Patellofemoral Pain SyndromePHENOPATNCT05441332
Kinematic and Neuromuscular Deficiencies Phenotypes Associated With Patellofemoral Pain Syndrome
A study testing EOS Radiation and Semi-structured interview in people with Patellofemoral Pain Syndrome, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
Trial summary
The purpose of this study is to describe and compare the kinematic deficiencies specifically associated with each of the 3 main clinical phenotypes of patellofemoral pain syndrome. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Patellofemoral Pain Syndrome
- What is being tested?
- EOS Radiation and Semi-structured interview
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteFrance
- Study dates
- 9 Dec 2022to 27 Feb 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Medical diagnosis of SDFP :
- Anterior pain of the knee, mechanical, in front of and around the patella noted at more than 3/10 on a simple numerical scale (ligament or meniscal damage, synovial plicae, tendinopathies, apophysitis, neuromas, and osteoarthritis FT are differential diagnoses),
- Pain during any of the following activities: Going up / down stairs, squats, jumps, jogging, sitting, crouching.
- Duration of knee anterior pain greater than 1 month
- Affiliation to a social insurance
- Signature of the consent to participate
Who cannot join
- Neurological disorders affecting the lower extremities
- Radiographic FT osteoarthritis
- History of surgery or trauma to the lower limb less than 1 year old
- Intra-articular knee infiltration ≤ 2 months
- Cognitive or behavioral problems making it impossible to assess
- Participates in intervention research or is in the exclusion period following a previous research, if applicable
Show all 9Show fewer
- Unable to speak, read and write French
- Patients under guardianship or curatorship,
- Patients receiving AME (French State Medical aid)
Trial locations and contacts
1 site in 1 country.
France1 site
Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis - Hôpital Cochin
Paris, Île-de-France Region, 75014
About this study
Official title: Kinematic and Neuromuscular Deficiencies Phenotypes Associated With Patellofemoral Pain Syndrome : a Cross-sectional Interventional Study
The purpose of this study is to describe and compare the kinematic deficiencies specifically associated with each of the 3 main clinical phenotypes of patellofemoral pain syndrome. The prevalence of patellofemoral pain is high with a high rate of chronicity and recurrence and an overrepresentation of young, athletic and female populations. There are multiple classifications of patellofemoral pain syndrome. A pragmatic classification distinguishes 3 main clinical phenotypes of patellofemoral pain syndrome: with objectively displaceable patella, with extra-patellar alignment problems and without alignment problems.
The pathophysiology of patellofemoral pain syndrome is multifactorial involving static and dynamic dysfunctions of the hip, knee and foot, which remain incompletely elucidated to date. The links between the clinical and biomechanical aspects are still unclear and the kinematic and neuromuscular deficiencies associated with the 3 main clinical phenotypes are poorly understood. A validated non-invasive device allows the 3D evaluation of femorotibial rotations during walking.
Read the detailed description
The diagnostic process is based on clinical examination. The evolution of measuring tools like radios, RMI and kinematics device allows a more precise diagnostic of patellofemoral Pain syndrome. We still don't know what kind of gait parameters could help to categorize the different phenotypes. With a better understanding of these phenotypes the investigators will be able to propose a better personalized rehabilitation.
Patellofemoral pain syndrome is defined as an anterior knee pain in front of and around the patella. The diagnosis of patellofemoral pain syndrome is based on clinical examination and standard imaging.
The pathophysiology of the patellofemoral pain syndrome is multifactorial involving static and dynamic dysfunctions of the hip, knee and foot, which remain incompletely elucidated to date. The prevalence of patellofemoral pain is high with a high rate of chronicity and recurrence and an overrepresentation of young, athletic and female populations. A pragmatic classification distinguishes 3 main clinical phenotypes of patellofemoral pain syndrome: with objectively displaceable patella, with extra-patellar alignment problems and without alignment problems.
The links between the clinic and biomechanics are still unclear and the kinematics and neuromuscular impairments associated with the 3 main clinical phenotypes are poorly understood.
The KneeKG is an optoelectronic kinematic assessment device using non-invasive sensors and dedicated to real-time measurement of 3D femoro-tibial position and rotations. The kinematic, neuro-muscular, postural and proprioceptive assessments will allow us to better understand the pathophysiology of the patellofemoral pain syndrome, to establish a more accurate diagnosis of the disease, and provide a better understanding of its causes.
