Ventilatory DefectViReVentPoCovNCT05441657
Visualizing Regional Lung Ventilation in Patients With Postacute-COVID-19
An observational study of Ventilatory Defect and COVID-19, run by Jan-Christoph Lewejohann at 1 site in Germany.
Trial summary
There is a lack of data of spontaneous breathing patients with post-COVID-19 syndrome (PCS) examined by Electrical impedance tomography (EIT). We compare 100 patients with PCS with 50 healthy probands. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Ventilatory Defect, COVID-19, Post-acute COVID-19 Syndrome
- How many people
- 150 participants
- Where
- 1 siteGermany
- Study dates
- 14 Apr 2022to 28 Aug 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: 100 patients with postacute COVID-19 syndrome who present themselves at the outpatient clinic of the University hospital in Jena (JUH) were examined by EIT. 50 lunghealthy volunteers were examined by EIT at JUH.
Who may be able to join
- for control group: no current lung diseases, over 18 years old
- for patients with postacute COVID-19 syndrome: over 18 years, positive SARS-CoV-2-PCR
Who cannot join
- heart pacemaker
- epilepsy
- BMI over 50
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Visualisation of Changes in Regional Ventilation in Dyspnoeic Postacute COVID-19 Patients: A Case-control Study Using Electrical Impedance Tomography (EIT)
There is a lack of data of spontaneous breathing patients with post-COVID-19 syndrome (PCS) examined by Electrical impedance tomography (EIT). We compare 100 patients with PCS with 50 healthy probands.
Read the detailed description
When treating patients with dyspnoea, conventional diagnostic tools (computed tomography, spirometry, body plethysmography) often fail to detect pathological changes, making it difficult for the treating physician to choose an appropriate therapeutic approach. Therefore, it would be desirable to have an examination method that reveals the pulmonary changes in postacute Corona-Virus-Disease-2019 (COVID-19) syndrome (PCS) patients that remain hidden from other diagnostic procedures.
Electrical impedance tomography (EIT) is a non-invasive and radiation-free imaging technique that can show the regional ventilation of the lungs almost "in real-time" based on the changes in the electrical impedance of the thorax during inspiration and expiration. This method is based on the observation that the electrical conductivities of biological tissues vary considerably depending on their nature and functional state. Clinical questions in which the inhomogeneity of lung ventilation is to be analysed (e.g., under- or overinflation of individual lung areas, lung collapse, etc.) can be investigated particularly well with EIT since intrathoracic impedance changes correlate strongly with changes in regional lung ventilation.
Up to now, EIT has mainly been used as a monitoring method in intensive care medicine to adapt ventilation settings and other therapeutic measures to the individual needs of patients. In this field, the method has proven useful for obtaining an overview of the distribution of a respiratory volume in a transverse EIT slice, comparing different lung regions, identifying inhomogeneities and assessing regional ventilation during spontaneous breathing.
The aim of this case-control study is to use EIT data obtained during routine examinations of post-COVID patients to analyse whether patients with PCS show more distinct lung alterations than the control group. Maybe these lung alterations correlate with dyspnea most patients report subjectively.
- Conditions
- Ventilatory Defect, COVID-19, Post-acute COVID-19 Syndrome, Electric Impedance Tomography, Post-COVID-19 Syndrome
- Keywords
- post-acute COVID-19 syndrome, EIT, Electric impedance tomographie, long-COVID, post-COVID-19 Syndrome (PCS)
- Medical subject headings
- COVID-19, Post-Acute COVID-19 Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| dyspnoeic patients with post-acute COVID-19 syndrome | 100 patients with/without persisting dyspnea after COVID-19 disease were examined by Electric Impedance Tomography (EIT). | |
| control group | 50 healthy volunteers with no lung disease were voluntarily examined by Electric Impedance Tomography. |
What is being measured
The primary outcome is the main question the study is designed to answer.
