Biological MaturationBiMaPlExNCT05442593
Biological Maturation and Plyometric Exercise
A study testing Plyometric training in people with Biological Maturation, run by University of Thessaly at 1 site in Greece.
Trial summary
Plyometric training comprises one of the most widely used training methods in both individual and team sports, and is widely used by coaches as one of the main training in both adults, and children. Plyometric training highly includes the component of eccentric contraction. Read more about this study
- Who is it for?
- Ages 8 to 15 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Biological Maturation
- What is being tested?
- Plyometric training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteGreece
- Study dates
- 27 Jun 2022to 30 Jul 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 15 years
- Men only
- Healthy volunteers accepted
- Child
Who may be able to join
- Normal BMI
- No history of growth irregularities
- No musculoskeletal injuries for at least six months prior to the study
- No use of drugs or ergogenic supplements for at least one month prior to the study
- No participation at exercise with eccentric component for at least three days prior to the study
- No energy drinks consumption before each experimental trial
Who cannot join
- Abnormal BMI
- History of growth irregularities
- Musculoskeletal injuries in the last six months prior to the study
- Use of drugs or ergogenic supplements in the last month prior to the study
- Participation at exercise with eccentric component in the last three days prior to the study
- Energy drinks consumption before each experimental trial
Trial locations and contacts
1 site in 1 country.
Greece1 site
Department of Physical Education and Sport Science, Uninersity of Thessaly
Trikala, Thessaly, 42100
About this study
Official title: The Effect of Biological Maturation on Indices of Exercise-induced Muscle Damage, Neuromuscular Fatigue and Performance After Acute Plyometric Exercise
Plyometric training comprises one of the most widely used training methods in both individual and team sports, and is widely used by coaches as one of the main training in both adults, and children. Plyometric training highly includes the component of eccentric contraction. However, eccentric muscle action, especially when unaccustomed, can lead to exercise-induced muscle damage (EIMD), which is accompanied by increased delayed onset of muscle soreness (DOMS), inflammatory responses, increased levels of muscle proteins into the circulation, oxidative stress, and reduction of muscle function and performance the following days. Although plyometric training is widely used in children and may lead to EIMD, there is limited data regarding the acute effects of plyometric exercise training in children. Additionally, the effect of the biological maturation status of children on EIMD after acute plyometric exercise training has not been investigated. The aim of this study is to examine the effect of biological maturation on EIMD after acute plyometric exercise training in children.
Read the detailed description
Plyometric training comprises one of the most widely used training methods in both individual and team sports. Plyometric training has been shown to improve neuromuscular stimulation, jumping ability, muscle strength, flexibility, muscle mass and muscle performance, running speed and muscle power. Therefore, it is widely used by coaches as one of the main training methods, in both adults, and children).
Plyometric training consists of exercises performed through the stretch-shortening cycle of the muscle where the pre-activated muscle is first stretched (eccentric action) followed by the shortening (concentric) action. Therefore, plyometric training highly includes the component of eccentric contraction. However, eccentric muscle action, especially when unaccustomed, can lead to exercise-induced muscle damage (EIMD). EIMD, amongst others, is accompanied by increased delayed onset of muscle soreness (DOMS), inflammatory responses, oxidative stress, increased levels of muscle proteins and collagen into the circulation, and reduction of muscle function and performance.
The effect of acute plyometric training on EIMD, neuromuscular fatigue and performance has been adequately investigated in adults. Indicatively, an acute protocol of plyometric training increased DOMS, blood inflammatory markers, creatine kinase (CK) and lactate dehydrogenase (LDH) activity, while decreased jumping performance for up to 72 hours after the end of the training. In contrast, data regarding the effect of acute plyometric training on the above indices in children are scarce. Additionally, although some data exist on children versus adults, as far as we know, there is no relative data between children with different stages of biological maturation, regardless the common use of plyometric exercises in youth training. However, such data is crucial for both coaches and young athletes to effectively design the training microcycles and incorporate the training components, but also to reduce the risk of injury.
The aim of the present study is to examine the effect of different biological maturation on EIMD, metabolism, neuromuscular fatigue, oxidative stress, and muscle performance after acute plyometric exercise training in children.
