Stricture of Pelviureteric JunctureNCT05498532
Functional MRI Evaluation in Pyeloureteral Junction Syndrome in Children
An observational study of Stricture of Pelviureteric Juncture, run by Central Hospital, Nancy, France at 1 site in France.
Trial summary
Pyelo-ureteral junction syndrome is the most common urological abnormality in children. Functional MRI has been evaluated several times and has shown good correlation with scintigraphy, but tends to overestimate results. Moreover, those studies included a small number of cases. Read more about this study
- Who is it for?
- Ages 1 day to 17 years
- Conditions the study is for
- Stricture of Pelviureteric Juncture
- What is being tested?
- Functional MRI
- How many people
- 270 participants
- Where
- 1 siteFrance
- Study dates
- 1 Sep 2022to 30 Dec 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 day to 17 years
- All sexes
- No healthy volunteers
- Child
Study population: Children between 0 and 17 years old followed for pyelo-ureteral junction syndrome in the Children hospital of Nancy.
Who may be able to join
- children between 0 and 17 years old
- followed for pyelo-ureteral junction syndrome
Who cannot join
- none
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Functional MRI Usage for Pyelo-ureteral Junction Syndrome : Results of Nancy Children Hospital Cohort
Pyelo-ureteral junction syndrome is the most common urological abnormality in children.
Functional MRI has been evaluated several times and has shown good correlation with scintigraphy, but tends to overestimate results. Moreover, those studies included a small number of cases. Its sensitivity to detect crossing polar vessels is limited.
The investigators aimed to evaluate, in patients between 0 and 1 year old, the correlation between MRI and scintigraphy differential renal function.
The secondary objectives are the evaluation of MRI performances to detect polar vessels; the comparison of surgery times depending on MRI-only realization or MRI and scintigraphy realization.
- Conditions
- Stricture of Pelviureteric Juncture
- Being tested
- Functional MRI
- Keywords
- PUJS, MRI, Scintigraphy, Polar Vessel
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Functional MRIDiagnostic test
Also called Renal Scintigraphy
Anatomical MRI : T2 fiesta, SSFE, HASTE ; 3D T2 ; T1 FAT SAT ; LAVA Functional MRI : T1 FAT SAT with gadolinium
| Study group | Role | What they receive |
|---|---|---|
| PUJS patients | Patients between 0 and 17 years old treated or followed for pyelo-ureteral junction syndrome. Receives: Diagnostic Test: Functional MRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
MRI and scintigraphy differential renal function correlation
Evaluation of differential renal function between MRI and scintigraphy in children between 0 and 1 year old ; Pearson correlation coefficient
Measured: from january 2007 to december 2021
Secondary outcomes (3)
MRI and scintigraphy differential renal function correlation in operated patient
Evaluation of differential renal function between MRI and scintigraphy in children operated for PUJS; Pearson correlation coefficient
Measured: from january 2007 to december 2021
Time difference in patient operated for PUJS depending on MRI realisation ou MRI and scintigraphy realisation
Comparison between the mean time between MRI and surgery, and mean time between MRI, scintigraphy and surgery
Measured: from january 2007 to december 2021
performance of MRI in detecting polar vessel
Polar vessel : comparison between MRI results and operatory observation, sensitivity et specificity analysis
Measured: from january 2007 to december 2021
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Aug 2022
- Study start1 Sep 2022
- Primary completion15 Sep 2022
- Study completion30 Dec 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stricture of Pelviureteric JunctureStudies of the same condition, open and under way.
- More trials run by Central Hospital, Nancy, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 270 participants (actual)
Sponsor and investigators
- Lead sponsor
- Central Hospital, Nancy, France
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Charles Mazeaud, Central Hospital, Nancy, France
- Investigators
- Charles Mazeaud, Principal investigator, CHRU Nancy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05498532
- Sponsor's protocol ID
- 2022PI108
- Status last verified
- Aug 2022
- First submitted
- 10 Aug 2022
- Last updated
- 16 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Functional MRI Usage for Pyelo-ureteral Junction Syndrome : Results of Nancy Children Hospital Cohort
- ClinicalTrials.gov ID
- NCT05498532
- Acronym / sponsor ID
- 2022PI108
- Conditions
- Stricture of Pelviureteric Juncture
- Keywords
- PUJS, MRI, Scintigraphy, Polar Vessel
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 270 participants (actual)
- Lead sponsor
- Central Hospital, Nancy, FranceUniversity, hospital or other
- Study start
- 1 Sep 2022 (actual)
- Primary completion
- 15 Sep 2022 (actual)
- Study completion
- 30 Dec 2022 (actual)
- First posted
- 12 Aug 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Pyelo-ureteral junction syndrome is the most common urological abnormality in children.
Functional MRI has been evaluated several times and has shown good correlation with scintigraphy, but tends to overestimate results. Moreover, those studies included a small number of cases. Its sensitivity to detect crossing polar vessels is limited.
The investigators aimed to evaluate, in patients between 0 and 1 year old, the correlation between MRI and scintigraphy differential renal function.
The secondary objectives are the evaluation of MRI performances to detect polar vessels; the comparison of surgery times depending on MRI-only realization or MRI and scintigraphy realization.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| PUJS patients | – | Diagnostic Test: Functional MRIPatients between 0 and 17 years old treated or followed for pyelo-ureteral junction syndrome. |
Who may qualify
- Ages
- 1 day to 17 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
- Study population
- Children between 0 and 17 years old followed for pyelo-ureteral junction syndrome in the Children hospital of Nancy.
Key inclusion criteria (2 listed)
- children between 0 and 17 years old
- followed for pyelo-ureteral junction syndrome
Key exclusion criteria (1 listed)
- none
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Functional MRIAlso: Renal ScintigraphyAnatomical MRI : T2 fiesta, SSFE, HASTE ; 3D T2 ; T1 FAT SAT ; LAVA Functional MRI : T1 FAT SAT with gadolinium | Diagnostic test | PUJS patients |
Primary outcome
MRI and scintigraphy differential renal function correlation
Time frame: from january 2007 to december 2021
Evaluation of differential renal function between MRI and scintigraphy in children between 0 and 1 year old ; Pearson correlation coefficient
3 secondary outcomes
MRI and scintigraphy differential renal function correlation in operated patient
Time frame: from january 2007 to december 2021
Time difference in patient operated for PUJS depending on MRI realisation ou MRI and scintigraphy realisation
Time frame: from january 2007 to december 2021
performance of MRI in detecting polar vessel
Time frame: from january 2007 to december 2021
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Charles Mazeaud principal investigator
CHRU Nancy
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stricture of Pelviureteric Juncture, run by Central Hospital, Nancy, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
MRI and scintigraphy differential renal function correlation (time frame: from january 2007 to december 2021). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2026.