AzTrials
AzTrials

Neovascular Age-related Macular DegenerationVOYAGERNCT05476926

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

An observational study of Neovascular Age-related Macular Degeneration and Diabetic Macular Edema, run by Hoffmann-La Roche at 299 sites in 29 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

The VOYAGER study is a primary data collection, non-interventional, prospective, multinational, multicenter study. It is designed to collect real-world, long-term data to explore long-term effectiveness, safety, clinical insights, treatment patterns, and factors driving the treatment decisions among patients being… Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
Faricimab and Port Delivery System with Ranibizumab
How many people
6,000 participants
Where
299 sitesin 29 countries
Study dates
21 Nov 2022to 30 Nov 2027
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Patients being treated with specified Roche ophthalmology products approved in retinal indications in real-world, routine clinical practice.

Who may be able to join

  • 1. Have provided informed consent, as required per local regulations 2.a) Adult patient, as defined by local regulations and local product label, who is newly initiating treatment (or initiated treatment in the previous visit) with a specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye, according to the investigator's discretion in routine clinical practice; OR 2.b) Adult patient, as defined by local regulations and local product label, who is continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study in at least one eye after initiating that treatment in a Roche interventional trial.

Who cannot join

  • 1. Concomitant participation of the patient in an investigational ophthalmology clinical trial that includes receipt of any investigational drug or procedure within the last 28 days prior to enrollment (this restriction does not apply to patients who are rolling over from Roche interventional studies and continuing treatment with any specified approved Roche ophthalmology product in retinal indication of interest for this study)

Trial locations and contacts

299 sites in 29 countries.

