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HIV-1-infectionPhase 1NCT05414786

A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644)

A Phase 1 study testing eOD-GT8 60mer mRNA Vaccine (100µg) in people with HIV-1-infection, run by International AIDS Vaccine Initiative at 2 sites in 2 countries.

Unknown status

Status not confirmed. The sponsor has not verified this record for over two years, so it may be out of date.

Official record
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Trial summary

A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) in HIV-1 Uninfected Adults in Good General Health. Read more about this study

Who is it for?
Ages 18 to 50 yearsHealthy volunteers can take part
Conditions the study is for
HIV-1-infection
What is being tested?
eOD-GT8 60mer mRNA Vaccine (100µg)
Type of treatment
Vaccines
Could I receive a placebo?
No, everyone receives an active treatment
How many people
18 participants
Where
2 sitesin 2 countries
Study dates
25 May 2022to 30 Jun 2023
Phase
Phase 1
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 50 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Healthy adults as assessed by a medical history, physical examination, and laboratory tests who are at least 18 years at the time of screening and less than 51 years at the time of first IP administration;
  • Willing to comply with the requirements of the protocol and be available for follow-up for the planned duration of the study;
  • In the opinion of the PI or designee and based on Assessment of (informed consent) Understanding (AOU) results, has understood the information provided and potential impact and/or risks linked to IP administration and participation in the study; written informed consent will be obtained from the participant before any study-related procedures are performed;
  • Willing to undergo HIV testing, risk reduction counselling and receive HIV test results;
  • All women of reproductive potential who are engaging in sexual activity that could lead to pregnancy must commit to use an effective method of contraception at least 4 weeks prior to the first IP administration and for 4 months following the last IP administration. Effective contraception includes:
  • Intrauterine device
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  • Hormonal contraception, including contraceptive implant or injectable
  • Successful vasectomy in the male partner (considered successful if a woman reports that a male partner has documentation of azoospermia by microscopy [1 year ago], or a vasectomy more than 2 years ago with no resultant pregnancy despite sexual activity post vasectomy)
  • Not of reproductive potential, such as having undergone hysterectomy, bilateral oophorectomy or tubal ligation, postmenopausal (≥45 years of age with amenorrhea for at least 2 years, or any age with amenorrhea for at least 6 months and a serum follicle stimulating hormone (FSH) level >40 IU/L), surgically sterile Note: More restrictive measures may be required by the study sites.
  • All participants born female who are not heterosexually active at screening must agree to utilize an effective method of contraception if they become heterosexually active as outlined above;
  • All participants born female must be willing to undergo urine pregnancy tests at time points indicated in the Schedule of Activities (SOAs) (APPENDIX A or APPENDIX B);
  • All sexually active participants born male, regardless of reproductive potential, must be willing to use an effective method of contraception (such as consistent condom use) from the day of the first IP administration until at least 4 months after the last IP administration; Note: For Center for Family Health Research (CFHR) site, males in monogamous relationships whose partners are on a documented and effective contraceptive method will be exempt from this requirement.
  • Willing to forgo donations of blood, or any other tissues during the study and, for those who test HIV-positive due to IP-induced antibodies, until the anti-HIV antibody titers become undetectable.

