ObesitySNEEXNCT05472168
Impact of Olfactory Odour StimulatioN on Energy EXpenditure
A study testing Olfactory Stimulation in people with Obesity, run by University Hospital, Basel, Switzerland at 1 site in Switzerland.
Trial summary
In this preliminary short-term study it is investigated, whether a short olfactory stimulation with distinct odours impacts energy expenditure in patients with obesity and lean patients. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Obesity
- What is being tested?
- Olfactory Stimulation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 58 participants
- Where
- 1 siteSwitzerland
- Study dates
- 18 Jan 2022to 30 Oct 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- • Age 18-55 years
- Obesity (BMI ≥30 kg/m2) and Lean (BMI 18-25 kg/m2)
- Written informed consent
- Normosmia (defined by sniffing Sticks test)
Who cannot join
- • Chronic or acute sinusitis
- Surgical intervention of the nasal cavity or the paranasal sinus
- Known allergy to odors used in the study
- Smokers
- Current illicit drug abuse including daily marijuana and cannabidiol (CBD) consumption (alcohol ≤2 drinks per day allowed)
- Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease)
Show all 23Show fewer
- Diabetes mellitus
- Treatment with insulin sensitizing drugs including Glucagon-like Peptide (GLP)-1 analogues within the last 3 months
- History of neurodegenerative diseases, severe head trauma
- Severe renal impairment (e.g. estimated glomerular filtration rate <30 ml/min/m2)
- Known liver cirrhosis or other severe liver impairment
- Use of any kind of decongestant more than twice a week
- Use of cortisone-containing nasal spray within the last 3 months
- Acute upper respiratory tract infection
- Uncontrolled dysthyroidism
- Uncontrolled hypertension
- Regular use of psychopharmaceutic drugs
- Study participants aims to start a new diet or exercise program during the study
- Bariatric surgery
- Pregnancy/Lactation
- Onset of climacteric symptoms within one year (e.g. hot flashes and/or diaphoresis) OR initiation of hormonal replacement therapy in the last three months
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
- Participation in an interventional study within the last 3 months
Trial locations and contacts
1 site in 1 country.
Switzerland1 site, 1 recruiting
- Recruiting
University Hospital Basel
Basel
Katharina Timper, Prof.Dr.med., +41 61 328 57 42, katharina.timper@usb.ch
Anouk Hoogkamer, +41 61 328 55 20, anouklisa.hoogkamer@usb.ch
About this study
Official title: SNEEX - Impact of Olfactory Odour StimulatioN on Energy EXpenditure
In this preliminary short-term study it is investigated, whether a short olfactory stimulation with distinct odours impacts energy expenditure in patients with obesity and lean patients.
- Conditions
- Obesity
- Being tested
- Olfactory Stimulation
- Medical subject headings
- Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Olfactory StimulationOther
Also called Different odours
Participants are exposed to different odours and energy expenditure is assessed via indirect calorimetry.
| Study group | Role | What they receive |
|---|---|---|
| Obese | Other | Age 18-55 years Obesity (BMI ≥30 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test) Receives: Other: Olfactory Stimulation |
| Lean | Other | Age 18-55 years Lean (BMI 18-25 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test) Receives: Other: Olfactory Stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Energy Expenditure
change in energy expenditure as assessed via calorimetry after olfactory stimulation with different odours.
Measured: 6 hours
Secondary outcomes (5)
Energy Expenditure, Additional Odours
Change in energy expenditure as assessed via calorimetry after olfactory stimulation with Different odours
Measured: 6 hours
Heart Rate
change in heart rate variability upon olfactory stimulation with different odors as assessed via continuous ECG
Measured: 6 hours
Blood Pressure
Change in blood pressure upon olfactory stimulation with different odors as assessed via a blood pressure cuff at the upper arm according to Riva Rocci
Measured: 6 hours
Metabolic Parameters
Change in metabolic blood parameters upon acute olfactory stimulation with different odours
Measured: 6 hours
Glucose Levels
change in interstitial fluid glucose levels upon olfactory stimulation with different odours
Measured: 6 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2022
- Study start18 Jan 2022
- Primary completion30 Jun 2024 (estimated)
- Study completion30 Oct 2024 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ObesityStudies of the same condition, open and under way.
- More trials run by University Hospital, Basel, SwitzerlandThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 58 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Basel, Switzerland
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Katharina Timper, University Hospital, Basel, Switzerland
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05472168
- Sponsor's protocol ID
- Timper_Olfactory_2022
- Acronym
- SNEEX
- Status last verified
- Dec 2023
- First submitted
- 21 Jul 2022
- Last updated
- 20 Dec 2023
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Dec 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- SNEEX - Impact of Olfactory Odour StimulatioN on Energy EXpenditure
- ClinicalTrials.gov ID
- NCT05472168
- Acronym / sponsor ID
- SNEEX / Timper_Olfactory_2022
- Conditions
- Obesity
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 58 participants (estimated)
- Lead sponsor
- University Hospital, Basel, SwitzerlandUniversity, hospital or other
- Study start
- 18 Jan 2022 (actual)
- Primary completion
- 30 Jun 2024 (estimated)
- Study completion
- 30 Oct 2024 (estimated)
- First posted
- 25 Jul 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this preliminary short-term study it is investigated, whether a short olfactory stimulation with distinct odours impacts energy expenditure in patients with obesity and lean patients.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Obese | Other | Other: Olfactory StimulationAge 18-55 years Obesity (BMI ≥30 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test) |
| Lean | Other | Other: Olfactory StimulationAge 18-55 years Lean (BMI 18-25 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test) |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- • Age 18-55 years
Key exclusion criteria (23 listed)
- • Chronic or acute sinusitis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Olfactory StimulationAlso: Different odoursParticipants are exposed to different odours and energy expenditure is assessed via indirect calorimetry. | Other | Lean, Obese |
Primary outcome
Change in Energy Expenditure
Time frame: 6 hours
change in energy expenditure as assessed via calorimetry after olfactory stimulation with different odours.
5 secondary outcomes
Energy Expenditure, Additional Odours
Time frame: 6 hours
Heart Rate
Time frame: 6 hours
Blood Pressure
Time frame: 6 hours
Metabolic Parameters
Time frame: 6 hours
Glucose Levels
Time frame: 6 hours
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Dec 2023.
Related trials for Obesity
RecruitingObservational study
Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)
Obesity
Active, not recruitingPhase 4
Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic Disorders
Metabolic Abnormalities, Obesity & Overweight
Recruiting
Exercise Training and Vitamin D Metabolism
Obesity & Overweight, Vitamin D
Recruiting
Metabolic Health, Bones and Nuts During Weight Loss in Adults
Weight Loss, Bone Density
Active, not recruiting
Effect of Probiotics on Insulin Sensitivity in Overweight and Obese Pregnancy
Obesity & Overweight, Gestational Diabetes Mellitus (GDM)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Olfactory Stimulation in people with Obesity, run by University Hospital, Basel, Switzerland at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 23 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 20 Dec 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Energy Expenditure (time frame: 6 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Dec 2023.