299 sites in 29 countries

Japan47 sites

  • Chukyo Hospital

    Aichi, 457-8510

  • Sugita Eye Hospital

    Aichi, 460-0008

  • Nagoya City University Hospital

    Aichi, 467-8602

  • Akita University Hospital

    Akita, 010-8543

  • Chiba University Hospital

    Chiba, 260-8677

  • Juntendo University Urayasu Hospital

    Chiba, 279-0021

  • Nihon University Hospital

    Chiyoda-ku, Tokyo-To, 101-8309

  • University of Yamanashi Hospital

    Chuo-shi, 409-3898

  • Kyushu University Hospital

    Fukuoka, 812-8582

  • Kurume University Hospital

    Fukuoka, 830-0011

  • Gifu University Hospital

    Gifu, 501-1194

  • Hiroshima University Hospital

    Hiroshima, 734-8551

  • Sapporo City General Hospital

    Hokkaido, 060-8604

  • University of Tsukuba Hospital

    Ibaraki, 305-8576

  • Kozawa eye hospital and diabetes center

    Ibaraki, 310-0845

  • Kagawa University Hospital

    Kagawa, 761-0793

  • Kobe University Hospital

    Kobe, Hyōgo, 650-0017

  • NHO Tokyo Medical Center

    Meguro-ku, 152-8902

  • Mie University Hospital

    Mie, 514-8507

  • Fukushima Medical University Hospital

    Miyagi, 960-1295

  • Aichi Medical University Hospital

    Nagakute-shi, Aichi-ken, 480-1195

  • Shinshu University Hospital

    Nagano, 390-8621

  • Nagasaki University Hospital

    Nagasaki, 852-8501

  • Japanese Red Cross Nagasaki Genbaku Hospital

    Nagasaki, 852-8511

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560

  • Tazuke-kofukai Medical Research Institute Kitano Hospital

    Osaka, 530-8480

  • Osaka Metropolitan University Hospital

    Osaka, 545-8586

  • Kansai Medical University Hospital

    Osaka, 573-1191

  • Saitama Medical University Hospital

    Saitama, 350-0451

  • Toho University Sakura Medical Center

    Sakura-shi, Chiba, 285-8741

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-8648

  • Shiga University Of Medical Science Hospital

    Shiga, 520-2192

  • Jichi Medical University Hospital

    Shimotsuke-shi, Tochigi, 329-0498

  • Tokyo Medical University Hospital

    Shinjuku-ku, Tokyo-To, 160-0023

  • Keio University Hospital

    Shinjuku-ku, Tokyo-To, 160-8582

  • Seirei Hamamatsu General Hospital

    Shizuoka, 430-8558

  • Osaka University Hospital

    Suita, 565-0871

  • Osaka Medical and Pharmaceutical University Hospital

    Takatsuki-shi, 569-8686

  • Tokushima University Hospital

    Tokushima, 770-8503

  • Juntendo University Hospital

    Tokyo, 113-8431

  • Tokyo Women's Medical University Hospital

    Tokyo, 162-8666

  • Kyorin University Hospital

    Tokyo, 181-8611

  • Tokyo Medical University Hachioji Medical Center

    Tokyo, 193-0998

  • Yamagata University Hospital

    Yamagata, 990-9585

  • Yamaguchi University Hospital

    Yamaguchi, 755-8505

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024

  • University of Fukui Hospital

    Yoshida-gun, 910-1193

Other trials in Japan

France37 sites

  • Aix Vision

    Aix-en-Provence, 13090

  • CHU Amiens Picardie, Centre de Recherche Clinique

    Amiens, Somme, 80080

  • Hopital Avicenne

    Bobigny, Seine Saint Denis, 93000

  • Groupe Hospitalier Pellegrin

    Bordeaux, Gironde, 33800

  • Centre Rétine Gallien

    Bordeaux, 33000

  • Centre Hospitalier Intercommunal de Créteil

    Créteil, 94010

  • CHU Dijon - Hopital Francois Mitterrand

    Dijon, Cte-d'Or, 21079

  • Clinique du Val d'Ouest- Institut Rhône Alpin

    Écully, 69130

  • Clinique des Yeux Bordeaux

    Floirac, 33270

  • Centre d'Ophtalmologie

    Fontainebleau, 77300

  • Centre Optha Du Dauphine

    Grenoble, 38000

  • Hôpital Saint-Louis - La Rochelle

    La Rochelle, 17019

  • Visiopole Private Practice

    Lagord, 17140

  • Centre Hospitalier de Versailles

    Le Chesnay, Yvelines, 78150

  • Hopital Edouard Herriot - CHU Lyon

    Lyon, Rhone, 69003

  • Centre Hospitalier de la Croix Rousse

    Lyon, Rhone, 69004

