Guideline AdherenceNCT05447442
Guideline Adherence for Preoperative Anemia Management in a PAC
An observational study of Guideline Adherence and Anemia, run by Siriraj Hospital at 1 site in Thailand.
Trial summary
Anemia in surgical patients is a common seriously problem; around 40 % of patients presenting for major surgery are anemic problem. Patients with major surgery have significantly higher rates of acute blood loss. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Guideline Adherence, Anemia
- How many people
- 93 participants
- Where
- 1 siteThailand
- Study dates
- 1 Oct 2022to Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients who attend a preanesthesia clinic and have anemia.
Who may be able to join
None listed.
Who cannot join
- none
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Thailand1 site, 1 recruiting
- Recruiting
Siriraj hospital
Bangkok, Bangkok, 10700
Mingkwan Wongyingsinn, MD, MSc, (02)-419-7995, minkcheerful@hotmail.com
Mingkwan Wongyingsinn, MD, MSc
About this study
Official title: Adherence to the Hospital Guideline for Evaluation and Management of Preoperative Anemia in Preanesthesia Assessment Center (SIPAC), Siriraj Hospital
Anemia in surgical patients is a common seriously problem; around 40 % of patients presenting for major surgery are anemic problem. Patients with major surgery have significantly higher rates of acute blood loss. Whereas , patients with pre-operative anemia prone to be transfused blood component in pre-operative or intraoperative and postoperative periods that associated with worse outcomes , prolonged hospital stays , increased risk of morbidity and mortality . Therefore, patients undergoing major surgery should be optimization for pre-operative anemia.
In November 2021, Siriraj Preanesthesia Assessment Center (SIPAC) has developed and implemented a preoperative anemia management guideline which is one pillar of perioperative patient blood management. The objective of this guideline is to optimize red blood cell mass before patients having operation. The investigators are realize the important of pre-operative anemia of patients who undergoing elective surgery. The investigators will aim to evaluate adherence to the preoperative anemia management guideline protocol and perioperative outcomes and use the data of this study to setting guidelines for preoperative anemia evaluation and management in SIPAC of department of anesthesiology in Siriraj hospital for improving workflow and optimization before elective surgery, supporting to a reduction in blood transfusion, hospital stay, morbidity and health care costs of public health of Thailand.
Read the detailed description
From World Health Organization (WHO) criteria for diagnosing anemia is hemoglobin level lower than 12 g/dL for women and hemoglobin level lower than 13 g/dL for men. The most of anemic patients caused by Iron deficiency anemia and chronic disease.
From frank S Hong that study about of prevalence and causes of preoperative anemia in elective major surgery show that preoperative anemia affects 13.9% of patients undergoing elective surgery. The most common is iron deficiency anemia 27.4%. Other common causes of anemia including underlying malignancy 18.3 %, end stage renal disease 11.5 % and other chronic disease 7.2%.
At present, there are several study about efficiency of iron therapy in pre-operative anemia that shown an increase in hemoglobin and a decrease in red cell transfusion when treated with iron therapy in 4-6 weeks. Detection of preoperative anemia should be optimized and evaluated as soon as possible at least 14 days before elective surgery.
Musallam et al. studied the prevalence and outcomes of anemia in the dataset of the American College of surgeons' National Surgical Quality Improvement Program show that anemic patients undergoing cardiac surgery \& non-cardiac surgery present a higher mortality, prolonged hospital stay and more intensive care admission compared with patient non-anemic patients.
In November 2021, Siriraj Preanesthesia Assessment Center (SIPAC) has developed and implemented a preoperative anemia management guideline which is one pillar of perioperative patient blood management. The objective of this guideline is to optimize red blood cell mass before patients having operation. The investigators are realize the important of pre-operative anemia of patients who undergoing elective surgery. The investigators will aim to evaluate adherence to the preoperative anemia management guideline protocol and perioperative outcomes and use the data of this study to setting guidelines for preoperative anemia evaluation and management in SIPAC of department of anesthesiology in Siriraj hospital for improving workflow and optimization before elective surgery, supporting to a reduction in blood transfusion, hospital stay, morbidity and health care costs of public health of Thailand.
- Conditions
- Guideline Adherence, Anemia
- Medical subject headings
- Anemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Study group | Patients with anemia will be checked whether they would be assessed by protocol. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Protocol adherence
The trial monitors adherence to the protocol (yes/no).