Several studies have shown that better adherence to exercise is associated with greater benefit in terms of pain and function in chronic pathologies.
Semi-structured interviews will enable the investigators to assess the impact of information derived from kinematic examination of the knees on adherence to treatment.
- Conditions
- Patellofemoral Pain Syndrome
- Being tested
- EOS Radiation, Semi-structured interview
- Keywords
- Patellofemoral pain syndrome, 3D Kinematics, assessment, clinical phenotypes, dynamic deficiencies
- Medical subject headings
- Patellofemoral Pain Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EOS RadiationOther
Also called EOS X-ray exams
One EOS exam of lower extremities
Semi-structured interviewBehavioural
Semi-structured interview to identify factors influencing patient adherence behavior for a sub-group of 15 patients. By phone, between 1 to 3 months after inclusion.
| Study group | Role | What they receive |
|---|---|---|
| Patellofemoral pain syndrome | Experimental | Kinematic and neuromuscular assessment Receives: Other: EOS Radiation; Behavioral: Semi-structured interview |
What is being measured
The primary outcome is the main question the study is designed to answer.
Amplitude of rotation
Amplitude of rotation of the femur with respect to the tibia in the bearing phase in the 3 planes of space
Measured: Day of inclusion (up to 10 days)
Secondary outcomes (23)
Length measures
EOS femoro-tibial alignment
Measured: Day of inclusion (up to 10 days)
Q angle (in degree)
EOS femoro-tibial alignment
Measured: Day of inclusion (up to 10 days)
Varus valgus(in degree)
EOS femoro-tibial alignment
Measured: Day of inclusion (up to 10 days)
Peak torque (N.m)
Quadriceps isokinetic strenght
Measured: Day of inclusion (up to 10 days)
Total work (N.m)
Quadriceps isokinetic strenght
Measured: Day of inclusion (up to 10 days)
Peak torque (N.m)
Hamstrings isokinetic strenght
Measured: Day of inclusion (up to 10 days)
Total work (N.m)
Hamstrings isokinetic strenght
Measured: Day of inclusion (up to 10 days)
Quadriceps/Hamstring ratio : 2 measure/leg
Measured: Day of inclusion (up to 10 days)
Peak torque (N.m)
Hip abductors static strenght
Measured: Day of inclusion (up to 10 days)
Average torque (N.m)
Hip abductors static strenght
Measured: Day of inclusion (up to 10 days)
Time for reaching peak (s)
Hip abductors static strenght
Measured: Day of inclusion (up to 10 days)
Time difference in the onset between the m.vastus lateralis and m.vastus medialis contraction in ms
Activity of the quadriceps measured. Electromyogram was used to quantify the electric potential of quadriceps and referred to as 'quadriceps muscle EMG activity' throughout
Measured: Day of inclusion (up to 10 days)
Y test
Static and dynamic unipodal balance
Measured: Day of inclusion (up to 10 days)
Eccentric step-down test
Static and dynamic unipodal balance
Measured: Day of inclusion (up to 10 days)
Lateral step down test
Static and dynamic unipodal balance
Measured: Day of inclusion (up to 10 days)
Unipodal stabilometric evaluation
Static and dynamic unipodal balance
Measured: Day of inclusion (up to 10 days)
Foot posture index
Foot static
Measured: Day of inclusion (up to 10 days)
Navicular drop test
Foot static
Measured: Day of inclusion (up to 10 days)
Ober's test
Muscle hypoextensibility. Quadriceps, harmstrings, calves,
Measured: Day of inclusion (up to 10 days)
Visual Analog Scale
Determine pain / No pain = 0, maximal pain =100
Measured: Day of inclusion (up to 10 days)
Anterior knee pain scale (AKPS)
Questionnaire to determine pain / 13 questions, minimum score = 0 point, maximum score = 100 points
Measured: Day of inclusion (up to 10 days)
12-Item Short Form Survey (SF-12)
Quality of life, to determine pain
Measured: Day of inclusion (up to 10 days)
Semi-structured interview
Semi-structured interview for a sub-group of 15 patients identify factors influencing patient adherence behavior.
