeletal problems.
Any previous trauma or root canal therapy
Missing lower incisor.
Patients with congenital dentoskeletal disorders

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Mini-screw7 patients will receive an intrusive force delivered by elastics from 2 mini-screws between mandibular lateral incisor and mandibular canine.	Other	Mini-screw
Utility arch7 patients will receive an intrusive force delivered by intrusive utility arch.	Other	Utility arch
Nitinol reverse curve wire7 patients will receive an intrusive force delivered by Nitinol reverse curve wire	Other	Nitinol reverse curve wire

Primary outcome

Linear amount of root resorption
Time frame: Change in Linear Root resorption at 6 months
Cone beam computed tomography linear measurements
Volumetric amount of root resorption
Time frame: Change in Volumetric Root resorption at 6 months
Cone beam computed tomography volumetric measurements

Results and safety

This study is still under way. Results are not available in the source record yet.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 25 Apr 2025.
Background: PubMed 25737942Goel P, Tandon R, Agrawal KK. A comparative study of different intrusion methods and their effect on maxillary incisors. J Oral Biol Craniofac Res. 2014 Sep-Dec;4(3):186-91. doi: 10.1016/j.jobcr.2014.11.007. Epub 2014 Dec 6.
Background: PubMed 31306077Hamdan AM, Lewis SM, Kelleher KE, Elhady SN, Lindauer SJ. Does overbite reduction affect smile esthetics? Angle Orthod. 2019 Nov;89(6):847-854. doi: 10.2319/030819-177.1. Epub 2019 Jul 15.
Background: PubMed 35330027Piancino MG, Tortarolo A, Di Benedetto L, Crincoli V, Falla D. Chewing Patterns and Muscular Activation in Deep Bite Malocclusion. J Clin Med. 2022 Mar 19;11(6):1702. doi: 10.3390/jcm11061702.
Background: PubMed 1763835Nielsen IL. Vertical malocclusions: etiology, development, diagnosis and some aspects of treatment. Angle Orthod. 1991 Winter;61(4):247-60. doi: 10.1043/0003-3219(1991)0612.0.CO;2.
Background: PubMed 18684706Sonnesen L, Svensson P. Temporomandibular disorders and psychological status in adult patients with a deep bite. Eur J Orthod. 2008 Dec;30(6):621-9. doi: 10.1093/ejo/cjn044. Epub 2008 Aug 5.
Background: PubMed 32284893Guven BA, Ciger S. Evaluation of the Effect of Fixed Anterior Biteplane Treatment on Temporomandibular Joint in Patients with Deep Bite. Turk J Orthod. 2020 Mar 1;33(1):8-12. doi: 10.5152/TurkJOrthod.2020.19108. eCollection 2020 Mar.
Background: PubMed 29390172Millett DT, Cunningham SJ, O'Brien KD, Benson PE, de Oliveira CM. Orthodontic treatment for deep bite and retroclined upper front teeth in children. Cochrane Database Syst Rev. 2018 Feb 1;2(2):CD005972. doi: 10.1002/14651858.CD005972.pub4.
Background: PubMed 6937401Nanda R. The differential diagnosis and treatment of excessive overbite. Dent Clin North Am. 1981 Jan;25(1):69-84. No abstract available.
Background: PubMed 267433Burstone CR. Deep overbite correction by intrusion. Am J Orthod. 1977 Jul;72(1):1-22. doi: 10.1016/0002-9416(77)90121-x.

Related trials for Orthodontic Tooth Movement

Enrolling by invitation
Discision as Acceleration Method in Canine Retraction in Orthodontics With Aligner and Fixed Appliances in Young Adults a Split Mouth Study
Bimaxillary Protrusion, Class II Div 1 Malocclusion
Not yet recruiting
Impact of Various Acceleration Techniques on En-masse Retraction of Maxillary Anterior Teeth
Accelerate Tooth Movement
Active, not recruiting
Treatment of the Mandibular Dental Crowding With and Without Corticotomy Surgery
Dental Research, Orthodontics
Recruiting
Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction
Malocclusions, Canine Retraction
Enrolling by invitation
Evaluation of Corticotomy-Assisted Canine Retraction Rate
Malocclusion, Corticotomy

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.

Mahmoud S Nassar, student principal investigator

Al-Azhar University

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Mini-screw, Utility arch and Nitinol reverse curve wire in people with Orthodontic Tooth Movement and Intrusion of Tooth, run by Al-Azhar University at 1 site in Egypt.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: enrolling by invitation, as of the sponsor's last update on 25 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Linear amount of root resorption (time frame: Change in Linear Root resorption at 6 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05414019, which also lists 9 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Apr 2025.