  • Centre Ophtalmologique Rabelais

    Lyon, 69002

  • Centre Ophtalmologique Kleber

    Lyon, 69006

  • CH St Joseph

    Marseille, Bouches Du Rh(ne, 13285

  • Centre Monticelli Paradis d Ophtalmologie

    Marseille, 13008

  • Clinique de Montargis

    Montargis, 45200

  • Clinique Honore Cave

    Montauban, 82000

  • Alpes Retine

    Montbonnot-Saint-Martin, 38330

  • Centre Des Arceaux

    Montpellier, 34000

  • CHU de Nantes - Hotel Dieu

    Nantes, Loire Atlantique, 44093

  • Institut Ophtalmologique De l Ouest Jules Verne

    Nantes, Paris, 44300

  • CHU Nice - Hôpital Saint Roch

    Nice, 06006

  • Centre Ophtalmologique de L'Odeon

    Paris, 75006

  • Centre Ophtalmologique d?Imagerie et de Laser

    Paris, 75015

  • CHU Poitiers - Hôpital la Milétrie

    Poitiers, 86021

  • Clinique Mathilde

    Rouen, Seine Maritime, 76000

  • Centre St Exupery

    Saint-Cyr-sur-Loire, 37540

  • CHU de St-Etienne - Hopital Nord

    Saint-Étienne-de-Montluc, Pays de la Loire Region, 42055

  • Institut Sourdille

    Saint-Herblain, 44800

  • Clinique de l'Union

    Saint-Jean, 31240

  • Centre Ophtalmologique Maison-Rouge

    Strasbourg, Bas Rhin, 67000

  • Chu Toulouse

    Toulouse, 31059

Other trials in France

United Kingdom28 sites

  • Bedford Hospital

    Bedford, Bedfordshire, MK42 9DJ

  • Mater Infirmorum Hospital

    Belfast, BT14 6AB

  • University Hospitals Birmingham NHS Foundation Trust

    Birmingham, B15 2TH

  • Birmingham Midland Eye Centre

    Birmingham, B18 7QH

  • Bradford Royal Infirmary

    Bradford, BD9 6RJ

  • Bristol Eye Hospital

    Bristol, Avon, BS1 2LX

  • University Hospital of Wales

    Cardiff, CF14 4XW

  • Primary Care Centre

    Colchester, Essex, CO4 5JR

  • Frimley Park Hospital

    Frimley, GU16 7UJ

  • Gloucestershire Retinal Research Group

    Gloucester, Gloucestershire, GL1 3NN

  • James Paget University Hospitals NHS Foundation Trust

    Gorleston-on-Sea, Norfolk, NR31 6LA

  • North West London Hospitals NHS Trust

    Harrow, HA1 3UJ

  • John Radcliffe Hospital

    Headington, Oxfordshire, OX3 9DU

  • Hull Royal Infirmary

    Hull, East Riding Of Yorkshire, HU3 2KZ

  • St James University Hospital

    Leeds, LS9 7TF

  • Royal Liverpool University Hospital

    Liverpool, Merseyside, L7 8XP

  • Kings College Hospital

    London, Greater London, SE5 9NU

  • Moorfields Eye Hospital

    London, EC1V 2PD

  • Royal Free Hospital

    London, NW3 2QG

  • Maidstone Hospital

    Maidstone, Kent, ME16 9QQ

  • Manchester Royal Eye Hospital

    Manchester, M13 9WL

  • James Cook University Hospital

    Middlesbrough, TS4 3BW

  • Royal Victoria Infirmary

    Newcastle upon Tyne, NE1 4LP

  • Royal Hallamshire Hospital

    Sheffield, S10 2JF

  • Southampton General Hospital

    Southampton, SO16 6YD

  • Sunderland Eye Infirmary

    Sunderland, SR2 9HP

  • Torbay Hospital

    Torquay, Devon, TQ2 7AA

  • The Royal Wolverhampton Hospitals NHS Trust

    Wolverhampton, WV10 0QP

Other trials in United Kingdom

Germany25 sites

  • St. Gertrauden Krankenhaus Berlin, Augenheilkunde

    Berlin, 10713

  • Vivantes Klinikum Neukoelln

    Berlin, 12351

  • Klinikum Chemnitz gGmbH

    Chemnitz, 09116

  • Universitaetsklinikum Koeln

    Cologne, Koeln

  • Carl-Thiem-Klinikum Cottbus gGmbH - Augenklinik

    Cottbus, Brandenburg, 03048

  • Martin-Luther-Universitaet Halle-Wittenberg - Staedtisches Klinikum Dessau (SKD)

    Dessau, Saxony-Anhalt, 06847

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    Dresden, Saxony, 01307

  • Augenklinik des Universitaetsklinikums Erlangen

    Erlangen, Bavaria, 91054

  • Augenzentrum Prof. Koch GmbH

    Frankfurt am Main, Hesse, 60549

  • Universitaetsklinikum Frankfurt Goethe-Universitaet

    Frankfurt am Main, Hesse, 60590

  • Universitaetsmedizin Greifswald

    Greifswald, Mecklenburg-Vorpommern, 17475

  • Universitaetsklinikum Halle (Saale)