According to a preliminary power analysis (probability error: 0.05, power: 0.80, effect size: 0.30), a total sample of 9 participants per group was considered appropriate in order to detect statistically meaningful changes between groups. Thus, twenty healthy male children, aged 8-15 years old, will participate to the study. Written informed consent will be provided by the parents or legal guardians of children after they will be informed about all risks, discomforts, and benefits involved in the study. The procedures will be in accordance with the 1975 Declaration of Helsinki, as revised in 2013. Approval has been received from the bioethics committee of the Department of Physical Education and Sport Science, University of Thessaly.
The study will be performed in a parallel, repeated measures design. The participants will visit the Department's Exercise Physiology laboratory 9 times in total. During the 1st visit, the participants will be examined by a pediatric endocrinologist in order to estimate their biological maturation and be assigned το a condition of either pre-adolescent or adolescent. A familiarization period with the plyometric training protocol and the evaluation procedures with low intensity will be induced (1st, 2nd, 3rd visit). During the next week (4th and 5th visit), fasting blood samples will be collected in order to estimate testosterone levels, CBC, muscle damage, and oxidative stress markers. Participants will be instructed by a dietitian how to record a 7-days diet recalls to ensure that they do not consume to some greater extent nutrients that may affect EIMD, oxidative stress, and fatigue (e.g. antioxidants, amino acids, etc.). Additionally, assessment of body mass, body height, BMI, body composition, sprint performance, jumping performance, isokinetic strength (concentric, isometric, eccentric), aerobic capacity, EIMD (CK) will be performed. After at least 3 days (6th visit), participants will perform the acute bout of plyometric exercise training, that is 8 sets of 10 maximal squat-jumps with a 2-min rest between sets. DOMS will be estimated prior to and post-training, and lactate concentration prior to, and 4 min after the 4th set and 4 min after the 8th set. Neuromuscular fatigue (maximal voluntary isometric contraction, MVIC) estimation will be performed prior to, and 1 hour, 2 hours, and 3 hours post-training. Additionally, DOMS will be estimated at post-, 24 hours, 48 hours, and 72 hours (7th, 8th, and 9th visit) post-training. Sprint and muscle performance, CBC, CK, and oxidative stress indices will also be estimated at 24 hours, 48 hours, and 72 hours post-training.
- Conditions
- Biological Maturation
- Being tested
- Plyometric training
- Keywords
- children, plyometric exercise, muscle damage, muscle performance, neuromuscular fatigue
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Plyometric trainingOther
Participants will perform: 8 sets of 10 maximal countermovement jumps
| Study group | Role | What they receive |
|---|---|---|
| Pre-adolescents | Experimental | Acute plyometric training Receives: Other: Plyometric training |
| Adolescents | Experimental | Acute plyometric training Receives: Other: Plyometric training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in Creatine kinase
CK will be measured in plasma using a Clinical Chemistry Analyzer with commercially available kits.
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in blood lactate
Lactate will be measured in capillary blood with a hand-portable analyzer.
Measured: Baseline (pre), 4 minutes post-plyometric training
Changes in DOMS
DOMS of knee extensors and knee flexors of both lower extremities will be measured during palpation of the muscle belly and the distal region after performing three repetitions of a full squat and each participant will rate perceived soreness on a scale ranging from 1 (no soreness) to 10 (very sore).