Measured: From month 1 to month 3
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2022
- Study start9 Dec 2022
- Primary completion27 Sep 2024
- Study completion27 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Patellofemoral Pain SyndromeStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Collaborators
- URC-CIC Paris Descartes Necker Cochin
- Responsible party
- Sponsor
- Investigators
- Marvin COLEMAN, MSc, PhD student, Principal investigator, Assistance Publique - Hôpitaux de Paris
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05441332
- Sponsor's protocol ID
- APHP211433
- Other IDs
- 2021-A01928-33
- Acronym
- PHENOPAT
- Status last verified
- Jun 2026
- First submitted
- 14 Jun 2022
- Last updated
- 1 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Coleman M, Gizolme L, Hagemeister N, Nguyen C, Rannou F, Dietrich G, Lefevre-Colau MM, Roren A. 3D kinematic knee variables in people with unilateral patellofemoral pain syndrome: comparison of symptomatic and contralateral knees. Ann Phys Rehabil Med. 2026 Jun;69(5):102124. doi: 10.1016/j.rehab.2026.102124. Epub 2026 Apr 18. No abstract available.
PubMed 42001620
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Kinematic and Neuromuscular Deficiencies Phenotypes Associated With Patellofemoral Pain Syndrome : a Cross-sectional Interventional Study
- ClinicalTrials.gov ID
- NCT05441332
- Acronym / sponsor ID
- PHENOPAT / APHP211433
- Conditions
- Patellofemoral Pain Syndrome
- Keywords
- Patellofemoral pain syndrome, 3D Kinematics, assessment, clinical phenotypes, dynamic deficiencies
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Collaborators
- URC-CIC Paris Descartes Necker Cochin
- Study start
- 9 Dec 2022 (actual)
- Primary completion
- 27 Sep 2024 (actual)
- Study completion
- 27 Feb 2025 (actual)
- First posted
- 1 Jul 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to describe and compare the kinematic deficiencies specifically associated with each of the 3 main clinical phenotypes of patellofemoral pain syndrome. The prevalence of patellofemoral pain is high with a high rate of chronicity and recurrence and an overrepresentation of young, athletic and female populations. There are multiple classifications of patellofemoral pain syndrome. A pragmatic classification distinguishes 3 main clinical phenotypes of patellofemoral pain syndrome: with objectively displaceable patella, with extra-patellar alignment problems and without alignment problems.
The pathophysiology of patellofemoral pain syndrome is multifactorial involving static and dynamic dysfunctions of the hip, knee and foot, which remain incompletely elucidated to date. The links between the clinical and biomechanical aspects are still unclear and the kinematic and neuromuscular deficiencies associated with the 3 main clinical phenotypes are poorly understood. A validated non-invasive device allows the 3D evaluation of femorotibial rotations during walking.
Detailed description
The diagnostic process is based on clinical examination. The evolution of measuring tools like radios, RMI and kinematics device allows a more precise diagnostic of patellofemoral Pain syndrome. We still don't know what kind of gait parameters could help to categorize the different phenotypes. With a better understanding of these phenotypes the investigators will be able to propose a better personalized rehabilitation.
Patellofemoral pain syndrome is defined as an anterior knee pain in front of and around the patella. The diagnosis of patellofemoral pain syndrome is based on clinical examination and standard imaging.
The pathophysiology of the patellofemoral pain syndrome is multifactorial involving static and dynamic dysfunctions of the hip, knee and foot, which remain incompletely elucidated to date. The prevalence of patellofemoral pain is high with a high rate of chronicity and recurrence and an overrepresentation of young, athletic and female populations. A pragmatic classification distinguishes 3 main clinical phenotypes of patellofemoral pain syndrome: with objectively displaceable patella, with extra-patellar alignment problems and without alignment problems.
The links between the clinic and biomechanics are still unclear and the kinematics and neuromuscular impairments associated with the 3 main clinical phenotypes are poorly understood.
The KneeKG is an optoelectronic kinematic assessment device using non-invasive sensors and dedicated to real-time measurement of 3D femoro-tibial position and rotations. The kinematic, neuro-muscular, postural and proprioceptive assessments will allow us to better understand the pathophysiology of the patellofemoral pain syndrome, to establish a more accurate diagnosis of the disease, and provide a better understanding of its causes.
Several studies have shown that better adherence to exercise is associated with greater benefit in terms of pain and function in chronic pathologies.