    Halle, 06120

  • Medizinische Hochschule Hannover

    Hanover, Lower Saxony, 30625

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120

  • Universitaetsklinikum Leipzig

    Leipzig, Saxony, 04103

  • Universitaetsklinikum Schleswig-Holstein - Campus Luebeck

    Lübeck, Schleswig-Holstein, 23538

  • Apotheke am Klinikum Ludwigshafen

    Ludwigshafen am Rhein, Rhineland-Palatinate, 67063

  • Universitätsklinikum Mannheim

    Mannheim, 68305

  • Klinikum Ernst von Bergmann gGmbH

    Potsdam, Brandenburg, 14467

  • Praxis Dr. Amin Gamael

    Rostock, 18057

  • Universitaetsaugenklinik Rostock

    Rostock, 18057

  • Knappschaftskrankenhaus Sulzbach

    Sulzbach, 66280

  • Medical Eye Research Xpertx Institut gGmbH

    Trier, Bavaria, 86438

  • Private Practice of Dr. Astrid Sader Moritz

    Würzburg, Bavaria, 97080

  • Augenzentrum Erzgebirge

    Zschopau, Saxony, 09405

Other trials in Germany

Italy25 sites

  • Ente Ecclesiastico Ospedale Generale Regionale F Miulli

    Acquaviva Delle Fonti, Piedmont, 70021

  • Azienda Ospedaliero Universitaria delle Marche

    Ancona, The Marches, 60126

  • Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari

    Bari, Apulia, 70124

  • Humanitas Gavazzeni

    Bergamo, Lombardy, 24125

  • Azienda Ospedaliera Universitaria "Policlinico - Vittorio Emanuele" (Presidio Gaspare Rodolico)

    Catania, Sicily, 95123

  • Azienda Ospedaliero Universitaria Mater Domini

    Catanzaro, Calabria, 88100

  • Ospedale Clinicizzato SS. Annunziata

    Chieti, Abruzzo, 66100

  • IRCCS Ospedale Policlinico San Martino

    Genoa, Liguria, 16132

  • Fondazione IRCCS CA? Granda Ospedale Maggiore Policlinico

    Milan, Lombardy, 20122

  • Ospedale San Giuseppe Fatebenefratelli

    Milan, Lombardy, 20123

  • Ospedale San Raffaele

    Milan, Lombardy, 20132

  • Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo (San Paolo-Polo Universitario)

    Milan, Lombardy, 20142

  • Azienda Socio Sanitaria Territoriale Fatebenefratelli (Presidio Ospedale Sacco)

    Milan, Lombardy

  • Fondazione IRCCS - San Gerardo dei Tintori

    Monza, Lombardy, 20900

  • Ospedale Monaldi - AORN dei Colli

    Naples, Campania, 80131

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

    Palermo, Sicily, 90127

  • Fondazione Ptv Policlinico Tor Vergata

    Rome, Lazio, 00133

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Rome, Lazio, 00168

  • G. B. Bietti Fondazione - IRCCS

    Rome, Lazio, 00184

  • Azienda Ospedaliera Sant'Andrea-Universitr di Roma La Sapien

    Rome, Lazio, 189

  • Ospedale Di Sassuolo

    Sassuolo, Sardinia, 41049

  • Ospedale Oftalmico

    Turin, Piedmont, 10122

  • Città della Salute e della Scienza di Torino. Presidio Molinette

    Turin, Piedmont, 10126

  • Ospedale Mauriziano Umberto I

    Turin, Piedmont, 10128

  • Azienda Ospedaliera di Udine Ospedale S. Maria della Misericordia

    Udine, Friuli Venezia Giulia, 33100

Other trials in Italy

Spain25 sites

  • Complejo Hospitalario Universitario de Albacete

    Albacete, 02006

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08025

  • Hospital Dos de Maig

    Barcelona, 08025

  • Hospital Universitari Vall dHebron (CEMCAT)

    Barcelona, 08035

  • Hospital Clinic de Barcelona

    Barcelona, 08036

  • Hospital de Basurto

    Bilbao, Vizcaya, 48013

  • Complejo Asistencial Universitario de Burgos

    Burgos, 09005

  • Hospital Universitario Puerta del Mar

    Cadiz, 11009

  • Hospital Universitario Reina Sofia

    Córdoba, 14004

  • Complejo Hospitalario Universitario de Ferrol

    Ferrol, LA Coruna, 15405

  • Hospital Universitario Virgen de Las Nieves

    Granada, 18012

  • Fundacio Privada Hospital Asil de Granollers

    Granollers, Barcelona, 08402

  • Hospital Universitari de Bellvitge

    L'Hospitalet de Llobregat, Barcelona, 08907

  • Hospital Universitario Insular de Gran Canaria

    Las Palmas de Gran Canaria, LAS Palmas, 35016

  • Complejo Hospitalario San Millán y San Pedro De La Rioja

    Logroño, La Rioja, 26006

  • Hospital Carlos Haya

    Málaga, 29010

  • Hospital Costa del Sol

    Marbella, Malaga, 29603

  • Hospital Universitario Virgen de La Arrixaca

    Murcia, 30120

  • Hospital Universitari Son Espases

    Palma de Mallorca, Balearic Islands, 07120

  • Hospital Universitario Nuestra Señora de la Candelaria

    Santa Cruz de Tenerife, Tenerife, 38010

  • Complejo Hospitalario Universitario de Santiago.