Who cannot join

  • Positive test for HIV-1 or HIV-2 infection;
  • Any clinically relevant abnormality on history or examination, including history of immunodeficiency or autoimmune disease; use of systemic corticosteroids (the use of topical or inhaled steroids is permitted), immunosuppressive, anticancer, antituberculosis or other medications considered significant by the Investigator within the previous 6 months; Note: The following exceptions are permitted and will not exclude study participation: use of corticosteroid nasal spray for rhinitis, topical corticosteroids for an acute uncomplicated dermatitis; or a short course (duration of 10 days or less, or a single IP administration) of corticosteroid for a non-chronic condition (based on Investigator clinical judgment) at least 2 weeks prior to enrolment in this study.
  • Any clinically significant acute or chronic medical condition that is considered progressive or in the opinion of the Investigator makes the participant unsuitable for participation in the study;
  • History of substance abuse or alcohol abuse;
  • Reported behaviour that puts the participant at risk for HIV infection within 6 months prior to screening, as defined by:
  • Unprotected sexual intercourse with a known HIV-infected person, a partner known to be at high risk for HIV infection or a casual partner (i.e., no continuing established relationship)
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  • Engaged in sex work
  • Frequent excessive daily alcohol use or frequent binge drinking, or any other use of illicit drugs
  • History of newly acquired syphilis, gonorrhea, non-gonococcal urethritis, herpes simplex virus-2, chlamydia, pelvic inflammatory disease, trichomonas, mucopurulent cervicitis, epididymitis, proctitis, lymphogranuloma venereum, chancroid, or hepatitis B-or hepatitis C;
  • Two or more sexual partners
  • If female, pregnant or planning a pregnancy during the period of enrolment until 4 months after the last IP administration; or lactating;
  • Bleeding disorder that was diagnosed by a physician (e.g., factor deficiency, coagulopathy or platelet disorder that requires special precautions) Note: A participant who states that he or she has easy bruising or bleeding but does not have a formal diagnosis and has IM vaccinations and blood draws without any adverse experience is eligible;
  • Infectious disease diagnosis: chronic hepatitis B-infection (HBsAg-positive), hepatitis C infection (HCV Ab-positive), or active syphilis (screening and confirmatory tests);
  • History of splenectomy;
  • Any of the following abnormal laboratory parameters listed below at screening:
  • Hematology
  • Hemoglobin <12.0 g/dl or <7.5 mmol/L
  • Absolute Neutrophil Count (ANC) - ≤1,000/mm3 or < 1.0 x 109 cells/L
  • Absolute Lymphocyte Count (ALC) - ≤650/mm3 or < 0.65 x 109 cells/L
  • Platelets - <125,000 cells/mm3 or <125 x 109 cells/L Chemistry
  • Creatinine - >1.1 x upper limit of normal (ULN)
  • AST - >1.25 x ULN
  • ALT - >1.25 x ULN Urinalysis
  • Clinically significant abnormal dipstick confirmed by microscopy:
  • Protein = 1+ or more Blood = 2+ or more (not due to menses) and >10 RBCs per high power field When available, the screening laboratory tests will be reviewed by the study physician. Screening laboratory test(s) may be repeated once at the discretion of the PI or designee to investigate any isolated abnormalities. If Urinalysis is the only exclusion criteria that is met, consider repeat urinalysis to confirm.
  • Receipt of live attenuated vaccine within the previous 30 days or planned receipt within 30 days after IP administration (Exception is live attenuated influenza vaccine which can be given within 14 days); or receipt of other vaccine (including all COVID-19 vaccinations) within the previous 14 days or planned receipt within 14 days after IP administration; Note: COVID-19 vaccinations: Participants should not have received any COVID-19 vaccinations in the 14 days before or 14 days after IP administration.
  • Receipt of blood transfusion or blood-derived products within the previous 3 months;
  • Participation in another clinical study of an IP currently, within the previous 3 months or expected participation during this study; concurrent participation in an observational study not requiring blood or tissue sample collection is not an exclusion; Note: COVID-19 immunoprophylaxis will be permitted prior to and/or during the study provided the agent has received either Emergency Use Approval by FDA, Conditional Marketing Authorization by the European Medicines Agency, or granted licensure by a country's regulatory agency.
  • Prior receipt of any investigational HIV vaccine candidate or HIV monoclonal antibody Note: Receipt of placebo in a previous HIV vaccine study or monoclonal antibody study will not exclude a participant from participation if documentation is available and the Medical Monitor gives approval.
  • History of significant local or systemic reactogenicity to vaccines (e.g., anaphylaxis, respiratory difficulties, angioedema, injection site necrosis or ulceration); (This includes individuals with history of anaphylaxis and/or severe hypersensitivity reaction to mRNA vaccines or its excipients)
  • Psychiatric condition that compromises the safety of the participant and precludes compliance with the protocol. Specifically excluded are persons with psychoses within the past 3 years, ongoing risk for suicide, or history of suicide attempt or gesture within the past 3 years;
  • Seizure disorder: A participant who has had a seizure in the last 3 years is excluded. (Not excluded: a participant with a history of seizures who has neither required medications nor had a seizure for 3 years);
  • History of malignancy in the past 5 years (prior to screening) or ongoing malignancy (a history of completely excised malignancy that is considered cured is not an exclusion);
  • Active, serious infections requiring antibiotic, antiviral or antifungal therapy within 30 days prior to enrolment;
  • Body mass index (BMI) ≥35;
  • Body weight <110 pounds (50 kg);
  • Prior daily use of NSAID/aspirin that cannot be held for 5 days prior to the leukapheresis procedure (if applicable at the study site);
  • If, in the opinion of the PI, it is not in the best interest of the participant to participate in the study.