Semi-structured interviews will enable the investigators to assess the impact of information derived from kinematic examination of the knees on adherence to treatment.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patellofemoral pain syndrome | Experimental | Other: EOS Radiation, Behavioral: Semi-structured interviewKinematic and neuromuscular assessment |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Medical diagnosis of SDFP :
- Anterior pain of the knee, mechanical, in front of and around the patella noted at more than 3/10 on a simple numerical scale (ligament or meniscal damage, synovial plicae, tendinopathies, apophysitis, neuromas, and osteoarthritis FT are differential diagnoses),
- Pain during any of the following activities: Going up / down stairs, squats, jumps, jogging, sitting, crouching.
- Duration of knee anterior pain greater than 1 month
- Affiliation to a social insurance
Key exclusion criteria (9 listed)
- Neurological disorders affecting the lower extremities
- Radiographic FT osteoarthritis
- History of surgery or trauma to the lower limb less than 1 year old
- Intra-articular knee infiltration ≤ 2 months
- Cognitive or behavioral problems making it impossible to assess
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EOS RadiationAlso: EOS X-ray examsOne EOS exam of lower extremities | Other | Patellofemoral pain syndrome |
| Semi-structured interviewSemi-structured interview to identify factors influencing patient adherence behavior for a sub-group of 15 patients. By phone, between 1 to 3 months after inclusion. | Behavioural | Patellofemoral pain syndrome |
Primary outcome
Amplitude of rotation
Time frame: Day of inclusion (up to 10 days)
Amplitude of rotation of the femur with respect to the tibia in the bearing phase in the 3 planes of space
23 secondary outcomes
Length measures
Time frame: Day of inclusion (up to 10 days)
Q angle (in degree)
Time frame: Day of inclusion (up to 10 days)
Varus valgus(in degree)
Time frame: Day of inclusion (up to 10 days)
Peak torque (N.m)
Time frame: Day of inclusion (up to 10 days)
Total work (N.m)
Time frame: Day of inclusion (up to 10 days)
Peak torque (N.m)
Time frame: Day of inclusion (up to 10 days)
Total work (N.m)
Time frame: Day of inclusion (up to 10 days)
Quadriceps/Hamstring ratio : 2 measure/leg
Time frame: Day of inclusion (up to 10 days)
Peak torque (N.m)
Time frame: Day of inclusion (up to 10 days)
Average torque (N.m)
Time frame: Day of inclusion (up to 10 days)
Time for reaching peak (s)
Time frame: Day of inclusion (up to 10 days)
Time difference in the onset between the m.vastus lateralis and m.vastus medialis contraction in ms
Time frame: Day of inclusion (up to 10 days)
Y test
Time frame: Day of inclusion (up to 10 days)
Eccentric step-down test
Time frame: Day of inclusion (up to 10 days)
Lateral step down test
Time frame: Day of inclusion (up to 10 days)
Unipodal stabilometric evaluation
Time frame: Day of inclusion (up to 10 days)
Foot posture index
Time frame: Day of inclusion (up to 10 days)
Navicular drop test
Time frame: Day of inclusion (up to 10 days)
Ober's test
Time frame: Day of inclusion (up to 10 days)
Visual Analog Scale
Time frame: Day of inclusion (up to 10 days)
Anterior knee pain scale (AKPS)
Time frame: Day of inclusion (up to 10 days)
12-Item Short Form Survey (SF-12)
Time frame: Day of inclusion (up to 10 days)
Semi-structured interview
Time frame: From month 1 to month 3
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2026.
- Results publication: PubMed 42001620Coleman M, Gizolme L, Hagemeister N, Nguyen C, Rannou F, Dietrich G, Lefevre-Colau MM, Roren A. 3D kinematic knee variables in people with unilateral patellofemoral pain syndrome: comparison of symptomatic and contralateral knees. Ann Phys Rehabil Med. 2026 Jun;69(5):102124. doi: 10.1016/j.rehab.2026.102124. Epub 2026 Apr 18. No abstract available.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Marvin COLEMAN, MSc, PhD student principal investigator
Assistance Publique - Hôpitaux de Paris
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing EOS Radiation and Semi-structured interview in people with Patellofemoral Pain Syndrome, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Amplitude of rotation (time frame: Day of inclusion (up to 10 days)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05441332, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2026.