Measured: Through study completion, an average of 1 month
Secondary outcomes (1)
Perioperative transfusion
Transfusion during perioperative period
Measured: 1 month after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Jul 2022
- Study start1 Oct 2022
- Primary completionNov 2026 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Guideline AdherenceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 93 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Siriraj Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mingkwan Wongyingsinn, MD, Siriraj Hospital
- Investigators
- Mingkwan Wongyingsinn, Principal investigator, Siriraj Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05447442
- Sponsor's protocol ID
- 273/2565
- Status last verified
- Jun 2025
- First submitted
- 18 Jun 2022
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Adherence to the Hospital Guideline for Evaluation and Management of Preoperative Anemia in Preanesthesia Assessment Center (SIPAC), Siriraj Hospital
- ClinicalTrials.gov ID
- NCT05447442
- Acronym / sponsor ID
- 273/2565
- Conditions
- Guideline Adherence, Anemia
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 93 participants (estimated)
- Lead sponsor
- Siriraj HospitalUniversity, hospital or other
- Study start
- 1 Oct 2022 (actual)
- Primary completion
- Nov 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 7 Jul 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Anemia in surgical patients is a common seriously problem; around 40 % of patients presenting for major surgery are anemic problem. Patients with major surgery have significantly higher rates of acute blood loss. Whereas , patients with pre-operative anemia prone to be transfused blood component in pre-operative or intraoperative and postoperative periods that associated with worse outcomes , prolonged hospital stays , increased risk of morbidity and mortality . Therefore, patients undergoing major surgery should be optimization for pre-operative anemia.
In November 2021, Siriraj Preanesthesia Assessment Center (SIPAC) has developed and implemented a preoperative anemia management guideline which is one pillar of perioperative patient blood management. The objective of this guideline is to optimize red blood cell mass before patients having operation. The investigators are realize the important of pre-operative anemia of patients who undergoing elective surgery. The investigators will aim to evaluate adherence to the preoperative anemia management guideline protocol and perioperative outcomes and use the data of this study to setting guidelines for preoperative anemia evaluation and management in SIPAC of department of anesthesiology in Siriraj hospital for improving workflow and optimization before elective surgery, supporting to a reduction in blood transfusion, hospital stay, morbidity and health care costs of public health of Thailand.
Detailed description
From World Health Organization (WHO) criteria for diagnosing anemia is hemoglobin level lower than 12 g/dL for women and hemoglobin level lower than 13 g/dL for men. The most of anemic patients caused by Iron deficiency anemia and chronic disease.
From frank S Hong that study about of prevalence and causes of preoperative anemia in elective major surgery show that preoperative anemia affects 13.9% of patients undergoing elective surgery. The most common is iron deficiency anemia 27.4%. Other common causes of anemia including underlying malignancy 18.3 %, end stage renal disease 11.5 % and other chronic disease 7.2%.
At present, there are several study about efficiency of iron therapy in pre-operative anemia that shown an increase in hemoglobin and a decrease in red cell transfusion when treated with iron therapy in 4-6 weeks. Detection of preoperative anemia should be optimized and evaluated as soon as possible at least 14 days before elective surgery.
Musallam et al. studied the prevalence and outcomes of anemia in the dataset of the American College of surgeons' National Surgical Quality Improvement Program show that anemic patients undergoing cardiac surgery \& non-cardiac surgery present a higher mortality, prolonged hospital stay and more intensive care admission compared with patient non-anemic patients.
In November 2021, Siriraj Preanesthesia Assessment Center (SIPAC) has developed and implemented a preoperative anemia management guideline which is one pillar of perioperative patient blood management. The objective of this guideline is to optimize red blood cell mass before patients having operation. The investigators are realize the important of pre-operative anemia of patients who undergoing elective surgery. The investigators will aim to evaluate adherence to the preoperative anemia management guideline protocol and perioperative outcomes and use the data of this study to setting guidelines for preoperative anemia evaluation and management in SIPAC of department of anesthesiology in Siriraj hospital for improving workflow and optimization before elective surgery, supporting to a reduction in blood transfusion, hospital stay, morbidity and health care costs of public health of Thailand.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Study group | – | –Patients with anemia will be checked whether they would be assessed by protocol. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients who attend a preanesthesia clinic and have anemia.
Key inclusion criteria (0 listed)
Key exclusion criteria (1 listed)
- none
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Protocol adherence
Time frame: Through study completion, an average of 1 month
The trial monitors adherence to the protocol (yes/no).
1 secondary outcome
Perioperative transfusion
Time frame: 1 month after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mingkwan Wongyingsinn principal investigator
Siriraj Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Guideline Adherence and Anemia, run by Siriraj Hospital at 1 site in Thailand.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mingkwan Wongyingsinn, MD (024197995, mingkwan.won@mahidol.ac.th), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Protocol adherence (time frame: Through study completion, an average of 1 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.