    Santiago de Compostela, LA Coruna, 15706

  • Hospital Universitario Virgen Del Rocio Sevila

    Seville, 41013

  • Hospital Universitario Rio Hortega

    Valladolid, 47012

  • Hospital Xeral-Cies de Vigo

    Vigo, Pontevedra, 36204

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009

Other trials in Spain

United States18 sites

  • Advanced Research

    Coral Springs, Florida, 33067

  • Erie Retinal Surgery

    Erie, Pennsylvania, 16507

  • Cumberland Valley Retina Consultants PC

    Hagerstown, Maryland, 21740

  • University Retina and Macula Associates, PC

    Lemont, Illinois, 60439

  • Retina Associates of Kentucky

    Lexington, Kentucky, 40509

  • Piedmont Eye Center

    Lynchburg, Virginia, 24502

  • Tennessee Retina PC

    Nashville, Tennessee, 37203

  • Wagner Macula and Retina Center

    Norfolk, Virginia, 23502-3933

  • California Eye Specialists Medical group Inc.

    Pasadena, California, 91107

  • Retina Specialty Institute

    Pensacola, Florida, 32503

  • Retinal Research Institute, LLC

    Phoenix, Arizona, 85014

  • Associated Retinal Consultants PC

    Royal Oak, Michigan, 48073

  • Retinal Consultants Medical Group

    Sacramento, California, 95825

  • University of Utah, John Moran Eye Center

    Salt Lake City, Utah, 84132

  • Brown Retina Institute

    San Antonio, Texas, 78251-4551

  • Retina Center of Texas

    Southlake, Texas, 76092-1352

  • Spokane Eye Clinical Research

    Spokane, Washington, 99204

  • Springfield Clinic, Llp

    Springfield, Illinois, 62703

Other trials in United States

Switzerland13 sites

  • Kantonsspital Aarau AG

    Aarau, 5001

  • Universitätsspital Basel

    Basel, 4031

  • Augenklinik am Lindenhofspital

    Bern, 3007

  • Inselspital-Universitaetsspital Bern

    Bern, 3010

  • Vista Augenklinik Binningen

    Binningen, 4102

  • Hôpitaux Universitaires de Genève

    Geneva, 1205

  • Hôpital ophtalmique Jules-Gonin

    Lausanne, 1004

  • Swiss Visio Montchoisi

    Lausanne, 1006

  • LUKS Spitalbetriebe AG

    Lucerne, 6000

  • Ospedale Regionale di Lugano

    Lugano, 6900

  • Pallas Klinik Olten

    Olten, 4600

  • Kantonsspital St. Gallen

    Sankt Gallen, 9007

  • Stadtspital Triemli

    Zurich, 8055

Other trials in Switzerland

Canada11 sites

  • Institut De L'Oeil Des Laurentides

    Boisbriand, Quebec, J7H 0E8

  • Toronto Retina Institute

    Don Mills, Ontario, M1E 4A7

  • St Joseph's Centre for Mountain Health Services

    Hamilton, Ontario, L9C 0E3

  • St. Joseph's Health Care - London

    London, Ontario, N6A 4V2

  • Clinique d'ophtalmologie et de Retine de l'est

    Montreal, Quebec, H1TY 0E2

  • Eye Health MD (Opthalmology)