Trial locations and contacts

2 sites in 2 countries.

2 sites in 2 countries

Rwanda1 site

  • Center for Family Health Research

    Kigali, 250

Other trials in Rwanda

South Africa1 site

  • Aurum Tembisa Clinical Research Centre

    Johannesburg, 1332

Other trials in South Africa

About this study

Official title: A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) in HIV-1 Uninfected Adults in Good General Health

A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) in HIV-1 Uninfected Adults in Good General Health.

Read the detailed description

A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) in HIV-1 Uninfected Adults in Good General Health. The hypothesis is that eOD-GT8 60mer mRNA Vaccine as a "germline-targeting" immunogen will generate detectable VRC01-class IgG B-cells in African populations. Eighteen participants. An over-enrollment of up to 2 participants will be permitted to facilitate rapid enrollment. Participants who leave the study for any reason will not be replaced. Adults ≥18 and ≤50 years of age who meet all protocol inclusion criteria, who do not meet any protocol exclusion criteria, who understand the study (as demonstrated by the Assessment of [Informed Consent] Understanding [AOU]), and who can provide written informed consent. Administration of eOD-GT8 60mer mRNA Vaccine (100µg) will occur on Week 0 and Week 8. There is no blinding and no randomization in this open-label study. Participants will be screened up to 56 days before the first IP administration and will be actively followed for 6 months after the last IP administration.

The total study duration including screening and enrollment is approximately 13 months. A participant is expected to be in the study for 10 months from screening to last study visit. The study is expected to screen and enroll over 3 months.

Conditions
HIV-1-infection
Being tested
eOD-GT8 60mer mRNA Vaccine (100µg)
Keywords
eOD-GT8 60mer mRNA Vaccine

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • eOD-GT8 60mer mRNA Vaccine (100µg)Biological

    • 2 doses eOD-GT8 60mer mRNA Vaccine (100µg), 2 vaccinations, 8 weeks apart
    • No control group. There is no blinding and no randomization in this open label study
Study groups in NCT05414786
Study groupRoleWhat they receive
Experimental groupExperimental* 2 doses eOD-GT8 60mer mRNA Vaccine (100µg), 2 vaccinations, 8 weeks apart * No control group. There is no blinding and no randomization in this open label study
Receives: Biological: eOD-GT8 60mer mRNA Vaccine (100µg)

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Evaluate the safety and tolerability of eOD-GT8 60mer mRNA Vaccine

    To evaluate the safety and tolerability of eOD-GT8 60mer mRNA Vaccine, including local and systemic solicited AEs from Day 1 to Day 7 inclusive after each IP administration, Grade 2 or higher unsolicited AEs from the day of each IP administration through 28 days after, participants with SAEs throughout the study period and participants with MAAEs and AESIs from the first day of IP administration through 24 weeks post final IP administration

    Measured: 16 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted10 Jun 2022
  2. Study start25 May 2022
  3. Primary completion30 Jun 2023 (estimated)
  4. Study completion30 Jun 2023 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1
Primary purpose
Prevention
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
18 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05414786
Sponsor's protocol ID
IAVI G003
Status last verified
Mar 2023
First submitted
26 May 2022
Last updated
10 Mar 2023
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: This will be done with the clinical trial team, collaborators and funding agencies. Also, as information becomes available, this will be shared with the site and study participants. Results dissemination plans will be developed and implemented as the study progresses.

Publications

  • Libera M, Caputo V, Laterza G, Moudoud L, Soggiu A, Bonizzi L, Diotti RA. The Question of HIV Vaccine: Why Is a Solution Not Yet Available? J Immunol Res. 2024 Apr 8;2024:2147912. doi: 10.1155/2024/2147912. eCollection 2024.

    PubMed 38628675

Questions about this trial

What is this clinical trial studying?

A Phase 1 study testing eOD-GT8 60mer mRNA Vaccine (100µg) in people with HIV-1-infection, run by International AIDS Vaccine Initiative at 2 sites in 2 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 13 inclusion and 38 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: status not confirmed, as of the sponsor's last update on 10 Mar 2023. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in Rwanda, South Africa. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Evaluate the safety and tolerability of eOD-GT8 60mer mRNA Vaccine (time frame: 16 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05414786, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2023.

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