pathogenic changes in regional lung ventilation
pathogenic changes in regional lung ventilation considered
Measured: until July 2022
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2022
- Study start14 Apr 2022
- Primary completion19 Apr 2023
- Study completion28 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ventilatory DefectStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Retrospective
- Enrolment
- 150 participants (actual)
Sponsor and investigators
- Lead sponsor
- Jan-Christoph Lewejohann
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Jan-Christoph Lewejohann, Jena University Hospital
- Investigators
- Jan-Christoph Lewejohann, Dr.med., Study director, Jena University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05441657
- Sponsor's protocol ID
- KIM-IV-EIT-04
- Acronym
- ViReVentPoCov
- Status last verified
- Sep 2025
- First submitted
- 29 Jun 2022
- Last updated
- 25 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Visualisation of Changes in Regional Ventilation in Dyspnoeic Postacute COVID-19 Patients: A Case-control Study Using Electrical Impedance Tomography (EIT)
- ClinicalTrials.gov ID
- NCT05441657
- Acronym / sponsor ID
- ViReVentPoCov / KIM-IV-EIT-04
- Conditions
- Ventilatory Defect, COVID-19, Post-acute COVID-19 Syndrome, Electric Impedance Tomography, Post-COVID-19 Syndrome
- Keywords
- post-acute COVID-19 syndrome, EIT, Electric impedance tomographie, long-COVID, post-COVID-19 Syndrome (PCS)
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 150 participants (actual)
- Lead sponsor
- Jan-Christoph LewejohannUniversity, hospital or other
- Study start
- 14 Apr 2022 (actual)
- Primary completion
- 19 Apr 2023 (actual)
- Study completion
- 28 Aug 2025 (actual)
- First posted
- 1 Jul 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There is a lack of data of spontaneous breathing patients with post-COVID-19 syndrome (PCS) examined by Electrical impedance tomography (EIT). We compare 100 patients with PCS with 50 healthy probands.
Detailed description
When treating patients with dyspnoea, conventional diagnostic tools (computed tomography, spirometry, body plethysmography) often fail to detect pathological changes, making it difficult for the treating physician to choose an appropriate therapeutic approach. Therefore, it would be desirable to have an examination method that reveals the pulmonary changes in postacute Corona-Virus-Disease-2019 (COVID-19) syndrome (PCS) patients that remain hidden from other diagnostic procedures.
Electrical impedance tomography (EIT) is a non-invasive and radiation-free imaging technique that can show the regional ventilation of the lungs almost "in real-time" based on the changes in the electrical impedance of the thorax during inspiration and expiration. This method is based on the observation that the electrical conductivities of biological tissues vary considerably depending on their nature and functional state. Clinical questions in which the inhomogeneity of lung ventilation is to be analysed (e.g., under- or overinflation of individual lung areas, lung collapse, etc.) can be investigated particularly well with EIT since intrathoracic impedance changes correlate strongly with changes in regional lung ventilation.
Up to now, EIT has mainly been used as a monitoring method in intensive care medicine to adapt ventilation settings and other therapeutic measures to the individual needs of patients. In this field, the method has proven useful for obtaining an overview of the distribution of a respiratory volume in a transverse EIT slice, comparing different lung regions, identifying inhomogeneities and assessing regional ventilation during spontaneous breathing.
The aim of this case-control study is to use EIT data obtained during routine examinations of post-COVID patients to analyse whether patients with PCS show more distinct lung alterations than the control group. Maybe these lung alterations correlate with dyspnea most patients report subjectively.
Study design
- Observational model
- Case-control
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| dyspnoeic patients with post-acute COVID-19 syndrome | – | –100 patients with/without persisting dyspnea after COVID-19 disease were examined by Electric Impedance Tomography (EIT). |
| control group | – | –50 healthy volunteers with no lung disease were voluntarily examined by Electric Impedance Tomography. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- 100 patients with postacute COVID-19 syndrome who present themselves at the outpatient clinic of the University hospital in Jena (JUH) were examined by EIT. 50 lunghealthy volunteers were examined by EIT at JUH.
Key inclusion criteria (2 listed)
- for control group: no current lung diseases, over 18 years old
- for patients with postacute COVID-19 syndrome: over 18 years, positive SARS-CoV-2-PCR
Key exclusion criteria (3 listed)
- heart pacemaker
- epilepsy
- BMI over 50
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
pathogenic changes in regional lung ventilation
Time frame: until July 2022
pathogenic changes in regional lung ventilation considered
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jan-Christoph Lewejohann, Dr.med. study director
Jena University Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ventilatory Defect and COVID-19, run by Jan-Christoph Lewejohann at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pathogenic changes in regional lung ventilation (time frame: until July 2022). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2025.