    Montreal, Quebec, H4P 2S4

  • Retina Surgical Associates

    New Westminster, British Columbia, V3L 5H1

  • Retina Institute of Ottawa

    Ottawa, Ontario, K2B 7E9

  • Centre Oculaire de Quebec

    Québec, G1V 1T6

  • Retina MD Clinic

    Sainte-Catherine, Quebec, J5C 1V9

  • Clarity eye Institute

    Vaughan, Ontario, L4K 0J4

Other trials in Canada

Australia8 sites

  • Lions Outback Vision Service in Broome

    Broome, Western Australia, 6725

  • Centre For Eye Research Australia

    East Melbourne, Victoria, 3002

  • Sunshine Coast University Hospital

    Geebung, Queensland, 4034

  • Retina and Macula Specialists

    Hurstville, New South Wales, 2220

  • Cabrini Hospital Malvern

    Melbourne, Victoria, 3144

  • The Lions Eye Institute

    Nedlands, Western Australia, 6009

  • Retina Specialists Victoria

    Rowville, Victoria, 3178

  • Sydney West Retina

    Westmead, New South Wales, 2145

Other trials in Australia

Israel7 sites

  • Rambam Health Care Campus

    Haifa, 31096

  • Wolfson Medical Center

    Holon, 58100

  • Hadassah

    Jerusalem, 9112001

  • Meir Medical Center

    Kfar Saba, 4428164

  • Rabin MC

    Petah Tikva, 49100

  • Tel-Aviv Sourasky Medical Center

    Tel Aviv, 6423906

  • Assuta Hashalom Medical Center

    Tel Aviv, 6789140

Other trials in Israel

Thailand7 sites

  • Ramathibodi Hospital

    Bangkok, 10400

  • Siriraj Hospital

    Bangkok, 10700

  • Maharaj Nakorn Chiang Mai Hospital

    Chiang Mai, 50200

  • Songklanagarind Hospital

    Hat Yai, Changwat Songkhla, 90110

  • Srinagarind Hospital

    Muang, Changwat Khon Kaen, 40002

  • Metta Pracharak Hospital

    Nakhon Pathom, RAI Khing, 73210

  • King Chulalongkorn Memorial Hospital

    Pathum Wan, Bangkok, 10330

Other trials in Thailand

Argentina5 sites

  • Instituto Oftalmologico de Buenos Aires S.A.

    Buenos Aires, C1056AAN

  • Centro Oftalmologico Dr. Charles S.A.

    Ciudad Autonoma Buenos Aires, C1116ABA

  • Salud Ocular

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1056

  • Centro Privado de Ojos Romagosa S.A

    Córdoba, 5000

  • CEO Centro de Especialidades Oftalmologicas Tucuman

    San Miguel de Tucumán, T4000IOA

Other trials in Argentina

Bulgaria5 sites

  • Medical Center for Eye Health ? Focus Ltd

    Sofia, 1303

  • Specialized Eye Hospital Pentagram

    Sofia, 1319

  • Specialized Hospital for Active Treatment of Ophthalmologic Diseases ?Zora?, OOD

    Sofia, 1784

  • Eye Clinic St. Petka - Varna

    Varna, 9000

  • SHEDAT - Varna EOOD

    Varna, 9002

Other trials in Bulgaria

Croatia5 sites

  • General Hospital Karlovac

    Karlovac, 47000

  • Clinical Hospital Centre Osijek

    Osijek, 31000

  • Clinical Hospital Centre Rijeka

    Rijeka, 51000

  • Special Hospital for Ophthalmology Svjetlost

    Zagreb, 10000

  • University Hospital Center Zagreb

    Zagreb, 10000

Other trials in Croatia

Singapore5 sites

  • National University Hospital

    Singapore, 119228

  • Singapore National Eye Centre

    Singapore, 169608

  • Eye & Retina Surgeons

    Singapore, 248649

  • Tan Tock Seng Hospital

    Singapore, 308433

  • Eagle Eye Centre

    Singapore, 329563

Other trials in Singapore

Poland4 sites

  • Centrum Diagnostyki i Mikrochirurgii Oka LENS

    Olsztyn, 10-424

  • Szpital im. Jozefa Strusia

    Poznan, 61-285

  • Szpital Specjalistyczny im Soko?owskiego

    Wałbrzych, 58-309

  • Wojskowy Instytut Medyczny - Panstwowy Instytut Badawczy

    Warsaw, 04-141

Other trials in Poland

Czechia3 sites

  • Nemocnice Pardubickeho kraje a.s.