Measured: Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours postplyometric training
Changes in 10m sprint time
10m sprint time will be measured using light cells Chronojump system
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in 30m sprint time
30m sprint time will be measured using light cells Chronojump system
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in squat jump
Squat jump height will be measured using a Chronojump contact platform
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in counermovement jump
Counermovement jump height will be measured using a Chronojump contact platform
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in concentric peak torque
Concentric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in eccentric peak torque
Eccentric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer
Measured: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in isometric peak torque
Isometric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer
Measured: Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Changes in maximal voluntary isometric contraction (MVIC)
MVIC of knee extensors will be measured on an isokinetic dynamometer
Measured: Baseline (pre), post-, 1 hour post-, 2 hours post-, 3 hours post-plyometric training
Secondary outcomes (10)
Biological maturation stage
Biological maturation stage will be estimated based on Tanner stage through physical examination by a pediatric endocrinologist
Measured: Baseline
Testosterone levels
Testosterone levels will be estimated via ELISA method with a commercially available kit
Measured: Baseline
Age from Peak Height Velocity (APHV)
APHV will be calculated via an appropriate equation
Measured: Baseline
Body weight
Body weight will be measured on a beam balance with stadiometer
Measured: Baseline
Body height
Body height will be measured on a beam balance with stadiometer
Measured: Baseline
Body mass index (BMI)
BMI will be measured on a beam balance with stadiometer
Measured: Baseline
Maximal oxygen consumption (VO2max)
Maximal oxygen consumption will be estimeted through 20-m shuttle run test
Measured: Baseline
Body fat
Body fat will be measured by using Dual-emission X-ray absorptiometry
Measured: Baseline
Lean body mass
Lean body masswill be measured by using Dual-emission X-ray absorptiometry
Measured: Baseline
Dietary intake
Dietary intake will be assessed using 7-day diet recalls
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jul 2022
- Study start27 Jun 2022
- Primary completion30 Jul 2022
- Study completion30 Jul 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Biological MaturationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be assigned to different groups according to their biological maturation and they will perform the same acute plyometric exercise
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Thessaly
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Chariklia K. Deli, University of Thessaly
- Investigators
- Chariklia K Deli, PhD, Study chair, University of Thessaly
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05442593
- Sponsor's protocol ID
- Biol. Matur. - Plyometric Ex.
- Acronym
- BiMaPlEx
- Status last verified
- Nov 2022
- First submitted
- 23 Jun 2022
- Last updated
- 4 Nov 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Marginson V, Rowlands AV, Gleeson NP, Eston RG. Comparison of the symptoms of exercise-induced muscle damage after an initial and repeated bout of plyometric exercise in men and boys. J Appl Physiol (1985). 2005 Sep;99(3):1174-81. doi: 10.1152/japplphysiol.01193.2004. Epub 2005 Apr 7.
PubMed 15817716Deli CK, Fatouros IG, Paschalis V, Georgakouli K, Zalavras A, Avloniti A, Koutedakis Y, Jamurtas AZ. A Comparison of Exercise-Induced Muscle Damage Following Maximal Eccentric Contractions in Men and Boys. Pediatr Exerc Sci. 2017 Aug;29(3):316-325. doi: 10.1123/pes.2016-0185. Epub 2017 Feb 6.
PubMed 28165870Asadi A, Ramirez-Campillo R, Arazi H, Saez de Villarreal E. The effects of maturation on jumping ability and sprint adaptations to plyometric training in youth soccer players. J Sports Sci. 2018 Nov;36(21):2405-2411. doi: 10.1080/02640414.2018.1459151. Epub 2018 Apr 3.
PubMed 29611771
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Biological Maturation on Indices of Exercise-induced Muscle Damage, Neuromuscular Fatigue and Performance After Acute Plyometric Exercise
- ClinicalTrials.gov ID
- NCT05442593
- Acronym / sponsor ID
- BiMaPlEx / Biol. Matur. - Plyometric Ex.
- Conditions
- Biological Maturation
- Keywords
- children, plyometric exercise, muscle damage, muscle performance, neuromuscular fatigue
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- University of ThessalyUniversity, hospital or other
- Study start
- 27 Jun 2022 (actual)
- Primary completion
- 30 Jul 2022 (actual)
- Study completion
- 30 Jul 2022 (actual)
- First posted
- 5 Jul 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Plyometric training comprises one of the most widely used training methods in both individual and team sports, and is widely used by coaches as one of the main training in both adults, and children. Plyometric training highly includes the component of eccentric contraction. However, eccentric muscle action, especially when unaccustomed, can lead to exercise-induced muscle damage (EIMD), which is accompanied by increased delayed onset of muscle soreness (DOMS), inflammatory responses, increased levels of muscle proteins into the circulation, oxidative stress, and reduction of muscle function and performance the following days. Although plyometric training is widely used in children and may lead to EIMD, there is limited data regarding the acute effects of plyometric exercise training in children. Additionally, the effect of the biological maturation status of children on EIMD after acute plyometric exercise training has not been investigated. The aim of this study is to examine the effect of biological maturation on EIMD after acute plyometric exercise training in children.