    Pardubice, 530 03

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34

  • Tomas Bata Regional Hospital

    Zlín, 762 75

Other trials in Czechia

Denmark3 sites

  • Ålborg Universitets Hospital

    Aalborg, 9100

  • Rigshospitalet Glostrup

    Glostrup Municipality, 2600

  • Sjllands Universitetshospital

    Roskilde, 4000

Other trials in Denmark

Taiwan3 sites

  • Shin Kong Wu Ho-Su Memorial Hospital

    Taipei, 111

  • Far Eastern Memorial Hospital

    Taipei, 220

  • Chang Gung Memorial Hospital - Linkou

    Taoyuan, 333

Other trials in Taiwan

United Arab Emirates3 sites

  • Burjeel Hopital

    Abu Dhabi, 7400

  • Medcare Eye Center - Dubai

    Dubai, 251533

  • Magrabi Eye Hospital

    Dubai Healthcare City, 36267

Other trials in United Arab Emirates

Chile2 sites

  • Centro de la Vision

    Las Condes, 7600830

  • Red Salud UC Christus

    Santiago, Santiago Metropolitan, 7620002

Other trials in Chile

Hong Kong2 sites

  • Grantham Hospital

    Hong Kong, 00000

  • Hong Kong Eye Hospital

    Kowloon, 000000

Other trials in Hong Kong

South Korea2 sites

  • Yeungnam University Hospital

    Daegu, 42415

  • CHA Bundang Medical Center, CHA University

    Seongnam-si, Gyeonggi-do, 13496

Other trials in South Korea

Sweden2 sites

  • Lund University Hospital

    Lund, 22185

  • St Eriks Eye Hospital

    Stockholm, 171 64

Other trials in Sweden

Egypt1 site

  • Egypt Air Hospital

    Cairo, 0000

Other trials in Egypt

Puerto Rico1 site

  • Emanuelli Research and Development Center

    Arecibo, 00612

Other trials in Puerto Rico

Saudi Arabia1 site

  • King Khaled Eye Specialist Hospital

    Riyadh, 12329

Other trials in Saudi Arabia

Slovenia1 site

  • Univerzitetni Klinicni Center Ljubljana Ocesna Klinika

    Ljubljana, 1000

Other trials in Slovenia

About this study

Official title: Real-World, Long-Term Data Collection to Gain Clinical Insights Into Roche Ophthalmology Products (VOYAGER STUDY)

The VOYAGER study is a primary data collection, non-interventional, prospective, multinational, multicenter study. It is designed to collect real-world, long-term data to explore long-term effectiveness, safety, clinical insights, treatment patterns, and factors driving the treatment decisions among patients being treated with specified Roche ophthalmology products in approved retinal indications (Faricimab for neovascular age-related macular degeneration [nAMD], diabetic macular edema [DME], and retinal vein occlusion; Port Delivery System with Ranibizumab for nAMD) in routine clinical practice. This study will not provide or make recommendations on use of any products including Roche products; treatment decisions will be determined by the treating physician and must be made independently to the decision to participate in this study. Participation in this study will not change or influence a patient's standard of care in any way.

Being tested
Faricimab, Port Delivery System with Ranibizumab
Medical subject headings
Retinal Vein Occlusion

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • FaricimabDrug

    Also called VABYSMO™, RO6867461, RG7716

    Faricimab will be administered as per local clinical practice and local labeling.

  • Port Delivery System with RanibizumabCombination product

    Also called SUSVIMO™, RG6321

    The port delivery system with ranibizumab will be administered as per local clinical practice and local labeling.

Study groups in NCT05476926
Study groupRoleWhat they receive
Cohort 1: Faricimab for nAMDNot described
Receives: Drug: Faricimab
Cohort 2: Faricimab for DMENot described
Receives: Drug: Faricimab
Cohort 3: Port Delivery System with Ranibizumab for nAMDNot described
Receives: Combination Product: Port Delivery System with Ranibizumab
Cohort 4: Faricimab for BRVONot described
Receives: Drug: Faricimab
Cohort 5: Faricimab for CRVO/HRVONot described
Receives: Drug: Faricimab

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change in Visual Acuity from Baseline at 1 Year, per Approved Retinal Indication and Product

    Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.

    Measured: Baseline and 1 year

Secondary outcomes (17)

  1. Change in Visual Acuity from Baseline Over Time, per Approved Retinal Indication and Product

    Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.

    Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

  2. Percentage of Eyes on Each Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other) Over Time, per Approved Retinal Indication and Product

    Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

  3. Number of Treatments Over Time, per Approved Retinal Indication and Product

    Measured: At 3, 6, and 12 months, and annually thereafter (up to 5 years)

  4. Cumulative Time Spent on Each Treatment per Eye, Overall and per Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product

    Measured: From Baseline until end of study (up to 5 years)

  5. Percentage of Eyes with Treatment Switch by Reason for Switch Over Time, per Approved Retinal Indication and Product

    Measured: At 3, 6, and 12 months, and annually thereafter (up to 5 years)

  6. Percentage of Eyes with Treatment Regimen Switch (Fixed, Treat-and-Extend, As Needed, or Other) by Reason for Switch Over Time, per Approved Retinal Indication and Product

    Measured: At 3, 6, and 12 months, and annually thereafter (up to 5 years)

  7. Total Number of Visits per Year, per Approved Retinal Indication and Product

    Measured: Annually (up to 5 years)

  8. Number of Visits With or Without Treatment per Year, per Approved Retinal Indication and Product

    Measured: Annually (up to 5 years)

  9. Time Interval Between Treatments per Year, per Approved Retinal Indication and Product

    Measured: Annually (up to 5 years)

  10. Number of Eyes Treated with Ocular Concomitant and Subsequent Medications by Type and Frequency During the Study, per Approved Retinal Indication and Product

    Measured: From Baseline until end of study (up to 5 years)

  11. Change in Visual Acuity from Baseline Over Time, According to Treatment Regimen (Fixed, Treat-and-Extend, As Needed, or Other), per Approved Retinal Indication and Product

    Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.

    Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

  12. Change in Visual Acuity from Baseline Over Time, According to Number of Treatments, per Approved Retinal Indication and Product

    Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.

    Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

  13. Change in Visual Acuity from Baseline Over Time, According to Total Number of Visits, per Approved Retinal Indication and Product

    Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.

    Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

  14. Change in Visual Acuity from Baseline Over Time, According to Treatment Schedule, per Approved Retinal Indication and Product

    Visual acuity will be collected as measured per local practice and then will be converted to the approximate ETDRS letter score.

    Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

  15. Change in Central Subfield Thickness (CST) from Baseline Over Time, per Approved Retinal Indication and Product

    Measured: Baseline, 3, 6, and 12 months, and annually thereafter (up to 5 years)

  16. Number of Participants with at Least One Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product

    Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.

    Measured: From Baseline until end of study (up to 5 years)

  17. Number of Participants with at Least One Non-Ocular Adverse Event, by Severity and Seriousness, per Approved Retinal Indication and Product

    Severity and seriousness will be independently assessed for each adverse event (AE). The terms "severe" and "serious" are not synonymous. Severity refers to the intensity of an AE (e.g., rated as mild, moderate, or severe); the event itself may be of relatively minor medical significance.

    Measured: From Baseline until end of study (up to 5 years)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Jul 2022
  2. Study start21 Nov 2022
  3. Primary completion30 Nov 2026 (estimated)
  4. Study completion30 Nov 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
6,000 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05476926
Sponsor's protocol ID
MR41927
Acronym
VOYAGER
Status last verified
Oct 2026
First submitted
25 Jul 2022
Last updated
2 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: For eligible studies, qualified researchers may request access to individual patient level clinical data. See Roche's commitment to transparency of clinical study information here: https://go.roche.com/data\_sharing

Publications

  • Bailey C, Pearce I, Dinah C, Dodds M, Vidal-Brime L, Wilson A, Ellis J, Hall J, Pohler R, Shi B, Toshev D, Guymer R. Automated data collection from an electronic medical record for a prospective real-world study in patients with retinal disease (VOYAGER). Clin Trials. 2025 Dec;22(6):637-648. doi: 10.1177/17407745251358235. Epub 2025 Aug 31.

    PubMed 40886069

Questions about this trial

What is this clinical trial studying?

An observational study of Neovascular Age-related Macular Degeneration and Diabetic Macular Edema, run by Hoffmann-La Roche at 299 sites in 29 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 299 sites in Japan, France, United Kingdom, Germany, Italy and 24 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in Visual Acuity from Baseline at 1 Year, per Approved Retinal Indication and Product (time frame: Baseline and 1 year). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05476926, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.

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