Detailed description
Plyometric training comprises one of the most widely used training methods in both individual and team sports. Plyometric training has been shown to improve neuromuscular stimulation, jumping ability, muscle strength, flexibility, muscle mass and muscle performance, running speed and muscle power. Therefore, it is widely used by coaches as one of the main training methods, in both adults, and children).
Plyometric training consists of exercises performed through the stretch-shortening cycle of the muscle where the pre-activated muscle is first stretched (eccentric action) followed by the shortening (concentric) action. Therefore, plyometric training highly includes the component of eccentric contraction. However, eccentric muscle action, especially when unaccustomed, can lead to exercise-induced muscle damage (EIMD). EIMD, amongst others, is accompanied by increased delayed onset of muscle soreness (DOMS), inflammatory responses, oxidative stress, increased levels of muscle proteins and collagen into the circulation, and reduction of muscle function and performance.
The effect of acute plyometric training on EIMD, neuromuscular fatigue and performance has been adequately investigated in adults. Indicatively, an acute protocol of plyometric training increased DOMS, blood inflammatory markers, creatine kinase (CK) and lactate dehydrogenase (LDH) activity, while decreased jumping performance for up to 72 hours after the end of the training. In contrast, data regarding the effect of acute plyometric training on the above indices in children are scarce. Additionally, although some data exist on children versus adults, as far as we know, there is no relative data between children with different stages of biological maturation, regardless the common use of plyometric exercises in youth training. However, such data is crucial for both coaches and young athletes to effectively design the training microcycles and incorporate the training components, but also to reduce the risk of injury.
The aim of the present study is to examine the effect of different biological maturation on EIMD, metabolism, neuromuscular fatigue, oxidative stress, and muscle performance after acute plyometric exercise training in children.
According to a preliminary power analysis (probability error: 0.05, power: 0.80, effect size: 0.30), a total sample of 9 participants per group was considered appropriate in order to detect statistically meaningful changes between groups. Thus, twenty healthy male children, aged 8-15 years old, will participate to the study. Written informed consent will be provided by the parents or legal guardians of children after they will be informed about all risks, discomforts, and benefits involved in the study. The procedures will be in accordance with the 1975 Declaration of Helsinki, as revised in 2013. Approval has been received from the bioethics committee of the Department of Physical Education and Sport Science, University of Thessaly.
The study will be performed in a parallel, repeated measures design. The participants will visit the Department's Exercise Physiology laboratory 9 times in total. During the 1st visit, the participants will be examined by a pediatric endocrinologist in order to estimate their biological maturation and be assigned το a condition of either pre-adolescent or adolescent. A familiarization period with the plyometric training protocol and the evaluation procedures with low intensity will be induced (1st, 2nd, 3rd visit). During the next week (4th and 5th visit), fasting blood samples will be collected in order to estimate testosterone levels, CBC, muscle damage, and oxidative stress markers. Participants will be instructed by a dietitian how to record a 7-days diet recalls to ensure that they do not consume to some greater extent nutrients that may affect EIMD, oxidative stress, and fatigue (e.g. antioxidants, amino acids, etc.). Additionally, assessment of body mass, body height, BMI, body composition, sprint performance, jumping performance, isokinetic strength (concentric, isometric, eccentric), aerobic capacity, EIMD (CK) will be performed. After at least 3 days (6th visit), participants will perform the acute bout of plyometric exercise training, that is 8 sets of 10 maximal squat-jumps with a 2-min rest between sets. DOMS will be estimated prior to and post-training, and lactate concentration prior to, and 4 min after the 4th set and 4 min after the 8th set. Neuromuscular fatigue (maximal voluntary isometric contraction, MVIC) estimation will be performed prior to, and 1 hour, 2 hours, and 3 hours post-training. Additionally, DOMS will be estimated at post-, 24 hours, 48 hours, and 72 hours (7th, 8th, and 9th visit) post-training. Sprint and muscle performance, CBC, CK, and oxidative stress indices will also be estimated at 24 hours, 48 hours, and 72 hours post-training.
Study design
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be assigned to different groups according to their biological maturation and they will perform the same acute plyometric exercise
| Arm | Type | Receives |
|---|---|---|
| Pre-adolescents | Experimental | Other: Plyometric trainingAcute plyometric training |
| Adolescents | Experimental | Other: Plyometric trainingAcute plyometric training |
Who may qualify
- Ages
- 8 to 15 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (6 listed)
- Normal BMI
- No history of growth irregularities
- No musculoskeletal injuries for at least six months prior to the study
- No use of drugs or ergogenic supplements for at least one month prior to the study
- No participation at exercise with eccentric component for at least three days prior to the study
Key exclusion criteria (6 listed)
- Abnormal BMI
- History of growth irregularities
- Musculoskeletal injuries in the last six months prior to the study
- Use of drugs or ergogenic supplements in the last month prior to the study
- Participation at exercise with eccentric component in the last three days prior to the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Plyometric trainingParticipants will perform: 8 sets of 10 maximal countermovement jumps | Other | Adolescents, Pre-adolescents |
Primary outcome
Changes in Creatine kinase
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
CK will be measured in plasma using a Clinical Chemistry Analyzer with commercially available kits.
Changes in blood lactate
Time frame: Baseline (pre), 4 minutes post-plyometric training
Lactate will be measured in capillary blood with a hand-portable analyzer.
Changes in DOMS
Time frame: Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours postplyometric training
DOMS of knee extensors and knee flexors of both lower extremities will be measured during palpation of the muscle belly and the distal region after performing three repetitions of a full squat and each participant will rate perceived soreness on a scale ranging from 1 (no soreness) to 10 (very sore).
Changes in 10m sprint time
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
10m sprint time will be measured using light cells Chronojump system
Changes in 30m sprint time
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
30m sprint time will be measured using light cells Chronojump system
Changes in squat jump
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Squat jump height will be measured using a Chronojump contact platform
Changes in counermovement jump
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Counermovement jump height will be measured using a Chronojump contact platform
Changes in concentric peak torque
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Concentric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer
Changes in eccentric peak torque
Time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Eccentric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer
Changes in isometric peak torque
Time frame: Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours post-plyometric training
Isometric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer
Changes in maximal voluntary isometric contraction (MVIC)
Time frame: Baseline (pre), post-, 1 hour post-, 2 hours post-, 3 hours post-plyometric training
MVIC of knee extensors will be measured on an isokinetic dynamometer
10 secondary outcomes
Biological maturation stage
Time frame: Baseline
Testosterone levels
Time frame: Baseline
Age from Peak Height Velocity (APHV)
Time frame: Baseline
Body weight
Time frame: Baseline
Body height
Time frame: Baseline
Body mass index (BMI)
Time frame: Baseline
Maximal oxygen consumption (VO2max)
Time frame: Baseline
Body fat
Time frame: Baseline
Lean body mass
Time frame: Baseline
Dietary intake
Time frame: Baseline
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2022.
- Background: PubMed 15817716Marginson V, Rowlands AV, Gleeson NP, Eston RG. Comparison of the symptoms of exercise-induced muscle damage after an initial and repeated bout of plyometric exercise in men and boys. J Appl Physiol (1985). 2005 Sep;99(3):1174-81. doi: 10.1152/japplphysiol.01193.2004. Epub 2005 Apr 7.
- Background: PubMed 28165870Deli CK, Fatouros IG, Paschalis V, Georgakouli K, Zalavras A, Avloniti A, Koutedakis Y, Jamurtas AZ. A Comparison of Exercise-Induced Muscle Damage Following Maximal Eccentric Contractions in Men and Boys. Pediatr Exerc Sci. 2017 Aug;29(3):316-325. doi: 10.1123/pes.2016-0185. Epub 2017 Feb 6.
- Background: PubMed 29611771Asadi A, Ramirez-Campillo R, Arazi H, Saez de Villarreal E. The effects of maturation on jumping ability and sprint adaptations to plyometric training in youth soccer players. J Sports Sci. 2018 Nov;36(21):2405-2411. doi: 10.1080/02640414.2018.1459151. Epub 2018 Apr 3.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Chariklia K Deli, PhD study chair
University of Thessaly
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Plyometric training in people with Biological Maturation, run by University of Thessaly at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Nov 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in Creatine kinase (time frame: Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training). The study lists 11 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05442593, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2022.